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Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept studySarkar, Indrani 17 January 2007 (has links) (PDF)
The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.
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Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept studySarkar, Indrani 26 September 2006 (has links)
The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.
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