<p>Mechanical instruments, such as saw and bur are commonly used for bone cutting during orthopedics surgeries. These conventional instruments showed good bone removal efficiency. Nonetheless, there are some issues with the use of the mechanical tools, such as ill-placed screws and elevation of tissue temperature, which results in thermal damage to the surrounding tissues. These difficulties accompanied with using mechanical tools led to laser ablation investigations. Lasers, including continues wave (CW) and pulsed, were considered to be a promising tool for bone ablation. When compared to mechanical tools, lasers produce less thermal damage to the surrounding tissues due to their ability to focus on a very small spot, which also produces more precise ablation. Lasers also produce no significant mechanical vibrations within the surrounding tissue and thus less mechanical damage and cracks occur during ablation. Performances of laser ablations are measured by several factors; such as collateral damage, machining time, ablated depth, and ablative precision. In this thesis work, a literature review was conducted with the aim of understanding the bone characteristics that are related to the optical properties of bone, which leads to a better understanding for ablation mechanisms. This helps in a proper choice of laser parameters for a certain tissue ablation, and thus avoiding collateral damage.</p> <p>Some laser parameters (pulse energy, scanning speed, and number of passes) were characterized as a first step towards producing large holes. The effect of each one of these laser parameters on the groove depth was found. The feasibility of the ultrafast laser in creating large scale holes was examined, using two scanning strategies: (i) concentric circles scanning, the largest crater depth measured using this procedure was 3.81 mm, (ii) helical scanning, which was used to reduce the machining time, using this procedure a micropillar was created with 12 passes in just 2.5 minutes.</p> / Master of Applied Science (MASc)

No description available.

The phenomenon of spallation, a process by which pieces of char "pop off" a heat shield, has been investigated as it occurs in carbon-reinforced phenolic ablators. Spallation is shown to be the result of a pressure buildup within the char. This pressure increase results from occlusion of the char and the consequent blockage of now. By selective fiber orientation, the spallation process can be alleviated. / Master of Science

A complex chemical system of teflon/air mixture over an axisymmetric decoy at hypersonic reentry flight conditions has been analyzed by using the nonequilibrium viscous shock-layer method. The equilibrium catalytic wall boundary condition was used to obtain the species concentration at the wall. The species conservation equation for binary mixture (air/teflon) was solved to obtain the concentration of freestream air at the wall. Two test cases were chosen to demonstrate the capability of the current code. Due to lack of experimental or theoretical data, the surface measurable quantities from the current code(VSLTEF) were compared with the equivalent air injection and no-mass injection data obtained from VSL7S code. The current code predicts a higher total heat-transfer rate than that predicted by the seven species nonequilibrium air code (VSL7S) with the same injection rate due to the high diffusional heat-transfer rate. The wall pressure was not affected by blowing, while the skin-friction coefficient was decreased (i.e., 43 % reduction for teflon ablation case ; 53 % for nonequilibrium air injection case at 125 kft) when compared with that of no-mass injection case. A shock-layer peak temperature drop ( 1512° R for 125 kft altitude and 848°R for 175 kft altitude) was observed at both cases. The temperature drops were chiefly due to endothermic reactions (dissociation) of the teflon ablation species. Due to large blowing of teflon, the average molecular weight increased substantially and resulted in a reduction of the specific heat ratio γ and an increase in the Prandtl number at the wall. The impurity of sodium was the major source of free electrons near the wall at the end of the vehicle at 125 kft altitude; however, at 175 kft altitude NO⁺ was the major source of free electrons over the entire body. The peak concentration of Na⁺ increased along the body, but that of NO⁺ decreased at both altitudes; While the chemical reaction rate data used is believed to be the best currently available, uncertainties in this data as were cited by Cresswell et al.(1967) may lead to quantitative changes in the above teflon ablation results. / Ph. D.

Irreversible electroporation (IRE) is a non-thermal ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell morphology is larger, more abundant nuclei, our team set out to explore the possibility of preferentially targeting this physical and geometrical characteristic. / Master of Science

