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Single-particle tracking experiments have measured the distribution of dwell times of various DNAbinding species — including CRISPR-Cas9, TetR, and LacI — diffusing in living cells. The observed truncated power law distribution has direct and indirect implications. One direct implication is that the observed dwell time distribution is inconsistent with the Gaussian distribution of binding energies generally obtained from bioinformatics. Consideration of length scales of the nucleus and the measurement is essential to understanding the dwell time distribution.

Yes / A new simplified approach is proposed to evaluate the vertical refractivity profile within the lowest 1 km of atmosphere from the analysis of surface refractivity, Ns, in areas where upper air data are not available. Upper-air measurements from the nearest available radiosonde location with similar surface profile to these sites are utilized. The profiles of Ns and refractivity extrapolated to sea level, No, obtained from surface meteorological data using both fixed stations and radiosonde are investigated and compared. Vertical refractivity gradient, ΔN, is evaluated at three atmospheric layer heights within the first kilometer above the ground in addition to propagation parameters relevant to each atmospheric layer. At six sites, different approaches are compared for the analysis of three important parameters; namely effective earth radius factor, k, anomalous propagation probability parameter, β0, and point refractivity gradient at 65 m not exceeded for 1% of time, dN1. The k-factor parameter is investigated using a new weighted average approach of ΔN at 65 m, 100 m and 1 km layers above the ground. The results are compared with the latest ITU maps and tables for the same area.

In this dissertation, I extend the analysis of human dynamics to human movements in online activities. My work starts with a discussion of the human information foraging process based on three large collections of empirical search click-through logs collected in different time periods. With the analogy of viewing the click-through on search engine result pages as a random walk, a variety of quantities like the distributions of step length and waiting time as well as mean-squared displacements, correlations and entropies are discussed. Notable differences between the different logs reveal an increased efficiency of the search engines, which is found to be related to the vanishing of the heavy-tailed characteristics of step lengths in newer logs as well as the switch from superdiffusion to normal diffusion in the diffusive processes of the random walks. In the language of foraging, the newer logs indicate that online searches overwhelmingly yield local searches, whereas for the older logs the foraging processes are a combination of local searches and relocation phases that are power-law distributed. The investigation highlights the presence of intermittent search processes in online searches, where phases of local explorations are separated by power-law distributed relocation jumps. In the second part of this dissertation I focus on an in-depth analysis of online gambling behaviors. For this analysis the collected empirical gambling logs reveal the wide existence of heavy-tailed statistics in various quantities in different online gambling games. For example, when players are allowed to choose arbitrary bet values, the bet values present log-normal distributions, meanwhile if they are restricted to use items as wagers, the distribution becomes truncated power laws. Under the analogy of viewing the net change of income of each player as a random walk, the mean-squared displacement and first-passage time distribution of these net income random walks both exhibit anomalous diffusion. In particular, in an online lottery game the mean-squared displacement presents a crossover from a superdiffusive to a normal diffusive regime, which is reproduced using simulations and explained analytically. This investigation also reveals the scaling characteristics and probability reweighting in risk attitude of online gamblers, which may help to interpret behaviors in economic systems. This work was supported by the US National Science Foundation through grants DMR-1205309 and DMR-1606814. / Ph. D. / Humans are complex, meanwhile understanding the complex human behaviors is of crucial importance in solving many social problems. In recent years, socio physicists have made substantial progress in human dynamics research. In this dissertation, I extend this type of analysis to human movements in online activities. My work starts with a discussion of the human information foraging process. This investigation is based on empirical search logs and an analogy of viewing the click-through on search engine result pages as a random walk. With an increased efficiency of the search engines, the heavy-tailed characteristics of step lengths disappear, and the diffusive processes of the random walkers switch from superdiffusion to normal diffusion. In the language of foraging, the newer logs indicate that online searches overwhelmingly yield local searches, whereas for the older logs the foraging processes are a combination of local searches and relocation phases that are power-law distributed. The investigation highlights the presence of intermittent search processes in online searches, where phases of local explorations are separated by power-law distributed relocation jumps. In the second part of this dissertation I focus on an in-depth analysis of online gambling behaviors, where the collected empirical gambling logs reveal the wide existence of heavy-tailed statistics in various quantities. Using an analogy of viewing the net change of income of each player as a random walk, the mean-squared displacement and first-passage time distribution of these net income random walks exhibit anomalous diffusion. This investigation also reveals the scaling characteristics and probability reweighting in risk attitude of online gamblers, which may help to interpret behaviors in economic systems. This work was supported by the US National Science Foundation through grants DMR-1205309 and DMR-1606814.

