Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2018-12-17T15:46:17Z No. of bitstreams: 1 RIBEIRO_ANDRE_TES.pdf: 4012990 bytes, checksum: 5933986cd6984b54d4f8aa39de819ad9 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-12-18T16:44:11Z (GMT) No. of bitstreams: 1 RIBEIRO_ANDRE_TES.pdf: 4012990 bytes, checksum: 5933986cd6984b54d4f8aa39de819ad9 (MD5) / Made available in DSpace on 2018-12-18T16:51:19Z (GMT). No. of bitstreams: 1 RIBEIRO_ANDRE_TES.pdf: 4012990 bytes, checksum: 5933986cd6984b54d4f8aa39de819ad9 (MD5) Previous issue date: 2018-07-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Introduction: Fragility is a common clinical syndrome in the elderly, which causes great risks to health, disabilities, hospitalizations and consequently a high risk of mortality. The available knowledge about the multiple aspects of fragility in the elderly suggests that it is a predictor of changes in body composition, with a decline in lean mass, and in this way, a relevance in the study of the subject in long-lived patients is observed. In this aspect, the present study proposes the use of Ultrasound (US) because it is a portable method, with ease of handling and not be influenced by skinfolds, which minimizes possible inter and intra-rater variations, therefore, with greater reliability in relation to the results presented. Objectives: To identify the characteristics of the body composition through the US in the groups of non-frailty and frailty oldest-old. Methods: The greatest possible number of oldest-old were traced through the Geriatrics General Ambulatory of Hospital S?o Lucas / PUCRS. Personal and social data were collected through a questionnaire. Fragility data were obtained through five phenotypes. Body composition data were obtained through the portable US. For the analysis of the data, the sample was separated into two groups, according to the classification of fragility: frailty and non-frailty. Percentage differences between the categorical variables were calculated through the creation of cross tables between the variables. Numerical variables were presented through means, standard deviations and variances. Results: 52 elderly people with a mean age of 90.10 ? 4.49 years were evaluated. 63.5% were classified as non-frailty and 36.5% frailty. The majority of the sample is composed of women (73.1%). White race totals 86.5% and 80.5% are widowers. 31.6% of the frailty oldest-old live alone. The average amenities were higher for the frailty (3.21 ? 1.14) compared to non-frailty (2.15 ? 1.67). In the analysis of schooling, those who reported having elementary education (? 8th grade) had a higher odds ratio [RP1,22 (CI95% 1.00-1.49)] to develop fragility compared to the reference category (? high school) (p = 0.046). Through the classification of the percentage of body fat (%F) by the US, it was observed that the female longevity with scores above 33 %F, presented a higher odds ratio [RP1,81 (IC95% 1,30-2, 52)] to develop fragility compared to the category with the reference %F (<29 %F) (p <0.001). For males, those who obtained scores above 26 %F had a greater chance [RP1,81 (IC95% 1.30-2.52)] of developing fragility compared to the category with the reference %F (<23 %F) (p <0.001).Conclusion: The present study showed persuasive results between fragility syndrome and body composition. Through the analysis of body composition by Ultrasound and according to the points of cuts predicted in the literature, it was possible to identify associations between obesity and increased risk of frailty in longevity. It was concluded that, the higher the body fat levels and the lower the lean mass (sarcopenic obesity), the greater the level of fragility of the longevity above 80 years of age. / Introdu??o: Fragilidade ? uma s?ndrome cl?nica comum em idosos, que ocasiona grandes riscos para a sa?de, incapacidades, hospitaliza??es e como consequ?ncia grande risco de mortalidade. O conhecimento dispon?vel sobre os m?ltiplos aspectos da fragilidade em idosos sugerem que esta seja preditora de altera??es na composi??o corporal, com decl?nio da massa magra, e desta maneira, observa-se uma relev?ncia no estudo do tema em pacientes longevos. Neste aspecto, o presente estudo prop?e o uso do Ultrassom (US) por ser um m?todo port?til, com facilidade de manuseio e n?o ser influenci?vel pelas dobras cut?neas corporais, o que minimiza poss?veis varia??es inter e intra-avaliador, portanto, com maior confiabilidade em rela??o aos resultados apresentados. Objetivos: Identificar as caracter?sticas da composi??o corporal atrav?s do US nos grupos de longevos n?o fr?geis e com fragilidade. M?todos: Os longevos foram rastreados atrav?s do Ambulat?rio Geral de Geriatria do Hospital S?o Lucas/PUCRS. Os dados pessoais e sociais foram coletados atrav?s de um question?rio. Dados de fragilidade foram obtidos atrav?s de cinco fen?tipos. Dados de composi??o corporal foram obtidos atrav?s do US port?til. Para a an?lise dos dados, a amostra foi separada em dois grupos, de acordo com a classifica??o da fragilidade: fr?gil e n?o fr?gil. As vari?veis num?ricas foram apresentadas atrav?s das m?dias, desvio padr?es e vari?ncias. Aprovado pelo CEP-PUCRS sob n?mero CAEE 68165117.6.0000.5336. Resultados: A amostra foi composta por 52 idosos longevos com idade m?dia de 90,10?4,49 anos. 63,5% foram classificados como n?o-fr?geis e 36,5% fr?geis. A maioria s?o mulheres (73,1%). Ra?a branca soma 86,5% e 80,5% s?o vi?vos. 31,6% dos longevos fr?geis moram sozinhos. A m?dia de comorbidades foi maior para os fr?geis (3,21?1,14) comparada aos n?o-fr?geis (2,15?1,67). Na an?lise da escolaridade, longevos que relataram ter ensino fundamental (?8?s?rie), apresentaram maior raz?o de chance [RP1,22(IC95%1,00-1,49)] de desenvolver a fragilidade frente ? categoria de refer?ncia (?Ensino M?dio) (p=0,046). Atrav?s da classifica??o do percentual de gordura corporal (%G) pelo US, observou-se que os longevos do sexo feminino com escores acima de 33 %G, apresentaram maior raz?o de chance [RP1,81(IC95%1,30-2,52)] de desenvolver a fragilidade frente ? categoria com o %G de refer?ncia (<29%G) (p<0,001). Para o sexo masculino, os que obtiveram escores acima de 26 %G, apresentaram maior chance !5 [RP1,81(IC95%1,30-2,52)] de desenvolver a fragilidade frente ? categoria com o %G de refer?ncia (<23%G) (p<0,001). Conclus?o: O presente estudo mostrou resultados persuasivos entre a s?ndrome de fragilidade e a composi??o corporal. Atrav?s das an?lises de composi??o corporal por Ultrassom e conforme os pontos de cortes preditos pela literatura, foi poss?vel identificar associa??es entre obesidade e aumento do risco de fragilidade em longevos. Concluiu-se que, quanto maiores os n?veis de gordura corporal e menores os de massa magra (obesidade sarcop?nica),maior ? o n?vel de fragilidade dos longevos acima de 80 anos de idade.

