The thesis is focused on financial analysis of the building company PRAGIS a.s. This thesis contains the theoretical and practical part. The theoretical part deals with the methods of financial analysis. The practical part focuses on the application of selected methods for financial analysis of the company PRAGIS a.s. between years 2005 and 2010.

The thesis focuses on entrance of a strategic investor into the foreign market through a mergers or acquisitions. The main aim of the paper is to show the process of pre-acquisition analysis. First, a brief description of a mergers and acquisitions problematic will be provided as well as the acquisition process itself. Within the pre-acquisition analysis there are discussed different factors which play an important role in evaluating of the target market as well as in the selection of an acquisition candidate. Next, the thesis provides an evaluation of the target company, particulary a description of various tools and methods used in evaluating the financial aspects of a company. The goal of the practical part is to assess the target market selected by the investor, to illustrate the procedure for collecting a suitable candidate and then the accomplishment of a financial analysis of the company.

This thesis is focused on estimation of general economical situation of the firm Oděvní podnik, a.s. from year 2003 to 2009. The thesis is divided into two main parts. In first part the methodology is defined. Second part evaluates the company through the use of methods, which are defined in first part. The main methods I used are ratio analysis and analysis of absolute indicators. One part of this thesis is focused on application of bankruptcy and creditworthy models. The aim was to find out if this models are able to predict the bad financial situation, in which the company at present is.

This thesis was written within the framework of a biomanipulation project where young-of-the-year (YOY) pikeperch (Sander lucioperca) were stocked to a Baltic Sea bay to improve water quality through a top-down trophic cascade. The aim of my doctorial studies was however focused on a broader ecological question, namely predation (the main driving force in a biomanipulation). Hence, this thesis consists of four papers where we study the interactions between predator and prey using fish and zooplankton and how these interactions can be measured. In paper I we evaluated the performance of different diet analysis methods by individual based modelling and found that when having a nutritional gain perspective, mass based methods described diets best. Paper II investigated how the explorative, foraging and anti-predator behaviour of the YOY pikeperch used for stocking were affected by their rearing environment (pond vs. tank rearing). The more complex and varied environment in the semi-natural ponds seemed to promote a more flexible and active behaviour, better equipping young fish for survival in the wild. For paper III we studied the diel vertical migration in the six copepodite stages of the zooplankton Acartia spp. and Eurytemora affinis in relation to fish biomass, phytoplankton abundance and temperature. Both species migrated and in addition showed increased migration range with size within species, indicating evasion from visual predators. Paper IV addressed the movement of littoral Eurasian perch (Perca fluviatilis) via stable isotope signatures (13C and 15N) and body condition. We found clear indications of sedentarity and intra-habitat dietary differences. Interactions between predators and prey are complex and affected by both physiological and environmental characteristics as well as behavioural traits. The results in this thesis suggest that different species and even different life stages pursue different strategies to survive. / At the time of doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Submitted.  Paper 2: In press.  Paper 4: Submitted.

Microarray expression analysis was carried out to identify genes with a role in epithelial ovarian cancer (EOC). The U133A Affymetrix GeneChipRTM was used to determine the expression patterns of the 3p25.3-ptel genes represented on the microarray in 14 primary cultures of normal ovarian surface epithelial (NOSE) samples, 25 frozen malignant ovarian tumor samples and four EOC cell lines. Seven genes with differential expression patterns in the tumor samples compared to the NOSE samples were identified as candidates for further analysis, starting with ARPC4, SRGAP3 and ATP2B2. Although none of the candidates had been previously studied in ovarian cancer, several had either family or pathway members that had. Expression patterns seemed unaffected by either tumor histopathological subtype or the allelic imbalances observed with loss of heterozygosity (LOH) analysis. The absence of association with genomic context suggested that differential expression was the result of transcriptional regulation rather than direct targeting.

