Given the current obesity epidemic in tandem with the aging US population, it is imperative to identify methods for reducing cardiovascular disease (CVD) risk that will be efficacious for both sexes. Arterial stiffness (AS) is an independent risk factor for a first cardiovascular event that increases with advancing age and obesity. Previous studies have found that modest weight loss (WL) of 5 to 10 percent successfully reduces AS and other risk factors for CVD. However, it remains unclear whether WL via caloric restriction reduces AS similarly among sexes. We tested the hypothesis that WL via caloric restriction would reduce AS more in men than women because men accumulate more abdominal visceral fat (VF) and lose more with WL compared with women of similar age and adiposity. To test our hypothesis AS was assessed from measurements of pulse wave velocity and ultrasonography of the carotid artery (Ã -SI). Total body and VF were measured using dual energy x-ray absorptiometry and computed tomography scans, respectively. Subjects underwent a 12-week WL intervention. No baseline differences in AS were observed between sexes. However, men were heavier and demonstrated higher levels of VF while women were fatter and had higher levels of abdominal subcutaneous fat. Contrary to our hypothesis both sexes experienced similar decreases in AS with WL despite greater reductions in VF in men. Our findings suggest that VF loss is not the primary mechanism mediating reductions in AS with WL. Future studies are needed to determine the mechanisms of arterial destiffening with WL. / Master of Science

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Hydrate-bearing sediments may contribute to the availability of energy resources, affect climate change, or cause seafloor instability. The comprehensive study of hydrate-bearing sediments documented in this manuscript includes physicochemical aspects of hydrate nucleation near mineral surfaces, the validity of THF as a substitute guest molecule for the study of hydrate-bearing sediments, and the effects of hydrate formation on the electromagnetic and the mechanical properties of various soils with a wide range of specific surface. Natural marine sediments are included as part of this investigation to explore the effects of inherent fabric, salts, organic matter, and stress history on the geophysical properties of hydrate-bearing sediments. Experiments are designed to reproduce the state of effective stress in the field at the time of hydrate formation. A comprehensive set of instruments is deployed in this study, and the unprecedented development of electrical resistivity tomography for the study of hydrate formation and dissociation is also documented in detail. Results from this research have important implications for geophysical field characterization and monitoring processes such as production.

[Truncated abstract] Seismic tomography has been extensively used in geophysics for different purposes such as geological mapping and prospecting for oil and gas. In geophysics, ultrasound or electromagnetic waves are normally used to provide the tomographic information. In the geotechnical area, seismic tomography is emerging as a promising technique that can be used to determine the spatial variability of shear wave velocities and hence the small strain stiffness of geomaterials. Although some studies have been undertaken to incorporate seismic measurement into centrifuge modelling, there has been to date no attempt to build a complete seismic tomography facility with high resolution for use in a geotechnical centrifuge. Such a powerful facility can help in better understanding of soil behaviour by providing a complete picture of the spatial variation of the soil property of concern. The main aim of this study was to develop a high-resolution seismic tomography (ST) system for the beam centrifuge at the University of Western Australia (UWA) by which the shear wave velocity and hence maximum shear modulus could be determined anywhere in the centrifuge model. ... This limitation was the requirement to use an a priori model. The exact solutions in the different examples presented in this chapter were known, and they were used as a priori models into the inversion process. However, in practice the exact solution is unknown, and the aim of the tomographic inversion is to obtain a solution that best describes the measured data. Carrying out inversion without using an a priori model can yield an output model that hints at the nature of the model. This output can then be used as the starting point in an iterative process, in which the output from one step is used as an a priori model for reinverting the original data in a subsequent step. In this case, this process slightly improved the output tomogram and decreased the value of root mean squares of travel time residuals (Rrms). An alternative inversion strategy was proposed based on the results obtained in this study. It involves using a searching algorithm. A searching process can be carried out based on the output from the first iteration (without using an a priori model). The search can involve varying the parameters that describe buried anomalies, such as the size of the anomaly, the velocity value in the anomaly, and the location of the anomaly. The aim is to search for the combination of anomaly parameters that minimises the resulting error parameters (mainly Rrmx, but also the average error and the standard deviation of the error). For more subtle cases, such as the velocity model under a footing, where inversion without using an a priori model did not recover the input model, a searching algorithm involving applying perturbations to the exact Boussinesq model can be performed. Not only can the searching procedure involve adding perturbation to the velocity values in the Boussinesq model, but it can also add perturbation to the shape of the velocity distribution below the footing. The searching process can continue until a model that fits the data with a minimum error is found, i.e., minimising Rrms.