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-07-26T14:02:23Z No. of bitstreams: 1 DIS_VIVIAN_CUNHA_TANSCHEIT_COMPLETO.pdf: 868762 bytes, checksum: 536b7649ac48a271688dbc5fac314b6d (MD5) / Made available in DSpace on 2016-07-26T14:02:24Z (GMT). No. of bitstreams: 1 DIS_VIVIAN_CUNHA_TANSCHEIT_COMPLETO.pdf: 868762 bytes, checksum: 536b7649ac48a271688dbc5fac314b6d (MD5) Previous issue date: 2016-03-29 / Introduction: Kidney transplantation is the most effective therapy for chronic renal patients; complications as the delayed graft function (DGF) are common, generating long-term consequences for the prognosis of kidney transplant. The impact of total body volume immediate pre renal transplant in outcome of transplantation is unknown, as well as the influence of the dialysis modality pre transplantation in the occurrence of DGF. The body volume can be measured by bioimpedance, which helps to quantify body water, its distribution and consequent classification in euvolemic, hypovolemic or hypervolemic. Objective: To evaluate volume status by bioelectrical impedance method in patients on dialysis undergoing kidney transplantation and relate to the need for dialysis post operatively. Methods: A prospective longitudinal observational study included chronic renal patients, who underwent a kidney transplant at the Hospital S?o Lucas, Pontifical Catholic University of Rio Grande do Sul between October 2014 and December 2015. The evaluation of the body composition was performed using the body composition monitor - BCM (Fresenius Medical Care), pre renal transplantation, immediately before going to the operating room, and patients were followed during the first week of recovery. DGF was defined as the need of dialysis during the first week after transplantation. Student's t test to compare continuous variables and categorical we used the chi-square test or Fisher's exact test. The significance level was set at alpha = 0.05 and we used the statistical package SPSS version 17 for Windows. This study was approved by the ethics committee of the institution protocol number 826 866. Results: We studied 36 kidney transplant patients (50.3 +14.4 years; 22 male), classified according to body volume, mostly were hypervolemic (16, 44.4%), and euvolemic (15, 41.7 %). DGF was seen in 25 (69.4%) patients, hyperkalemia was the main indication for dialysis (19, 59.2%) and 27 (75%) were discharged with a gain of renal function. The volemic status showed no significant association with the occurrence of DGF (P = 0.610), while peritoneal dialysis (PD) was associated with reduced need for dialysis in the first week after surgery (P = 0.006). Conclusions: Preoperative volemic status in patients undergoing renal transplantation has no association with the incidence of DGF, the volume status was similar between modalities (PD patients and hemodialysis). The data suggest that DP before transplantation decreases the chances of occurrence of DGF. / Introdu??o: O transplante renal ? a terapia mais eficaz para o paciente renal cr?nico, por?m pode apresentar complica??es como a fun??o retardada do enxerto (DGF), gerando consequ?ncias a longo prazo no progn?stico dos transplantados renais. O impacto da volemia pr?-transplante renal no desfecho imediato do transplante ? desconhecido, assim como a influ?ncia da modalidade de di?lise pr?-transplante na ocorr?ncia de DGF. O volume corporal pode ser avaliado por bioimped?ncia, o que auxilia na quantifica??o da ?gua corp?rea, sua distribui??o e consequente classifica??o em euvol?mico, hipovol?mico ou hipervol?mico. Objetivo: Avaliar, pelo m?todo de bioimped?ncia el?trica, o estado vol?mico pr?-transplante de pacientes submetidos ao transplante renal e relacionar com a necessidade de di?lise no p?s-operat?rio. M?todos: Estudo observacional prospectivo e longitudinal, incluiu pacientes renais cr?nicos submetidos a transplante renal no Hospital S?o Lucas da Pontif?cia Universidade Cat?lica do Rio Grande do Sul no per?odo entre outubro de 2014 e dezembro de 2015. A avalia??o da composi??o corporal foi realizada utilizando o monitor de composi??o corporal - BCM (Fresenius Medical Care), no pr?-operat?rio do transplante renal, imediatamente antes da ida ao bloco cir?rgico, e os pacientes foram acompanhados durante a primeira semana de recupera??o. DGF foi definida como a necessidade de di?lise na primeira semana p?s transplante. Foi aplicado o teste t de Student para compara??o de vari?veis cont?nuas e para as categ?ricas usou-se o teste do qui quadrado ou teste exato de Fisher. O n?vel de signific?ncia adotado foi de alfa=0,05 e para as an?lises empregou-se o pacote estat?stico SPSS vers?o 17 para Windows. Este estudo foi aprovado pelo Comit? de ?tica da institui??o atrav?s do Parecer n?826.866. Resultados: Foram estudados 36 pacientes transplantados renais (50,3 +14,4 anos; 22 masculinos), classificados de acordo com a volemia, em sua maioria como hipervol?micos (16, 44,4%) e euvol?micos (15, 41,7%). DGF foi vista em 25 (69,4%) pacientes, sendo a hipercalemia a principal indica??o de di?lise (19, 59,2%) e 27 (75%) tiveram alta hospitalar com ganho de fun??o renal. A volemia n?o foi associada ? ocorr?ncia de DGF (P=0,610), por?m a di?lise peritoneal (DP) foi relacionada com menor necessidade de di?lise na primeira semana de p?s-operat?rio (P=0,006). Conclus?es: A volemia pr?