Introduction: Unhealthy alcohol use is a substantial problem among college students and can lead to a variety of negative consequences. Commercially available web-based brief alcohol intervention (WBI) programs have demonstrated efficacy in a range of student groups and have been widely disseminated to colleges to address this issue. However, the majority of published WBI studies required participants to complete baseline research assessments (RA) about their alcohol use before the WBI and reactivity to the RA may have inflated WBI efficacy estimates in these studies. The present study tested whether there was an additive effect of RA administered online plus a WBI on alcohol consumption, alcohol consequences, and protective behaviors related to alcohol used in the past month compared to the effects of only a WBI. It was hypothesized that participants randomized to the RA+WBI condition would have significantly lower alcohol consumption in the past month, fewer alcohol-related problems, and use more protective behaviors related to alcohol consumption in the past month than participants randomized to the WBI only condition. Methods: Undergraduate students (n= 856) from universities in the United States and Canada were recruited for this online study. Seventy percent of the sample was female and 82% were Caucasian. The sample had a mean age was 20.0. Sixty four percent (n= 547) of participants who were randomized completed the WBI. Sixty-eight percent completed the one month follow up questionnaire. Results: Multiple regression analyses using 20 multiply imputed datasets revealed that there were no significant differences in groups at follow up on alcohol use measures, alcohol related problems, or protective behaviors used when controlling for variables with theoretical and statistical relevance to the models. A repeated measures analysis of covariance indicated that there was a significant decrease in peak estimated blood alcohol concentration from baseline to follow up, but no differential effect by randomization group. The results suggested there was a moderate effect of the WBI consistent with studies of WBI efficacy in the literature and that there were no substantial assessment reactivity effects. Discussion: The current study contributes to the literature by identifying an experimental condition under which assessment reactivity may not be present and does not appear to cloud the detection of WBI efficacy when measured within subjects. The results indicate that WBI researchers may be justified in conducting brief pretreatment research assessments online to collect information about participant alcohol use without biasing within subjects estimates of WBI efficacy. Universities using these programs may likely observe similar effect sizes to those reported in the literature, however effectiveness studies are warranted.

The topic of the thesis focuses on nutrition for people addicted to alcohol. The theoretical part of the thesis is to describe and adequate nutrition recommendations, which should people addicted to alcohol optimally receive. This section will describe the appropriate food components in the context of a variety of somatic and psychological changes in clients addicted to alcohol. There is also described the problems with the long-term consumption of high doses of alcohol occur in the context of micro and macronutrients. Pointed out the possible signs and risk inherent in inadequate nutrition in alcoholism carries. Also in this section above, which each term medical complications of alcohol bears. In the practical part of the thesis using of quantitative research focuses on finding the eating habits of clients psychiatric hospital in Opava and Prague. The aim of this section is to determine whether ingested during a stay in a psychiatric hospital corresponds to the nutritional needs of clients. To gather data, I used a questionnaire ADS (scale depending on the alcohol) (Skinner & Horn, 1984). I also used a food frequency questionnaire. (Institutet DANONE, 2000). The questionnaire focused on the evaluation of dependency on alcohol and nutrition. Synovate interviewed male. Man I chose, because between them...

For over 50 years, synthetic petrochemical-based plastics have been produced in ever growing volumes globally and since their first commercial introduction; they have been continually developed with regards to quality, colour, durability, and resistance. With some exceptions, such as polyurethanes, most plastics are very stable and are not readily degraded when they enter the ground as waste, taking decades to biodegrade and therefore are major pollutants of terrestrial and marine ecosystems. During the last thirty years, extensive research has been conducted to develop biodegradable plastics as more environmentally benign alternatives to traditional plastic polymers. Polyvinyl alcohol (PVA) is a water-soluble polymer which has recently attracted interest for the manufacture of biodegradable plastic materials. PVA is widely used as a paper coating, in adhesives and films, as a finishing agent in the textile industries and in forming oxygen impermeable films. Consequently, waste-water can contain a considerable amount of PVA and can contaminate the wider environment where the rate of biodegradation is slow. Despite its growing use, relatively little is known about its degradation and in particular the role of fungi in this process. In this study, a number of fungal strains capable of degrading PVA from uncontaminated soil from eight different sites were isolated by enrichment in mineral salts medium containing PVA as a sole carbon source and subsequently identified by sequencing the ITS and 5.8S rDNA region. The most frequently isolated fungal strains were identified as Galactomyces geotrichum, Trichosporon laibachii, Fimetariella rabenhorsti and Fusarium oxysporum. G. geotrichum was shown to grow and utilise PVA as the sole carbon source with a mean doubling time of ca. 6-7 h and was similar on PVA with molecular weight ranges of 13-23 KDa, 30-50 KDa and 85-124 KDa. When solid PVA films were buried in compost, Galactomyces geotrichum was also found to be the principal colonizing fungus at 25°C, whereas at 45°C and 55°C, the principle species recovered was the thermophile Talaromyces emersonii. ESEM revealed that the surface of the PVA films were heavily covered with fungal mycelia and DGGE analysis of the surface mycelium confirmed that the fungi recovered from the surface of the PVA film constituted the majority of the colonising fungi. When PVA was added to soil at 25°C, and in compost at 25°C and 45°C, terminal restriction fragment length polymorphism (T-RFLP) revealed that the fungal community rapidly changed over two weeks with the appearance of novel species, presumably due to selection for degraders, but returned to a population that was similar to the starting population within six weeks, indicating that PVA contamination causes a temporary shift in the fungal community.

