Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-06-02T13:07:50Z No. of bitstreams: 2 Dissertação - Polliana Conceição Garcia - 2015.pdf: 2210434 bytes, checksum: 2904fb672abe80d906ef6e87a1f9d87d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-06-02T13:09:30Z (GMT) No. of bitstreams: 2 Dissertação - Polliana Conceição Garcia - 2015.pdf: 2210434 bytes, checksum: 2904fb672abe80d906ef6e87a1f9d87d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Made available in DSpace on 2016-06-02T13:09:30Z (GMT). No. of bitstreams: 2 Dissertação - Polliana Conceição Garcia - 2015.pdf: 2210434 bytes, checksum: 2904fb672abe80d906ef6e87a1f9d87d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-12-18 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / Several clinical and epidemiological studies have shown that the association between obesity and cardiovascular risk begins early in childhood, which makes crucial the identification and control of childhood obesity associated changes as strategies to prevent adult cardiovascular diseases. The present study aimed to evaluate the relationship between the degree of adiposity and the presence of cardiovascular risk factors in children. Additionally, we investigated possible associations between anthropometric variables and blood pressure values, lipid profile components, blood glucose levels and atherogenic index. The study was conducted with children of both sexes and aged 6 to 10 years, enrolled in a public educational institution in the city of Jataí-GO. We collected anthropometric measures, blood pressure values and blood samples for fasting glucose and lipid profile (enzymatic methods) determination. Children were distributed into 3 groups: control (n=51), overweight (n=29) and obese (n=36). The daily time devoted on sedentary activities was higher, while the time spent on physical activities was lower in obese children, when compared to the control group. obese children had also higher levels of triglycerides (TG), very low density lipoprotein cholesterol (VLDL-C), total cholesterol/ high-density lipoprotein cholesterol (CT/HDL-C) and TG/HDL, along with decreased HDL-C, when compared to children with normal weight. There was a positive association between anthropometric indicators (body mass índex, waist circumference, waist-to-height ratio e skinfold thicknesses) and the variables: systolic blood pressure, diastolic blood pressure, TGs, HDL-C, VLDL-C and atherogenic index. HDL-C correlated negatively with the anthropometric variables. We conclude that increased adiposity in childhood contributes to the occurrence of cardiovascular risk factors, including high blood pressure, changes in lipid profile and increase in atherogenic indexes. / Diversos estudos clínicos e epidemiológicos têm revelado que a associação existente entre obesidade e risco cardiovascular inicia-se durante a infância, o que torna imprescindível a identificação e o controle das alterações associadas à obesidade infantil como estratégia na prevenção de doenças cardiovasculares na fase adulta. O objetivo do presente estudo foi avaliar a relação entre o grau de adiposidade e a presença de fatores de risco cardiovasculares em crianças. Adicionalmente, investigamos possíveis associações entre variáveis antropométricas e valores de pressão arterial, componentes do perfil lipídico, níveis glicêmicos e índices aterogênicos. O estudo foi realizado com crianças de ambos os sexos e com idade entre 6 e 10 anos, matriculadas em uma instituição de ensino pública do município de Jataí-GO. Foram coletadas medidas antropométricas, valores de pressão arterial e amostras de sangue para testes de glicemia de jejum e perfil lipídico (métodos enzimáticos). As crianças foram distribuídas em 3 grupos: controle (n=51), sobrepeso (29) e obeso (n=36). Nossos resultados demonstraram que o tempo diário dedicado a atividades sedentárias foi maior, enquanto o tempo gasto em atividades físicas foi menor nas crianças obesas, quando comparadas ao grupo controle. As crianças obesas apresentaram ainda valores significativamente maiores de triglicérides (TG), colesterol de lipoproteínas de densidade muito baixa (VLDL-C), colesterol total/colesterol de lipoproteína de alta densidade (CT/HDL-C) e TG/HDL-C, além de diminuição do HDL-C em relação às crianças com peso normal. Houve associação positiva entre os indicadores antropométricos (índice de massa corporal, circunferência da cintura, razão cintura-estatura e dobras cutâneas) e as variáveis: pressão arterial sistólica, pressão arterial diastólica, TGs, HDL-C, VLDL-C e índices aterogênicos, enquanto o HDL-C correlacionou-se negativamente com as variáveis antropométricas. Concluímos que o excesso de tecido adiposo na infância contribui para a ocorrência de fatores de risco cardiovasculares, como a elevação da pressão arterial, o perfil lipídico inadequado e o aumento de índices aterogênicos.

Background: Circulating long-chain (LCSFAs) and very long-chain saturated fatty acids (VLSFAs) have been differentially linked to risk of incident heart failure (HF). In patients with heart failure with preserved ejection fraction (HFpEF), associations of blood SFA levels with patient characteristics are unknown. Methods: From the Aldo-DHF-RCT, whole blood SFAs were analyzed at baseline in n = 404 using the HS-Omega-3-Index methodology. Patient characteristics were 67 8 years, 53% female, NYHA II/III (87%/13%), ejection fraction 50%, E/e’ 7.1 1.5; and median NT-proBNP 158 ng/L (IQR 82–298). Spearman´s correlation coefficients and linear regression analyses, using sex and age as covariates, were used to describe associations of blood SFAs with metabolic phenotype, functional capacity, cardiac function, and neurohumoral activation at baseline and after 12-month follow-up (12 mFU). Results: In line with prior data supporting a potential role of de novo lipogenesis-related LCSFAs in the development of HF, we showed that baseline blood levels of C14:0 and C16:0 were associated with cardiovascular risk factors and/or lower exercise capacity in patients with HFpEF at baseline/12 mFU. Contrarily, the three major circulating VLSFAs, lignoceric acid (C24:0), behenic acid (C22:0), and arachidic acid (C20:0), as well as the LCSFA C18:0, were broadly associated with a lower risk phenotype, particularly a lower risk lipid profile. No associations were found between cardiac function and blood SFAs. Conclusions: Blood SFAs were differentially linked to biomarkers and anthropometric markers indicative of a higher- /lower-risk cardiometabolic phenotype in HFpEF patients. Blood SFA warrant further investigation as prognostic markers in HFpEF. One Sentence Summary: In patients with HFpEF, individual circulating blood SFAs were differentially associated with cardiometabolic phenotype and aerobic capacity.