The seismic cone penetration test (SCPTu) is the most efficient means for geotechnical site characterization and the evaluation of seismic ground hazards. In this thesis, software systems including ShearPro, ClusterPro, and InSituData, are developed to automate post processing of these SCPTu data. ShearPro is developed to automate the post-processing of the shear wave signals. ClusterPro uses the proposed three-dimensional cluster analysis approach for soil stratification. InSituData facilitates the post processing of penetration data for seismic ground hazards analysis. A new three-dimensional soil classification chart is also proposed in this thesis to help discern soil layers that may be subject to seismic ground hazards, such as loose liquefied sands and silty sands. These methods are then applied to SCPTu data collected at previously-identifed paleoliquefaction sites located in the New Madrid Seismic Zone (NMSZ). For liquefaction evaluation, the cyclic stress ratio (CSR) is computed using site response analysis by DeepSoil and a measured profile of shear waves derived from the 30-m SCPTU soundings and deep suspension loggings in AR and TN. The natural resistance of the soil to liquefaction, termed the cyclic resistance ratios (CRRs), is evaluated based on both deterministic procedures and probabilistic procedures. Based on liquefaction evaluation results at selected paleoliquefaction sites, regional CRR criteria for liquefaction are developed for the NMSZ. As even the latest major earthquakes in NMSZ occurred nearly 200 years ago, aging effects might be an important factor to consider in utilizing the liquefaction criteria to assess the seismic parameters associated with the previous earthquakes. The aging effects in the NMSZ were investigated through large scale blast-induced liquefaction tests conducted in the NMSZ. Then a procedure to estimate seismic parameters associated with previous earthquakes is proposed. It utilizes both the liquefaction criteria based on SCPTu tests and the empirical attenuation relations developed for the corresponding regions. The approach is validated through data evaluation related to the 1989 Loma Prieta earthquakes in California and then applied to previous historic earthquakes in the NMSZ.

The pipeline is playing an important role in industry nowadays. However, the inner wall of pipeline may suffer corrosion after a long service time. When excessive corrosion occurred, not only the transported material inside the pipe will let out but also serious accident may be induced. So, it¡¦s necessary to monitor pipeline thickness regularly. Conventionally, since most piping systems were subjected to high-temperature working environments, hence if an operator intend to examine the thickness of a pipeline, the whole piping system need to be shutdown and resulted in financial losses. Therefore, to develop on-line thickness measurement technique for pipelines subjected to high-temperature working environment is indispensable. ¡@¡@In this study, low-cost PZT sensors (Pb(ZrxTi1-x)O3), which can sustain high-temperature working environment, were used to execute the thickness measurements. A single PZT, which was bonded on the surface of a pipe as an actuator and a receiver simultaneously. Then, by utilizing the GUI(Graphic User Interface) system, which was designed in this study, the echo signal can be analyzed and the thickness of the pipe can be determined on-line and automatically. It is noted that the wave speed changed as environmental temperature increased. So, in this study, by using A36 steel plates and steel tubes as a specimens, a modified temperature versus wave velocity curve was proposed.. The experimental results showed that non-conservative thickness measurements will be obtained if modified wave speed was not adopted when working temperature increased. keywords¡GThickness measurement, PZT sensor, GUI system, Modified wave velocity curve.

