Introduction: Atypical Antipsychotics (AAPs) are approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder. AAPs are commonly used off-label to treat depression, post-traumatic stress disorder and neuropsychiatric symptoms in dementia due to lack of alternative treatment options and treatment resistance. Concerns for off-label use arise since AAPs increase the risk of cardiovascular events and death. The objectives were 1) describe patterns of RU and costs among off-label AAPs users in a nationally representative population 2) identify prevalence of off-label use in the Medicare population 3) compare RU and costs between off-label AAPs users and non-users with mental health conditions in Medicare. Methods: For the first objective, the Medical Expenditure Panel Survey (MEPS) datasets were used. AAPs users greater than 18 years were identified in this cross-sectional study. Generalized Linear Models (GLM) were used to estimate costs among users and non-users after controlling for age sex, gender, insurance type, marriage status, income and comorbidity index. For the second and third objective, Medicare datasets were used to identify prevalence, RU, and costs of off-label use in Medicare beneficiaries 18 years and older. RU and costs between propensity score matched AAPs user and non-user cohorts were compared in a retrospective cohort study. Results: The adjusted odds of having an office-based outpatient (OR=2.47, 95%CI: 1.55-3.92) or inpatient (OR=1.63, 95%CI: 1.26-2.10) visit were significantly higher among off-label AAPs users. Adjusted office-based visit ($1,943 vs. $1,346), prescription ($4,153 vs. $1,252) and total ($10,694 vs. $4,823) costs were significantly higher among users (p<0.0001). Among Medicare beneficiaries, approximately 37% of AAPs users had no FDA approved diagnosis. The typical off-label user was a white 70-year-old male. Common off-label uses were depression, anxiety and neurotic disorders and dementia. Off-label AAPs users had significantly higher mental health outpatient ($461 vs $297), prescription ($2,349 vs $282) and total ($3,665 vs $1,297) costs per beneficiary than non-users. About 30% of AAPs users had at least one mental health outpatient visit during the year versus 23% of non-users; no significant differences were found in inpatient visits. AAPs non-users had significantly higher all-cause inpatient costs ($6,945 vs. $4,841) per beneficiary (p Conclusion: In a nationally representative population comprising a younger age group AAPs users had higher all-cause RU and total costs than non-users. Off-label prescribing of AAPs continued to be a prevalent practice affecting 37% of Medicare AAPs users. Off-label AAPs users had higher mental health costs but no significant differences in all-cause total health care costs in a Medicare population. Off-label use of AAPs can be a cost-effective option if future research shows off-label use is associated with increased effectiveness, which offsets any additional costs.

A model for health care utilization was applied to a sample of low income women. Demographic Predisposing, Psychosocial Predisposing, Illness Level, and Enabling indicators were examined separately for African American (n = 266), Anglo American (n = 200), and Mexican American (n = 210) women. Structural Equation Modeling revealed that for African American and Anglo American women, Illness Level, the only significant path to Utilization, had a mediating effect on Psychosocial Predisposing indicators. The model for Mexican Americans was the most complex with Enabling indicators affecting Illness Level and Utilization. Psychosocial Predisposing indicators were mediated by Illness Level and Enabling indicators which both directly affected Utilization. Implications of the results for future research are addressed.

