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This study intended to determine if, by using coefficients of variation derived from data collected by Fisher [1989], it would be possible to develop prediction equations to discriminate between sincere and deceptive isokinetic knee extension tests, whether these equations could be applied to a new sample, and whether prediction accuracy is dependent on test speed. Fisher [1989] trained 76 college-age males subjects to either give a true maximal response or fake an injury during an isokinetic knee extension/flexion test at 60, 180, and 300 deg/sec. Data were transmitted to a computer running Segmental Curve Analysis [Wynn, 1988; Sebolt and Earles-Price, 1989], which computed six variables for each torque curve: peak torque (PT), torque at five degrees prior to and post-PT (T-5, T+5), area to five degrees prior to PT (A-5), area beyond five degrees post-PT (A+5), and area between five degrees pre- and post-PT (A55). Coefficients of variation were computed for each variable, which were used to develop prediction equations for each speed, and for all speeds combined. The prediction equations accurately predicted condition assignments (p = 0.572 - 0.79) when applied to Fisher's [1989] data. A second sample was solicited, trained, and tested in a manner similar to Fisher [1989], and the same prediction equations were applied. There was no significant difference (p < 0.05) in the prediction accuracy of these equations between their application to Fisher's [1989] data or to data collected in the current study. Furthermore, there appeared to be no significant effect of test speed on prediction accuracy. These data suggest that coefficients of variation could be used to discriminate between sincere and deceptive isokinetic performances. / Master of Science

Tendon pathologies, including both chronic injuries and acute tendon tears, are some of the most common musculoskeletal injuries. Chronic tendon injury, or tendinopathy, occurs both in athletes and in the general population, and can interfere with quality of life and ability to work. Overuse of the tendon during exercise plays a role in up to 50% of injuries in athletes, and affects multiple parts of the body including the supraspinatus tendon in the shoulder, and the Achilles tendon in the ankle. Acute tears of tendons and ligaments, on the other hand, add substantially to the socioeconomic burden of tendon disease as a whole. These injuries also affect both upper and lower extremities, including the shoulder, ankle, hand, and wrist. Historically, inflammatory processes have been thought to be of little importance in tendon pathology, due to the largely avascular nature of the healthy tissue. However, more recent literature has identified the presence of inflammation in both acute and chronic tendon injury. Because the literature on inflammation in tendon is in its relatively nascent stages, there remain gaps in knowledge that hinder progress in the development of therapeutics to improve healing. A more complete characterization of the inflammatory response in tendon is needed, by defining the relative roles of different molecular pathways, and determining how these pathways interact with tendon mechanobiology. To investigate these questions, an in vitro model was developed, wherein the complexity of the in vivo healing environment was simulated by applying M1 macrophage conditioned media (M1-CM) to tendon fibroblasts (TFs). This was motivated by the well-established role of macrophages in driving tendon inflammatory responses. Characterization of the M1-CM and its effect on TFs revealed a robust inflammatory response, including upregulation of over 500 genes and increased secretion of several cytokines in TFs. Next, multiple immune-related pathways were manipulated in TFs in order to identify those necessary for inflammatory responses. Both the NF-kB pathway and the JAK/STAT signaling pathway were inhibited, to determine their respective roles in propagating inflammation. It was determined that both JAK/STAT and NF-kB were necessary for the response to M1-CM, and each pathway was responsible for different downstream responses to inflammation in TFs. Finally, the role of mechanical loading in tendon responses to inflammation was assessed, as mechanical stimulation is crucial for proper tendon function in homeostasis and in healing. We found that the TF response to loading was altered by the presence of an inflammatory stimulus, with more genes being downregulated by loading under inflammatory conditions. Analysis of the genes that responded differently to loading with inflammation present suggested changes in pathways involving extracellular matrix organization and G protein signaling. In summary, this work served to more completely characterize the tendon inflammatory response. The results of these studies indicate that inflammation in tendon is mediated by both NF-kB and JAK/STAT signaling. Additionally, the application of loading may serve to reduce ECM degradation processes, and calm the inflammatory response in tendon, without suppressing it entirely.