by Lee Suk Fan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 140-157). / Abstracts in English and Chinese. / Acknowledgements --- p.ii / Abstract --- p.iii / 槪論 --- p.v / List of Abbreviations --- p.vii / Chapter Chapter 1 --- Introduction --- p.1 / Chapter Chapter 2 --- Sex Difference in Alcohol Consumption on Hamster --- p.31 / Chapter Chapter 3 --- Effect of Chronic Alcohol Consumption --- p.65 / Chapter Chapter 4 --- Effect of Green Tea Polyphenols on Alcohol Metabolizing Enzymes in Hamster --- p.108 / Chapter Chapter 5 --- Conclusion --- p.135 / References --- p.140

Background. The prevalence of alcohol dependence, defined as being physically and psychologically dependent on alcohol, among homeless people is 8%-58% compared to 4%-16% of alcohol dependence prevalence in the general population. Homelessness also contributes to alcohol dependence, and alcohol dependence is more difficult to treat and manage when combined with homelessness and alcohol-related harms. Alcohol harm reduction strategies for those with severe alcohol dependence and experiencing homelessness are gaining traction. There are 22 Managed Alcohol Programs (MAPs) in several cities across Canada. MAPs can reduce harms for people with severe alcohol dependence who live with acute, chronic, and social harms. In this research, I report on MAP participants views in the first six months of being in a MAP to provide insights into implementation of MAPs. Research Question. My central research question was: What are MAP participants perspectives of MAP during the early period of transition into MAP? With an objective to understand implementation from participants perspectives, I specifically asked: How are MAP participants situated in the world, what are their experiences, and what are the relational shifts that occur during early transition into MAP? Methodology and Theoretical Perspective. In my research, I used interpretive description informed by constructivism. I drew on relational theory to interpret my findings. The use of interpretive description, informed by constructivism and relational theory, brought forth greater insight into MAP participants views of and subsequent shifts in their relationships with the environment, alcohol, themselves, and others before and during MAP. Results/Findings. Participants perspectives focused on four key findings: (a) participants shifting perspectives of non-beverage alcohol when beverage alcohol was available in MAP, (b) participants motivation to change and insights into their own drinking, (c) reasons for drinking outside of MAP, and (d) relational insights and shifts in their connections with others. Conclusions. For individuals experiencing homelessness and severe alcohol dependence and its inherent associated harms, MAPs help to support relational shifts that support safer drinking patterns and/or meaningfully interrupt cycles of uncontrolled drinking as well as help to re-establish new relationships with alcohol, themselves, family, and friends. / Graduate

A recent line of research grounded in evolutionary theory has shown that exposure to women's fertility cues affects men's mating cognition and behavior. This area of research has not yet been examined in relation to alcohol. As alcohol has also been shown to facilitate the formation of sexual connections for males, establishing the intersection between these two lines of research seems necessary to understand the impetus behind human behavior. Ninety-eight male participants were primed with either the scent of a fertile woman or the scent of nonfertile woman and then completed measures assessing their level of attraction to pictures of women, beer consumption, approach behavior, and alcohol expectancies. Results of the study indicated that males' mating behaviors are affected by women's ovulatory cues, as men exposed to an ovulation prime drank significantly more and exhibited significantly more approach behavior than men exposed to a control prime. Furthermore, an interaction was found between sexual enhancement expectancies and prime condition on beer consumption, which indicated that there was no effect for sexual enhancement expectancies for those in the control prime condition, but for those in the ovulation prime condition, increased drinking was associated with higher sexual facilitation expectancies. These findings were consistent with previous research and support evolutionary theories of mating behavior while taking an integrative approach in trying to explain factors behind human behavior.

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Since the mid 1990s, alcohol policy in Sweden has undergone major changes and the restrictive policy instruments have been weakened. Alternative and compensatory preventive measures have been sought and the workplace is repeatedly referred to as an important and appropriate arena for prevention. Universal methods, such as disseminating information and education programs, are seen as crucial in order for individuals to be able to make informed choices about their alcohol consumption. The overall purpose of this thesis is to analyze the prerequisites for and the possibilities and barriers associated with alcohol education programs at workplaces. The first paper investigates the general interest in alcohol prevention at workplaces where no interventions had been undertaken. The second paper is an effect study which investigates the effects of a short alcohol education program provided to those employed at a company in Stockholm. In the third paper, the effects of a day-long alcohol education program provided to all persons employed by a municipality are studied. The fourth paper is an interview study, in which the aim is to analyze how the participants in alcohol education programs view their participation and the content and legitimacy of the intervention. The findings suggest that interest in prevention at workplaces is low among employers. In addition, there are difficulties linked to implementation and evaluation, and in achieving and registering any substantial effects. The effect studies noted a significant increase in alcohol-related knowledge and that binge drinking decreased among those who drank the most. The employees found the education programs interesting and valuable but mostly for others, i.e. those who drink too much. Taken together, the studies suggest that it is not reasonable to believe that workplace-based prevention will become a common and effective measure or that it will compensate for the weakened alcohol policy in Sweden. / <p>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Accepted. Paper 3: Submitted.</p>

