by Chin Miu Ling, Nathalie. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 130-143). / ABSTRACT --- p.i / ACKNOWLEDGEMENTS --- p.iii / LIST OF TABLES --- p.vii / LIST OF FIGURES --- p.x / INTRODUCTION --- p.1 / Chapter A --- Aminoglycosides --- p.1 / Chapter 1 --- Structure --- p.1 / Chapter 2 --- Classification --- p.1 / Chapter 3 --- Mode of action --- p.2 / Chapter 4 --- Types --- p.9 / Chapter B --- Mechanisms of aminoglycoside-resistance --- p.13 / Chapter C --- Aminoglycoside-modifying enzymes --- p.14 / Chapter 1 --- Classification --- p.19 / Chapter i --- Phosphotransferases --- p.19 / Chapter ii --- Adenylytransferases --- p.21 / Chapter iii --- Acetyltransferases --- p.22 / Chapter 2 --- Genes encoding AMEs --- p.24 / Chapter 3 --- Applications --- p.27 / Chapter D --- Prevalence of aminoglycoside-resistance --- p.28 / Chapter E --- Methods for the determination of aminoglycoside-modifying enzymes --- p.34 / Chapter 1 --- Examination of resistance phenotype --- p.35 / Chapter 2 --- Phosphocellulose paper binding assay --- p.38 / Chapter 3 --- Hybridization with specific gene probes --- p.39 / Chapter 4 --- Antibiotic inactivation --- p.44 / Chapter 5 --- High performance liquid chromatography (HPLC) --- p.44 / Chapter F --- Prevalence of aminoglycoside-modifying enzymes --- p.45 / Chapter G --- Objectives --- p.52 / MATERIALS AND METHODS --- p.53 / Materials --- p.53 / Chapter A --- Bacterial strains --- p.53 / Chapter 1 --- Standard strains --- p.53 / Chapter 2 --- Clinical isolates --- p.53 / Chapter B --- "Antibiotic, media, chemicals and instruments" --- p.55 / Methods --- p.55 / Chapter A --- Orevalence of aminoglycoside-resistance --- p.55 / Chapter B --- Susceptibility testing --- p.55 / Chapter C --- Characterization of aminoglycoside-modifying enzymes (AMEs) --- p.61 / Chapter 1 --- Extraction of enzymes --- p.61 / Chapter 2 --- Substrate profile analysis by the phosphocellulose paper binding assay --- p.62 / Chapter D --- Localization of resistance genes --- p.64 / Chapter 1 --- Genetic study --- p.64 / Chapter 2 --- Molecular studies --- p.67 / Chapter i --- Preparation of crude plasmid extracts --- p.68 / Chapter ii --- Agarose gel electrophoresis --- p.68 / Chapter E --- Plasmid profile analysis --- p.69 / Chapter F --- Plasmid fingerprinting --- p.69 / Chapter 1 --- Preparation of purified plasmid --- p.69 / Chapter 2 --- Restriction endonuclease digestion of plasmid DNA --- p.70 / Plan to achieve objectives --- p.71 / results --- p.73 / Chapter A --- Prevalence of aminoglycoside-resistant Gram-negative bacteria isolated in the Prince of Wales Hospital from 1989 to1992 --- p.73 / Chapter B --- "Susceptibility to 12 aminoglycosides of aminoglycoside-resistant E. coli, K pneumoniae and Ps. aeruginosa" --- p.78 / Chapter C --- "Aminoglycoside-modifying enzymes (AMEs) produced by E. coli, K pneumoniae and Ps. aeruginosa" --- p.88 / Chapter D --- Plasmid profile analysis --- p.93 / Chapter E --- Localization of aminoglycoside-resistance genes --- p.102 / discussion --- p.114 / Chapter A --- Aminoglycoside-resistance --- p.114 / Chapter B --- Mechanisms of aminoglycoside-resistance --- p.118 / Chapter C --- Genetic location of aminoglycoside-resistance and plasmid profiles --- p.122 / Chapter D --- Characterization of AMEs --- p.126 / Chapter E --- Areas for future research --- p.128 / references --- p.130 / appendix --- p.144

