Three experiments were conducted to examine the effect of association strength on TOT (tip-of-the-tongue states) and recall. Two hundred nineteen undergraduate students studied pictures and names of 24 imaginary animals that were presented on a large computer screen. The strength of association between the cue and target was manipulated by varying the number of times the picture and the name were presented simultaneously, while keeping the number of presentations for each picture or the target constant across conditions. After the study phase, participants were cued by each picture to recall the imaginary animal names. Participants were asked to rate their strength of TOT on a scale ranging 0 to 3 for each item if they could not think of the name at the moment. Participants also made subjective judgments as to how many times they saw the picture and name of the animal co-occur on the same screen at the study phase, and then they performed a recognition test at the end. The results indicated that the frequency and strength of TOTs linearly increased as a function of number of co-occurrences; the correlation between TOT strength and the participants?? subjective estimation of number of co-occurrences was greater than the correlation between TOT strength and the actual number of co-occurrences. This pattern of results was found even when recall increased along with the increase in number of co-occurrences and was more pronounced particularly when recall was reduced either by interference (Experiment 1) or by increased number of critical items (Experiments 2 & 3) and also by a reduced number of co-occurrence conditions and an increased gap between one level to the next (Experiment 3). Results suggest that an increase in association strength concomitantly increases TOT strength especially when the activation of the target is under threshold for recall and that people may use rules of thumb, or heuristic when they report TOTs by estimating the strength of the cue-target association.

Esta dissertação buscou analisar o efeito de priming semântico em uma tarefa de decisão lexical. No estudo 1, comparou-se o efeito de priming semântico entre crianças e universitários em dois SOAs (250ms e 500ms). Os resultados mostraram que no SOA de 250ms, apenas as crianças tiveram efeito de priming semântico. Quando o SOA foi de 500ms, ambos grupos apresentaram efeito de priming semântico, no entanto, este foi maior nas crianças. No estudo 2 foi investigada a relação entre o efeito de priming semântico nas crianças do estudo 1 e as variáveis força de associação e freqüência do alvo. Foram encontradas algumas fracas correlações entre estas variáveis. Conclui-se que variáveis como idade/escolaridade, SOA e força de associação são determinantes no efeito de priming semântico. / The aim of this study was to analyze the semantic priming effect in a lexical decision task. In study 1, the semantic priming effect in third graders and college students was compared. It was used two SOAs, 250ms and 500ms. The results showed that when SOA was 250ms, only third graders had semantic priming effects. When SOA was 500ms, both groups had semantic priming effects; however, the magnitude of it was bigger in children. In study 2, it was investigated the relation between semantic priming effects of third graders and the variables associative strength and frequency. Data demonstrated some weak correlations between these variables. We concluded that variables such age/educational group, SOA and associative strength are related to the semantic priming effect.

Esta dissertação buscou analisar o efeito de priming semântico em uma tarefa de decisão lexical. No estudo 1, comparou-se o efeito de priming semântico entre crianças e universitários em dois SOAs (250ms e 500ms). Os resultados mostraram que no SOA de 250ms, apenas as crianças tiveram efeito de priming semântico. Quando o SOA foi de 500ms, ambos grupos apresentaram efeito de priming semântico, no entanto, este foi maior nas crianças. No estudo 2 foi investigada a relação entre o efeito de priming semântico nas crianças do estudo 1 e as variáveis força de associação e freqüência do alvo. Foram encontradas algumas fracas correlações entre estas variáveis. Conclui-se que variáveis como idade/escolaridade, SOA e força de associação são determinantes no efeito de priming semântico. / The aim of this study was to analyze the semantic priming effect in a lexical decision task. In study 1, the semantic priming effect in third graders and college students was compared. It was used two SOAs, 250ms and 500ms. The results showed that when SOA was 250ms, only third graders had semantic priming effects. When SOA was 500ms, both groups had semantic priming effects; however, the magnitude of it was bigger in children. In study 2, it was investigated the relation between semantic priming effects of third graders and the variables associative strength and frequency. Data demonstrated some weak correlations between these variables. We concluded that variables such age/educational group, SOA and associative strength are related to the semantic priming effect.

Esta dissertação buscou analisar o efeito de priming semântico em uma tarefa de decisão lexical. No estudo 1, comparou-se o efeito de priming semântico entre crianças e universitários em dois SOAs (250ms e 500ms). Os resultados mostraram que no SOA de 250ms, apenas as crianças tiveram efeito de priming semântico. Quando o SOA foi de 500ms, ambos grupos apresentaram efeito de priming semântico, no entanto, este foi maior nas crianças. No estudo 2 foi investigada a relação entre o efeito de priming semântico nas crianças do estudo 1 e as variáveis força de associação e freqüência do alvo. Foram encontradas algumas fracas correlações entre estas variáveis. Conclui-se que variáveis como idade/escolaridade, SOA e força de associação são determinantes no efeito de priming semântico. / The aim of this study was to analyze the semantic priming effect in a lexical decision task. In study 1, the semantic priming effect in third graders and college students was compared. It was used two SOAs, 250ms and 500ms. The results showed that when SOA was 250ms, only third graders had semantic priming effects. When SOA was 500ms, both groups had semantic priming effects; however, the magnitude of it was bigger in children. In study 2, it was investigated the relation between semantic priming effects of third graders and the variables associative strength and frequency. Data demonstrated some weak correlations between these variables. We concluded that variables such age/educational group, SOA and associative strength are related to the semantic priming effect.

Les études d'association sur un génome complet (GWAS) sont conçues pour découvrir les combinaisons de points de polymorphisme (SNP) associées à des maladies. La découverte de ces associations permet d'élaborer de meilleures stratégies pour détecter, traiter ou prévenir les maladies. Récemment, l'utilisation de techniques d'extraction de patterns discriminatif a été investiguée dans le cadre de problématiques GWAS. Toutefois, la découverte de combinaisons de SNP dans de grands jeux de données GWAS est encore difficile à cause de la complexité des algorithmes utilisés. La thèse se propose donc d'améliorer l'état de l'art des approches d'extraction de motifs discriminants, dans le cadre d'extraction de combinaisons de SNP corrélées à un phénotype d'intérêt. Plusieurs solutions ont été proposées, s'attaquant aux problèmes majeurs en GWAS : évaluation de la force d'association, découverte efficace de combinaisons de SNP et visualisation de ces combinaisons. Les approches proposées sont également prometteuses pour d'autres tâches de bioinformatique comme la découverte d'expressions génique, la détection de motifs de phosphorylation et la détection de motifs de régulation. / Discovering high-order SNP combinations associated with diseases is an important task of bioinformatics. Once new genetic associations are identified, they can be used to develop better trategies to detect, treat and prevent the diseases. Recently, this issue has been effectively tackled with discriminative pattern mining algorithms. However, the number of SNPs is often very large, discovering of SNP combinations remains many challenges. To address these challenges this thesis has been advanced the state-of-the-art discriminative pattern mining techniques to discover SNP combinations associated with interesting phenotype. Different solutions have been proposed in this thesis to tackle GWAS analysis. These solutions focus on efficient association strength evaluation, statistically significant discriminative SNP combinations discovery and interesting SNP combinations visualization. The solutions proposed in this thesis are also promising for other tasks of bioinformatics such as differential gene expression discovery, phosphorylation motifs detection and regulatory motif combination mining.