No description available.

Zusammengestellt 2008 von Christian Leutemann.

No description available.

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2007. / Title from title screen (site viewed Dec. 5, 2007). PDF text: 79 p. : music ; 6 Mb. UMI publication number: AAT 3271908. Includes bibliographical references. Also available in microfilm and microfiche formats.

Thèse (M.Sc.)--Université Laval, 2005. / Bibliogr.: f. 75-90. Publié aussi en version électronique.

No description available.

Diss.--Theaterwissenschaft--Erlangen-Nürnberg--Friedrich-Alexander-Universität, 1996. / Bibliogr. p. 285-310.

"Seine Liebe zum Leben war vehement und jedem Zweife1 entzogen. Aber in dies von ihm geliebte Leben war der Tod eingeschlossen, der ihm, nach Hofmannsthals Wort, 'ein großer Gott der Seele' gewesen ist und den fruchtbaren, ja den verjüngenden Mächten der Erdtiefe verwandt" (MG 115 - Werner Bergengruen zum Tode von Bruno Goetz). Werner Bergengruen starb am 4. September 1964 - vierzehn Tage vor seinem zweiundsiebzigsten Geburtstag. Er hinterließ ein fast unübersehbar reiches Vferk, das von den ersten se1bstandig publizierten Werken des Jahres 1923 - zwei Bänden Erzählungen und einem Roman - bis in die Gegenwart reicht. [...]

Loss of function of the WRN protein causes the genetic disorder Werner Syndrome that is characterized by increased cancer and premature aging. WRN belongs to the RecQ helicase family that plays key roles in preventing genome instability. In response to treatment with genotoxins, WRN is subject to post-translational modification. The relationship of post-translational modification of WRN with its function in DNA metabolism is unknown. There is accumulating evidence suggesting that WRN contributes to the maintenance of genomic integrity through its involvement in DNA replication. Consistent with this notion, WS cells are sensitive to DNA replication inhibitors and DNA damaging agents that tend to block replication fork progression. The cells exhibit an extended S phase, as well as defects in normal bi-directional progression of replication forks diverging from the majority of replication origins. To elucidate the relationship between post-translational modifications of WRN with its function in DNA metabolism, here the acetylation of WRN was studied. In our studies, we provide evidence that WRN acetylation is a dynamic process that strongly correlates to blockage of replication by persistent DNA damage. We also determined the effect of WRN acetylation on its specificity and enzymatic functions. In addition, our studies reveal how agents that block replication regulate the nature of WRN interactions with RPA, a factor known to bind to single-stranded DNA generated at blocked replication forks. Our results demonstrated that WRN and RPA form a stable direct association under normal physiological conditions and treatments that block replication fork progression increase their association, further supporting the idea that WRN is involved in DNA replication through its action at blocked or stalled replication forks. Thus, these studies point to both 1) an important role for acetylation of WRN and 2) its interaction with RPA in the putative function of WRN in response to blocked replication. Overall, our results impact knowledge regarding the relationship between DNA damage, genome instability and the development and progression of aging and cancer.

Zugl.: Bonn, Univ., Diss., 2006