by Carrie Au-Yeang. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 45-54). / Abstract also in Chinese. / Chapter I. --- Abstract --- p.iii / Chapter II. --- Acknowledgements --- p.iv / Chapter III. --- Table of Contents --- p.v / Chapter IV. --- List of Abbreviations --- p.vii / Chapter V. --- List of Figures --- p.viii / Chapter VI. --- List of Tables --- p.ix / Chapter VII. --- Introduction --- p.1 / Chapter VIII. --- Literature Review --- p.3 / Chapter A. --- Mycobacterium tuberculosis Infections - clinical importance --- p.3 / Chapter B. --- Treatment of M. tuberculosis Infections - the past & present --- p.3 / Chapter C. --- Laboratory Supports for Treatment of Tuberculosis --- p.5 / Chapter D. --- The Postantibiotic Effects (PAE) --- p.6 / Chapter E. --- PAE of Antituberculosis Drugs Against Mycobacteria --- p.15 / Chapter F. --- Radiometric Measurement of growth --- p.16 / Chapter IX. --- Materials and Methods --- p.17 / Chapter A. --- Bacterial Strains and Their Maintenance --- p.17 / Chapter B. --- Antimicrobial Agents --- p.17 / Chapter C. --- Antimicrobial Susceptibility Testing --- p.18 / Chapter D. --- Assessment of PAE and KI In Vitro --- p.20 / Chapter E. --- Assessment of PAE and KI Ex Vivo --- p.22 / Chapter F. --- Determination of Drug Uptake --- p.25 / Chapter X. --- Results --- p.29 / Chapter A. --- In Vitro Susceptibility Testing of the M. tuberculosis Strains --- p.29 / Chapter B. --- PAE In Vitro - the Classical Viable Count Method --- p.29 / Chapter C. --- PAE Measured by the Bactec Method --- p.30 / Chapter D. --- PAE In Vitro - the Bactec Method --- p.30 / Chapter E. --- Postantibiotic Effects Ex Vivo by the Bactec Method --- p.31 / Chapter F. --- Bactericidal Activities In Vitro and Ex Vivo --- p.32 / Chapter XI. --- Discussion --- p.34 / Chapter A. --- Selection of M. tuberculosis isolates and Drug Susceptibility --- p.34 / Chapter B. --- PAE and KI In Vitro & Ex Vivo - the study methods --- p.34 / Chapter C. --- PAE In Vitro & Ex Vivo - single drug --- p.36 / Chapter D. --- PAE Ex Vivo - drug combinations --- p.38 / Chapter E. --- KI In vitro & Ex vivo --- p.39 / Chapter F. --- PAE and Clinical Therapeutic Regimens --- p.41 / Chapter G. --- Conclusion & Future Studies --- p.44 / Chapter XII. --- Literature Cited --- p.45 / Chapter XIII. --- Figures --- p.55 / Chapter IVX --- Tables --- p.68

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2009.

Thesis (Ph.D)--Malmö University, 2009. / Includes bibliographical references. Also available on the Internet.

Thesis (doctoral)--Karolinska Institutet, 1985. / Added t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (Ph.D.)--Memorial University of Newfoundland, 2002. / Bibliography: leaves 161-173.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1952. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 74-78).

Thesis (doctoral)--Rijksuniversiteit te Utrecht, 1963. / "Appendices" (1 v.) inserted in pocket at end.

Thesis (doctoral)--Rijksuniversiteit te Utrecht.

Thesis (doctoral)--Rijksuniversiteit te Utrecht, 1963. / "Appendices" (1 v.) inserted in pocket at end. eContent provider-neutral record in process. Description based on print version record.