eDNA is a fast and popular method to collect information about species presence in the environment. eDNA is DNA that is collected from environmental samples, such as water, from DNA that is expelled from organisms interacting with their environment. eDNA is an effective way to find species with small populations and alien species. There are two ways to analyze eDNA, with high-throughput DNA sequencing methods and DNA metabarcoding or use of species-specific primers and PCR. In this study, we focus on the latter, designing species-specific primers for Burbot, Brown trout, and Atlantic Salmon, testing their validity in detecting eDNA of these species with functional PCR. We also evaluated eDNA collection methods, testing different scenarios in aquarium tanks with different number of dead and alive fishes. Primers and experimental setup such as use of different temperatures of the PCR reaction used in this study didn’t result in a functional PCR as determined by electrophoresis gel. There are some problems with the design of the PCR methods for eDNA since the purpose is to design methods that can identify certain species. However, future development of eDNA methods will probably include sequencing and not detection of PCR product sizes. eDNA methods will complete traditional trapping methods like net and electrofishing, but not replace them. / eDNA är en snabb och populär metod för att samla information om arters abundans i miljön. eDNA är DNA taget från miljö prover, så som vatten, från DNA som frigörs från organismer som intrigerar med deras miljön. eDNA är ett effektivt sätt att hitta arter med små populationer och främmande arter. De finns två olika sätt att analysera eDNA, med DNA-sekvenseringsmetoder med hög genomströmning och DNA-metabarkodning eller användning av artspecifika primrar och PCR. I denna studie fokuserade vi på den senare, designade artspecifika primers för lake, lax och öring, testa deras validitet vid detektering av eDNA hos dessa arter med funktionell PCR. Vi utvärderade också eDNA-insamlingsmetoder, testa olika scenarier i akvarietankar med olika antal döda och levande fiskar. Primers och experimentell uppställning, såsom användning av olika temperaturer för PCR-reaktionen som användes i denna studie, resulterade inte i en funktionell PCR såsom bestämd av elektroforesgel. Det finns några problem med utformningen av PCR-metoderna för eDNA, eftersom syftet är att utforma metoder som kan identifiera vissa arter. Emellertid kommer framtida utveckling av eDNA-metoder troligtvis att inkludera sekvensering och inte detektering av PCR-produktstorlekar. eDNA-metoder kommer att komplettera traditionella fångstmetoder som nät- och elektrofiske, men inte ersätta dem.

The Financial analysis examines a general financial situation of the company from year 2000 to 2007. There were used classical methods for financial analysis. Parf of this thesis is about aplication of creditworthy and bankruptcy models. The aim was to find out if these models were able to predict the bad current situation of this firm.

L’un des challenges les plus importants des pays développés ou émergents est de soutenir l’innovation dans les PME. Mais la question centrale ici, est de savoir si l’innovation dépend exclusivement de la disponibilité des ressources. La capacité à innover ne dispose pas d'un cadre de référence pour son évaluation, en raison principalement de sa complexité et sa nature abstraite. Sans les indicateurs appropriés, il est impossible d'établir les objectifs et de déterminer les efforts et les ressources nécessaires pour améliorer la capacité d'innovation. Le laboratoire ERPI a développé une approche d’évaluation de cette capacité privilégiant les pratiques internes qui favorisent l’innovation dans les entreprises (IIP, Indice d’Innovation Potentielle) basée sur des méthodes d’analyse multicritère. Mais une fois obtenu un résultat, quels sont les points sur lesquels une entreprise peut jouer afin d’améliorer son système d'innovation ? Dans cette thèse, nous proposons un modèle d'optimisation qui réplique la procédure d'évaluation de la capacité à innover utilisée par l'IIP et qui nous permettra de générer un plan d'action pour améliorer la capacité à innover des PME. Le modèle considère différents facteurs (la situation particulière de l'entreprise, les efforts économiques associés à la stratégie proposée, etc.) afin de générer le plan d'action le plus approprié aux besoins de chaque PME. Ainsi, trois stratégies potentielles sont proposées : améliorer le classement actuel avec un minimum d'effort, maximiser les économies de ressources, maximiser l’IIP avec un budget défini. Des scénarii sont simulés afin de tester les résultats de la mise en œuvre des différentes stratégies / One of the most important challenges in the current industrial policy of developed and emerging countries is to support innovation in SMEs, issue which has been approach as a problem only dependent on the availability of resources. Innovation capability does not have an appropriate framework of evaluation, mainly because of its complexity and abstract nature. Without proper indicators, it is not possible to establish objectives and identify the efforts and resources necessary for its improvement. In response to this, the ERPI laboratory has developed an evaluation approach of innovation capability, taking into account internal practices to promote innovation. A field of knowledge has been developed in this direction allowing for the proposal of a novel metrology, the Potential Innovation index (PII), based on multi-criteria analysis methods for studying the dynamics within companies. In this thesis, we propose an optimization model that replicates the evaluation procedure of innovation capability to generate an action plan, i.e., the model returns concrete points in which companies can work to improve its innovation system. The model considers factors such as the particular situation of the company, the economic efforts associated with the proposed strategy, the goals of the entrepreneur, etc. Three optimization strategies are proposed: access to a higher category with a minimum of effort, maximize resource efficiency and maximize innovation performance with a defined budget. Scenarios are simulated to test the results of the implementation of the different strategies

