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Biophysical and structural characterization of bacteriophage lambda terminase : a DNA packaging enzyme /Ortega, Marcos Eduardo. January 2006 (has links)
Thesis (Ph.D. in Biochemistry) -- University of Colorado, 2006. / Typescript. Includes bibliographical references (leaves 118-126). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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Towards Elucidation of a Viral DNA Packaging MotorSchwartz, Chad T. 01 January 2013 (has links)
Previously, gp16, the ATPase protein of phi29 DNA packaging motor, was an enigma due to its tendency to form multiple oligomeric states. Recently we employed new methodologies to decipher both its stoichiometry and also the mechanism in which the protein functions to hydrolyze ATP and provide the driving force for DNA packaging. The oligomeric states were determined by biochemical and biophysical approaches. Contrary to many reported intriguing models of viral DNA packaging, it was found that phi29 DNA packaging motor permits the translocation of DNA unidirectionally and driven cooperatively by three rings of defined shape. The mechanism for the generation of force and the role of adenosine and phosphate in motor motion were demonstrated. It was concluded that phi29 genomic DNA is pushed to traverse the motor channel section by section with the aid of ATPase gp16, similar to the hexameric AAA+ family in the translocation of dsDNA. A new model of "Push through a One-way Valve" for the mechanism of viral DNA packaging motor was coined to describe the coordinated interaction among the hexameric packaging ATPase gp16 and the revolution mechanism of the dodecameric channel which serves as a control device to regulate the directional movement of dsDNA.
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Molecular Dynamics Studies of the Phi29 Connector-DNA complexKumar, Rajendra 18 July 2014 (has links)
No description available.
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Structure and Function Study of Phi29 DNA packaging motorFang, Huaming January 2012 (has links)
No description available.
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