Since its conception in 2005, irreversible electroporation (IRE), a non-thermal tumor ablation modality, was investigated for safety and efficacy in clinical applications concerning different organs. IRE utilizes high voltage (~3kV), short duration (~100us) pulses to create transient nanoscale defects in the plasma membrane to cause cell death due to irreversible defects, osmotic imbalances and ATP loss. More recently, high-frequency irreversible electroporation (H-FIRE), which employs narrow bipolar pulses (~0.5-10us) delivered in bursts (on time ~100us), was invented to provide benefits such as the mitigation of intense muscle contractions associated with IRE-based treatments. Furthermore, H-FIRE exhibits the potential to improve lesion predictability in homogeneous and heterogeneous tissue masses. Therapeutic IRE and H-FIRE utilize source and sink electrodes inserted into or around the tumor to deliver the treatment. Prediction of the ablation size, for a set of parameters, can be achieved by the use of pre-treatment planning algorithms that calculate the induced electric field distribution in the target tissue. An electric field above a certain threshold induces cell death and parameters are tuned to ensure complete tumor coverage while sparing the nearby healthy tissue. IRE studies have shown that the underlying field is influenced by the increase in tissue conductivity due to enhanced membrane permeability, and treatment outcome can be improved when this nonlinearity is accounted for in numerical models. Since IRE pulses far exceed the time constant of the cell (~1us), the tissue response can be treated as essentially DC a static approximation can be used to predict the field distribution. Alternately, as H-FIRE pulses are on the order of the time constant of the membrane, the tissue response can no longer be treated as DC. The complexity of the H-FIRE-induced field distribution is further enhanced due to the dispersion and non-linearity in biological tissue impedance during treatment. In this dissertation, we have studied the electromagnetic fields induced in tissue during H-FIRE using several experimental and modeling techniques. In addition, we have characterized the nonlinearity and dispersion in tissue impedance during H-FIRE treatments and proposed simpler methods to predict the field distribution to enable easier translation to the clinic. / Ph. D. / Development within urbanized regions increase impervious surfaces, which further cause significant storm events in watersheds. The increased impervious surfaces result in hotter stormwater particularly during hot summers, which has diverse effects on aquatic health of downstream receiving streams. The main objective of the current study is to evaluate the thermal impact of urbanization on aquatic health habitats in Stroubles Creek Watershed, Blacksburg, Virginia. To aim this goal and achieve the thermal evaluation of the highly urbanized Stroubles Creek Watershed, a U.S. Environmental Protection Agency’s Storm Water Management Model (SWMM) and a Minnesota Urban Heat Export Tool (MINUHET) models from scratch of the Stroubles Creek watershed, using Town of Blacksburg and Virginia Tech Physical Facility information were developed. This necessitated combining information from a wide variety of sources, including geologic maps, geodatabases, hydraulic models, computer-aided design (CAD) files, and scanned as-built information. In addition to the models, a hybrid model was developed that combines SWMM and MINHET outputs. The temperatures and heat loads at the downstream of the watershed were predicted using SWMM, MINUHET, and Hybrid models for two summer periods of 2016 and 2015, and the predicted temperature were compared to the criteria for survival of aquatic health such as trout. Furthermore, a number of thermal mitigation strategies such as bioretentions systems, concrete pavements (which has lighter color compared to asphalt pavements), and increased vegetation canopies were simulated within the MINUHET and SWMM models configurations to reduce simulated temperatures and heat loads at the watershed scale. The simulated temperatures and heat loads represented that concrete pavements results in better performance of thermal mitigation within watersheds than bioretention systems, and increased vegetation canopies.

Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) is now a well established analytical technique used to sample solid materials and determine their elemental composition. Two areas that are becoming increasingly important, and for which LA-ICP-MS is a key tool, are bio-imaging and the analysis of micro-particulates. However, current instrumental designs limit the practicality of the technique for these applications. This study investigates the development of a high speed, high efficiency LA-ICP-MS interface through modelling of the flow dynamics of a newly designed laser ablation cell and experimental investigation of single laser pulse response. Through this work the Sniffer-Dual Concentric Injector interface was realised. This interface reduced particle residence times within the laser cell and transport tubing. The interface was also used to investigate turbulence related aerosol dispersion within the ICP and potential designs to overcome this. The resulting design yields an interface with improved sensitivity and reduced aerosol dispersion such that a lower limit of detection is achieved, important when considering the mass of analyte in a single cell or micro-particulate, compared to existing designs. Thus the interface can be used to improve image spatial resolution as the ablation spot size, and thus pixel information, can be reduced; and also reduces total analysis time. The calibration technique Laser Ablation of a Sample In Liquid (LASIL) was also investigated as a means of calibration for solid samples. The investigation lead to the development of LASIL in a droplet, a technique that can be used to calibrate solid samples when a matrix matched standard is unavailable. The mechanism of the technique resulted in an improved laser-energy sample coupling efficiency and a reduction in the liquid to ablated mass ratio, thus decreasing sampling time. As the technique captures the ablated particulate in solution, post chemistry techniques can be used to remove analyte interferences.