Orientador: José Maria Campos dos Santos / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica / Made available in DSpace on 2018-08-27T18:23:30Z (GMT). No. of bitstreams: 1 Moraes_ElsonCesar_D.pdf: 11465202 bytes, checksum: 1ad71136d449760c1a551cda489beaca (MD5) Previous issue date: 2015 / Resumo: Neste trabalho, estudam-se fenômenos de propagação de ondas acústicas em cavidades unidimensionais e bidimensionais e se propõe uma metodologia para a análise do comportamento acústico com o objetivo de identificar a propagação de onda nessas estruturas em médias e altas frequências. Para isso se utilizou os métodos originados da Análise de Fluxo de Energia (EFA) que têm como variáveis primárias a densidade de energia e fluxo de energia. Duas formulações foram usadas para resolver as equações diferenciais de energia aproximada derivada do EFA: o Método dos Elementos Finitos de Energia (EFEM) e o Método do Elemento Espectral de Energia (ESEM). O Método do Elemento Espectral (SEM) foi outra formulação estudada para resolver as equações diferenciais de propagações de ondas em cavidades acústicas unidimensionais, bem como para validar a metodologia proposta. Diferentes tipos de cavidades acústicas unidimensionais foram investigadas e implementas tais como: guia de onda simples, guia de onda com descontinuidade geométrica e guia de onda com descontinuidade das propriedades médias. Para isso, desenvolveu-se relações de acoplamento que descrevem essas descontinuidades acústicas. Um exemplo simulado envolvendo uma cavidade acústica retangular fechada é analisado com ESEM e os resultados são comparados com aqueles obtidos pelo EFA, EFEM e a Solução Analítica Acústica (SAA) da equação forçada de Helmholtz para cavidades retangulares bidimensionais fechadas. Uma investigação experimental do comportamento acústico de uma cavidade acústica bidimensional fechada foi realizada para verificar e validar os resultados do ESEM. De maneira geral, se observou que os resultados obtidos pelos modelos simulados apresentaram um comportamento semelhante ao resultado encontrado experimentalmente / Abstract: In this research, propagation phenomena of acoustic waves in one-dimensional and two-dimensional cavities is investigated and a methodology, based on energy methods, is proposed to predict acoustic response of these structures, at mid and high frequencies. These methods, originated from Energy Flow Analysis, use as primary variables the energy density and the energy flow. Two methodologies are used to solve approximated energy differential equations derived from EFA: Energy Finite Element Method (EFEM) and Energy Spectral Element Method (ESEM). The Spectral Element Method (SEM), is used to solve the wave propagation differential equations of acoustic in one-dimensional cavities, moreover this method is applied to validate the proposed methodology. Different acoustics cavities were investigated, such as simple waveguide, waveguide with geometric discontinuity and waveguide with discontinuity of the average properties. To this purpose, coupling relationships that represent those discontinuities are developed. A simulated example involving a closed rectangular acoustic cavity is analyzed with ESEM and the results are compared with those obtained by EFA, the Energy Finite Element Method (EFEM) and the acoustic analytical solution (SAA) of forced Helmholtz equation for rectangular two-dimensional closed cavities. An experimental investigation of acoustic response of a closed two-dimensional acoustic cavity was performed to verify the results of ESEM. The simulated models results, calculated in terms of energy variables, to analyze cavity, showed a good agreement with the experimental result / Doutorado / Mecanica dos Sólidos e Projeto Mecanico / Doutor em Engenharia Mecânica

This thesis deals with the financial health of the company KABLO ELEKTRO, a.s. Vrchlabí between the years 2002 – 2006 using selected methods of financial analysis. Possible steps leading to improvement of the company’s financial situation are suggested.