Dissertation submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic Durban University of Technology, 2013. / Objectives: Myofascial pain dysfunction is a common musculoskeletal disorder, known to affect athletes. This research aimed to create a map of myofascial trigger points (MFTPs), to ascertain sport specific combinations. Design and Setting: This IRB approved study was a cross-sectional, observational study. Participants: Forty swimmers and forty non-swimmers (soccer players). Measurements : All participants underwent one assessment, non-intervention session where primary measures included: shoulder disability index (SDI), myofascial diagnostic scale (MDS), algometer and numerical pain rating scale (NRS). Manual palpation, the MDS and an algometer assessed MFTPs and the SDI overall function. SPSS version 20 (IBM) using Pearson’s chi square tests / Fisher’s exact tests compared MFTP locations between the groups, and non-parametric Mann-Whitney tests compared continuous measures (due to significant non-normal distribution), with a p-value <0.05 level of significance. Results: MFTP presence is very uncommon in swimmers, with associated pain and loss of function being very low on average. No evidence was found that swimmers were affected more than non swimmers by MFTPs related pain or loss of function, but has indicated that algometer measurements for infraspinatus MFTP 1, were significantly higher (p<0.027) (showing decreased tenderness) than the values in non swimmers. Conclusions: These results contradict the literature which suggests that unique activity specific patterns of MFTPs exist. This may be as a result of underlying systemic causes of MFTPs that obscured the pattern in this study. It is therefore suggested that larger trials with more participants per group be done in order to verify the results of this study.

Thesis (MOccTher)--Stellenbosch University, 2014. / ENGLISH ABSTRACT: Introduction: This research was conducted to establish the assessment practices of occupational therapists working with clients with upper limb injuries and/or conditions. This was done to get an updated account of frequency and variation in the use of various assessment tools as well as reasons offered for infrequent use. Methodology: A quantitative cross-sectional survey design was used. A convenience sample of therapists attending courses was recruited for the study. A questionnaire was developed for the study and face and content validity established through pilot testing. The questionnaire consisted of three sections containing demographic information and questions about upper limb assessment practices. Descriptive statistics were calculated for numerical and categorical data to describe the demographic characteristics and to identify the measurement tools that were used most frequently. The Chi-Square test of associations was used to determine whether there were any associations between frequency of use and demographic factors. Results: Questionnaires were completed by 81 (71%) respondents. Twenty-two (27.2%) of the respondents had more than five years’ experience in the field of hand therapy while the remainder (n=52, 64.2%) had less than five years. The more experienced therapists worked in the private sector (n=49, 60.5%) with two (0.03%) experienced therapists being employed in the public sector. The diagnoses that were seen most commonly were nerve injuries (90.1%), fractures (88.8%) and tendon injuries (85.1%). Of the 81 respondents 15 (18.5%) held post graduate qualifications in the field of hand therapy. Goniometry (68 of 81, 84.0%), manual muscle testing (62 of 81, 76.5%) and testing for flexor digitorum profundus and superficialis function (61 of 81, 76.3%) were used most frequently. Performance tests were used infrequently or not at all. The most common reasons for non-use of performance tests were that they were not available in the practice setting or respondents were not familiar with them. Significant associations were found between frequency of using measurement tools and practice setting, years of experience and holding a post graduate qualification in the field of hand therapy. There was a significant association between working in the private sector and using a dynamometer (p < 0.001), and working in government settings and frequent use of the test for localisation (p = 0.021). Therapists with more than five years’ experience in the field of hand therapy were significantly more likely to use Semmes Weinstein monofilaments (p = 0.034) as were those holding a post graduate qualification in hand therapy (p <0.001). Conclusion: The results of this study have serious implications in terms of the upper limb assessment practices of occupational therapists, especially in the context of evidence-based practice which has become crucial not only for the credibility of the profession, but also for its survival. Information obtained through this research could aid to guide education and training at an undergraduate and post graduate level and assist to direct a research focus for hand therapy in the South African context. / AFRIKAANSE OPSOMMING: Inleiding: Hierdie navorsing is uitgevoer om die bepalingspraktyke van arbeidsterapeute