This dissertation attempts to uncover the causal relationship between alcohol abuse and both income growth and crime. These two research questions are investigated in three essays: Essay I investigates the relationship between alcohol abuse and income growth in the United States; Essay II examines the impact of alcohol abuse on income growth at the international level; Essay III investigates the effect of alcohol abuse on crime in the united states. Essay I of this dissertation uses state level data from the United States for the period 1970-1998 to estimate the impact of alcohol abuse on income growth by utilizing per capita beer consumption as the measure of alcohol abuse. Results suggest that, even though generally small, there is a negative relationship between alcohol abuse and income growth once the endogeneity between income growth and per capita beer consumption is addressed by utilizing levels of excise alcohol taxes and the Minimum Drinking Age Law of 21 as instruments. These results indirectly favor the previous research on two dimensions: First, alcohol abuse generates a significant burden on the economy; Second, increases in excise alcohol taxes would be efficient in terms of income growth. Essay II of this dissertation uses data from 72 countries for the period 1960-1995 to estimate the impact of alcohol abuse on income growth by utilizing per capita beer, wine, liquor, and total ethanol consumption as the measures of alcohol abuse. Results suggest that, even though generally small, there is a negative significant relationship between per capita beer consumption and income growth once the endogeneity between income growth and per capita beer consumption is addressed with system GMM dynamic panel estimators. These results show that per capita beer consumption is the medium of alcohol abuse not only in the United States, but also around the world. Moreover, these results favor the previous research on the fact that alcohol abuse generates a significant burden on economies. Essay III of this dissertation uses state level data from the United States for the period 1982-2000 to investigate the relationship between crime and alcohol abuse by utilizing per capita beer consumption as the measure of alcohol abuse. Potential endogeneity between per capita beer consumption and crime is addressed by using excise beer taxes and alcohol control measures as instruments. Results show that alcohol abuse seems to have a positive impact overall on the crime rate. Nevertheless, the effect is not uniform among different crime types. In the case of property crime types, results suggest that alcohol abuse plays a more important role in crime types that require a lesser degree of organization and more spontaneity (i.e., larceny theft versus burglary and motor vehicle theft). In the case of violent crime types, results suggest that the impact of alcohol abuse is more pressing in non-murder crime types versus murder. These results have policy implications: excise alcohol taxes and alcohol control policies may play a role in reducing certain crime types, which are larceny theft, rape, robbery, and aggravated assault, but not the other crime types, which are burglary, motor vehicle theft, and murder.

This thesis focuses on the effects of lactobacilli and their end-products, lactic acid and acetic acid, on 'Saccharomyces cerevisiae' growth and fermentation, and on antimicrobials used to manage such contaminants. To assess the effects of the bacteria, normal gravity (22-24 g/100 ml dissolved solids) wheat mashes inoculated with yeast at ~106 colony forming units (CFU)/ml were deliberately infected (coinoculated) with each of five industrially important strains of lactobacilli at ~10 5, ~106, ~107, ~10 8, and ~109 CFU/ml. Controls with yeast alone or with bacteria alone (~107 CFU/ml) were included. End-products, yeast growth and fermentation rates were monitored. Results indicated that production of lactic acid by lactobacilli and suspected competition of the bacteria with yeast cells for essential growth factors in the fermenting medium were the major reasons for reductions in yeast growth and decreases in final ethanol yield. A chemically defined minimal medium was used to determine the effects of added acetic and lactic acid, and their mode of action on two strains of ' S. cerevisiae'. The effects of these two acids on yeast intracellular pH (pHi), plasma membrane H+-ATPase activity and on the plasma membrane lipid composition were studied. It was found that the specific growth rates ([mu]) of the two yeast strains decreased exponentially (R2 > 0.9) as the concentrations of acetic or lactic acid were increased. Acetic and lactic acids synergistically reduced the specific growth rate of yeast. Acetic acid caused the yeast cell to expend ATP to pump out excess protons that result from the passive diffusion of the acid into the cell at medium pH (pHe) followed by its dissociation within the cell as a result of higher pHi. Lactic acid (0.5 % w/v) caused intracellular acidification (which could lead to arrest in glycolytic flux) as a result of a significant decrease (P = 0.05) in the plasma membrane H +-ATPase activity. Moreover, the plasma membrane fluidity was reduced due to decrease in unsaturated fatty acyl residues. Among the antimicrobials studied, urea hydrogen peroxide (UHP) was superior compared to stabilized chlorine dioxide and nisin, but its bactericidal activity was greatly affected by the presence of particulate matter. When used near 30 mmoles/L (in unclarified mash), in addition to its bactericidal effect, UHP provided near optimum levels of assimilable nitrogen and oxygen that aided in vigorous yeast fermentation. This process was patented.