The project investigates an aesthetic of assembly. It established a visual expression though exploring the relationship between disassembly and assembly in the context of laminated timbers. These explorations are manifested in a learning institution in relationship to an existing CLT factor in Långshyttan. The project becomes a dynamic celebration of assembly and a continuous learning environment as the building continues to disassemble and reassemble to counter the obsolescent of new technological inventions in a rapidly developing industry driven by industrialization and technological determination.  The new building feeds of the factory for purely disassembled parts in terms of discarded waste and a pure form of assembly in terms of unprocessed CLT blanks. The production of industrial produced mass timber elements has further moved the production of buildings into factories and the erection of buildings at site consist primarily of an assembly of  predesigned parts. Architectural advancements is inseparable from technological paradigms and the production of construction timber should carry with it new architectural expressions.

Haloxylon persicum is a xerophytic desert tree that grows mostly in deserts in West and Central Asia. This tree is very tolerant to the harsh conditions of deserts, mainly drought and heat. As a part of the Kingdom of Saudi Arabia Native Genome Project, a voucher specimen was identified, and the genome of this plant was sequenced, assembled, and annotated. The chromosome level assembly was performed using the integration of PacBio Hifi reads and Bionano optical maps, resulting in 9 chromosome-sized molecules that only exhibit 3 gaps located in highly repetitive regions. The annotation of the transposable elements in the genome shows that more than 55% of the genome consists of transposable elements. Moreover, genes were predicted using Iso-seq and RNA-seq and annotated using publicly available protein databases, resulting in the identification of more than 45,000 predicted genes, of which ≈ 10,000 have RNA evidence. The genome assembly and annotation of Haloxylon persicum will: provide valuable insight on the evolutionary history of desert plants, aid in discovering the mechanisms developed by this species to cope with the extreme desert conditions and unveil the possibilities and opportunities of neo-domesticating this plant. Furthermore, this assembly can serve as a reference for assembling other plant species in the KSA Native genome project or any other project worldwide.

One of the original goals of phylogeography was to use genetic data to identify historical events that might contribute to breaks among biotic communities. In this study, we examine the phylogeography of a common livebearing fish (Poecilia gillii) from Costa Rica. Our goal was to see if phylogeographic breaks in this species were congruent with previously-defined boundaries among four fish community provinces. We hypothesized that if abiotic factors influence both community boundaries and genetic structuring in P. gillii then we would find four monophyletic clades within our focal species that were geographically separated along community boundary lines. Similarly, we expected to find most of the genetic variation in P. gillii partitioned among these four geographic regions. We generated DNA sequence data (mitochondrial cyt b and nuclear S7 small ribosomal subunit) for 260 individuals from 42 populations distributed across Costa Rica. We analyzed these data using phylogenetic (parsimony and likelihood) and coalescent approaches to estimate phylogenetic relationships among haplotypes, patterns of gene flow, and effective population size. Contrary to our expectations, we did not find four monophyletic groups that mapped cleanly to our geographic community provinces. However, one of our clades was restricted to a single province, suggesting that common earth history events could be responsible for both genetic structuring in P. gillii and fish community composition in this area. However, our results show a complex pattern of gene flow throughout other regions in Costa Rica where genetic structuring is not governed by community province boundaries.

No description available.

Yes / This paper presents the design of a multi-agent framework that aids engineers in the adaptation of modular production systems. The framework includes general implementations of agents and other software components for self-learning and adaptation, sensor data analysis, system modelling and simulation, as well as human-computer interaction. During an adaptation process, operators make changes to the production system, in order to increase capacity or manufacture a product variant. These changes are automatically captured and evaluated by the framework, building an experience base of adjustments that is then used to infer adaptation knowledge. The architecture of the framework consists of agents divided in two layers: the agents in the lower layer are associated with individual production modules, whereas the agents in the higher layer are associated with the entire production line. Modelling, learning, and adaptations can be performed at both levels, using a semantic model to specify the structure and capabilities of the production system. An evaluation of a prototype implementation has been conducted on an industrial assembly system. The results indicate that the use of the framework in a typical adaptation process provides a significant reduction in time and resources required. / This work was supported in part by the European Commission [grant agreement n. 314762].

