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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Factor Structure of the Anorexia Bulimia Inventory

Dobmeyer, Anne C. 01 May 1997 (has links)
The Anorexia Bulimia Inventory, a recently developed self-report questionnaire for the assessment of eating disorders, addresses two major limitations found in existing self-report eating disorder inventories. First, it comprehensively assesses the diagnostic symptoms of both bulimia and anorexia nervosa; and second, it assesses the frequently cooccurring problem areas (e.g., depression, anergia) that may be targeted in treatment planning for eating disorders. Although initial research on the psychometrics of the instrument appears promising, no research has yet investigated its factor structure. Therefore, the goal of the present study was to investigate the factor structure of the Anorexia Bulimia Inventory. Principal axis factor analysis with a varimax rotation was used on a combined clinical and nonclinical sample. The overall sample (N = 1,675) was randomly divided to provide a replication of the factor analysis. Using the two separate samples and the combined, total sample, one seven-factor solution and two eight-factor solutions emerged. All factors met conventional standards for internal consistency, with the exception of one factor consisting of only three items. The results of this study suggest that the factor structure of the Anorexia Bulimia Inventory closely parallels the intuitively designed subscales. All nine subscales emerged as separate, interpretable factors in at least one sample. Four subscales were clearly corroborated by the factor analysis, suggesting that these factors represent stable constructs that are relevant to populations at-risk for the development of eating disorders. The factor analyses provided moderate corroboration of four other subscales. Although these four factors did show deviations across samples, they all emerged as interpretable factors, suggesting that the constructs likely reflect some of the prominent ideational and behavioral issues relevant to at-risk populations. Finally, one subscale emerged as an interpretable factor in only one sample. This failure to replicate across samples may reflect problems in the wording or choice of items included on the subscale, or it could indicate that these issues are less relevant for at-risk populations. The results of this study, together with the existing evidence of the measure's psychometric properties, support the use of the Anorexia Bulimia Inventory in the assessment of eating disorders.
2

Utilização de peptídeo sintético (P10) associado ao tratamento com drogas antifúngicas no controle da paracoccidioidomicose experimental / Use of synthetic peptide (P10) associate with antifungal drugs to the treatment in the control of experimental paracoccidioidomyicosis.

Marques, Alexandre Ferreira 17 August 2007 (has links)
A paracoccidioidomicose (PCM), doença sistêmica de caráter granulomatoso, causada pelo fungo termodimórfico Paracoccidioides brasiliensis. A PCM é endêmica na América Latina e atinge principalmente indivíduos do sexo masculino com atividades econômica ligada a agricultura. Os pacientes com PCM exigem tratamento a base de sulfametoxazol/trimetoprim, anfotericina B, e derivados azólicos por longos períodos. A gp43, possui 416 aminoácidos, onde um trecho específico de 15 aminoácidos (QTLIAIHTLAIRYAN) designado como (P10), é reconhecido pelos linfócitos T de camundongos e humanos. No presente estudo avaliamos o efeito aditivo da imunização do P10 com às drogas antifúngicas utilizadas no tratamento da PCM. Nossos resultados indicam um efeito aditivo entre a imunização com P10 e o tratamento medicamentoso em camundongos Balb/c infectados. Associado a redução significativa da carga fúngica no pulmão, baço e fígado desses animais, detectamos aumento dos níveis de IL-12 e IFN-? e diminuição de IL-4 e IL-10. / Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis, a thermal dimorphic fungus. PCM is endemic in Latin America affecting mainly rural workers. The patients with PCM demand treatment the base of sulfametoxazole/trimethoprim, amphotericin B and derivatives azolic. The gp43 has 416-mer and mice and human T lymphocytes are stimulated by a 15-mer peptide designated as P10 (QTLIAIHTLAIRYAN). In the present work we evaluated the additive effect of P10 immunization and antifungal drugs utilizing in PCM treatment. Ours results showed an additive protective effect between immunization with P10 and drugs treatment with infected Balb/c mice. Associated to the reduction of fungal burden in the lung, spleen and liver we observed increase of levels of IL-12 and IFN-? and reduction of IL-4 and IL-10.
3

Utilização de peptídeo sintético (P10) associado ao tratamento com drogas antifúngicas no controle da paracoccidioidomicose experimental / Use of synthetic peptide (P10) associate with antifungal drugs to the treatment in the control of experimental paracoccidioidomyicosis.

Alexandre Ferreira Marques 17 August 2007 (has links)
A paracoccidioidomicose (PCM), doença sistêmica de caráter granulomatoso, causada pelo fungo termodimórfico Paracoccidioides brasiliensis. A PCM é endêmica na América Latina e atinge principalmente indivíduos do sexo masculino com atividades econômica ligada a agricultura. Os pacientes com PCM exigem tratamento a base de sulfametoxazol/trimetoprim, anfotericina B, e derivados azólicos por longos períodos. A gp43, possui 416 aminoácidos, onde um trecho específico de 15 aminoácidos (QTLIAIHTLAIRYAN) designado como (P10), é reconhecido pelos linfócitos T de camundongos e humanos. No presente estudo avaliamos o efeito aditivo da imunização do P10 com às drogas antifúngicas utilizadas no tratamento da PCM. Nossos resultados indicam um efeito aditivo entre a imunização com P10 e o tratamento medicamentoso em camundongos Balb/c infectados. Associado a redução significativa da carga fúngica no pulmão, baço e fígado desses animais, detectamos aumento dos níveis de IL-12 e IFN-? e diminuição de IL-4 e IL-10. / Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis, a thermal dimorphic fungus. PCM is endemic in Latin America affecting mainly rural workers. The patients with PCM demand treatment the base of sulfametoxazole/trimethoprim, amphotericin B and derivatives azolic. The gp43 has 416-mer and mice and human T lymphocytes are stimulated by a 15-mer peptide designated as P10 (QTLIAIHTLAIRYAN). In the present work we evaluated the additive effect of P10 immunization and antifungal drugs utilizing in PCM treatment. Ours results showed an additive protective effect between immunization with P10 and drugs treatment with infected Balb/c mice. Associated to the reduction of fungal burden in the lung, spleen and liver we observed increase of levels of IL-12 and IFN-? and reduction of IL-4 and IL-10.

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