As competition grows among manufacturing companies, greater emphasis has recently been placed on product aesthetics and decreasing the product development time. This is promoting and standardizing widespread use of sculptured surface styling within product design. Therefore, industries are looking for high efficiency machining strategies for sculptured surface machining (SSM). Many researchers have produced various methods in tool path generation for SSM. Five-axis curvature matched machining (CM2) is the most efficient. With the widespread use of 5-axis mill in industries, CM2 is a better solution for improving the machining efficiency for product concept models. CM2 has very good performance for global machining of single patch surface or a quilt of simple sculptured surface patches. But when CM2 is used to generate tool paths for global machining of a large region of complex sculptured surface such as the top or side skins of a vehicle, there will be some limitations, that is, the performance will be influenced greatly in some steep areas where the lead angle of the tool becomes larger to match the curvature or avoid gouging. Larger lead angles mean smaller effective curvatures at the leading edge of the tool bottom where it contacts the part surfaces. Therefore, the density of CM2 tool path is very high in these steep regions. By setting a smaller upper limit for the lead angle, the density of tool path will not be very high in the steep regions, but there will be some uncut materials. This thesis focuses on how to determine the uncut or rework areas of the previous CM2 and how to define the boundary of these regions. Strategies for generating more efficiency CM2 tool paths are also discussed. These methods will be tested by applying finish global machining to a one-fourth scale Ford GT model.

Proper positioning of Microelectromechanical Systems (MEMS) components influences the functionality of the device, especially in devices where the motion is in the range of hundreds of micrometers. There are two main obstacles to positioning: off-axis displacement, and position determination. This work studies four large-displacement devices, their axial and transverse stiffness, and piezoresistive response. Methods for improving the device characteristics are described. The folded-beam suspension, small X-Bob, large X-Bob and double X-Bob were characterized using non-dimensional metrics that measure the displacement with regard to the size of the device, and transverse stiffness with regard to axial stiffness. The stiffness in each direction was determined using microprobes to induce displacement, and microfabricated force gauges to determine the applied force. The large X-Bob was optimized, increasing the transverse stiffness metric by 67%. Four-point resistance testing and microprobes were used to determine the piezoresistive response of the devices. The piezoresistive response of the X-Bob was maximized using an optimization routine. The resulting piezoresistive response was over seven times larger than that of the initial design. Piezoresistive encoders for ratcheting actuation of large-displacement MEMS are introduced. Four encoders were studied and were found to provide information on the performance of the ratcheting actuation system at frequencies up to 920 Hz. The PMT encoder produced unique signals corresponding to distinct ideal and non-ideal operation of the ratchet wheel actuation system. Encoders may be useful for future applications which require position determination.

The early environment impacts many aspects of an individual’s developing phenotype. In particular, early environmental conditions are important for shaping the hypothalamic-pituitary-adrenal (HPA) axis, which coordinates an individual’s stress response. These developmental changes are likely mediated by epigenetic modifications, functional changes to the genome that can alter gene expression in response to environmental variation, resulting in significant phenotypic differences (Kundakovic and Champagne 2015; Richards 2006). Determining how early life variation alters epigenetic modifications (such as DNA methylation) of genes throughout the HPA axis, and how these marks change over time, in wild organisms is important for understanding their potential long-term fitness consequences. Here, I examine DNA methylation modifications in the HPA axis in relation to early environmental variation in free-living house sparrows (Passer domesticus). In Chapter 1, I show a relationship between natural variation in the early environment and DNA methylation marks of numerous genes related to HPA axis function, which in turn predict growth trajectories. In Chapter 2, I show that early life stress in particular impacts DNA methylation in genes critical to HPA axis function, but does so differently depending on the life history stage in which stress is encountered. Finally, in Chapter 3, I find that these early life marks have long-term effects past the developmental period, predicting longevity as well as lifetime reproductive output in a sex-specific manner. Overall, my dissertation adds to a growing understanding of the dynamic role of epigenetic modifications in mediating phenotypic responses to the early life environment in wild birds, and demonstrates the potential long-term fitness outcomes of these changes.

In modern manufacturing industries, many applications require precision motion control of multi-agent systems, like multi-joint robot arms and multi-axis machine tools. Cutter (end effector) should stay as close as possible to the reference trajectory to ensure the quality of the final products. In conventional computer numerical control (CNC), the control unit of each axis is independently designed to achieve the best individual tracking performance. However, this becomes less effective when dealing with multi-axis contour following tasks because of the lack of coordination among axes. This dissertation studies the control of multi-axis machine tools with focus on reducing the contour error. The proposed research explicitly addresses the minimization of contour error and treats the multi-axis machine tool as a multi-input-multi-output (MIMO) system instead of several decoupled single-input-single-output (SISO) systems. New control schemes are developed to achieve superior contour following performance even in the presence of disturbances. This study also extends the applications of the proposed control system from plane contours to regular contours in R3. The effectiveness of the developed control systems is experimentally verified on a micro milling machine.