-operat?ria dos pacientes transplantados renais n?o foi associada ? incid?ncia de DGF, o estado vol?mico foi similar entre os pacientes em DP e hemodi?lise. Os dados sugerem que fazer DP antes do transplante diminui as chances da ocorr?ncia de DGF.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-05T00:08:46Z No. of bitstreams: 1 JonatasCardosoDaSilveira_DISSERT.pdf: 960551 bytes, checksum: 6a74842dfe817418a8368241ea11424f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-16T21:23:01Z (GMT) No. of bitstreams: 1 JonatasCardosoDaSilveira_DISSERT.pdf: 960551 bytes, checksum: 6a74842dfe817418a8368241ea11424f (MD5) / Made available in DSpace on 2017-10-16T21:23:01Z (GMT). No. of bitstreams: 1 JonatasCardosoDaSilveira_DISSERT.pdf: 960551 bytes, checksum: 6a74842dfe817418a8368241ea11424f (MD5) Previous issue date: 2017-03-31 / A distribui??o de massa de um indiv?duo est? fortemente relacionada com os n?veis gerais de sa?de e condicionamento f?sico do mesmo. Para Mouad e Matias (2015), atrav?s da composi??o corporal (CC) ? poss?vel saber informa??es como tamanho, forma, constitui??o e caracter?sticas gen?ticas e adquiridas da pessoa ou at? mesmo de uma popula??o. Objetivo: Testar a validade de predi??o da massa livre de gordura de atletas universit?rios de futebol por equa??es de bioimpedanciometria, utilizando a Absortometria de Raios X de Dupla Energia como padr?o. M?todos: A amostra foi composta por 39 homens, da sele??o de futebol universit?ria da Universidade Federal do Rio Grande do Norte. As medidas de DXA e da BIA foram coletadas no mesmo dia no laborat?rio da institui??o. Para c?lculo de composi??o por BIA foi utilizado um software da Biotetronic, que propos as equa??es de Segal et. Al. (1988), Gray et. Al. (1989), Lohman (1992) e Carvalho e Neto (1998). Na an?lise dos dados foi verificada suanormalidade, e efetuada an?lise descritiva de m?dia e desvio padr?o, test T de Student para amostra dependentes (p < 0,05), modelos de regress?o linear, coeficientes de correla??o de Pearson (R), os coeficientes de determina??o (R2) e o erro padr?o de estimativa (EPE), assim como o coeficiente de correla?ao de concord?ncia (CCC), al?m do m?todo de Bland Altman. Conclus?o: Os resultados sugerem que para todas as equa??es, propostas pelo software da BIA, quando comparadas ao m?todo de referencia (DXA) os coeficientes de correla??o e concord?ncia foram classificados como fracos. Havendo ainda a necessidade de produ??o de novas equa??es que atendam ao estudo de uma popula??o espec?fica ou maior controle de in?meras vari?veis capazes de alterar os n?veis de resist?ncia e reat?ncia do sujeito naquele momento. / The distribution of mass of is strongly related with the general levels of health and physical conditioning. For Mouad and Matthias (2015), through the body composition (BC) it is possible to know information such as size, shape, composition and genetic traits and acquired by the person or even of a population. Objective: Test the validity of prediction of fat-free mass of soccer athletes by equations of bioimpedanciometry, using the Absortometry of dual-energy X-ray as a default. Methods: The sample was composed of 39 men, of the college soccer team of Universidade Federal do Rio Grande do Norte. The measures of DXA AND BIA were collected on the same day in the laboratory of the institution. For calculation of composition by BIA was used software from Biotetronic, who proposed the equations of Segal et al. Al. (1988), Gray et al. Al. (1989), Lohman (1992) and Carvalho and Neto (1998). In the analysis of data was verified the normality, and performed a descriptive analysis of media and, standard deviation test T-Test for dependent samples (p < 0.05), linear regression models, Pearson correlation coefficients (R), the coefficient of determination (R2) and the standard error of estimate (EPE), as well as the coefficient of correlance of concordance (CCC), in addition to the method of Bland Altman. Conclusion: The results suggest that for all the equations proposed by the software of the BIA, when compared to the method of reference (DXA) the coefficients of correlation and concordance were classified as weak. There is still need for production of new equations that meet the study of a specific population or greater control of numerous variables that can alter the levels of resistance and reactance of the subject at that moment.