This thesis describes the optimisation of the calorimeter design for collider experiments at the future Compact Linear Collider (CLIC) and the International Linear Collider (ILC). The detector design of these experiments is built around high-granularity Particle Flow Calorimetry that, in contrast to traditional calorimetry, uses the energy measurements for charged particles from the tracking detectors. This can only be realised if calorimetric energy deposits from charged particles can be separated from those of neutral particles. This is made possible with fine granularity calorimeters and sophisticated pattern recognition software, which is provided by the PandoraPFA algorithm. This thesis presents results on Particle Flow calorimetry performance for a number of detector configurations. To obtain these results a new calibration procedure was developed and applied to the detector simulation and reconstruction to ensure optimal performance was achieved for each detector configuration considered. This thesis also describes the development of a software compensation technique that vastly improves the intrinsic energy resolution of a Particle Flow Calorimetry detector. This technique is implemented within the PandoraPFA framework and demonstrates the gains that can be made by fully exploiting the information provided by the fine granularity calorimeters envisaged at a future linear collider. A study of the sensitivity of the CLIC experiment to anomalous gauge couplings that {affect} vector boson scattering processes is presented. These anomalous couplings provide insight into possible beyond standard model physics. This study, which utilises the excellent jet energy resolution from Particle Flow Calorimetry, was performed at centre-of-mass energies of 1.4 TeV and 3 TeV with integrated luminosities of 1.5$\text{ab}^{-1}$ and 2$\text{ab}^{-1}$ respectively. The precision achievable at CLIC is shown to be approximately one to two orders of magnitude better than that currently offered by the LHC. In addition, a study into various technology options for the CLIC vertex detector is described.

In den letzten Jahren führte die Verbindung zwischen Topologie und kondensierter Materie zur Entdeckung vieler interessanter und exotischer elektronischer Effekte. Während sich die Forschung anfangs auf elektronische Systeme mit einer Bandlücke wie den topologischen Isolator konzentrierte, erhalten in letzter Zeit topologische Halbmetalle viel Aufmerksamkeit. Das bekannteste Beispiel sind Weyl-Halbmetalle, die an beliebigen Punkten in der Brillouin-Zone lineare Kreuzungen von nicht entarteten Bändern aufweist. An diese Punkte ist eine spezielle Quantenzahl namens Chiralität gebunden, die die Existenz von Weyl-Punktpaaren erzwingt. Diese Paare sind topologisch geschützt und wirken als Quellen und Senken der Berry-Krümmung, einem topologischen Feld im reziproken Raum. Diese Berry-Krümmung steht in direktem Zusammenhang mit dem anomalen Hall-Effekt, der die Entstehung einer Querspannung aus einem Längsstrom in einem magnetischen Material beschreibt. Analog existiert auch der anomale Nernst-Effekt, bei dem der longitudinale Strom durch einen thermischen Gradienten ersetzt wird. Dieser Effekt ermöglicht die Umwandlung von Wärme in elektrische Energie und ist zudem stark an die Berry-Krümmung gebunden. In dieser Arbeit werden die anomalen Transporteffekte zunächst in fundamentalen Modellsystemen untersucht. Hier wird eine Kombination aus analytischen und numerischen Methoden verwendet, um Quantisierungen sowohl des Hall- und Nernst- als auch des thermischen Hall-Effekts in zweidimensionalen Systemen mit und ohne externen Magnetfeldern zu zeigen. Eine Erweiterung in drei Dimensionen zeigt eine Quasi-Quantisierung, bei der die Leitfähigkeiten Werte der jeweiligen zweidimensionalen Quanten skaliert durch charakteristische Wellenvektoren annehmen. Im nächsten Schritt werden verschiedene Mechanismen zur Erzeugung starker Berry-Krümmung und damit großer anomaler Hall- und Nernst-Effekte sowohl in Modellsystemen als auch in realen Materialien untersucht. Dies ermöglicht die Identifizierung und Isolierung vielversprechender Effekte in den einfachen Modellen, in denen wichtige Merkmale untersucht werden können. Die Ergebnisse können dann auf die realen Materialien übertragen werden, wo die jeweiligen Effekte erkennbar sind. Hier werden sowohl Weyl-Punkte als auch Knotenlinien in Kombination mit Magnetismus als vielversprechende Eigenschaften identifiziert und Materialrealisierungen in