Yes / Modern manufacturing companies face increased pressures to adapt to shorter product life cycles and the need to reconfigure more frequently their production systems to offer new product variants. This paper proposes a new multi-agent architecture utilising “plug and produce” principles for configuration and reconfiguration of production systems with minimum human intervention. A new decision-making approach for system reconfiguration based on tasks re-allocation is presented using goal driven methods. The application of the proposed architecture is described with a number of architectural views and its deployment is illustrated using a validation scenario implemented on an industrial assembly platform. The proposed methodology provides an innovative application of a multi-agent control environment and architecture with the objective of significantly reducing the time for deployment and ramp-up of small footprint assembly systems. / The reported research has been part of the EU FP7 research project “PRIME”

Nanoparticles are regarded as exciting new building blocks for functional materials due to their fascinating physical properties because of the nano-confinement. Organizing nanoparticles into ordered hierarchical structures are highly desired for constructing novel optical and electrical artificial materials that are different from their isolated state or thermodynamics random ensembles. My research integrates the surface chemistry of nanoparticles, interfacial assembly and lithography techniques to construct nanoparticle based functional structures. We designed and synthesized tailor-made ligands for gold, semiconductor and magnetic nanoparticle, to modulate the assembly process and collective properties of the assembled structures, by controlling the key parameters such as particle-interface interaction, dielectric environments and inter-particle coupling etc. Top-down technologies such as micro contact printing, photolithography and nanoimprint lithography are used to guide the assembly into arbitrarily predesigned structures for potential device applications.

The development and maintenance of multicellular organisms depends fundamentally on cell division, a series of events largely mediated by the mitotic spindle. Errors in spindle formation and/or function are often associated with severe consequences, most notably cancer. In order to elucidate the cause of such errors and the potential for therapeutic intervention, it is imperative to attain a clear understanding of how cell division normally operates. In this regard, this dissertation focuses on the activity of two microtubule-based motor proteins, Eg5 and dynein, prior to and immediately following nuclear envelope breakdown during mitosis. I show that prophase microtubules are remarkably more dynamic than their metaphase counterparts, moving both toward and away from centrosomes across a wide distribution of rates. Inhibition of Eg5, dynein and Kif2a revealed that a subset of this motion is consistent with microtubule flux, a well-established phenomenon temporally limited to metaphase and anaphase spindles by the preceding literature. My data indicates that flux is operational throughout all of mitosis, possibly functioning at early stages to collect centrosomal components. Immediately following prophase, cells begin assembling bipolar spindles. While the establishment of spindle bipolarity fails in the physical or functional absence of Eg5, I show that co-inhibition of dynein restores a cell’s ability to organize microtubules into a bipolar structure. Despite inhibition of both Eg5 and dynein, these spindles are morphologically and functionally equivalent to controls. Together, these data suggest that Eg5 and dynein share an antagonistic relationship and that a balance of forces, rather than a definitive set of players, is important for spindle assembly and function. To determine how Eg5- and dynein-mediated forces functionally coordinate to bring about antagonism during spindle assembly, I utilize a nocodazole washout assay. I show, via in vivo imaging and in silico modeling, that spindle collapse in the absence of functional Eg5 requires dynein activity and an initial intercentrosomal distance of less than 5.5μm. These data are consistent with a model in which dynein antagonizes Eg5 by crosslinking and sliding antiparallel microtubules, a novel role for dynein within the framework of spindle assembly.

Malware is the source or a catalyst for many of the attacks on our cyberspace. Malware analysts and other cybersecurity professionals are responsible for responding to and understanding attacks to mount a defense against the attacks in our cyberspace. The sheer amount of malware alone makes this a difficult task, but malware is also increasing in complexity. This research provides empirical evidence that a hybrid approach using token-based and semantic-based code clones can identify similarities between malware. In addition, the use of different normalization techniques and the use of undirected matrices versus directed matrices were studied. Lastly, the impact of the use of inexact code clones was evaluated. Our results showed that our approach to determining the similarity between malware outperforms two methods currently used in malware analyses. In addition, we showed that overly generalized normalization of code sections would hinder the performance of the proposed method. At the same time, there is no significant difference between the use of directed and undirected matrices. This research also confirmed the positive impact of using inexact code clones when determining similarity.

Thesis advisor: John Baldovin / Thesis advisor: Thomas M. Groome / This thesis proposes a connection between the theology of the assembly and the education offered by the Society of Jesus in its schools. For young people, the school should be a place where they learn that life in community is the fullest form of life. Sacramentality is a constitutive dimension of the Church and the Christian faith, and inspires us to live our faith in all situations and circumstances. As a result, liturgy has a significant impact on the formation and transformation of the Christian community. It is essential that the liturgy is adequate to allow members to express their faith in God and experience God's life through the love they receive for the world. Although not all students in Jesuit schools are Catholic, the Jesuit school is an assembly where all members must develop a sacramental look at reality. Liturgy can be a link between all these elements, for when it is "sacramenally adequate," it is a source of nourishment and continual conversation for the faith life of a Christian community. In summary, this thesis argues that assembly theology and Jesuit education must go together to form a sacramentally adequate Christian community where the liturgy is a source of ongoing transformation and conversion. / Thesis (STL) — Boston College, 2023. / Submitted to: Boston College. School of Theology and Ministry. / Discipline: Sacred Theology.