Call number: LD2668 .T4 1986 G66 / Master of Science / Animal Science and Industry

Healthcare utilizations are typically measured independently of each other; neglecting the interdependencies between services. An episode of care is suitable for measuring healthcare utilizations of patients with complex health conditions because it tracks all contacts throughout the healthcare system. The overall goal of this research was to construct an episode of care data system to study healthcare utilizations and costs of chronic obstructive pulmonary disease (COPD) exacerbations. To achieve this goal, four related studies were undertaken. The first study (Chapter 2) evaluated the agreement between emergency department (ED) data and hospital records for capturing transitions between the two care settings. Using the κ statistic as a measure of concordance, we found good agreement between the two data sources for intra-facility transfers; but only fair agreement for inter-facility transfers. The results show that linking multiple data sources would be important to identify all related healthcare utilization across care settings. The second study (Chapter 3) linked hospital data, ED data, physician billing claims, and outpatient drug records to construct an episode of care data system for COPD patients. Latent class analysis was used to identify COPD patient groups with distinct healthcare pathways. Pathways were associated with outcomes such as mortality and costs. A few individuals followed complex pathways and incurred high costs. Building on the previous study, the next one (Chapter 4) predicted whether high-cost patients in one episode also incurred high costs in subsequent episodes. Using logistic regression models, we found that patient information routinely collected in administrative health data could satisfactorily predict those who become persistent high users. The final study (Chapter 5) used a cross-validation approach to compare the performance of eight alternative linear regression models for predicting costs of episodes of COPD exacerbations. The results indicate that the robust regression model, a model not often considered for cost prediction, was among the best models for predicting episode-based costs. Overall, this research demonstrated how population-based administrative health databases could be linked to construct an episode of care data system for a chronic health condition. The resulting data system supported novel investigations of healthcare system-wide utilizations and costs. / May 2016

Thesis advisor: Betty Blythe / This dissertation is a secondary analysis of a preexisting dataset, the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN), Assessments 0-4 produced by the National Data Archive on Child Abuse and Neglect (NDACAN) located in the Family Development Center at Cornell University (2001). This is a large scale dataset employing five sites across the United States. Three sites are used: the Northwest, South and Southwest as they contain the largest numbers exhibiting the behavior of interest, hurting animals by children. These sites have sample sizes of 261, 221 and 327 children, respectively. The samples were chosen for varying levels of risk for child abuse and neglect; data collection began in 1991 and is ongoing. The children were born between 1989 and 1996. The number of children who hurt animals at each site was as follows: 16 (South Site), 25 (Northwest Site) and 36 (Southwest Site). Hypotheses were that more males than females would hurt animals; females who hurt animals would show more internalizing problems than males who hurt animals; males who hurt animals would show more externalizing problems than females who hurt animals and children who hurt animals would experience higher rates of physical abuse than children who have not hurt animals. An additional hypothesis was that hurting animals would correlate with aggressive and delinquent behaviors and attention problems as measured by the Child Behavior Checklist (CBCL, Achenbach, 1991). Only one hypothesis was fully supported: aggression, delinquent behavior and attention problems all correlate with higher rates of these behaviors exhibited by children who hurt animals. Aggression, in particular, was associated with the behavior of hurting animals. Physical abuse was not correlated with hurting animals and only one site (the Southwest) showed a statistically significant difference between males and females for this behavior with males more likely to do so. Other findings of interest show correlations between hurting animals and aspects of parenting, day care utilization and foster care placement at at least one site. / Thesis (PhD) — Boston College, 2009. / Submitted to: Boston College. Graduate School of Social Work. / Discipline: Social Work.