Les impulsions laser de quelques cycles optiques offrent des capacités remarquables dans l’interaction laser-matière, en particulier pour l’ablation de matériaux diélectriques. Cependant, la focalisation d’impulsions laser ultracourtes dans l’air implique des limitations naturelles à la propagation linéaire du faisceau en amont de la cible. Dans ce contexte, on étudie l’ablation en surface de matériaux diélectriques lorsqu’ils sont irradiés par une impulsion unique de 12 fs dans l’air, dans des gammes d’intensités situées au-dessous et au-dessus de l’apparition des effets non linéaires dans l’air. En particulier, nous avons établi le lien entre la distribution en fluence en fonction des régimes de focalisation linéaire et non linéaire, et les diamètres des cratères. Nous avons démontré que le profil des cratères peut être prédit malgré les importantes modifications du faisceau laser à haute énergie, pour deux matériaux : la silice fondue et le saphir. Puis, après avoir identifié un régime d’ablation où le faisceau laser n’est pas affecté par ces effets non linéaires, nous avons développé un ensemble de diagnostics permettant de caractériser le plasma crée. Nous avons discuté et comparé les résultats obtenus sur les deux matériaux. En régime d’ablation, il apparaît alors que la densité du plasma est inférieure ou proche de la densité critique. De plus, la pénétration du faisceau est plus importante dans le cas du saphir que de la silice fondue donnant lieu à des cratères plus profonds. / Few-cycle laser pulses offer remarkable capabilities for laser-matter interaction, especially for ablation of transparent dielectric materials. However, focusing ultrashort laser pulses in air implies natural limitations to linear beam propagation prior the target. In this context, we study the surface ablation of dielectrics with single 12 fs laser pulses in air, at intensities below and above the apparition of nonlinear effects in air. In particular, we establish the link between the fluence distribution at the laser focus, spanning from linear- to nonlinear- focusing regimes, and the ablated crater diameters. We demonstrate that the crater profile can be predicted despite significant beam reshaping taking place at high fluence, for fused silica and sapphire. Then, we identify an ablation regime where the beam is still unaffected by nonlinear effects in air. In these conditions, we developed an energy balance experiment, allowing characterizing the created plasma. We discuss and compare the results acquired on fused silica and sapphire. We show that in ablation regime the density plasma is below or nearby the critical density. Moreover, the beam penetration is higher in sapphire than in fused silica, yielding deeper craters.

Cette thèse est centrée sur le couplage entre les phénomènes d’écoulement, d’ablation et de rayonnement au voisinage du point d’arrêt de véhicules d’entrée atmosphérique pourvus d’un système de protection thermique de type carbonephénolique. La recherche est divisée en trois parties : 1) le développement de méthodes numériques et d’outils pour la simulation d’écoulements hypersoniques hors équilibre autour de corps émoussés, 2) la mise en oeuvre d’un nouveau modèle de transport du rayonnement hors équilibre dans ces écoulements, y compris dans les couches limites contaminées par les produits d’ablation, et 3) l’application de ces outils à des conditions réelles de vol.Les effets du couplage entre l’ablation et le rayonnement sont étudiés pour les rentrées terrestres. Il est démontré que les produits d’ablation dans la couche limite peuvent augmenter le blocage radiatif à la surface du véhicule. Pour les conditions de flux maximum d’Apollo 4, les effets de couplage entre le rayonnement et l’ablation réduisent le flux conductif de 35%. L’accord avec les données radiométriques est excellent, ce qui valide partiellement la méthode de couplage et la base de données radiatives. L’importance d’une modélisation précise du soufflage du carbone dans la couche limite est également établie. / This thesis focuses on the coupling between flow, ablation, and radiation phenomena encountered in the stagnation region of atmospheric entry vehicles with carbon-phenolic thermal protection systems. The research is divided into three parts : 1) development of numerical methods and tools for the simulation of hypersonic, non equilibrium flows over blunt bodies, 2) implementation of a new radiation transport model for calculating nonequilibrium radiative heat transfer in atmospheric entry flows, including ablation contominated boundary layers, and 3) application of these tools to study real flight conditions.The effects of coupled ablation and radiation are studied for Earth entries. It’s shown that ablation products in the boundary layer can increase the radiation blockage to the surface of the vehicle. An analysis of the Apollo 4 peak heating condition shows coupled radiation and ablation effects reduce the conducted heat flux by as much as 35% for a fixed wall temperature of 2500 K. Comparison with the radiometer data shows excellent agreement, partially validating the coupling methodology and radiation database. The importance of accurately modeling the amount of carbon blown into the boundary layer is demonstrated by contrasting the results of other researchers.