Made available in DSpace on 2015-04-14T13:53:21Z (GMT). No. of bitstreams: 1 405285.pdf: 5127311 bytes, checksum: 6985ebb23448b5399737bcdf27f20488 (MD5) Previous issue date: 2008-08-14 / Introdu??o: A popula??o idosa ? a que mais cresce no mundo, atualmente. Na literatura cient?fica espec?fica, relacionada ? ?rea de geriatria e gerontologia, poucos s?o os estudos populacionais que abordam, com a devida profundidade, os aspectos morfofuncionais relacionados ? sa?de dos idosos. O fato de ainda haver um desconhecimento das caracter?sticas em diferentes ?mbitos (social, educacional, morfofuncional, fisiol?gico, psicol?gico, etc.) desse nicho populacional, somado ao r?pido e crescente incremento de tal grupo, poder? levar a um colapso das pol?ticas p?blicas empregadas nos dias atuais. Objetivos: Descrever o perfil antropom?trico dos idosos de Porto Alegre. Verificar se a faixa et?ria influencia nos valores m?dios dos par?metros antropom?tricos avaliados para os dois g?neros. Verificar a influ?ncia do m?todo de determina??o da composi??o corporal nos valores m?dios de percentual de gordura dos idosos de Porto Alegre. Metodologia: Na primeira fase, foram selecionados randomicamente 1.164 idosos de uma popula??o de 168.577 indiv?duos (com 60 anos ou mais), de ambos os sexos, residentes no munic?pio de Porto Alegre. Na segunda fase, foram avaliados 472 idosos (n= 472, 335 mulheres, 137 homens). A massa corporal, estatura, dobras cut?neas, bioimped?ncia (BIO) (balan?a e manual), perimetrias e di?metros ?sseos foram mensurados. A partir de tais dados, foram calculados: o IMC, a RAQ, a RCQ e o %GC pelas equa??es de Jackson e Pollock (J&P), de Tran e Weltman (T&W) (mulheres apenas), de Deurenberg (DEU) e pelas BIO manual e balan?a. Classificou-se o IMC, utilizando-se duas distintas tabelas de classifica??o (OPAS e OMS). Foram utilizados os seguintes tratamentos estat?sticos (p&#8804;0,05 para todos): teste t de Student, para amostras independentes; Mann-Whitney; ANOVA one way com Bonferroni post hoc test; Kruskal-Wallis com Dunn post hoc test; ANOVA, para amostras repetidas com Bonferroni post hoc test; Friedman com Dunn post hoc test; teste t de Student, para amostras pareadas; Wilcoxon; Sign test e as correla??es de Pearson e Spearman. Resultados: Primeiramente, os resultados foram descritos (m?dia e DP) e apresentados estratificados por g?nero. A influ?ncia do g?nero foi avaliada, sendo encontradas diferen?as estatisticamente significativas em todas as vari?veis mensuradas, exceto em rela??o ? idade, ao di?metro femoral e ?s perimetrias abdominal e da panturrilha. Em seguida, os resultados foram descritos em m?dia, DP e percentis (5%, 10%, 25%, 50%, 75%, 90% e 95%), estratificados por g?nero e grupo et?rio (60-69, 70-79, 80-89 e mais de 90 anos). Avaliados os resultados para a influ?ncia da faixa et?ria no comportamento das vari?veis, foram encontradas signific?ncias estat?sticas para massa corporal (homens e mulheres), e, somente com rela??o ?s mulheres, para estatura, IMC, %GC de J&P, BIO manual, somat?rio das dobras, perimetria abdominal e perimetria da cintura. No que se refere ?s correla??es, essas foram estatisticamente significativas para todos os m?todos testados. Conclus?o: O estudo se mostrou adequado, alcan?ando os objetivos propostos, apresentando um padr?o de refer?ncia do comportamento das vari?veis antropom?tricas e composi??o corporal dos idosos de Porto Alegre. Os m?todos de avalia??o parecem influenciar os valores absolutos das vari?veis, por?m, pelo fato de apresentarem correla??o significativa, sugerem uma similaridade de comportamento.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-19T13:29:23Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2537968 bytes, checksum: 818511856a7e650015c59ec1bcccaedc (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido a falta de capa institucional. on 2017-07-28T20:35:05Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-31T13:19:01Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-03T17:49:44Z (GMT) No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Made available in DSpace on 2017-08-03T18:05:42Z (GMT). No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) Previous issue date: 2017-04-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Organic changes caused by aging cause clinical manifestations in several situations common to elderly patients. Among them, the aging process is associated with a decline in muscle mass and strength. Several factors are involved in this mechanism, among them low D vitamin. OBJECTIVES: verify the effect of D vitamin supplementation on handgrip strength and body composition in elderly women. METHODS: A longitudinal, interventional, uncontrolled study with 54 elderly women at community who do not have severe disabling diseases and do not take D vitamin supplementation. Serum (25 (OH) D) below 30 ng / mL were inclusion criteria in the study. The elderly women performed handgrip strength test (FM), body composition examination by DXA and laboratory tests (parathyroid hormone (PTH), urea (Ur), creatinine (Cr), serum calcium (Ca++) and interleukin-6)). Participants with serum vitamin D levels between 20-29.9 ng/mL were supplemented with 2000 IU per day of cholecalciferol for twelve weeks and those with levels below 20 ng/mL received 10000 IU per day of cholecalciferol for the same period. All had concomitant taking of calcium carbonate 1 g per day. At the end, handgrip strength test, biochemical evaluation and body composition were repeated. For the description of the sample, mean, standard deviation and percentage were used. For data correlation with normal distribution were used Pearson correlation test, and for comparison, Student's T test and for data with non-normal distribution, median, Spearman, Mann-Whitney U and Wilcoxon correlation test. RESULTS: Of the 54 elderly women included in the study, 52 concluded. The mean age was 72 ? 9 years. The mean value before and after supplementation were 25 (OH) D 18.9 ? 6.65 and 38.15 (24.4 ? 126.2) (p= 0,000), PTH 87.15 ? 40.08 and 67.55 ? 30.04 (p = 0,000), IL-6 3.6 (1.5 ? 15.8) and 2.25 (1.5 ? 45.9) (p = 0.04), FM 42.17 ? 14.12 and 42.55 ? 12.78 (p = 0,733), MM 38663 ? 5546 and 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 and 9,4 ? 