Liquid crystals have been a major subject of research for the past decades. Aside from the variety of structures they can form, they exhibit a vast range of optical phenomena. Many of these phenomena found applications in technology and became an essential part of it. In this dissertation thesis we continue the line to propose a number of new applications of optical effects in liquid crystals and develop their theoretical framework. One such application is the possibility of beam combining using Orientational Stimulated Scattering in a nematic liquid crystal cell. Our numerical study of the OSS process shows that normally this possibility does not exist. However, we found that if a number of special conditions is satisfied efficient beam combining with OSS can be done. These conditions require a combination of special geometric arrangement of incident beams, their profiles, nematic material, and more. When these conditions are fulfilled, power of the beamlets can be coherently combined into a single beam, with high conversion efficiency while the shape and wave-front of the output beam are still of good quality. We also studied the dynamics of the OSS process itself and observed (in a numerical model) a number of notorious instabilities caused by effects of back-conversion iv process. Additionally, there was found a numerical solitary-wave solution associated with this back-conversion process. As a liquid crystal display application, we consider a nematic liquid crystal layer with the anisotropy axis modulated at a fixed rate in the transverse direction with respect to light propagation direction. If the layer locally constitutes a half-wave plate, then the thinscreen approximation predicts 100% -efficient diffraction of normal incident wave. If this diffracted light is blocked by an aperture only transmitting the zero-th order, the cell is in dark state. If now the periodic structure is washed out by applying voltage across the cell and light passes through the cell undiffracted, the light will pass through the aperture as well and the cell will be in its bright state. Such properties of this periodically aligned nematic layer suggest it as a candidate element in projection display cells. We studied the possibility to implement such layer through anchoring at both surfaces of the cell. It was found that each cell has a thickness threshold for which the periodic structure can exist. The anchored periodic structure cannot exist if thickness of the cell exceeds this threshold. For the case when the periodic structure exists, we found the structure distortion in comparison with the preferable ideal sinusoidal profile. To complete description of the electromechanical properties of the periodic cell, we studied its behavior at Freedericksz transition. Optical performance was successfully described with the coupled-mode theory. While influence of director distortion is shown to be negligibly small, the walk-off effects appear to be larger. In summary, there are good prospects for use of this periodically v aligned cell as a pixel in projection displays but experimental study and optimization need to be performed. In the next part we discuss another modulated liquid crystal structure in which the director periodically swings in the direction of light propagation. The main characteristic of such structure is the presence of bandgap. Cholesteric liquid crystals are known to possess bandgap for one of two circular polarizations of light. However, unlike the cholesterics the bandgap of the proposed structure is independent of polarization of normally incident light. This means that no preparation of light is needed in order for the structure to work in, for example, liquid crystal displays. The polarization universality comes at the cost of bandgap size, whose maximum possible value ∆ωPTN compared to that of cholesterics ∆ωCh is approximately twice smaller: ∆ωPTN ≈ 0.58∆ωCh if modulation profile is sinusoidal, and ∆ωPTN ≈ 0.64∆ωCh if it is rectangular. This structure has not yet been experimentally demonstrated, and we discuss possible ways to make it.

Since the Islamic Revolution in 1979 Iran has employed a deliberate and successful strategy centered around the use and support of various proxies, notably Hezbollah and Hamas who are part of the Iranian led Axis of Resistance. There is a vast literature that has studied different aspects of this Iranian proxy dimension, but relatively little research has been conducted on propaganda as a unifying mechanism. This thesis thus expanded upon the current literature through a content analysis of the propaganda produced by Iran, Hezbollah, and Hamas in order to gain a fuller understanding of how cross-group cohesion has been achieved. The analysis incorporated social identity theory, and identified how the propaganda could be used in accordance with three theoretical dimensions: Identity constructions, Justification for Violence, and Weaponization of the ummah. The findings revealed how cross-group cohesion was achieved through the creation of a dichotomous worldview, consisting of an ingroup that is existentially threatened by an outgroup consisting of the West and Jews. Moreover, they use conspiratorial rhetoric combined with victimhood in order to frame the struggle as an ongoing religious war against Islam. The thesis concludes with a theoretical discussion on the normative assumptions that underpin the propaganda, arguing that the cross-group cohesion is dependent on the creation of shared identities based on victimhood, religious references, and the creation of shared external enemies.