A dissertation submitted to the Faculty of Science University of the Witwatersrand, Johannesburg for the degree of Master of Science / The object of this dissertation is to develop a cost effective plasticiser/water-reducer from tannin extracts which does not retard initial strength development. Model compounds of tannins indicated the suitability of substiuued phenols for this purpose, Catechol with adjacent hydroxide groups gave a good combination of improved workability with compressive strengths equivalent to the control. Combinations with ammonia and torrnaldehyde resulted in some greatly improved performances, but also reduced stability of the additives. Urea and metabisulphite did provide some improvements ai!1ddid not adversely affect shelf life. Some of the tannin extracts tested on their own gave considerate improvements in workability and some strengths. To improve the stability of extract solutions, tannins were modified with urea, metabisulphite, small amounts of potassium hydroxide and a alcohol mixture used for pretreatment. Only the first two listed were consistently effective without producing any disadvantages. They even further improved the concrete performance of condensed tannins in particular. Small additions of TEA or its acetate salt resulted to better one day strengths of the modified tannins. Analytical techniques such as infrared and nuclear magnetic resonance were used to monitor some; modifications of the tannins and their result. A test representing early hydration conditions and X-ray diffraction provided clues to the additives mechanism in its interaction with cement. The additives performance was evaluated by comparison with a leading plasticiser/water-reducer, an independent concrete testing laboratory and conduction calorimetry by a research and testing council. A tannin based plasticiser made largely from local raw materials was quickly accepted during a recession by brick and precast manufactures . / Andrew Chakane 2018

Equacionar a problemática do aumento da geração de resíduos sólidos é tarefa complexa, que envolve entre outras, questões de ordem ambiental, de saúde pública e econômica. Quando se trata de disposição final de resíduos sólidos, o aterro sanitário é a única técnica utilizada ambientalmente correta, porém ainda são poucas as cidades que a emprega. Espera-se que nos próximos anos, aumente o número de municípios com aterro sanitário e deste modo, surge um outro problema de cunho ambiental, e em nível mais global, que se refere aos gases liberados pelos aterros sanitários, durante a decomposição anaeróbia da parte orgânica dos resíduos. Estão entre estes gases, o dióxido de carbono e o metano, que contribuem para o efeito estufa. Se por um lado o metano é prejudicial, quando se trata de efeito estufa, por outro lado, pode ser utilizado para fins energéticos como fonte de energia renovável e justamente substituindo os combustíveis fósseis, que representam a maior fonte dos chamados gases de efeito estufa. O presente trabalho, tem como objetivo inicial, levantar as alternativas para o uso de gases de aterro sanitário como fonte de energia, em um segundo momento do trabalho, relacionar as fases da digestão anaeróbia com a produção de metano, através da análise de amostras coletadas em diferentes pontos e profundidades do aterro do município de Piracicaba/SP. / Finding a solution to the problematic of increasing of solid waste is a complex task, which compromises several questions, of order environmental, public health and economic. Referring to the final disposal of solid waste, the landfill is the only right environmenty way use it. Some years from now, is expected a municipality number increasing with landfill and like that, there will be another environmental problem, and more world wide, because the release gases by landfills, during the anaerobic digestion there are. Among these gases carbon dioxide and methane, that contribute to the greenhouse effect. The methane is prejudicial, but on the other hand, it can be used to energetic purpose as renovable energy source in order to substitute fossil fuel. Those are the largest source of greenhouse gas. The goal of this research is to realize a bibliographical study about projects in using landfill gas as energy. Another purpose of it, is to relate the fases of the biodegradability with methane production, using as case study the landfill Pau Queimado (burned wood), located in Piracicaba/SP. According to the result of this research look forward to contributing with dates that can help to evaluate the use of methane as renovable energy source, and as a consequence, reducing the greenhouse effect.

O crescente consumo de medicamentos psicoativos (MPA) pela população brasileira e mundial no século XXI, atrelado ao fato de que algumas dessas substâncias podem gerar dependência física e/ou psíquica nos sujeitos que os utilizam, apontam para a necessidade de desenvolver estudos epidemiológicos que forneçam subsídios para o planejamento de intervenções em saúde que garantam o uso racional desses medicamentos. Este estudo transversal visa estimar a prevalência e caracterizar o perfil de utilização de MPA entre usuários de medicamentos atendidos por todas as farmácias das unidades de saúde do município de Ribeirão Preto-SP, relacionando esses achados com fatores associados ao consumo dessas substâncias. Uma amostra de 1355 usuários de medicamentos (psicoativos ou não) foi entrevistada nas filas das referidas farmácias de setembro a dezembro de 2012. Os pesquisadores coletaram dados sociodemográficos e relacionados à saúde dos indivíduos, além de registrarem todos os medicamentos contidos nas prescrições. Em seguida, três