Nonlinear site response analyses are generally preferred over equivalent linear analyses for soft soil sites subjected to high-intensity input ground motions. However, both nonlinear and equivalent linear analyses often result in large induced shear strains (3-10%) at soft sites, and these large strains may generate unusual characteristics in the predicted surface ground motions. One source of the overestimated shear strains may be attributed to unrealistically low shear strengths implied by commonly used modulus reduction curves. Therefore, modulus reduction and damping curves can be modified at shear strains greater than 0.1% to provide a more realistic soil model for site response. However, even after these modifications, nonlinear and equivalent linear site response analyses still may generate unusual surface acceleration time histories and Fourier amplitude spectra at soft soil sites when subjected to high-intensity input ground motions. As part of this work, equivalent linear and nonlinear 1D site response analyses for the well-known Treasure Island site demonstrate the challenges associated with accurately modeling large shear strains, and subsequent surface response, at soft soil sites. Accounting for the uncertainties associated with the shear wave velocity profile is an important part of a properly executed site response analyses. Surface wave data from Grenoble, France and Mirandola, Italy have been used to determine shear wave velocity (Vs) profiles from inversion of surface wave data. Furthermore, Vs profiles from inversion have been used to determine boundary, median and statistically-based randomly generated profiles. The theoretical dispersion curves from the inversion analyses as well as the boundary, median and randomly generated Vs profiles are compared with experimentally measured surface wave data. It is found that the median theoretical dispersion curve provides a satisfactory fit to the experimental data, but the boundary type theoretical dispersion curves do not. Randomly generated profiles result in some theoretical dispersion curves that fit the experimental data, and many that do not. Site response analyses revealed that the greater variability in the response spectra and amplification factors were determined from the randomly generated Vs profiles than the inversion or boundary Vs profiles.

Using a specially constructed Gas Hydrate Resonant Column (GHRC), the University of Southampton explored different methods of hydrate synthesis and measured the properties of the resulting sediments, such as shear wave velocity (Vs), compressional wave velocity (Vp) and their respective attenuation measurements (Qs -1 and Qp -1). Two approaches were considered. The first utilises an excess gas technique, where known water volume in the pore space dictates the quantity of hydrate. The second approach uses a known quantity of methane gas within the water saturated pore space to constrain the volume of hydrate. Results from the two techniques show that hydrates formed in excess gas environments cause stiffening of the sediment structure at low concentrations (3%), whereas, even at high concentrations of hydrate (40%) in excess water environments, only moderate increase in stiffness was observed. Additionally, attenuation results show a peak in damping at approximately 5% hydrate in excess gas tests, whereas in excess water tests, damping continues to increase with increasing hydrate content in the pore space. By considering the results from the two approaches, it becomes apparent that formation method has an influence on the properties of the hydrate bearing sand, and must therefore influence the morphology of the hydrate in the pore space.

During the past two decades, University of Kentucky researchers have been acquiring seismic refraction/reflection data, as well as seismic downhole data, for characterizing the seismic velocity models of the soil/sediment overburden in the central United States. The dataset includes densely spaced measurements for urban microzonation studies and coarsely spaced measurements for regional assessments. The 519 measurements and their derivative products often were not in an organized electronic form, however, limiting their accessibility for use by other researchers. In order to make these data more accessible, this project constructed a database using the ArcGIS 9.1 software. The data have been formatted and integrated into a system serving a wider array of users. The seismic shear-wave velocity models collected at various locations are archived with corresponding x-, y-, and z-coordinate information. Flexibility has been included to allow input of additional data in the future (e.g., seismograms, strong ground-motion parameters and time histories, weak-motion waveform data, etc.). Using the completed database, maps of the region showing derivative dynamic site period (DSP) and weighted shear-wave velocity of the upper 30 m of soil (V30) were created using the ArcGIS 9.1 Geostatistical Analyst extension for examination of the distribution of pertinent dynamic properties for seismic hazard assessments. Both geostatistical and deterministic techniques were employed. Interpolation of V30 data yielded inaccurate predictions because of the high lateral variation in soil layer lithology in the Jackson Purchase Region. As a result of the relatively uniform distribution of depths to bedrock, the predictions of DSP values suggested a high degree of accuracy.

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