wat werk met kliënte met boonste ledemaat beserings en/of toestande vas te stel om sodoende ‘n beeld te verkry van die frekwensie en variasie van die gebruik van bepalingsinstrumente. Redes aangebied vir ongereelde gebruik hiervan is ook ondersoek. Metode: 'n Kwantitatiewe deursnee-opname-ontwerp is gebruik. ’n Gerieflikheidssteekproef van terapeute wat kursusse bygewoon het, is gewerf vir die studie. ‘n Vraelys is ontwikkel vir die studie, en voorkoms- en inhoudsgeldigheid is bepaal deur ‘n loodstudie. Die vraelys het bestaan uit drie afdelings met demografiese inligting en vrae oor boonste ledemaat bepalingspraktyke. Beskrywende statistiek is bereken vir numeriese en kategoriese data ten einde die demografiese eienskappe te beskryf en die bepalingsmetodes wat die meeste gebruik is, te identifiseer. Die Chi-kwadraat toets is gebruik om te bepaal of daar enige assosiasies tussen die frekwensie van gebruik en demografiese faktore bestaan. Resultate: Vraelyste is deur 81 (71%) respondente voltooi. Twee-en-twintig (27,2%) van die respondente het meer as vyf jaar ondervinding in die veld van handterapie gehad, terwyl die res (n = 52, 64.2%) minder as vyf jaar gehad het. Die meer ervare terapeute het gewerk in die privaatsektor (n = 49, 60.5%) met twee (0,03%) ervare terapeute in diens van die staat. Senuweebeserings (90.1%), frakture (88,8%) en tendonbeserings (85.1%) was die meeste gesien. Van die 81 respondente het 15 (18,5%) ‘n nagraadse kwalifikasie in die veld van handterapie gehad. Goniometer (68 van 81, 84.0%), spiertoetsing (62 van 81, 76,5%) en die toetse vir fleksor digitorum profundus en superficialis funksie (61 van 81, 76,3%) is die meeste gebruik. Vaardigheidstoetse is selde of glad nie gebruik nie. Die mees algemene redes aangevoer vir die feit dat vaardigheidstoetse nie gebruik is nie, was dat dit óf nie beskikbaar is in die respondent se werksarea nie, óf dat respondente nie vertroud is met die toetse nie. Beduidende assosiasies is gevind tussen die frekwensie van die gebruik van bepalingsmetodes en werksarea, jare ervaring in handterapie en 'n nagraadse kwalifikasie in die veld van die handterapie. Daar was 'n beduidende assosiasie tussen terapeute werksaam in privaatpraktyk en die gebruik van 'n dinamometer (p < 0,001) en terapeute werksaam in die staat en gereelde gebruik van die lokalisasie toets (p = 0.021). Terapeute met meer as vyf jaar ondervinding, sowel as diegene met ’n nagraadse kwalifikasie in handterapie was beduidend meer geneig om Semmes Weinstein monofilaments te gebruik (p = 0,034 en p < 0,001 respektiewelik). Gevolgtrekking : Die bevindinge van hierdie studie het ernstige implikasies in terme van die arbeidsterapie bepalingspraktyke van die boonste ledemaat, veral in die konteks van bewys-gebaseerde praktykvoering (evidence based practice) wat noodsaaklik geword het nie net vir die geloofwaardigheid van die beroep nie, maar ook vir die oorlewing daarvan. Inligting wat verkry is deur middel van hierdie navorsing kan help met onderrig en opleiding op 'n voor-en nagraadse vlak. Dit kan ook help om navorsing in handterapie te rig binne die Suid- Afrikaanse konteks.

Thesis (MScPhysio)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: Background Traumatic spinal cord injury (SCI) remains one of the most serious and devastating injuries often resulting in permanent disability and with life changing implications for the individual and his/her family. Successful reintegration into community life and employment after SCI is considered important goals of rehabilitation as this has been positively associated with quality of life, self esteem and life satisfaction. The International Classification of Functioning, Disability and Health (ICF) allows researchers to identify the impact of environmental factors on functioning and disability. Minimal research, particularly in South Africa, has been done on the impact of the environment on persons living with various health conditions and specifically spinal cord injury. Objectives The main purpose of this study was to describe and compare the level of participation of persons with traumatic SCI at two time points (discharge and six months after discharge) from the inpatient rehabilitation setting and to identify the environmental barriers experienced. Methods A prospective, descriptive study was conducted using consecutive sampling. All patients with traumatic SCI that were discharged from September 1, 2008 from the Western Cape Rehabilitation Centre (WCRC) who were eligible for this study were included. Two questionnaires (one based on the ICF and one purposely-developed) and the International Standards for the Classification of SCI (ISCSCI) were used. Data were analyzed with the statistical software package STATISTICA. Results A person sustaining a traumatic SCI in the Cape Metropolitan area of the Western Cape Province is most likely to be a male, young (20 to 29 years), of the Black or Coloured race and living in the Cape Flats suburbs. More than half of the subjects had a grade eight to ten level of education which together with the lack of employers’ responsibilities towards part-time workers might explain the low percentage (11%) of employment at six months