No description available.

Hyperlipidemia caused by a diet high in saturated fat can lead to visceral fat weight gain, obesity, and metabolic syndrome. Being over-weight from visceral fat has been linked to increased risk of developing most age-related diseases and disability, along with a lower income potential and quality of life. However, researchers are just beginning to understand the biological mechanisms that regulate the conversion of excess calories into visceral fat storage rather than glycogen or muscle. Epidemiological studies have repeatedly shown a comorbid association between age-related diseases involving hyperlipemia and circulating levels of uric acid, but not a direct association. This study utilized archival data from 31 healthy, middle-aged adults, who participated in a randomized, double-blind, crossover clinical trial on blood markers of lipidemia and inflammation following a high saturated fat (HSF) verses a "healthy" polyunsaturated fat (PUFA) meal. This primary study was conducted and funded by the National Institute on Aging. A secondary analysis of this data using Pearson's correlation with least squares (2-tailed) regression modeling found that when stratified by gender, baseline uric acid level was an independent and significant predictor of the lipemic response from the HSF, but not the PUFA meal. The linear regression plots indicated that males with uric acid levels above 4.5, and females above 3.0 mg/dL, had a progressively increased lipemic response to the HSF meal. The public health utility of this finding may include the clinical use of the gender-specific linear regression plots of uric acid values to identify and advise individuals at risk for hyperlipidemia from a diet high in saturated fats.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18450号 / 医博第3905号 / 新制||医||1004(附属図書館) / 31328 / 京都大学大学院医学研究科医学専攻 / (主査)教授 伊達 洋至, 教授 稲垣 暢也, 教授 森田 智視 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19400号 / 医博第4051号 / 新制||医||1012(附属図書館) / 32425 / 京都大学大学院医学研究科医学専攻 / (主査)教授 横出 正之, 教授 福原 俊一, 教授 山下 潤 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21304号 / 人健博第60号 / 新制||人健||5(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 古田 真里枝, 教授 藤井 康友, 教授 横出 正之 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DGAM

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13233号 / 論医博第2173号 / 新制||医||1036(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 川村 孝, 教授 横出 正之, 教授 福原 俊一 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

Although intestinal involvement occurs in more than half of the cases with KS that are HIV positive, it is uncommon in the classical form, as it occurs in approximately 10% of the patients. We present the case of a 60-year-old male patient with a one-year disease time characterized by having violaceous lesions on the feet and the hands, slightly pruritic and 2 months of epigastralgia and constipation with weight loss of approximately 12 percent of his total body weight. In the physical examination multiple violaceous papule-like lesions are shown on the hands and the feet, some coalescing to form plaques. Laboratory tests revealed a mild normocytic normocytic anemia, the serology for viral hepatitis B and C was negative, HIV negative and ELISA test too. An upper endoscopy was performed and multiple maculopapular and erythematous-violaceous lesions were observed in the esoph-agus, the stomach and the duodenum. In the colonoscopy, multiple lesions with similar characteristics in the ileum, throughout the colon and in the rectum were recognized. The biopsy result was compatible with the KS in all lesions and it was confirmed with the positive HVV-8 immunohis-tochemistry. This case highlights the likelihood of presenting GI SK in elderly patients with gastrointestinal compromise and cutaneous findings, HIV negatives as well as the need to realize an adequate discarding by performing endoscopic studies with the biopsies to optimize treatment. / Revisión por pares

HRP applied to cut dorsal and ventral roots of the cat sacral spinal cord labeled afferent axons with swellings in close apposition to labeled preganglionic neurons (PGNs) in the sacral parasympathetic nucleus. Electron microscopy allowed characterization of synaptic contacts between afferents and PGNs. The results suggest that both the dorsal and ventral root afferents can directly activate autonomic preganglionic neurons.

Insulin sensitivity has been positively correlated with a healthy and extended lifespan, while insulin resistance, decreased insulin sensitivity, has been linked to aging and is the main indicative of type 2 diabetes. Growth Hormone Receptor/ Binding Protein Knockout mice (GHRKO), although obese, are characterized by high insulin sensitivity and a prolonged lifespan. Due to the absence of growth hormone receptors (GHR), growth hormone (GH) is unable to activate its downstream pathway. Interestingly, the secretory activity of visceral fat in GHRKO mice is altered stimulating insulin sensitivity. In this study, we transplanted normal (N) mice with GHRKO visceral fat pads to determine the role of visceral fat developed with the absence of GH signaling on the insulin-signaling pathway in animals with physiologically normal GH action. We found that the visceral fat transplant (VFT) helped the normal mice gain the beneficial effects of fat developed in the absence of GH and caused improvement of their whole body insulin sensitivity when comparing with sham-operated mice and with mice that received visceral fat from N animals. In presented study, RT-PCR was used to determine the levels of hepatic mRNA expression between three experimental groups including Normal-sham mice (N-S), normal mice transplanted with visceral fat from normal animals (N-N), and normal mice receiving visceral fat from GHRKO mice (N-KO). Additionally, Western Blot and ELISA were used to determine the level of total and phosphorylated proteins. By studying the effect of visceral fat transplant from GHRKO or N mice on the whole body insulin signaling in N male mice, and testing different genes expression and proteins quantification, we can shed light on the mechanism by which white adipose tissue (WAT) regulates whole body insulin sensitivity and longevity as well as understanding the role of WATs in development of diabetes and the process behind insulin resistance.

No description available.