0,35 (p = 0,004). The correlation analysis between variables after the intervention showed an inverse correlation between 25 (OH) D and PTH, FM and IL-6 and between Ca++ and IL-6. Direct correlations occurred between FM and MM and between FM and Ca++. CONCLUSION: Vitamin D supplementation increased serum levels of 25 (OH) D significantly, as well as reduced serum PTH and IL-6 levels, without changes in handgrip strength and total body lean mass. / Mudan?as org?nicas provocadas pelo envelhecimento originam manifesta??es cl?nicas em v?rias situa??es habituais aos pacientes idosos. Dentre elas, o processo de envelhecimento est? associado a um decl?nio na massa e for?a muscular. V?rios fatores est?o envolvidos nesse mecanismo, dentre eles, destaca-se a defici?ncia da vitamina D. OBJETIVO: verificar o efeito da suplementa??o de vitamina D na for?a de preens?o palmar e composi??o corporal em idosas. M?TODOS: Estudo longitudinal, intervencionista, n?o controlado com 54 idosas da comunidade que n?o possuam doen?as incapacitantes graves e que n?o utilizem reposi??o de vitamina D. N?veis s?ricos de vitamina D (25(OH)D) inferiores a 30 ng/mL foram crit?rios de inclus?o no estudo. As idosas realizaram teste de for?a de preens?o manual (FM), exame de composi??o corporal por DXA e exames laboratoriais (paratorm?nio (PTH), ureia (Ur), creatinina (Cr), c?lcio s?rico (Ca++) e interleucina-6 (IL-6)). As participantes com n?veis s?ricos de vitamina D entre 20 ? 29,9 ng/mL foram suplementadas com 2000 UI ao dia de colecalciferol durante dozes semanas e as com n?veis inferiores a 20 ng/mL receberam 10000 UI ao dia de colecalciferol pelo mesmo per?odo. Todas fizeram uso concomitante de carbonato de c?lcio 1 g ao dia. Ao final do per?odo de reposi??o, foram repetidos os testes de for?a manual, avalia??o bioqu?mica e composi??o corporal. Para a descri??o da amostra, foram utilizados m?dia, desvio-padr?o e percentual. Para a correla??o dos dados com distribui??o normal foi utilizado o teste de correla??o de Pearson, e para compara??o, teste T de Student e para os dados com distribui??o n?o-normal, utilizou-se o teste de correla??o de Spearman, Mann-Whitney U e Wilcoxon. RESULTADOS: Das 54 participantes, 52 idosas aderiram ao estudo, com idade m?dia de 72 ? 9 anos. Os valores m?dios antes e depois da interven??o foram 25(OH)D 18,9 ? 6,65 e 38,15 (24,4 ? 126,2) (p= 0,000), PTH 87,15 ? 40,08 e 67,55 ? 30,04 (p = 0,000), IL-6 3,6 (1,5 ? 15,8) e 2,25 (1,5 ? 45,9) (p = 0,04), FM 42,17 ? 14,12 e 42,55 ? 12,78 (p = 0,733) , Massa Magra (MM) 38663 ? 5546 e 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 e 9,4 ? 0,35 (p = 0,004). A an?lise de correla??o entre as vari?veis ap?s a interven??o demonstrou rela??o inversa entre 25(OH)D e PTH, FM e IL -6 e entre Ca++ e IL-6. Correla??es diretas ocorreram entre FM e MM e entre FM e Ca++ CONCLUS?O: A suplementa??o de vitamina D aumentou os n?veis s?ricos de 25(OH)D, bem como reduziu os valores de PTH e IL-6, n?o havendo modifica??es na for?a de preens?o palmar e massa magra corporal total.

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-06-15T11:36:19Z No. of bitstreams: 1 469479 - Texto Completo.pdf: 2563289 bytes, checksum: 2184e2738a496b030cd61b0f8c50e376 (MD5) / Made available in DSpace on 2015-06-15T11:36:19Z (GMT). No. of bitstreams: 1 469479 - Texto Completo.pdf: 2563289 bytes, checksum: 2184e2738a496b030cd61b0f8c50e376 (MD5) Previous issue date: 2015-03-26 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Chronic kidney disease is a progressive condition, with no healing prospect, yet extended upholding under adequate monitoring and treatment. Approximately 100,000 patients currently undergo dialysis therapy - ninety percent on hemodialysis. Mortality ratio varies between 15 to 20%, being cardiovascular events mainly responsible. Among mental ailments thwarting kidney disease patients, depression is the most frequently associated co-morbidity, and linked to increased mortality and morbidity rates. In patients undergoing hemodialysis, malnourishment may relate with depressive symptoms, besides inflammation and cardiovascular diseases. Life style changes induced by end-stage renal disease impose a number of limitations that end up affecting the quality of life. Protein depletion is commonly observed in patients submitted to hemodialysis, and is associated with higher mortality. Strangely enough, it may be accompanied by weight gain and central fat accumulation. The role of adipocytokines in chronic kidney disease has recently drawn attention: association of serum chemerin to metabolic syndrome indicators, inflammation and obesity has been suggested. The aim of this study was to longitudinally evaluate nutritional status, presence of depressive symptoms, quality of life and mortality of hemodialysis patients, in a cohort study at the S?o Lucas Hospital /PUCRS, Porto Alegre, Brazil. Stable patients, undergoing hemodialysis for at least three months, were enrolled and evaluated at twelve month-intervals, thereafter. Participants were assessed for: depressive symptoms using the Beck Depression Inventory and for quality of life perception by the WHOQOL-bref questionnaire. Anthropometric data: weight, height, waist circumference; blood collection: for biochemical determinations, high-sensitivity C-reactive protein, chemerin; body composition analysis by direct segmental multi frequency bioimpedance, were obtained at a mid week dialysis session. One hundred and five participants were included. Patients classified as having standard percentage of body fat predominated, although more than half of the enrolled participants presented with excess body fat. There was no significant difference in the rate of depressive symptoms or in the quality of life between groups, classified by nutritional status. The cause more often associated with the outcome death by any cause was cardiovascular event, followed by infection. Lean body mass had a protective effect on survival. Chemerin may have an anti-inflammatory effect, being associated with increased body fat percentage and augmented waist circumference, on end-stage renal disease patients. / A doen?a renal cr?nica ? uma doen?a progressiva, que n?o contempla expectativa de cura, mas o prolongamento da cronicidade, com acompanhamento e tratamento adequados. Quase 100.000 pacientes s?o submetidos a tratamento dial?tico, 90% em hemodi?lise. A taxa de mortalidade bruta varia entre 15 a 20%, sendo eventos cardiovasculares os principais respons?veis. Dentre os problemas mentais que acometem pacientes com doen?a renal, depress?o ? a comorbidade mais frequente, associada a aumento das taxas de