Darbo objektas – kariūnų blauzdą tiesiančių ir lenkiančių raumenų funkcinių ypatybių nustatymas ir palyginimas metų eigoje. Tikslas – nustatyti, kaip pasikeičia kariūnų blauzdos raumenų funkcinės ypatybės per 6 mėnesių trukmės fizinio rengimo ciklą. Uždaviniai: 1. Nustatyti blauzdą tiesiančių ir lenkiančių raumenų susitraukimo vidutinį galingumą, maksimalią jėgą, susitraukimo kampą, nuovargį ir atsigavimo kaitą. 2. Palyginti blauzdos raumenų nuovargio ir atsigavimo skirtumą, tarp pirmojo ir antrojo testavimo, esant dinaminiam raumens susitraukimui. Hipotezė - manome, kad atliekant antrąjį testavimą kariūnai po 6 mėn. studijų turi būti fiziškai pajėgesni, labiau turi pasireikšti blauzdą tiesiančių ir lenkiančių raumenų nuovargis ir atsigavimas. Išvados: 1. Abiejų testavimų metu blauzdą tiesiančių ir lenkiančių raumenų susitraukimo vidutinė galia krūvio metu sumažėjo, o praėjus 5 min. po krūvio atsigavo. 2. Blauzdą tiesiančių raumenų maksimali jėga bei atliktas darbas I-ojo testavimo metu yra didesnis negu blauzdą lenkiančių raumenų, tačiau II-ojo testavimo metu pastebimas didesnis nuovargis abiejų raumenų. 3. Blauzdą tiesiančių raumenų maksimalios jėgos kampas abiejų testavimų metu yra vienodas, tačiau blauzdą lenkiančių raumenų II-ojo testavimo metu yra didesnis. 4. Pastebimas ryškus blauzdos raumenų atsigavimas abiejų testavimų metu. / Object of this work – to determine function features of cadets’ shank straighten and bend muscle and to make comparison in the course of year. Aim – to find out how function features of cadets’ shank muscle are changing during 6 months physical training period. Tasks: 1. To establish contraction average power, maximum power, peak torque, tiredness and recuperation alternation of shank straighten and bend muscle. 2. To compare the difference between 1st and 2nd test of shank muscle tiredness and recuperation when there is dynamic contraction of the muscle Hypothesis – it is thought that during 2nd test after 6 months cadets should have more physical power, there should be displayed more intense tiredness and recuperation of shank straighten and bend muscle. Conclusions: 1. During 1st and 2nd test muscle contraction average power in the course of strain has decreased and after 5 min. it has recuperated. 2. Maximum power of shank straighten muscle and work done during the 1st test is bigger than of bend muscle, but during 2nd test there is seen larger tiredness of both muscle. 3. Peak torque of shank straighten muscle during both tests is the same, but peak torque of shank bend muscle is bigger during the 2nd test. 4. There is seen a distinct shank muscle recuperation during both test.

The twin screw extrusion technique has been explored to produce lyotropic liquid crystal coated powder precursor by exploiting Pluronic F127 thermoreversible gelation property to get powder precursor without granular aggregates or with less compacted granular aggregates. The highly soluble chlorpheniramine maleate loaded in Pluronic F127 solution coated MCC particles prepared through twin screw extrusion was examined to produce the cubic phase (gel) for the development of controlled release formulation and for coating of very fine particles which cannot be achieved by traditional bead coaters. Controlled release formulations are beneficial in reducing the frequency of administration of highly soluble drugs having short half life and also to address the problem of polypharmacy in old age patients by reduction of dosage frequency. An unusual refrigerated temperature (5 C) profile for twin screw extrusion was selected based on the complex viscoelastic flow behaviour of Pluronic F127 solution which was found to be highly temperature sensitive. The Pluronic F127 solution was found to be Newtonian in flow and less viscoelastic at low temperature, such that low temperature (5 C) conditions were found to be suitable for mixing and coating the MCC particles to avoid compacted aggregates. At higher temperatures (35-40 C) Pluronic F127 solution exhibited shear thinning and prominent viscoelasticity, properties which were exploited to force CPM containing Pluronic F127 solution to stick over the MCC surface. This was achieved by elevating the temperature of the last zone of the extrusion barrel. It was found that to avoid compacted aggregates the MCC must be five times the weight of the Pluronic F127 solution and processed at a screw speed of 400 RPM or above at refrigerated temperature. Processing was not found to be smooth at ambient temperature with frictional heat and high torque generation due to significant compaction of coated particles which can be attributed to the elastic behaviour of Pluronic F127 solution at temperatures between ambient to typical body temperature. PLM images confirmed the cubic phase formation (gel) by Pluronic F127 coating which was found to be thick with maximum Pluronic F127 concentration (25%). SEM images showed smoothing of surface topography, and stretching and elongation of MCC fibres after extrusion which is indicative of coating through extrusion processing. Plastic deformation was observed for the lower Pluronic F127 concentration and higher MCC proportions. There was a significant decrease in work done for cohesion by the powder flow analyser observed in the batches with more aggregates compared with batches with least aggregates. A regression analysis study on factorial design batches was conducted to investigate the significant independent variables and their impact on dependent variables for example % torque, geometric mean diameter and work done for cohesion, and to quantitatively evaluate them. From the regression analysis data it was found that the coefficient of determination for all three dependent variables was in the range of 55-62%. The pharmaceutical performance of the prepared coated LLC precursor through twin screw extrusion in terms of controlled release was found to be very disappointing. Almost 100% chlorpheniramine maleate was released within 10-15mins, defined as providing burst release. The MDSC method was developed within this work to detect Pluronic F127 solution cubic phase formation. The MDSC method was developed to consider sample size, effect of heating and cooling, sample heat capacity, and the parameters for highest sensitivity which can be followed by sample accurately without the phase lag to produce accurate repeatable results.

L'elaborato si propone di analizzare le conseguenze dannose scaturenti dalla violazione dell'art. 2103 c.c. Nel primo capitolo ci si sofferma sul concetto di danno, rendendo notizia delle varie teorie concernenti il sistema di responsabilità civile. Nel secondo capitolo si esplorano le diverse ipotesi di danno. in particolare: danni da inadempimento, alla professionalità, alla salute ed esistenziale. Nel terzo capitolo si affronta il tema della tutela assicurativa del danno biologico, ponendo in evidenza i rapporti tra l'indennizzo erogato dall'I.N.A.I.L. ed il risarcimento del danno differenziale. / The dissertation concerns torts and liability in case of transgression of the paragraph 2103 of the Italian civil code. The first chapter is dedicated to torts and liability theories. The second chapter is about various kinds of torts, in the Italian civil code regulation. The author speaks about downgrading consequences, involving workers' health and competences. Moreover he speaks about the loss of enjoyment of life, pain and suffering, caused by the employer's unlawful behaviour. The third chapter concerns workers' insurance, halfway social insurance and accident insurance.