Afin de déterminer l’état dans lequel les fragments arrivent au sol et leurs points d’impact, une compréhension fine des phénomènes physiques intervenant lors de la rentrée atmosphérique des débris spatiaux, ainsi qu’un effort important de modélisation sont nécessaires. Il s’agit en particulier d’analyser et de modéliser des phénomènes physiques peu pris en compte jusqu’à présent par les approches existantes et connues. Durant cette thèse une modélisation des interactions entre fragments en régime continu hypersonique et supersonique pour des écoulements de gaz parfait et de gaz réel a été proposée. Ceci a permis de montrer l’influence significative de ce phénomène sur la dynamique et la survie d’une sphère située dans la couche de choc générée par un premier fragment. D’autre part, un modèle pour l’estimation des coefficients aérodynamiques de force et de moment ainsi que le coefficient de flux de chaleur en régime hypersonique du moléculaire libre au continu est proposé. En complément des régimes hypersonique et supersonique, un modèle préliminaire pour le calcul des coefficients aérodynamiques en régime transsonique a été développé. Un modèle de conduction thermique adapté à la rentrée des débris spatiaux a été développé. Les influences du modèle de conduction, de l’épaisseur de paroi et de la prise en compte de la dépendance en température de la conductivité thermique et de la capacité calorifique sur la distribution de température dans la paroi ont été montrées. D’autre part, une étude expérimentale sur l’oxydation de l’alliage de titane TA6V a été menée au laboratoire PROMES-CNRS d’Odeillo sous plasma d’air. Les premiers résultats confirment la nécessité de tenir compte de l’oxydation de la paroi en particulier dans un environnement à haute température où l’oxygène est dissocié comme c’est le cas pour les rentrées atmosphériques terrestres de débris spatiaux. Par ailleurs, un modèle de dégradation thermique de la paroi par fusion (ablation) a été mis en place. Ces modèles ont été implantés dans le code MUSIC/FAST de l’ONERA. Celui-ci, initialement conçu pour l’analyse pré-mission de la rentrée de véhicules ou de capsules, a été évalué, consolidé et amélioré pour son application à la rentrée des débris spatiaux.Les coefficients aérodynamiques et aérothermodynamiques calculés par le code ont été confrontés aux données issues de la littérature pour différentes géométries. Enfin, la rentrée atmosphérique d’un réservoir sphérique a été simulée permettant d’évaluer l’influence de différents paramètres (pente, propriétés des matériaux, propriétés de la paroi interne du réservoir, épaisseur de la paroi) sur la trajectoire du fragment et son état lors de son impact au sol. / In order to determine the conditions in which fragments reach the Earth as well as their impact point locations,a deep comprehension of the physical phenomena occurring during the atmospheric re-entry of space debris is necessary, as well as an important effort in the development of models. Especially, it is important to analyse and develop models for the physical phenomena neglected in the existing and known approaches. During this thesis, some effort was put into the development of a fragment interaction model in continuum hypersonic and supersonic regime, in perfect and real gas at equilibrium. It was critical to understand the significant influenceof this phenomenon on the dynamics and survival of a sphere situated in the shock wave generated by a primary fragment. On the other hand, a model allowing the aerodynamic force and moment coefficients estimation anda model to evaluate the heat flux coefficient in hypersonic regime from free-molecular to continuum flow have been proposed. Subsequently, a first model to compute the aerodynamic coefficients in transonic regime has beendeveloped. A thermal conduction model adapted to the study of atmospheric re-entry of space debris has been developed. The significant influence of the conduction model, the wall thickness and the thermal dependence of material properties such as thermal conductivity and specific heat capacity on the wall thermal distribution have been shown. A first wall ablation model by melting has been set up. On the other hand, an experimental study on the oxidation of the TA6V titanium alloy has been conducted at PROMES-CNRS laboratory, Odeillo,in plasma air environment. The results confirm the necessity to take into account the wall oxidation, especially in a high temperature environment where oxygen is dissociated, as encountered in Earth atmospheric re-entry of space debris. A model for the thermal degradation of the wall by melting (ablation) has been developed. These models have been implemented in the ONERA code named MUSIC/FAST. This one, initially designed for spacecraftre-entry pre-mission analysis, has been evaluated, consolidated and improved for space debris atmosphericre-entry applications. For validation purpose, the aerodynamics and aerothermodynamics coefficients computed by the code have been compared to the ones found in literature, for various geometries. Finally, the atmosphericre-entry of a spherical tank has been simulated allowing the evaluation of the influence of different parameters(angle of climb, material properties, internal wall properties and wall thickness) on the fragment trajectory andits state when it reaches the ground.