morbimortalidade. Desnutri??o pode se relacionar com sintomas de depress?o, assim como inflama??o e doen?a cardiovascular, em pacientes tratados por hemodi?lise. As mudan?as de estilo de vida induzidas pela doen?a renal cr?nica terminal causam in?meras limita??es que afetam a qualidade de vida. Deple??o proteica em pacientes submetidos a hemodi?lise ? frequentemente observada, e se associa com elevada mortalidade. Curiosamente, pode se acompanhar por excesso de peso e ac?mulo de gordura central. O papel das adipocitocinas na doen?a renal cr?nica tem despertado interesse: associa??o de quemerina s?rica com indicadores de s?ndrome metab?lica, inflama??o e obesidade foram sugeridas. O objetivo do presente estudo ? correlacionar estado nutricional, sintomas de depress?o, qualidade de vida e mortalidade em hemodi?lise. Foi realizado estudo prospectivo de coorte com pacientes em hemodi?lise no Hospital S?o Lucas/PUCRS, Porto Alegre, Brasil. Os pacientes estavam h? tr?s ou mais meses em hemodi?lise, clinicamente est?veis. A cada doze meses, pacientes inclu?dos no estudo foram reavaliados para: sintomas de depress?o ? por question?rio Beck de depress?o; percep??o da qualidade de vida ? pelo question?rio WHOQOL-bref; medidas antropom?tricas ? peso, altura, circunfer?ncia da cintura; coleta de sangue - para dosagens de par?metros bioqu?micos, prote?na C-reativa e quemerina; an?lise da composi??o corporal ? por bioimped?ncia segmentar de multi-frequ?ncias. Foram inclu?dos 105 pacientes. Houve um predom?nio de pacientes com percentagem de gordura padr?o, mas mais da metade dos pacientes tinha excesso de gordura corporal. N?o houve diferen?a na presen?a de sintomas depressivos e na qualidade de vida entre os grupos classificados por estado nutricional. A principal causa associada ao desfecho ?bito por qualquer causa foi evento cardiovascular, seguida por infec??o. A massa muscular apresentou efeito protetor para sobrevida. Quemerina s?rica aparentemente tem a??o anti-inflamat?ria em pacientes com doen?a renal cr?nica terminal, e est? associada a percentual de gordura corporal e a circunfer?ncia da cintura aumentada.

Made available in DSpace on 2015-04-14T13:33:09Z (GMT). No. of bitstreams: 1 459023.pdf: 766453 bytes, checksum: df09225ab12d18f640f368a0a5436a50 (MD5) Previous issue date: 2014-03-31 / Introduction : Cystic Fibrosis (CF) is a disease of autosomal recessive character, chronic and progressive, with involvement in various organs and systems. Respiratory and gastrointestinal disorders are more prevalent, which usually results in nutritional deficit. However, when there is a worsening of the clinical condition, requiring hospitalization, the risk of nutritional inbalance increases. The aim of this study was to evaluate variation in weight and body composition during hospitalization of children and adolescents with cystic fibrosis who received hypercaloric and hyperlipidic diet during hospitalization. Methods : This is a longitudinal study involving children and adolescents with CF hospitalized at S?o Lucas's Hospital/ PUCRS. Bioimpedance analysis was used to assess body composition. The evaluation took place within 48 hours after admission and 24 hours prior to hospital discharge. The energy and nutrient intake was investigated through a food record during three consecutive days. Comparisons between weight and body composition during hospitalization were performed through the corresponding statistical tests (t test and the Mann - Whitney test). Differences were considered significant at p < 0.05. Results : The sample consisted of 13 patients, 8 (62 %) male. The mean age was 10.8 ? 3.61 years. The mean hospital stay was 14.5 ? 3.75 days. At the beginning of hospitalization, most patients were eutrophic (n = 9). Regarding categorization by pulmonary function, patients had moderate pulmonary disease according to FEV1 (52.08 ? 22.2). Patients received hypercaloric and hyperlipidic diet during hospitalization , and the findings showed significant changes in the variables, weight and fat mass (weight = 1.47 kg and fat mass 1.06 kg , p < 0.0001). Conclusion : The hypercaloric and hyperlipidic diet recommended during hospitalization was associated with significant weight gain and fat mass, with improvement of the nutritional status of most patients. / Introdu??o : A Fibrose C?stica (FC) ? uma doen?a gen?tica de car?ter autoss?mico recessivo, cr?nica e progressiva, com acometimento em diversos ?rg?os e sistemas. As altera??es respirat?rias e gastrointestinais s?o mais prevalentes, o que resulta geralmente em um comprometimento nutricional. Todavia, quando existe uma piora do estado cl?nico com necessidade de interna??o hospitalar, o risco ou fal?ncia nutricional aumenta. O objetivo deste estudo foi avaliar a varia??o de peso e da composi??o corporal durante a interna??o hospitalar de crian?as e adolescentes portadores de Fibrose C?stica que receberam dieta hipercal?rica e hiperlip?dica durante a interna??o hospitalar. M?todos : Estudo longitudinal, envolvendo crian?as e adolescentes com Fibrose C?stica internados no Hospital S?o Lucas/PUCRS. A an?lise de bioimped?ncia foi utilizada para avalia??o da composi??o corporal. A avalia??o ocorreu em at? 48 horas ap?s a interna??o e 24 horas antes da alta hospitalar. A ingest?o energ?tica e de nutrientes foi investigada por meio do registro alimentar de tr?s dias consecutivos. As compara??es entre o peso e a composi??o corporal durante a interna??o foram realizadas mediante os testes estat?sticos correspondentes (teste t e teste de Mann-Whitney). As diferen?as foram consideradas significativas com p < 0,05. Resultados : A amostra estudada constituiu-se de 13 pacientes, sendo 8 (62%) do sexo masculino. A m?dia de idade foi de 10,8? 3,61 anos. O tempo m?dio de interna??o foi 14,5?3,75 dias. No in?cio da interna??o, a maioria dos pacientes encontravam-se eutr?ficos (n=9). Quanto ? categoriza??o pela fun??o pulmonar, os pacientes apresentaram doen?a pulmonar moderada conforme os valores de VEF1 (52,08?22,2). Os pacientes receberam dieta hipercal?rica e hiperlip?dica durante a interna??o, e os achados demonstraram altera??o significativa nas m?dias das vari?veis, peso e massa gorda (peso= 1,47 kg e massa gorda 1,06 kg; p<0,0001). Conclus?o : A dieta hipercal?rica e hiperlip?dica preconizada durante a interna??o esteve associada a um ganho significativo de peso e de massa gorda, com melhoria do estado nutricional de grande parte dos pacientes.

