Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-19T13:29:23Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2537968 bytes, checksum: 818511856a7e650015c59ec1bcccaedc (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido a falta de capa institucional. on 2017-07-28T20:35:05Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-31T13:19:01Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-03T17:49:44Z (GMT) No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Made available in DSpace on 2017-08-03T18:05:42Z (GMT). No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) Previous issue date: 2017-04-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Organic changes caused by aging cause clinical manifestations in several situations common to elderly patients. Among them, the aging process is associated with a decline in muscle mass and strength. Several factors are involved in this mechanism, among them low D vitamin. OBJECTIVES: verify the effect of D vitamin supplementation on handgrip strength and body composition in elderly women. METHODS: A longitudinal, interventional, uncontrolled study with 54 elderly women at community who do not have severe disabling diseases and do not take D vitamin supplementation. Serum (25 (OH) D) below 30 ng / mL were inclusion criteria in the study. The elderly women performed handgrip strength test (FM), body composition examination by DXA and laboratory tests (parathyroid hormone (PTH), urea (Ur), creatinine (Cr), serum calcium (Ca++) and interleukin-6)). Participants with serum vitamin D levels between 20-29.9 ng/mL were supplemented with 2000 IU per day of cholecalciferol for twelve weeks and those with levels below 20 ng/mL received 10000 IU per day of cholecalciferol for the same period. All had concomitant taking of calcium carbonate 1 g per day. At the end, handgrip strength test, biochemical evaluation and body composition were repeated. For the description of the sample, mean, standard deviation and percentage were used. For data correlation with normal distribution were used Pearson correlation test, and for comparison, Student's T test and for data with non-normal distribution, median, Spearman, Mann-Whitney U and Wilcoxon correlation test. RESULTS: Of the 54 elderly women included in the study, 52 concluded. The mean age was 72 ? 9 years. The mean value before and after supplementation were 25 (OH) D 18.9 ? 6.65 and 38.15 (24.4 ? 126.2) (p= 0,000), PTH 87.15 ? 40.08 and 67.55 ? 30.04 (p = 0,000), IL-6 3.6 (1.5 ? 15.8) and 2.25 (1.5 ? 45.9) (p = 0.04), FM 42.17 ? 14.12 and 42.55 ? 12.78 (p = 0,733), MM 38663 ? 5546 and 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 and 9,4 ? 0,35 (p = 0,004). The correlation analysis between variables after the intervention showed an inverse correlation between 25 (OH) D and PTH, FM and IL-6 and between Ca++ and IL-6. Direct correlations occurred between FM and MM and between FM and Ca++. CONCLUSION: Vitamin D supplementation increased serum levels of 25 (OH) D significantly, as well as reduced serum PTH and IL-6 levels, without changes in handgrip strength and total body lean mass. / Mudan?as org?nicas provocadas pelo envelhecimento originam manifesta??es cl?nicas em v?rias situa??es habituais aos pacientes idosos. Dentre elas, o processo de envelhecimento est? associado a um decl?nio na massa e for?a muscular. V?rios fatores est?o envolvidos nesse mecanismo, dentre eles, destaca-se a defici?ncia da vitamina D. OBJETIVO: verificar o efeito da suplementa??o de vitamina D na for?a de preens?o palmar e composi??o corporal em idosas. M?TODOS: Estudo longitudinal, intervencionista, n?o controlado com 54 idosas da comunidade que n?o possuam doen?as incapacitantes graves e que n?o utilizem reposi??o de vitamina D. N?veis s?ricos de vitamina D (25(OH)D) inferiores a 30 ng/mL foram crit?rios de inclus?o no estudo. As idosas realizaram teste de for?a de preens?o manual (FM), exame de composi??o corporal por DXA e exames laboratoriais (paratorm?nio (PTH), ureia (Ur), creatinina (Cr), c?lcio s?rico (Ca++) e interleucina-6 (IL-6)). As participantes com n?veis s?ricos de vitamina D entre 20 ? 29,9 ng/mL foram suplementadas com 2000 UI ao dia de colecalciferol durante dozes semanas e as com n?veis inferiores a 20 ng/mL receberam 10000 UI ao dia de colecalciferol pelo mesmo per?odo. Todas fizeram uso concomitante de carbonato de c?lcio 1 g ao dia. Ao final do per?odo de reposi??o, foram repetidos os testes de for?a manual, avalia??o bioqu?mica e composi??o corporal. Para a descri??o da amostra, foram utilizados m?dia, desvio-padr?o e percentual. Para a correla??o dos dados com distribui??o normal foi utilizado o teste de correla??o de Pearson, e para compara??o, teste T de Student e para os dados com distribui??o n?o-normal, utilizou-se o teste de correla??o de Spearman, Mann-Whitney U e Wilcoxon. RESULTADOS: Das 54 participantes, 52 idosas aderiram ao estudo, com idade m?dia de 72 ? 9 anos. Os valores m?dios antes e depois da interven??o foram 25(OH)D 18,9 ? 6,65 e 38,15 (24,4 ? 126,2) (p= 0,000), PTH 87,15 ? 40,08 e 67,55 ? 30,04 (p = 0,000), IL-6 3,6 (1,5 ? 15,8) e 2,25 (1,5 ? 45,9) (p = 0,04), FM 42,17 ? 14,12 e 42,55 ? 12,78 (p = 0,733) , Massa Magra (MM) 38663 ? 5546 e 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 e 9,4 ? 0,35 (p = 0,004). A an?lise de correla??o entre as vari?veis ap?s a interven??o demonstrou rela??o inversa entre 25(OH)D e PTH, FM e IL -6 e entre Ca++ e IL-6. Correla??es diretas ocorreram entre FM e MM e entre FM e Ca++ CONCLUS?O: A suplementa??o de vitamina D aumentou os n?veis s?ricos de 25(OH)D, bem como reduziu os valores de PTH e IL-6, n?o havendo modifica??es na for?a de preens?o palmar e massa magra corporal total.