instrumentos foram aplicados para avaliar as variáveis clínicas (i) conhecimento dos indivíduos sobre a farmacoterapia, (ii) adesão à farmacoterapia e (iii) qualidade de vida relacionada à saúde (QdV). A prevalência de uso de MPA foi 31,0% (n=420), sendo que os mais prescritos foram antidepressivos (53,5%) e benzodiazepínicos (24,6%). A maioria dos usuários de MPA era do gênero feminino (81,9%), vivia com companheiro (52,6%), não trabalhava (70,7%), possuía plano de saúde privado (69,2%) e renda per capita de até um salário mínimo (54,0%), não realizava acompanhamento com psicólogo (93,3%), não praticava atividade física regular (78,3%), consumia café diariamente (81,0%), não consumia álcool (86,7%), não fumava (81,4%) e não encontrava-se em polifarmácia (62,4%). A idade média foi 54,5 (DP 13,9) e a escolaridade média correspondeu ao Ensino Fundamental incompleto. Pouco mais da metade dos usuários de MPA exibiram conhecimento satisfatório sobre a farmacoterapia e foram considerados aderentes (57,8% e 53,0%, respectivamente) e a maioria não apresentou QdV satisfatória (73,1%). Houve diferença estatisticamente significativa (p<0,05) entre usuários de MPA e não usuários para as variáveis gênero, faixa etária, situação conjugal, moradia, situação profissional, cuidador, acompanhamento com psicólogo, atividade física regular, consumo de álcool, tabagismo, polifarmácia, conhecimento médio sobre a farmacoterapia, adesão média à farmacoterapia, QdV satisfatória, índice médio EQ- 5D e QdV autorreferida média. Os valores de odds ratio (OR) ajustados mostraram que os fatores associados positivamente com o uso de MPA foram gênero feminino (OR = 2,02; IC 95% 1,31; 3,11) e maior idade (ORref./idosos = 0,36; IC 95% 0,13; 0,99). Dentre os usuários de benzodiazepínicos, 51,1% relatou estar em uso desses MPA há dois anos ou mais, dos quais 55,1% eram idosos. Aproximadamente um em cada três indivíduos utilizava pelo menos um MPA no período estudado, sendo que idosos e mulheres apresentaram maiores chances de uso. Os MPA mais prevalentes foram os antidepressivos e os benzodiazepínicos, sendo a maioria dos usuários destes últimos estava em tratamento com esses MPA há mais de dois anos, dos quais mais da metade eram idosos / The increasing consumption of psychoactive drugs (PAD) in Brazil and worldwide, linked to the fact that some of these substances can cause physical and/or psychic dependence in their users, indicate the need to develop epidemiological studies providing support for planning of health interventions so as to ensure the rational use of these medicines. This cross-sectional study aims to estimate the prevalence and characterize the usage profile of PAD among drug users served by all health facilities\' pharmacies in Ribeirão Preto-SP, relating these findings with factors associated with the consumption of these substances. From september to december 2012, a sample of 1355 drug users (psychoactive or not) was interviewed while waiting in the pharmacies to get their medication. The researchers collected sociodemographic and health related data of individuals, in addition to registering all drugs contained in prescriptions. Then, three instruments were applied to assess the clinical variables (i) knowledge of pharmacotherapy, (ii) adherence to the pharmacotherapy and (iii) health related quality of life (QoL). The prevalence of PAD usage was 31,0% (n = 420), and the most prescribed were antidepressants (53,5%) and benzodiazepines (24,6%). Most PAD users were female (81,9%), lived with a partner (52,6%), did not have a job (70,7%), had a private health insurance (69,2%) and income per capita up to the minimum wage (54,0%), did not undergo follow-up with a psychologist (93,3%), did not practice regular physical activity (78,3%), consumed coffee daily (81,0%), did not consume alcohol (86,7%), did not smoke (81,4%) and were not found in polypharmacy (62,4%). The mean age was 54,5 (SD 13,9) and the average schooling corresponded to incomplete primary education. Over half of the users of MPA exhibited satisfactory knowledge about pharmacotherapy and were considered adherent (57,8% and 53,0%, respectively), and most showed no satisfactory QoL (73,1%). There was a statistically significant difference (p <0.05) between PAD users and nonusers for the variables gender, age, marital status, housing, employment status, caregiver, follow up with psychologist, regular physical activity, alcohol consumption, smoking, polypharmacy, average knowledge about pharmacotherapy, mean adherence to pharmacotherapy, satisfactory QoL, mean EQ-5D index and average self-reported QoL. The adjusted odds ratios (OR) showed that the factors positively associated with the PAD use were female gender (OR = 2,02; 95% CI 1,31; 3,11) and age (ORref./elderly = 0,36, 95% CI 0,13; 0,99). Considering benzodiazepines users, 51,1% reported being in use these PAD for at least two years, 55,1% of whom were elderly. Approximately one in three individuals used at least one PAD in the period studied, while the elderly and women were more likely to use. The most prevalent PAD were antidepressants and benzodiazepines, with most users of the latter receiving these MPA for over two years, of which more than half were elderly.