Made available in DSpace on 2015-04-14T13:35:34Z (GMT). No. of bitstreams: 1 441495.pdf: 393716 bytes, checksum: 44d5110d0dc89507b042452bde0134c9 (MD5) Previous issue date: 2012-08-29 / Objective: The aim of this study was to evaluate the relationship between body weight gain and small solute transport by the peritoneum Methods: A retrospective review was conducted of the records from 50 patients over the age of 18 years, all of whom had undergone peritoneal dialysis for at least one year. Weight changes were recorded at quarterly intervals until completion of one year of therapy and were subsequently compared with the categories of peritoneal transport. Biochemical markers including glucose, albumin and lipid profile were evaluated at the beginning of therapy and again one year later. Results: A significant effect of time on the mean body weight of the study participants was detected, as shown by the Repeated Measures Analysis of Variance. The final BMI mean was significantly higher than the initial. A significant reduction in serum albumin also occurred. However, no significant difference was found when comparing the weight change over the first year of treatment to the categories from the peritoneal equilibration test. Conclusion: This study was unable to demonstrate the existence of an association between the initial peritoneal membrane small solute transport with weight changes in patients undergoing peritoneal dialysis. The acknowledged multifactorial nature of obesity may be a possible explanation for our findings. The glucose uptake rate by the peritoneum does not seem to be responsible, therefore, it is necessary to search for factors linked to peritoneal dialysis that would have a greater influence on the observed alterations in nutritional status / Objetivo: o objetivo do presente estudo foi avaliar a rela??o entre aumento do peso corp?reo dos pacientes em di?lise peritoneal e a fun??o de transporte de solutos pelo perit?nio. M?todos: os registros de 50 pacientes maiores de 18 anos, que realizavam di?lise peritoneal h? no m?nimo de um ano, foram revisados retrospectivamente. As altera??es de peso foram registradas em intervalos trimestrais at? completarem um ano de terapia e, posteriormente, foram comparados com as categorias de transporte peritoneal avaliadas pelo teste de equil?brio peritoneal ?s quais pertenciam os pacientes. Marcadores bioqu?micos inclu?ram glicose, albumina e perfil lip?dico avaliados no inicio e ap?s um ano de terapia. Resultados: Foi detectado um efeito significativo do tempo em di?lise na m?dia de peso dos investigados, quanto realizada a an?lise de vari?ncia para medidas repetidas. A m?dia final do ?ndice de massa corporal (IMC) mostrou-se significativamente maior que a inicial. Tamb?m ocorreu uma redu??o significativa da albumina s?rica. A varia??o do peso ao longo do primeiro ano de tratamento n?o foi significativamente diferente entre as categorias do teste de equil?brio peritoneal. Conclus?es: o presente estudo n?o demonstrou a exist?ncia de uma associa??o entre as caracter?sticas do transporte de membrana peritoneal e absor??o de glicose, com as altera??es de peso em pacientes em di?lise peritoneal. A reconhecida natureza multifatorial da obesidade pode ser uma poss?vel explica??o para nossos achados. Entretanto, mais estudos s?o necess?rios a fim de identificar quais destes fatores ligados a di?lise peritoneal teriam uma maior influ?ncia sobre as altera??es no estado nutricional e na composi??o corporal desta popula??o de pacientes

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-12-09T10:49:13Z No. of bitstreams: 1 TES_LETICIA_BISCAINO_ALVES_COMPLETO.pdf: 315468 bytes, checksum: 9d81c5ea452d3e8945c4a3ecb7ea4a0d (MD5) / Made available in DSpace on 2016-12-09T10:49:13Z (GMT). No. of bitstreams: 1 TES_LETICIA_BISCAINO_ALVES_COMPLETO.pdf: 315468 bytes, checksum: 9d81c5ea452d3e8945c4a3ecb7ea4a0d (MD5) Previous issue date: 2016-09-01 / Introduction: The indication for bariatric surgery based on body mass index is being questioned due to the fact that it does not take body composition into consideration. Objective: Determine the patient's body composition prior to indicating bariatric surgery. Methods: Being included in the study, were patients treated at the Center for Obesity and Metabolic Syndrome at Hospital S?o Lucas da PUCRS for obesity. Body composition was measured by using an Bioelectrical impedance analysis device, model InBody 770. For the analysis of data, body fat percentage, lean mass percentage, waist, waist/hip ratio, visceral fat area, BMI and surgical indication were considered. Results: A total of 407 subjects were evaluated, 87 (21.4%) men, with the mean age being 36 years. In men, with and without indication for bariatric surgery, BMI, body fat percentage and visceral fat area were 44.3 kg/m? and 34.2 kg/m? (P <0.001), 45.1% and 37.6% (P = 0.001), 243.6 cm? and 187.5 cm? (P <0.001), respectively. In women, with and without indication for bariatric surgery, BMI, body fat percentage and visceral fat area were 42.2 kg/m? and 34.6 kg/m? (P <0.001), 50.7 % and 46.7 % (P < 0.001), 241.7 cm? and 204.2 cm? (P <0.001), respectively. Conclusion: This study showed a significant difference in body composition between men and women, among the obese with and without indication for bariatric surgery. / Introdu??o: A indica??o da cirurgia bari?trica baseada no ?ndice de massa corporal est? sendo questionada visto que este n?o discrimina a composi??o corporal. Objetivo: Determinar a composi??o corporal do paciente com indica??o de cirurgia bari?trica. M?todos: