Thesis (Ph. D.)--University of Florida, 2000. / Title from first page of PDF file. Document formatted into pages; contains xxii, 263 p.; also contains graphics. Abbreviated abstract copied from student-submitted information. Vita. Includes bibliographical references (p. 252-262).

Thesis--Catholic University of America. / Bibliography: p. 203-217.

Thesis (PhD(Pharmacology-Faculty of Health Sciences))--University of Pretoria, 2001. / Includes bibliographical references.

Thesis--School of Advanced Airpower Studies, Maxwell Air Force Base, Ala., 1991-92. / Title from title screen (viewed Oct. 28, 2003). "October 1995." Includes bibliographical references.

With no doubt, staging Hassan Moghaddam’s play Ja’far Khan Returns from the West in 1922 contributed a lot to improving the modern theater movement in Iran. Before this drama, the Iranian theater was pressing for a compelling pattern to free this old genre from the old structures of theater and provide it with the opportunity to explore novel areas. In traditional Iranian theatre, the dramatic expression was mostly in the form of dance and mime; puppetry, and Islamic religious epic drama (ta`ziyeh-khvani). Ja’far Khan Returns from the West opens up a new window to the traditional Iranian theatre and helps with establishing the fundamental principles of modern theatre in Iran. Moghaddam does not focus on the stories of kings as in the old comic theatre; nor narrates elegies or reenacts the martyrdom of Imam Hossein. The author, on the other hand, rather than depicting stories about old Persia, tries to address and criticize one of the major issues of his own time: the infatuation of the majority of young Iranians with the West; their alienation from their own culture; their devotion to assimilation with the West and taking it as a model; their belief in surrendering to the Western civilization totally and unconditionally. Unfortunately although the play became one of the most celebrated pieces at the time, after its author’s early death, Moghaddam’s works and influence gradually diminished. Even in landmarks of theatre history in Iran, little effort is devoted to introducing the late author to the new generation of theatre enthusiasts. This paper seeks to bring the significance of Hassan Moghaddam and his works, especially Ja’far Khan Returns from the West, into attention and discuss the importance of the play in general and its relation to westernization in particular. / text

The purpose of this investigation was to determine and characterise the anti-oxidant activity of the methanol extract of the leaves of Halleria lucida utilizing the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. The methanol extract of the leaves of H. lucida displayed promising anti-oxidant activity with an IC50 value of 8.49±0.12 μg/ml and was subsequently subjected to activity-guided fractionation resulting in the isolation of a flavone-type flavonoid and phenylpropanoid glycoside, namely luteolin-5-O-β-D-glucoside and verbascoside (acteoside), respectively. Both compounds displayed promising anti-oxidant activities with IC50 values of 6.12±0.40 and 7.18±0.08 μg/ml for luteolin-5-O-β-D-glucoside and verbascoside, respectively. Furthermore, isobologram construction was undertaken to determine pharmacological interactions between the isolated molecules resulting in a concentration-dependent additive and antagonistic interaction being recognised.

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Gene silencing in Saccharomyces cerevisiae has been conclusively linked to histone deacetylation and the subsequent formation of heterochromatin. The participating histone deacetylases have also been well characterized. In contrast, the opposing histone acetyltransferases (HAT) and their mechanism of action remain elusive. In particular, very little is known about the effects of two of the nine HATs in S. cerevisiae, ESA1 and RTT109. The focus of my research was to test if these HATs influence the silencing of genes at the subtelomeric regions of S.cerevisiae and to assess their mechanism of action. To address these issues I used a panel of recombinant telomeric constructs that harbor the URA3 reporter gene. These constructs were inserted at the VIIL telomere of the mutant strains esa1-414 and ∆rtt109. The level of gene repression of the URA3 reporter in each construct in both of these strains has been assessed by a routine assay measuring the sensitivity of the strain to the drug 5-fluoro-orotic acid. My results indicate than none of these HATs plays a specific major role in gene repression at telomeres. Instead, they show general anti-silencing activity that cannot be linked to any specific sub-telomeric elements. Like many other HATs, Esa1 and Rtt109 seem to operate through global acetylation of histones rather than through specific recruitment. These results provide additional insight in the function of the HATs in gene silencing and suggest that there are multiple mechanisms that we do not yet understand. The information provided here would help in future studies to determine the mode of action of anti-silencers and subtelomeric elements involved in telomeric silencing. These issues are of fundamental significance and will contribute to the dynamic and expanding field of epigenetics. / NSERC 400478

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