der Klasse der Heusler-Verbindungen vorgeschlagen. Diese Verbindungen sind eine sehr vielseitige Materialklasse, in der unter anderem auch magnetische topologische Metalle zu finden sind. Um ein tieferes Verständnis der anomalen Transporteffekte zu erhalten sowie Faustregeln für Hochleistungsverbindungen abzuleiten, wurde eine High-Throughput-Rechnung von magnetisch-kubischen Voll-Heusler-Verbindungen durchgeführt. Diese Berechnung zeigt die Bedeutung von Spiegelebenen in magnetischen Materialien für große anomale Hall- und Nernst-Effekte und zeigt, dass einige der Heusler-Verbindungen die höchsten bisher berichteten Literaturwerte bei diesen Effekten übertreffen. Auch andere interessante Effekte im Zusammenhang mit Weyl-Punkten werden untersucht. Beim bekannten Weyl-Halbmetall NbP weisen die Weyl-Punkte aufgrund der hohen Symmetrie des Kristalls eine hohe Entartung auf. Die Anwendung von einachsigem Zug reduziert jedoch die Symmetrien und hebt damit die Entartungen auf. Eine theoretische Untersuchung zeigt, dass die Weyl-Punkte bei einachsigem Zug energetisch verschoben werden und, was noch wichtiger ist, dass sie bei realistischen Werten das Fermi-Niveau durchschreiten. Dies macht NbP zu einer vielversprechenden Plattform, um die Weyl-Physik weiter zu untersuchen. Die theoretischen Ergebnisse werden mit experimentellen Messungen von Shubnikov-de-Haas-Oszillationen unter einachsigem Zug kombiniert und es wird eine gute Übereinstimmung mit den theoretischen Ergebnissen gefunden. Als erster Schritt in Richtung neuer Berechnungsmethoden wird die Idee eines Weyl-Halbmetall-basierten Chiralitätsfilters für Elektronen untersucht. An der Grenzfläche zweier Weyl-Halbmetalle kann in Abhängigkeit von den genauen Weyl-Punktparametern nur eine Chiralität übertragen werden. Hier wird ein effektives geometrisches Modell erstellt und zur Untersuchung realer Materialgrenzflächen eingesetzt. Während im Allgemeinen eine Filterwirkung möglich erscheint, zeigten die untersuchten Materialien keine geeignete Kombination. Hier können weitere Studien mit Fokus auf magnetische Weyl-Halbmetalle oder Multifold-Fermion-Materialien durchgeführt werden.:List of publications Preface 1. Theoretical background 1.1. Berry curvature and Weyl semimetals 1.1.1. From the adiabatic evolution to the Berry phase 1.1.2. From the Berry phase to the Berry curvature 1.1.3. Topological phases of condensed matter 1.1.4. Weyl semimetals 1.1.5. Dirac semimetals 1.1.6. Nodal line semimetals 1.2. Density-functional theory 1.2.1. Born-Oppenheimer approximation 1.2.2. Hohenberg-Kohn theorems 1.2.3. Kohn-Sham formalism 1.2.4. Exchange-correlation functional 1.2.5. Pseudopotentials 1.2.6. Basis functions 1.2.7. VASP 1.3. Tight-binding Hamiltonian from Wannier functions 1.3.1. Wannier functions 1.3.2. Constructing Wannier functions from DFT 1.3.3. Generating a Wannier tight-binding Hamiltonian 1.3.4. Necessity of the tight-binding Hamiltonian 1.4. Linear response theory 1.4.1. General introduction to linear response 1.4.2. Anomalous Hall effect 1.4.3. Anomalous Nernst effect 1.4.4. Anomalous thermal Hall effect 1.4.5. Common features of anomalous transport effects 1.4.6. Symmetry considerations for Berry curvature related transport effects 1.4.7. Magneto-optic Kerr effect 1.4.8. About the efficiency of the calculations 2. (Quasi-)Quantization in the Hall, thermal Hall, and Nernst effects 2.1. Quantization with an external magnetic field 2.1.1. Two-dimensional case 2.1.2. Three-dimensional case 2.2. Quantization without an external field 2.2.1. Two-dimensional case 2.2.2. Three-dimensional case . 2.3. A remark on the spin Hall effect 2.4. A remark on the quasi-quantization of the three-dimensional conductivities 2.5. Conclusions 3. Understanding anomalous transport 3.1. Anomalous transport without a net magnetic moment 3.1.1. Toy model 3.1.2. Ti2MnAl and related compounds 3.2. Large Berry curvature enhancement from nodal line gapping 3.2.1. Toy model 3.2.2. Fe2MnP and related compounds 3.2.3. Co2MnGa 3.3. Topological features away from the Fermi level and the anomalous Nernst effect 3.3.1. Toy model . 