Abstraction is an inductive process through which specific details become united by a general concept. Abstraction incorporates two sub-skills: concept identification which involves recognizing patterns created by an external agent, and concept formation which is more difficult, requiring independent creation of a schema to organize information. Impairments in concept identification and formation are theorized to underlie a variety of practical difficulties of individuals with autism spectrum disorder (ASD; e.g., failure to generalize learning in one context to a similar, but new context). However, past research has yielded mixed results, with some finding significant impairment and others finding intact concept identification and formation. Contradictory findings may be due to differences in assessment methodology. We assessed concept identification and formation abilities using the Delis-Kaplan Executive Function System (D-KEFS) Sorting task. We hypothesized that (1) we would replicate previous findings of intact concept identification but impaired concept formation in individuals with ASD (Minshew et al., 2002); (2) impairments in concept formation would remain even after accounting for differences in IQ, working memory ability, and test anxiety; and (3) worse impairments would be associated with more severe autism symptoms. The sample consisted of 27 high-functioning (IQ > 80) adolescents with ASD and 27 age- (M 14.8 years) and IQ- (M 102.8) matched typically-developing controls. One-way ANOVAs explored group differences on task performance variables. As hypothesized, our sample demonstrated intact concept identification abilities, F(1, 52) = 2.90, p = 0.095, but impaired concept formation abilities, F(1, 52) = 6.53, p = 0.01. A linear regression analysis revealed that working memory ability and test anxiety were not significant predictors of concept formation abilities. After accounting for IQ in a regression model, our hypothesis was partly borne out in that individuals with ASD continued to show impairment in concept formation, yet at trend-level significance (p = 0.058). Two-tailed Pearson correlations revealed no significant correlations between a measure of autism symptomatology and concept formation or concept identification ability. Our findings add to a growing body of research showing a dissociation between concept identification and concept formation abilities in individuals with ASD. This dissociation existing at trend-level significance after statistically controlling for IQ suggests that it may exist across levels of cognitive functioning in ASD. Our finding that concept formation ability was not significantly associated with a measure autism symptomatology somewhat weakens the theoretical significance of concept formation deficits in ASD.

Prior research has suggested that any cortical volume (CV) abnormalities in Autism Spectrum Disorder (ASD) need to be further explored by examination of the two determinants of CV, that being cortical thickness (CT) and pial surface area (PSA; Murphy, Beecham, Craig, & Ecker, 2011). The current study suggests that the two determinants of CV should be explored even in the presence of null CV findings, if structure-function analyses are significant (i.e., bi-lateral precentral gyrus and neuropsychological motor test) as demonstrated in the current sample (see Duffield et al., 2013). The only significant anatomic finding was reduced CT in the left frontal motor regions (primarily left precentral gyrus), which also corresponded to the only significant relationship between a motor variable (i.e., grooved pegboard test) and motor region-of-interest (ROI) where ASD had a stronger relationship than typically developing controls (TDC; ASD > TDC). Left hemisphere biased CT group differences has been shown to have the highest classification accuracy (i.e., designation of ASD versus TDC) of morphological parameters (Ecker et al., 2010), yet PSA has been shown to have far greater modulation of CV abnormalities. This is particularly true for subthreshold PSA (Ecker et al., 2013). These prior findings are not only consistent with the current motor ROI findings, but also provide an explanatory framework for the functional neuroanatomy of a generally worse left handed performance (i.e., non-dominant hand) for ASD compared to controls in a generally right handed dominant sample (no significant group differences on handedness). The only significant motor ROI finding was in the left hemisphere (i.e., ipsilateral to worse left handed performance), but subthreshold PSA findings in the right precentral were found and likely provide explanatory power of motor performances in the aggregate, despite a lack of significant statistical differences in a specific motor ROI individually.

Children with Autism Spectrum Disorder (ASD) commonly present with reading comprehension impairments that impede their academic achievement and independent living. Research suggests that intervening on listening comprehension deficits of preschool children with ASD may contribute to improved reading comprehension proficiency in the school aged years. Dialogic reading is an empirically supported shared reading method known to increase the oral language and listening comprehension of young children with and without language impairments prior to formalized schooling. This study utilized a single subject repeated acquisition design to evaluate the effect of a parent-delivered dialogic reading intervention on the independent and accurate responding of preschool children with ASD. Overall, results showed that the dialogic reading intervention was highly effective for increasing the independent and accurate responding for two of the three participants; however minimally effective for the third. Although the parent participants demonstrated varying levels of procedural fidelity to the dialogic reading procedures, they perceived the intervention to be both feasible and effective when implemented with their preschool children with ASD. Limitations and implications for future research are discussed. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection

The causes of autism spectrum disorder (ASD) are not all known, but it is suspected that the serotonin transporter (SERT) plays an important role for some subjects with ASD. Mutations in the SLC6A4 gene, that encodes SERT, including the Ala56 mutation (Gly56Ala), have been found in some autism patients. This mutation makes the transporter more active and reduces the probability of serotonergic neurotransmission in the brain, which is linked to behavioral changes that are associated with core domain deficits of ASD 1. Depression also has been linked to decreases in the availability of serotonin (5-hydroxytryptamine; 5-HT) in the central nervous system (CNS), and is associated with reduced hippocampal neurogenesis. Selective serotonin reuptake inhibitors (SSRIs), drugs used to block SERTs, are used to treat depression and/or anxiety by inhibiting SERT to increase synaptic 5-HT levels. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection

The purpose of this study was to explore self-care strategies among parents with a child diagnosed with autism spectrum disorder. The study used a survey design to detect the extent to which respondents used self-care strategies to alleviate high stress levels associated with caring for an ASD child. The study was comprised of twenty eight respondents. The study found that the higher the level of education completed by the parent the greater the likelihood that self-care strategies were utilized. The study also found that the age of the ASD child was a factor in the level of physical self-care being incorporated among parents. Psychological self-care was also found to affect other categories of self-care. Both females and males listed lack of time as the greatest obstacle in implementing self-care. The study recommends that viewing self-care as important and finding small ways to incorporate self-care strategies might well improve other areas of parent well-being.

Autism Spectrum Disorder (Autism Spectrum Disorder) is a neurodevelopmental syndrome characterized by impairment to social communication adjoined by the presence of rigidity, restricted interests, and/or repetitive behaviors. Diagnosis of Autism Spectrum Disorder recently shifted from a series of pervasive developmental disorders recognized in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; American Psychiatric Association, 2000) to a single, comprehensive diagnosis in the 5th edition of the same manual (DSM-5; APA, 2013). To evaluate the appropriateness in this shift in diagnostic practice, the current study evaluates the consistency in symptom presentation amongst the previous DSM-IV-TR diagnoses. Additionally, this study identifies several novel considerations for Autism Spectrum Disorder symptom presentation in high ability youth. Thus, the current study addresses broad considerations for discrete versus continuous symptom presentation in Autism Spectrum Disorder, as well as contributes to the limited literature addressing Autism Spectrum Disorder symptom presentation features in high ability youth. A review of literature on theory, conceptualization, and assessment of Autism Spectrum Disorder is provided, as well as a review of relevant literature for high ability youth diagnosed with Autism Spectrum Disorder. Progression of Autism Spectrum Disorder diagnosis is discussed, with emphasis upon the current debate regarding shifts from utilization of many diagnoses to a single, comprehensive diagnosis. Next, unique challenges associated with Autism Spectrum Disorder in high ability youth are identified, including current conceptualization, assessment, and treatment considerations. Due to identified gaps in consistent understanding of Autism Spectrum Disorder presentation, including Autism Spectrum Disorder in high ability youth, the author conducted two complementary studies. The first of these studies evaluated consistency in parent ratings on Autism Spectrum Disorder screening tools across previously used diagnostic labels (i.e., Autistic Disorder (AD), Asperger's Syndrome (AS), and Pervasive Developmental Disorder, Not Otherwise Specified (PDD-NOS)) now subsumed under Autism Spectrum Disorder diagnostic criteria in the DSM-5. The second study analyzed Autism Spectrum Disorder symptoms reported by parents of high ability youth. Data collection for this latter study included a novel research measure intended for identifying symptoms associated with high ability Autism Spectrum Disorder. Items on this form were derived through a card sort of items included in current symptom screening tools completed by content area experts. Additionally, this novel research measure included an open-ended item for parents of high ability youth to report additional symptoms. Results from the first study suggest that parents of children diagnosed with AD, AS, and Pervasive Developmental Disorder, Not Otherwise Specified do not differentially report symptoms on two current Autism Spectrum Disorder screening tools: (1) The Social Responsiveness Scale (SRS; Constantino & Gruber, 2005) and (2) the Autism Spectrum Screening Questionnaire (ASSQ; Ehlers, Gillberg, & Wing, 1999). Results from the second study provide evidence of parental perceptions of several nuances in symptom presentation associated with high ability youth with Autism Spectrum Disorder. Specifically, parents frequently endorsed impairment in development and maintenance of social relationships; however, insight into these weaknesses was not consistently reported as impaired. Additionally, restricted interests were acknowledged, with some parents identifying academic or pseudo-academic subjects as common areas of interest. The collective findings from these studies provide evidence of broad consistency in Autism Spectrum Disorder symptom presentation across previously used diagnoses, yet also unique symptom features for high ability youth. Implications for education, clinical practice, and research in both Autism Spectrum Disorder and twice-exceptionality are discussed.