after discharge from the WCRC. Complete paraplegia, occurring mainly in the thoracic cord, was the most common neurological disability found in this study. The most common secondary condition was pain followed by spasticity limiting function. The low incidence of pressure sores and urinary tract infections found in this study contradicts findings of previous studies.The majority of the subjects were discharged to the same house they were living in at the time of their injury. However, due to various architectural barriers, some of them were not able to function independently in their homes. Inaccessibility of public transport, the lack of recreational and sport facilities, lack of social support structures in the community and inadequate financial resources were the main environmental barriers experienced by these individuals. Conclusion The main finding of this study was the low employment rate and the difficulty experienced with reintegration at community level after SCI. The results of this study confirm the significant contribution of environmental factors in participation, especially those of transport and education in return to work. Fourteen years after the publication of the Integrated National Disability Strategy (INDS) White Paper (1997), legislative strategies to ensure that people with disabilities have equal access to social and economic opportunities remain lacking. / AFRIKAANSE OPSOMMING: Agtergrond Traumatiese spinaalkoordbesering (SKB) lei dikwels tot permanente verlamming en dit het lewensveranderende implikasies vir die individu en sy/haar familie. Suksesvolle herintegrasie in die gemeenskap en werkverrigting na SKB is belangrike doelstellings vir rehabilitasie omdat dit positief met lewenskwaliteit, selfrespek en lewens-bevrediging geassosieer word. Die Internasionale Klassifisering van Funksionering, Gestremdheid en Gesondheid (IKF) bied aan navorsers die geleentheid om die impak van omgewingsfaktore op funksionering en gestremdheid te identifiseer. Daar is veral in Suid-Afrika beperkte navorsing oor die impak van die omgewing op mense met verskillende gesondheidstoestande, spesifiek SKB. Doel Die hoofdoel van hierdie studie was om die vlak van deelname van mense met traumatiese SKB op twee verskillende tye te beskryf en te vergelyk, onmiddellik na hulle uit die rehabilitasiesentrum ontslaan is, en ses maande later. Die studie het ook ten doel gehad om die omgewingsfaktore te identifiseer wat deelname negatief beïnvloed. Metode Daar is van ’n beskrywende studie gebruik gemaak. Alle pasiënte met traumatiese SKB wat vanaf 1 September 2008 vanaf die Wes-Kaapse Rehabilitasiesentrum (WKRS) ontslaan is en wat voldoen het aan die insluitingskriteria is ingesluit. Twee vraelyste is gebruik om data in te samel – een is op die IKF gebaseer en een is spesifiek vir die studie ontwikkel. Daar is ook van die Internasionale Standaarde vir die Klassifisering van SKB (ISKSKB) gebruik gemaak om data in te samel. Data is met behulp van STATISTICA, ’n statistiese sagteware pakket, geanaliseer. Resultate Iemand wat ’n traumatiese SKB in die Kaapse metropolitaanse gebied van die Wes-Kaap provinsie opdoen, is mees waarskynlik ’n jong man (20 tot 29 jaar) van die Swart of Kleurling ras wat woonagtig in die voorstede op die Kaapse Vlakte is. Meer as die helfte van die deelnemers in die studie het slegs ’n opvoedingsvlak van graad agt tot tien. Hierdie aspek, tesame met die gebrek aan werkgewers se verantwoordelikheid teenoor deeltydse werknemers is dalk die rede waarom slegs 11% van die deelnemers ses maande na hulle uit die WKRS ontslaan is, werksaam was. Volledige paraplegie, hoofsaaklik as gevolg van ’n besering van die torakale spinaalkoord, was die algemeenste neurologiese besering wat in hierdie studie gevind is. Die algemeenste sekondêre komplikasie wat voorgekom het, was pyn gevolg deur spastisiteit. Die lae voorkoms van druksere en urienweginfeksies in dié studie is in teenstelling met bevindings van vorige studies. Die meeste deelnemers is ontslaan na dieselfde huis waar hulle voor die besering gewoon het, maar as gevolg van verskeie argitektoniese hindernisse, kon sommige van hulle nie onafhanklik binne hulle wonings funksioneer nie. Die ontoeganklikheid van openbare vervoer, die gebrek aan ontspannings- en sportfasiliteite, die gebrek aan sosiale ondersteuningsnetwerke in die gemeenskap en onvoldoende finansiële hulpbronne was die algemeenste omgewingshindernisse wat deur die deelnemers ondervind is. Samevatting Die belangrikste bevinding van dié studie was dat slegs ’n klein persentasie van die deelnemers ses maande na hul ontslaan is, werksaam was en dat herintegrasie in die gemeenskap na ’n SKB baie moeilik is. Die resultate van die studie bevestig die belangrike rol wat omgewingsfaktore by deelname speel, veral die faktore wat te make het met vervoer en die opvoedingsvlak wanneer daar na ’n werk teruggekeer word. Veertien jaar na die publikasie van die Geïntegreerde Nasionale Gestremdheidstrategie in 1997, is wetgewende strategieë om gelyke toegang tot sosiale en ekonomiese geleenthede vir persone met gestremdhede te verseker, steeds gebrekkig.

published_or_final_version / Community Medicine / Master / Master of Public Health