3.3.2. Co2FeGe and Co2FeSn 3.4. Conclusions 4. Heusler database calculation 4.1. Workflow 4.2. Importance of mirror planes 4.3. The right valence electron count 4.4. Correlation between anomalous Hall and Nernst effects 4.5. Selected special compounds 4.6. Conclusions 5. NbP under uniaxial strain 5.1. NbP and its symmetries 5.2. The influence of strain on the electronic structure 5.2.1. Shifting of the Weyl points 5.2.2. Splitting of the Fermi surfaces 5.3. Comparison with experimental results 5.4. Conclusions 6. A tunable chirality filter 6.1. Concept 6.2. Geometrical simplification and expansion for more Weyl points 6.3. Material selection 6.3.1. Workflow 6.3.2. Results for NbP and TaAs 6.3.3. Results for Ag2Se and Ag2S 6.4. Conclusions and perspective . Summary and outlook A. Numerical tricks A.1. Hamiltonian setup at several k points at once A.2. Precalculating prefactors B. Derivation of the conductivity (quasi-)quanta B.1. Two dimensions B.1.1. General formula and necessary approximations B.1.2. Useful integrals B.1.4. Quantized thermal Hall effect B.1.5. Quantized Nernst effect B.1.6. Flat bands and the Nernst effect B.2. Three dimensions B.2.1. General formula B.2.2. Three-dimensional electron gas B.2.3. Three-dimensional Weyl semimetal C. Heusler database tables D. Details on the NbP strain calculations E. Details on the geometrical matching procedure References List of abbreviations List of Figures List of Tables Acknowledgements Eigenständigkeitserklärung / In recent years, the connection between topology and condensed matter resulted in the discovery of many interesting and exotic electronic effects. While in the beginning, the research was focused on gapped electronic systems like the topological insulator, more recently, topological semimetals are getting a lot of attention. The most well-known example is the Weyl semimetal, which hosts linear crossings of non-degenerate bands at arbitrary points in the Brillouin zone. Tied to these points there is a special quantum number called chirality, which enforces the existence of Weyl point pairs. These pairs are topologically protected and act as sources and sinks of the Berry curvature, a topological field in reciprocal space. This Berry curvature is directly connected to the anomalous Hall effect, which describes the emergence of a transverse voltage from a longitudinal current in a magnetic material. Analogously, there also exists the anomalous Nernst effect, where the longitudinal current is replaced by a thermal gradient. This effect allows for the conversion of heat into electrical energy and is also strongly tied to the Berry curvature. In this work, the anomalous transport effects are at first studied in fundamental model systems. Here, a combination of analytical and numerical methods is used to reveal quantizations in both the Hall, the Nernst, and the thermal Hall effects in two-dimensional systems with and without external magnetic fields. An expansion into three dimensions shows a quasi-quantization, where the conductivities take values of the respective two-dimensional quanta scaled by characteristic wavevectors. In the next step, several mechanisms for the generation of strong Berry curvature and thus large anomalous Hall and Nernst effects are studied in both model systems and real materials. This allows for the identification and isolation of promising effects in the simple models, where important features can be studied. The results can then be applied to the real materials, where the respective effects can be recognized. Here, both Weyl points and nodal lines in combination with magnetism are identified as promising features and material realizations are proposed in the class of Heusler compounds. These compounds are a very versatile class of materials, where among others also magnetic topological metals can be found. To get a deeper understanding of the anomalous transport effects as well as to derive guidelines for high-performance compounds, a high-throughput calculation of magnetic cubic full Heusler compounds was carried out. This calculation reveals the importance of mirror planes in magnetic materials for large anomalous Hall and Nernst effects and shows that some of the Heusler compounds outperform the highest so-far reported literature values in these effects. Also other interesting effects related to Weyl points are investigated. In the well-known Weyl semimetal NbP, the Weyl points have a high degeneracy due to the high symmetry of the crystal. However, the application of uniaxial strain reduces the symmetries and therefore lifts the degeneracies. A theoretical investigation shows, that the Weyl points are moved in energy under uniaxial strain and, more importantly, that at reasonable strain values they cross the Fermi level. This renders NbP a promising platform to further study Weyl physics. The theoretical results are combined with experimental measurements of Shubnikov-de