No description available.

No description available.

This work consists of four separate chapters. Although they are seemingly different projects, they have a common feature - the application of organometallic chemistry. 1. Lusianthridin and denbinobin, the phenanthrene derivatives, can be found in plants of the family Orchidaceae. They exhibit cytostatic activity against cancer of human lung and ovarian and against promyelocytic leukemia. Therefore, new synthetic methods for these substances may be applied in research and development of new bioactive compounds. I prepared 9,10- disubstituted phenanthrenes through reactions of biphenylene with alkynes, which were catalyzed by iridium complexes. Phenanthridine derivatives are found naturally in the group benzo[c]phenanthridine alkaloids. The most famous of these include sanguinarine and chelerythrine. Sanguinarine selectively induces apoptosis (planned cell death) of human cancer cells and, therefore, is investigated as a potential antitumor agent. Chelerythrine selectively inhibits protein kinase C, leading again to apoptosis. I have studied reactions of biphenylene with nitriles catalyzed by rhodium complexes that have not been described yet. By this, I prepared a series of 6-substituted phenanthridines. 2. Carboranes are artificially prepared organic compounds of boron, which are not represented in...

Title: Comparative analysis of selected soccer kicks Objectives: The main objective of the study is to characterize the involvement of selected muscles during soccer kicks by time and space and subsequent comparison with specific exercises with expander by EMG measurement. Methods: The study has a character of a case study, comparative analysis of relative timing of movement and activity of selected muscles during soccer kicks by surface poly-electro-myographical analysis and kinematic analysis. Results: Timing of muscles involvement during soccer kicks is different than timing of muscles involvement during exercise with expander. Keywords: EMG, soccer, kick, muscles, activation

Inflammatory immune response is essential for maintaining the defense against invading pathogens, although its aberrant activation leads to impaired self tolerance and development of autoimmune pathologies. Interleukin-17A (also known as IL-17), is a major proinflammatory cytokine, which contributes to the development and maintenance of inflammation and provides protection against several bacterial and yeast infections. However, extreme activation of IL-17 signaling leads to autoimmune pathologies. Thus, a strict regulation of IL-17 signal transduction is crucial to prevent progression of autoimmunity. Non-degradative ubiquitination is one of the main mechanisms regulating IL-17 signaling. Main E3 ubiquitin ligase within this signal transduction is TRAF6, which is also participating in several signaling pathways within the immune system. Non-degradative polyubiquitin chains created within inflammatory signaling complexes recruit signaling proteins such as IKK complex and TAK1 kinase, crucial for triggering of NF-κB and MAPKs downstream pathways. However, activation of these pathways upon IL-17 is very weak in comparison with other inflammatory stimuli, indicating a presence of a strong negative feedback loop. In this thesis, we establish the role of several regulatory molecules in IL-17 signaling....

The topic of the diploma work is the village Milesov, the Czech Central Range. In a common level inquires into issues of czech villages in the area of Sudets, which were displaced after the Second World War. The work proposes particular ways focused on activation of the village supporting self-sufficiency and self-confidence.

Strategy of restoring the city values and its identity considering the strengthening of its social and economic position according to the current needs." The task of my thesis is trying to find the genuinity again, which will be making the city more stable and sustainable.

No description available.

KRATKY, Jakub. Monitoring the activation of selected muscle groups of clients with spinal cord injuries. Prague: Charles University, Faculty of Physical Education and Sport, 2013. 82 pages. Supervisor Doc. PaedDr. Karel Jelen, CSc The aim of this thesis is to monitor the activation of selected muscle groups (musculus deltoideus pars anterior, musculus deltoideus pars posterior, musculus triceps brachii caput laterale and musculus trapezius pars descendus) during double poling ergometry. Nine subjects with different spinal cord lesions volunteered to participate in the study. The surface electromyography is used to detect the musculus activation. The monitoring of four muscle groups is devided into three phases. Firstly, all the participants double-poled for one minute at moderate intensity according to the Borg scale. Each participant underwent a 10-minute intervention to correct the posture. In the last phase the volunteers exercised again for one minute at moderate intensity. The aim of the intervention is to decrease muscle activation of musculus deltoideus pars anterior and musculus trapezius pars descendus (muscles with a tendency to hypertonia during wheelchair propulsion and activity of daily living) and to increase muscle activation of musculus deltoideus pars posterior and musculus triceps...

The goal of the thesis was to characterize transcriptional profiles of in vivo and in vitro derived embryos during bovine minor and major embryonic genome activation and to identify mRNA transcripts newly synthesized during these stages. In our first work we have concentrated on the study of minor genome activation at the 4-cell stage of embryo. Using SSH, we have identified 31 amplicons homologous with already identified genes. We have selected 5 of these for detailed study of their expression during the whole period of preimplantation development: centromere protein, 350/400 kDa (CENPF, mitosin), splicing factor arginine/serine-rich 3 (SRFS3), high mobility group nucleosomal binding domain 2 (HMGN2) protein and eukaryotic translation initiation factors EIF4A2 a EIF4E. All these genes play an important role in the early embryo development. SRFS3 is the first described gene with an important function in preimplantation development, which is expressed already during bovine minor genome activation, and its transcription is α-amanitin sensitive during this period. We have selected CENPF gene for a more thorough study. By silencing its expression by the injection of CENPF dsRNA into the zygote, we have studied its function throughout the whole preimplantation development of bovine embryo....