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This thesis includes a theoretical and experimental analysis of electrophoresis of colloidal particles in non-Newtonian polymeric fluids with shear-rate dependent viscosities. A model is derived that predicts field dependent electrophoretic mobility in shear-thinning Carreau uids. The latter effect is experimentally investigated for submicron particles in solutions of linear polyacrylamide using capillary electrophoresis. The mobilitiies of the particles studied in these solutions did not depend on field strength, yet the mobilities were consistently an order of magnitude greater than in water and glycerol solutions with similar bulk viscosities. The increase in particle mobility could be attributed to several mechanisms, however it is consistent with the depletion of polymer apparent viscosity of the fluid as it migrates by electrophoresis is the same as experienced by the particle in Brownian diffusion. A comparison of particle mobility in both glycerol and polyacrylamide solutions to diffusion coefficients of the particles measured by dynamic light scattering supports this conclusion.

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This thesis proposes a new simulated annealing approach to solve multiple objective sequencing problems in mixed-model assembly lines. Mixed-model assembly lines are a type of production line where a variety of product models similar in product characteristics are assembled. Such an assembly line is increasingly accepted in industry to cope with the recently observed trend of diversification of customer demands. Sequencing problems are important for an efficient use of mixed-model assembly lines. There is a rich of criteria on which to judge sequences of product models in terms of line utilization. We consider three practically important objectives: the goal of minimizing the variation of the actual production from the desired production, which is minimizing usage variation, workload smoothing in order to reduce the chance of production delays and line stoppages and minimizing total set-ups cost. A considerate line manager would like to take into account all these factors. These are important for an efficient operation of mixed-model assembly lines. They work efficiently and find good solution in a very short time, even when the size of the problem is too large. The multiple objective sequencing problems is described and its mathematical formulation is provided. Simulated annealing algorithms are designed for near or optimal solutions and find an efficiency frontier of all efficient design configurations for the problem. This approach combines the SA methodology with a specific neighborhood search, which in the case of this study is a "swapping two sequence". Two annealing methods are proposed based on this approach, which differ only in cooling and freezing schedules. This research used correlation to describe the degree of relationship between results obtained by method B and other heuristics method and also for quality of our algorithm ANOVA's of output is constructed to analyse and evaluate the accuracy of the CPU time taken to determine near or optimal solution.

NMR studies of water oxygen-17 relaxation in aqueous sucrose and lysozyme solutions have been carried out to investigate the interactions of water with sucrose and lysozyme. The effect of sucrose and lysozyme concentration on water oxygen-17 relaxation has been studied in detail. The dependence of relaxation on frequency and pH has also been analysed. The existing model, describing the relaxation of water oxygen-17 in aqueous protein solutions suggested by Halle in 1981, is tested to see whether it gives a true representation. It is found that at low concentrations of sucrose and lysozyme, the experimental data give good agreement with the model. However, at saturated sucrose concentration the agreement is not so good. An extra contribution to the transverse relaxation rate is seen. A possible explanation for the extra contribution to the transverse relaxation rate at high sucrose content is discussed. The effect of ionic charge on oxygen-17 relaxation in lysozyme solutions is also investigated. It is observed that both the ionic charge of lysozyme as well as lysozyme aggregation strongly affect the relaxation of water oxygen-17. A method for analysing the experimental data for water oxygen-17 relaxation in aqueous sucrose and lysozyme solutions using Halle's model is presented and employed to calculate the various parameters of the model. The relaxation and chemical shift of calcium-43 in simple calcium salts, calcium acetate and calcium ascorbate have been studied as a function of concentration and pH. The complexation of calcium to sucrose and to lysozyme has also been investigated. In almost all cases, a significant calcium-43 chemical shift has been detected. The direct measurement of complexation and binding of calcium by relaxation time and chemical shift measurements has been of particular interest.

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Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 6 uppsatser.