Haas oscillations under uniaxial strain and a good agreement with the theoretical results is found. As a first step in the direction of new ways of computation, an idea of a Weyl semimetal based chirality filter for electrons is investigated. At the interface of two Weyl semimetals, depending on the exact Weyl point parameters, it is possible to transmit only one chirality. Here, an effective geometrical model is established and employed for the investigation of real material interfaces. While in general, a filtering effect seems possible, the investigated materials did not show any suitable combination. Here, further studies can be made with the focus on either magnetic Weyl semimetals of multifold-fermion materials.:List of publications Preface 1. Theoretical background 1.1. Berry curvature and Weyl semimetals 1.1.1. From the adiabatic evolution to the Berry phase 1.1.2. From the Berry phase to the Berry curvature 1.1.3. Topological phases of condensed matter 1.1.4. Weyl semimetals 1.1.5. Dirac semimetals 1.1.6. Nodal line semimetals 1.2. Density-functional theory 1.2.1. Born-Oppenheimer approximation 1.2.2. Hohenberg-Kohn theorems 1.2.3. Kohn-Sham formalism 1.2.4. Exchange-correlation functional 1.2.5. Pseudopotentials 1.2.6. Basis functions 1.2.7. VASP 1.3. Tight-binding Hamiltonian from Wannier functions 1.3.1. Wannier functions 1.3.2. Constructing Wannier functions from DFT 1.3.3. Generating a Wannier tight-binding Hamiltonian 1.3.4. Necessity of the tight-binding Hamiltonian 1.4. Linear response theory 1.4.1. General introduction to linear response 1.4.2. Anomalous Hall effect 1.4.3. Anomalous Nernst effect 1.4.4. Anomalous thermal Hall effect 1.4.5. Common features of anomalous transport effects 1.4.6. Symmetry considerations for Berry curvature related transport effects 1.4.7. Magneto-optic Kerr effect 1.4.8. About the efficiency of the calculations 2. (Quasi-)Quantization in the Hall, thermal Hall, and Nernst effects 2.1. Quantization with an external magnetic field 2.1.1. Two-dimensional case 2.1.2. Three-dimensional case 2.2. Quantization without an external field 2.2.1. Two-dimensional case 2.2.2. Three-dimensional case . 2.3. A remark on the spin Hall effect 2.4. A remark on the quasi-quantization of the three-dimensional conductivities 2.5. Conclusions 3. Understanding anomalous transport 3.1. Anomalous transport without a net magnetic moment 3.1.1. Toy model 3.1.2. Ti2MnAl and related compounds 3.2. Large Berry curvature enhancement from nodal line gapping 3.2.1. Toy model 3.2.2. Fe2MnP and related compounds 3.2.3. Co2MnGa 3.3. Topological features away from the Fermi level and the anomalous Nernst effect 3.3.1. Toy model . 3.3.2. Co2FeGe and Co2FeSn 3.4. Conclusions 4. Heusler database calculation 4.1. Workflow 4.2. Importance of mirror planes 4.3. The right valence electron count 4.4. Correlation between anomalous Hall and Nernst effects 4.5. Selected special compounds 4.6. Conclusions 5. NbP under uniaxial strain 5.1. NbP and its symmetries 5.2. The influence of strain on the electronic structure 5.2.1. Shifting of the Weyl points 5.2.2. Splitting of the Fermi surfaces 5.3. Comparison with experimental results 5.4. Conclusions 6. A tunable chirality filter 6.1. Concept 6.2. Geometrical simplification and expansion for more Weyl points 6.3. Material selection 6.3.1. Workflow 6.3.2. Results for NbP and TaAs 6.3.3. Results for Ag2Se and Ag2S 6.4. Conclusions and perspective . Summary and outlook A. Numerical tricks A.1. Hamiltonian setup at several k points at once A.2. Precalculating prefactors B. Derivation of the conductivity (quasi-)quanta B.1. Two dimensions B.1.1. General formula and necessary approximations B.1.2. Useful integrals B.1.4. Quantized thermal Hall effect B.1.5. Quantized Nernst effect B.1.6. Flat bands and the Nernst effect B.2. Three dimensions B.2.1. General formula B.2.2. Three-dimensional electron gas B.2.3. Three-dimensional Weyl semimetal C. Heusler database tables D. Details on the NbP strain calculations E. Details on the geometrical matching procedure References List of abbreviations List of Figures List of Tables Acknowledgements Eigenständigkeitserklärung