A Atenção Básica (AB), através da Estratégia Saúde da Família (ESF), caracteriza-se por um conjunto de ações de saúde, no âmbito individual e coletivo, que abrangem a promoção e a proteção da saúde, a prevenção de agravos, o diagnóstico, o tratamento. A AB fundamenta-se em quatro atributos essenciais: atenção ao primeiro contato, coordenação do cuidado, integralidade e longitudinalidade, que operados, possibilitam o acesso, a produção do cuidado e a identificação do perfil da população do território de adscrição. Considerando que dentro do território municipal encontram-se grupos heterogêneos, com perfis e necessidades particulares, traçar as características sociais e as singularidades do adoecer dos territórios de adscrição das ESF pode permitir adequar os serviços da equipe a essas necessidades. O objetivo do presente trabalho epidemiológico, é caracterizar, através do perfil de morbidade e sócio demográfico, os grupos cadastrados nas diferentes equipes e territórios de implantação da Estratégia Saúde da Família, tendo como campo de estudo o município de Patrocínio/MG. Nele existem 16 equipes da ESF, das quais três localizam-se na área central, uma na área rural e 12 na região periférica da cidade (três estratos). A fonte de dados foi os prontuários de pacientes usuários destas unidades assistenciais. Após calculado o tamanho amostral em 596 prontuários, o processo de amostragem ocorreu em múltiplas etapas. Foi feita uma amostragem estratificada das ESF com partilha proporcional entre os estratos, e dentro de cada ESF feita uma amostragem sistemática dos prontuários familiares. Um sorteio casual simples permitiu que fosse selecionado um indivíduo daquela família. Nos prontuários foram coletados os seguintes dados: idade, sexo, ocupação, escolaridade e diagnósticos referentes a última consulta médica realizada no ano de 2010. As variáveis foram transferidas para um banco de dados e descritas posteriormente. Os 564 prontuários analisados, trouxeram os seguintes resultados: na região periférica predominaram mulheres, na faixa etária de 40 60, maioria alfabetizadas (82%), com ocupações consideradas fora da População Economicamente Ativa (PEA) e uma maior freqüência das doenças do aparelho circulatório (18%). Na região central predominaram as mulheres, na faixa etária dos 20 40, pessoas alfabetizadas (92%), aposentados e doenças do aparelho circulatório. Na região rural houve maior prevalência de mulheres, idosos, alfabetizados (94%), fora da PEA e as doenças do aparelho circulatório também prevaleceram. Apesar das regiões apresentarem características parecidas, os achados posteriores de idades, ocupações e morbidades foram diferentes, o que confirma a idéia de diferenças regionais dentro de um mesmo município. Os resultados podem servir de instrumento para um melhor planejamento direcionado das ações em saúde. / Primary Care (PC), through the Family Health Strategy (FHS), is characterized by a set of health actions, both individually and collectively, covering the promotion and protection of health, disease prevention, diagnosis and the disease treatment. The PC is based on four essential attributes: attention to the first contact, care coordination, comprehensiveness and longitudinality. If worked properly, these attributes provide access to care production and helps to identify the population profile of the territory of ascription. Considering that within the municipal area there are heterogeneous groups, with different profiles and particular needs, outline the characteristics and peculiarities of the illness of the ascription territories allows the FHS team to adapt the services to its population profile of the health area. The aim of this epidemiological study, with a transversal nature, is to characterized, by the morbidity and social profiles, the groups registered in different teams and territories of the Family Health Strategy launching, having as a field study the city of Patrocínio / MG. In such study there are 16 teams of FHS, of which two are located in the central area, two in rural areas and 12 in the peripheral region of the city (three strata). The data source was the medical records of patients using these assistance units. After calculating the sample size of 596 records, the sampling process occurred in multiple steps. We conducted a stratified sampling with proportional share of the FHS between the strata, and within each FHS it was made a systematic sampling of family records. A simple casual draw permitted that it was selected one individual of each family. In the records it was collected the following data: age, sex, occupation, education, and diagnostics for the final medical evaluation conducted in 2010. Variables were transferred to a database and were described later. The 564 records analyzed, brought the following results: in the peripheral region there were the predominance of women, aged 40 60, most literate (82%), with occupations considered outside Economically active population (brasilian classification), and a higher frequency of cardiovascular diseases (18%). In the central region there were the predominance of women, aged 20 40, literate (92%), with a higher frequency of retirees and the circulatory diseases showed a higher frequency. In the country region, remembering that it has a small sample, there is a higher prevalence of women, the elderly (aged 60 90), literate (94%), outside of the PEA and circulatory diseases also prevailed. Although at first glance, the regions present similar characteristics, the later findings of ages, occupations and morbidity were different, which confirms the idea of regional differences within the same municipality. The results can serve as a tool for a better planning of directed health actions.