Autism Spectrum Disorders (ASDs) are frequently associated with communicative impairment, regardless of IQ or mental age. The most significant feature of this impairment tends to be in the dimension of both expressive and receptive prosody, possibly due to reduced neural connectivity between disparate brain areas responsible for language. Despite extensive overlap between the auditory and structural features linking prosody and music as well as extensive shared neural resources, music listening and performance are not impaired. In fact, there is some evidence that these abilities may even be heightened in some ASD individuals. Using behavioral and EEG/ERP methods, the present study sought to investigate this dissociation. A similar electrophysiological response has been observed for both prosody and music, the Closure Positive Shift (CPS), and Music CPS, respectively. This study used language and music stimuli in order to investigate the differences between language and music processing for individuals with ASDs and neuro-typicals. While a CPS was observed for language for the ASD group, it was substantially reduced in its distribution and amplitude. Further, the presence of an offset N1 response to the onset of pauses interfered with the clarity of the CPS response. In music, no music CPS was observed, however, a sustained centrally maximal positivity was observed for both the neuro-typical and ASD groups during the phrase boundary. Additionally, the ASD group showed a similar positivity in response to phrase boundaries in the condition in which the phrase-final note was prolonged. This positivity was similar to the language CPS in duration and amplitude, and suggests similar processing responses to phrase boundaries in language and music. The positivity in response to the second condition suggests that some individuals with ASDs may indeed have heightened processing ability for music. These results support the theories of functional under-connectivity in language and local bias toward sensory features of auditory information at the expense of global prosodic processing. Possible explanations, including the presence of repetition found in music, yet generally absent in language, are considered. / acase@tulane.edu

Significant symptoms of anxiety in individuals with autism spectrum disorder (ASD) may arise due to impaired emotion recognition. In light of reports showing ASD-specific developmental changes in amygdala volumes, we expanded a previous study of recognition of music-evoked emotions in ASD versus typical controls (CON). We explicitly compared both behavioral and psychophysiological response to music-evoked emotions of children (ages 8-11) and older adolescents (ages 16-18). A total of 91 participants (42 ASD) listened to segments of instrumental music that had been previously validated to evoke happy, sad, or scary emotional valence. We measured accuracy and reaction time while also collecting skin conductance response. The ASD group demonstrated reduced skin conductance response to the emotional music stimuli overall, compared to controls. The younger child groups, regardless of diagnosis showed greater physiological reactivity to scary stimuli than to the other emotions. Analysis of behavioral data demonstrated an interaction of age group and diagnostic group: for scary music, the older control group was more accurate than the younger control group while the opposite pattern was observed for the ASD group. These data suggest disrupted developmental trajectories for integrating physiological and cognitive cues in ASD. This lack of integration may underlie increased feelings of uncertainty and anxiety that are associated with more difficult and less adaptive decision making in ASD.

School-aged children with Autism Spectrum Disorder (ASD) experience significant difficulty with peer interaction (Lord & Bishop, 2010), an important aspect of childhood. Unresolved social skills difficulties lead to continued dysfunction in relationships which influence long term success. Research into the most effective strategies has increased but several questions remain. One approach that appears to help school-aged children is Cognitive Behavior Therapy (CBT) which focuses on changing how a person thinks about specific social situations as well as how they behave. This study evaluated the efficacy of a 15-week CBT-based social skills group intervention for boys aged 10-12 years diagnosed with an Autism Spectrum Disorder. Boys with average or better receptive language skills and IQ attended weekly sessions focused on teaching self-monitoring skills, social perception and affective knowledge, conversation skills, taking another persons perspective, social problem-solving, and friendship management skills. Group size varied from four to six participants. The intervention was based on two intervention programs available in the literature and was manualized. Eight of the fifteen participants were waitlisted (Delayed Treatment group) while the remaining participants began 15 sessions of intervention immediately (Immediate Treatment group). A repeated measures ANOVA was used to compare the Delayed Treatment group to the Immediate Treatment group on pre and post measures of social perception, peer interaction, social knowledge, pragmatic language, social responsiveness and general socialization skills. Compared to the Delayed Treatment group, the Immediate Treatment group showed significant improvements after intervention in social perception, peer interaction, and social knowledge. The Delayed Treatment group was also examined on all measures at three time points: prior to the waitlist time, pre-intervention, and post-intervention. Significant improvements only after intervention were present for peer interaction, social knowledge, and a parent report measure of socialization. The implications of these findings are discussed in relation to a model of social information-processing, the executive functioning theory of autism, and how cognitive behaviour therapy techniques may contribute to social skills intervention for children with ASD. The intervention used in this study shows promise but replication with larger samples is needed. / Rehabilitation Science

The discovery of mirror neurons and the mirror neuron system is one of the most interesting breakthroughs in the field of neuroscience in recent years. The topic stretches over a wide spectrum of research fields but one of the more prominent areas is concerned with the role of mirror neurons in autism spectrum disorder. It is hypothesized that an impaired mirror neuron system may be one of the main causes underlying the deficits seen in autistic individuals. Parallel to the broken mirror theory of autism there are critical voices claiming there is not enough empirical evidence to support such a theory. Research carried out in the area seems to offer support for both contradictory approaches making it hard to conclude the definite role of mirror neurons in this developmental disorder. Future research may offer conclusive answers concerning the role of the mirror neuron system in autism spectrum disorder as well as other important questions regarding the functional properties of the brain areas under question.