Conformational changes in human proteins can induce several types of diseases. The nature of the conformational changes is largely unknown, but some lead to amyloid fibril formation. Amyloid fibrils accumulate in the extra-cellular space of tissues resulting in disruption of organ function. Transthyretin (TTR) is a plasma protein involved in three amyloid diseases, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, and senile systemic amyloidosis. The latter disease involves conformational changes in the wild-type structure of the protein, whereas the others are caused by a gene mutation. Our goal is to increase the knowledge of why and how some proteins aggregate into amyloid fibrils by solving and analyzing structures of different TTR variants of which some can form amyloid fibrils, whereas others cannot. The crystal structures of wild-type TTR and many of its disease-causing mutants have previously been determined, and observed structural discrepancies between mutant and wild type were claimed to be of importance for amyloid formation. We performed a comparative analysis of all, at that point, known structures of TTR. As a reference for our study, we determined a 1.5 Å resolution structure of human wild-type TTR. We found that the previously reported structural differences between wild type and mutant TTR were insignificant and did not provide clues to the mechanism for amyloid formation. We showed the double mutant TTR-Ala108Tyr/Leu110Glu to be less amyloidogenic than wild-type transthyretin. Since the structure of few non-amyloidogenic mutants are known, we solved its structure in two space groups, C2 and P21212, where the latter was consistent with most of the structures of transthyretin. Only the highly amyloidogenic mutant ATTR-Leu55Pro has previously been solved in C2. The packing of molecules in our C2 crystal was close-to-identical to the ATTR-Leu55Pro crystal structure, ruling out the described ATTR-Leu55Pro packing interactions as significant for amyloidosis. The C2 structure displayed a large shift in residues Leu55-Leu58, a structural change previously found only in amyloidogenic TTR variants. Combined with previous data, this suggests that transthyretin in solution contains a mixture of molecules with different conformations. This metastability of transthyretin provides insight to why some proteins aggregate into amyloid fibrils. The natural ligand thyroxine has been shown to stabilize TTR. Small molecules, based on thyroxine, with the potential to serve as inhibitors for amyloid fibril formation are under development. Iodine is a component of thyroxine and we found that TTR also bound free iodide ions. Taking advantage of the anomalous scattering of iodide, we solved the iodide-bound TTR structure using the single-wavelength anomalous dispersion method. In addition, we determined the TTR-chloride structure. Both chloride and iodide stabilized transthyretin where iodide stabilized better. From the thyroxine-TTR structure, three halogen-binding pockets have been identified in each TTR monomer. We found three bound iodides per TTR monomer, two of which were in the thyroxine-binding channel. This indicates that only two of the three halogen-binding pockets in the thyroid-hormone binding channel are optimal for halogen binding. Our results might be useful for the continuing design of small molecule ligands, which in the end can lead to inhibitors for amyloid diseases.

The presented thesis deals with examing of telepathy, "extrasensory perception" and anomalous cognition phenomenons. In the first part of the thesis, theoretical background of problem is presented, particularly in historical, terminological and metodological sense. This part involves viewing of this discipline from "classic science" perspective and also deals with confrontation with contemporary scientific (especially physical) paradigms. Evaluation of cognitive and information theory aspects of "extra sensory communication" and related criticism of current terminology and paradigm are also included in this part. Second part of thesis is devoted to my experiment conducted on VŠE as a practical part of my thesis. The experiment was a replication of Multimodal Ganzfeld Experiment (Pütz et al., 2007) aimed to revalidate it's results and extend our knowledge about this anomalous phenomena. Experimental method, comparable works and design of my variant of experiment are presented here, as well as validating methodology and results. As a part of conclusion, results' interpretation, possible criticism and also discussion about alternative interpretations are provided. Third part of a work shortly presents AutoGanzfeld WebApp software, deisgned, implemented and used for purpose of data collection in my experiment. Keywords: telepathy, ESP, psi, extrasensory perception, ganzfeld, anomalous cognition, communication, information