Neste trabalho é apresentado o software de geração automática da escala periódica de trabalho dos profissionais da enfermagem. Este software tem a forma de uma Intranet, o que facilita a implantação do sistema, sendo desnecessário a instalação de softwares clientes do banco de dados ou qualquer outro tipo de configuração nas máquinas dos usuários. Outra característica relevante deste sistema é que ele se classifica como um Sistema de Apoio à Decisão, pois de posse das informações dos funcionários da instituição, ele gera uma sugestão da escala periódica de trabalho, uma vez que o enfermeiro encarregado da confecção dela pode, a qualquer momento, alterá-la manualmente. A escala é gerada para períodos, normalmente de um mês de duração. Cada funcionário está vinculado a um local de trabalho e a um cargo. No momento da geração da nova escala, é necessário informar, portanto, qual o período, qual o cargo e qual o local de trabalho para os quais se deseja elaborar a escala de trabalho. Para a elaboração da escala, utilizou-se a Programação 0/1, uma técnica de Programação Linear Inteira. Nesta técnica, as variáveis podem receber apenas dois valores, zero ou um. São geradas variáveis que representam cada uma, um funcionário em um dia do período e um turno do dia, onde se esta variável receber o valor 1, significa que o funcionário irá trabalhar e se receber o valor zero, significa que ele irá folgar no dia e turno indicados pela variável. Foram levantadas treze restrições para a geração da escala periódica de trabalho de acordo com Regulamento de Recursos Humanos da Instituição onde se desenvolveu o software. Estas restrições são regras que devem ser respeitadas pelo sistema ao gerar a escala de trabalho. Elas são descritas em um arquivo que é exportado para software LINGO, software que gera uma solução para problemas de Programação Linear e Não-Linear, desenvolvido pela LINDO Systems Inc, Chigago, USA e, que é o aplicativo capaz de resolver o problema de Programação 0/1 e calcular em quais dias e turnos cada um dos funcionários irá trabalhar. Após a geração deste arquivo, o software efetua o cálculo e um arquivo com os dados de resposta, que é importado para o sistema de geração automática da escala de trabalho e então disponibilizado em forma de tabela para consulta dos profissionais. Ao término do processo de geração, os funcionários podem avaliar o resultado do cálculo e, sugerir modificações, pois, se as informações que geram o arquivo de restrições forem modificadas, o resultado final consequentemente será outro. Por fim, a geração da escala de periódica de trabalho ficou reduzida a, em média, cinco segundos. / The software of automatic generation of the periodic work schedule of the nursing professionals is presented on this work. This software has the shape of an Intranet, what facilitates the system implementation and makes the installation of client softwares of the data bank or any other type of configuration at the users´ computers unnecessary. Another relevant characteristic of this system is that it classifies itself as a Decision-Maker Support System once it generates a suggestion for the work schedule based on the information of the institution employees and it can be also altered manually, at any moment, by the nurse who is responsible for organizing the schedule which is generated for periods or shifts that usually last a month. Each employee is linked to a workplace and a function. So when generating a new schedule, it is necessary to inform the period, the function and the workplace to have the desired work schedule elaborated. The Programming 0/1, a technique of Linear Programming; was used to elaborate the schedule. With this technique, the variables may receive only two values, zero or one. Variables that each one represents an employee on a day of the period and a day shift, where if this variable receives the value one, it means that the employee is going to work and if it receives the value zero, it means he / she is not going to work on the day and shift indicated by the variable. Thirteen restrictions to generate the work schedule according to the Regulation of the Human Resources of the Institution where the software was developed were taken into consideration. These restrictions are rules that must be respected by the system when generating the work schedule. They are described in a file that is exported to LINGO Software which generates a solution to problems of Linear and Non-Linear Programming problems and is developed by LINDO Systems Inc, Chicago, USA. This applicative is capable of solving the problem of Programming 0/1 and calculating on which days and shifts each one of the employees is going to work. After generating this file, the software calculates it and generates a file with the answers. That file is imported to the system of automatic generation of schedules and then made available as a grid so that the professionals may consult it. At the end of the generation process, the employees may evaluate the results of the calculations and suggest modifications. If the information that generates the file of restrictions is modified, the final result is consequently going to be another one. Finally, the generation of the periodic work schedule was reduced to about five seconds.