Past work has linked self-injurious behavior (SIB) to a history of traumatic experiences and to problems regulating affect. While this affect dysregulation is conceptualized as occurring at a biological (as well as a behavioral) level, relatively little is known about the biological mechanisms involved. The current study explored whether reactivity of the hypothalamic-pituitary-adrenal (HPA) axis to an interpersonal stressor mediated the relation between trauma and SIB in a sample of 178 18-21 year-old heterosexual dating couples. As predicted, both trauma experience and symptoms positively predicted SIB. While the mediating model was not supported, SIB was associated with an HPA axis response marked by heightened reactivity to interpersonal stress within the context of lower cortisol levels. Trauma symptoms and experience interacted with adult attachment security to predict HPA axis response in different ways for men and women, a compelling set of findings suggesting the importance of contextual factors in the study of trauma and HPA axis function. Future directions for the study of trauma, HPA axis reactivity, and SIB are discussed.

The present work generalizes the necessary condition of univariate symmetry of Patil et al. (2012) to the bivariate setting, develops a test of bivariate symmetry based on it, and generalizes the measure of asymmetry in Patil et al. (2014) to the bivariate setting. In doing so, as a byproduct, it pays attention to the interrelation between central symmetry and symmetry about an axis of a continuous bivariate density function.

Minimally invasive surgery (MIS) has several advantages over traditional methods. Scaling MIS instruments to smaller sizes and increasing their performance will enable surgeons to offer new procedures to a wider range of patients. In this work, two compliant mechanism-based minimally invasive surgical instrument wrist or gripper mechanisms are designed and analyzed.The cylindrical cross-axis flexural pivot (CCAFP) is a single-degree-of-freedom wrist mechanism that could be combined with existing gripper mechanisms to create a multi-degree-of freedom instrument. The simplicity of the CCAFP mechanism facilitates analysis and implementation. The flexures of the CCAFP are integral with the instrument shaft, enabling accessories to be passed through the lumen. The CCAFP is analyzed and determined to be a viable wrist mechanism for MIS instruments based on research results. A finite element (FE) model of the mechanism is created to analyze the force-deflection and strain-deflection relationships. Experimental results are used to verify the FE model. A 3 mm design is created that could undergo an angular deflection of +/- 90 degrees. The addition of cam surfaces to help guide the flexures and limit the maximum stress during deflection is explored. These cam surfaces can be integral to the instrument shaft along with the flexures. A 2 degree-of-freedom (DoF) CCAFP with intersecting axes of rotation is also introduced. The inverted L-Arm gripper compliant mechanism has 2 DoF, one wrist and one gripping. Three challenges associated with using compliant mechanisms in MIS instruments are considered: inadequate performance in compression, large flexure deformations, and a highly variable mechanical advantage. These challenges were resolved in the L-Arm design by inverting the flexures, tailoring flexure geometry and employing nitinol, and integrating pulleys into each jaw of the mechanism. The L-Arm was prototyped at several sizes to demonstrate functionality and scalability. A finite element model of the L-Arm flexure was created to determine the strain-deflection relationship. A fatigue test was completed to characterize nitinol for use in compliant mechanism MIS instruments.These concepts demonstrate the ability of compliant mechanisms to overcome the design and manufacturing challenges associated with MIS instruments at the 3 mm scale. The models and principles included in this work could be used in the application of compliant mechanisms to design new MIS instruments as well as in other areas that employ compliant mechanisms in a cylindrical form factor.

Direct detection of dark matter remains an important outstanding problem since abundant astrophysical evidence points towards its existence, but no experiment has succeeded in detecting it. Axions and axion-like-particles are some of the most compelling candidates for dark matter given their appearance in many theories of physics beyond the Standard Model and their relatively unexplored parameter space compared to other candidates. Recently, the Cosmic Axion Spin Precession Experiment-Electric (CASPEr-e) has used nuclear magnetic resonance (NMR) to search for effective magnetic fields created by axionic dark matter. By decreasing technical noise sources, CASPEr-e is projected to reach the standard quantum limit where spin projection noise is the dominant noise source limiting sensitivity. However, some axion models predict axion couplings to normal matter that would be too small for even a quantum limited CASPEr-e experiment to detect. This creates a need for surpassing the spin projection noise limit in NMR dark matter searches. In this thesis, I explore the prospects for surpassing the quantum limit in NMR by using spin squeezed states, entangled states with variance in one projection reduced below the standard quantum limit. First, I propose an experimental scheme for generating squeezed states by coupling the spins to an off-resonant circuit to create a One-Axis-Twist Hamiltonian. Then, using exact results and numerical simulations, I determine the amount of squeezing that can be achieved given decoherence and noise. Next, I perform modeling to show that squeezing can accelerate dark matter searches despite earlier results that argued squeezing cannot improve experimental sensitivity when subject to decoherence. Finally, I apply these results to the CASPEr-e experiment and show that at axion frequencies near 100MHz, squeezing can speed up the experiment by a factor of up to 30, corresponding to a sensitivity improvement by a factor of over 5.