Foram inclu?dos pacientes atendidos no Centro de Obesidade e S?ndrome Metab?lica do Hospital S?o Lucas da PUCRS para tratamento de obesidade. A composi??o corporal foi aferida por meio do aparelho de bioimped?ncia el?trica modelo InBody 770. Para a an?lise dos dados foram considerados percentual de gordura corporal, percentual de massa magra, cintura, rela??o cintura/quadril, ?rea de gordura visceral, IMC e a indica??o cir?rgica. Resultados: Foram avaliados 407 indiv?duos, 87 (21,4%) homens, com a m?dia de 36 anos. Em homens, com e sem indica??o de cirurgia bari?trica, o IMC, a porcentagem de gordura corporal e ?rea de gordura visceral foram 44,3 Kg/m? e 34,2 Kg/m? (P<0,001), 45,1 % e 37,6 % (P=0,001), 243,6 cm? e 187,5 cm? (P<0,001), respectivamente. Em mulheres, com e sem indica??o de cirurgia bari?trica, o IMC, a porcentagem de gordura corporal e ?rea de gordura visceral foram 42,2 Kg/m? e 34,6 Kg/m? (P<0,001), 50,7 % e 46.7 % (P<0,001), 241,7 cm? e 204,2 cm? (P<0,001), respectivamente. Conclus?o: Este estudo mostrou uma diferen?a significativa na composi??o corporal entre homens e mulheres, entre os obesos com e sem indica??o de cirurgia bari?trica.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2018-08-08T14:17:43Z No. of bitstreams: 1 SAFIAN_CLAUDIA_ALINE_DIS.pdf: 2337155 bytes, checksum: 87ead8f6373020e0552079ac1ee57eef (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-08-09T12:39:31Z (GMT) No. of bitstreams: 1 SAFIAN_CLAUDIA_ALINE_DIS.pdf: 2337155 bytes, checksum: 87ead8f6373020e0552079ac1ee57eef (MD5) / Made available in DSpace on 2018-08-09T13:06:32Z (GMT). No. of bitstreams: 1 SAFIAN_CLAUDIA_ALINE_DIS.pdf: 2337155 bytes, checksum: 87ead8f6373020e0552079ac1ee57eef (MD5) Previous issue date: 2018-03-07 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Introduction: Brazil has undergone considerable changes in the age distribution of its population, with the elderly being responsible for almost 26 million inhabitants. Allied to this reality, is a series of nutritional disorders in this population segment. An important factor related to quality of life and healthy aging is good nutrition throughout life. Objective: To observe the possible relationship between the nutritional status and the body composition of the longevity. Methodology: This is a descriptive, cross-sectional and analytical study, with elderly individuals aged 90 years or older. The instruments used were the Mini Nutritional Assessment to evaluate nutritional status, Anthropometry to evaluate weight, height and BMI, and bioimpedance to evaluate body composition. Results: The sample consisted of 72 elderly individuals, with a mean age of 93.7 years, most female(72%), white (82%) and widowed (64%). Of the total longevity, 19.4% were classified with nutritional risk based on the Mini Nutritional Assessment. All anthropometric parameters presented lower averages among participants with nutritional risk. Regarding the bioimpedance parameters, in general the risk-free individuals presented higher averages of weight, maximum ideal weight, minimum ideal weight, BMI, lean mass, fat mass, percentage of fat mass and minimum percentage of fat mass. Conclusions: It was observed that most of the longevity were classified without nutritional risk based on MAN. The importance of not only nutritional assessment and diet quality in the multiprofessional care of the longevity, but also the presence of a nutritionist was clear, since the measurement of the nutritional risk in the third age requires the joint analysis of the several existing methods for the nutritional evaluation, in order to obtain global diagnosis and accurate analysis of the nutritional status of the longevity. / Introdu??o:O Brasil vem passando por mudan?as consider?veis na distribui??o et?ria da sua popula??o, sendo os idosos respons?veis por quase 26 milh?es de habitantes. Aliada a essa realidade, encontra-se uma s?rie de desordens nutricionais nesse segmento populacional. Um importante fator relacionado ? qualidade de vida e ao envelhecimento sadio ? a boa nutri??o durante toda a vida. Objetivo:Observar a poss?velrela??o entre o estado nutricional e a composi??o corporal de longevos. Metodologia: Trata-se de um estudo descritivo, transversal e anal?tico, com idosos longevos de idade igual ou superior a 90 anos. Os instrumentos utilizados foram a Mini Avalia??o Nutricional (MAN) para avaliar o estado nutricional, Antropometria para avaliar o peso, altura e IMC, e a Bioimped?ncia para avaliar a composi??o corporal.Resultados:A amostra foi composta por 72 idosos longevos, com m?dia de idade de 93,7 anos, a maioria (72%) era mulher, cor branca (82%) e estado civil vi?vo (64%). Do total de longevos, 19,4% foram classificados com risco nutricional com base na Mini Avalia??o Nutricional. Todos os par?metros antropom?tricos apresentaram m?dias menores entre os participantes com risco nutricional. Em rela??o aos par?metros de bioimped?ncia, em geral os indiv?duos sem risco apresentaram maiores m?dias de peso, peso ideal m?ximo, peso ideal m?nimo, IMC, massa magra, massa gorda.Conclus?es:Observou-se que a maioria dos longevos foram classificados sem risco nutricional baseado no MAN. Ficou clara a import?ncia n?o somente da avalia??o nutricional e da qualidade da dieta na aten??o multiprofissional do longevo, mas tamb?m a presen?a de um nutricionista, poisa mensura??o do risco nutricional na terceira idade requer a an?lise conjunta dos diversos m?todos existentes para a avalia??o nutricional, a fim de obter diagn?stico global e an?lise acurada do estado nutricional do longevo.