This thesis concerns the unity of consciousness - in particular the phenomenal unity of consciousness. The idea that consciousness is 'phenomenally unified' is the idea that if we attempt to characterise 'what it is like' for a subject just by listing all of the distinct experiences had by that subject at and over time, we will leave something out. We will leave out the unity of those experiences - the way in which those experiences feature together in consciousness. We can distinguish between the unity of consciousness at a time, and the unity of consciousness over time. I do not attempt to provide an account of the unity of consciousness at a time here - I focus instead upon the issue of unity over time. Some theorists - Dainton and Tye for instance - have claimed that it is possible to provide a single account of unity that solves both problems of unity in the same way. My contribution to the issue of unity at a time shall be to argue that such a single account is not possible, due to important differences in the phenomenological constraints that apply to the two problems. I proceed by providing an account of what exactly the constraints on an account of unity over time are, and argue that accounts that commit to the 'Principle of Simultaneous Awareness' (the accounts of Le Poidevin, Tye, Husserl, and Broad) cannot meet these constraints. I then provide a diagnosis of what may have been driving acceptance of such a principle in the first place - I argue that driving such acceptance is a faiiure to identify the metaphysical category of 'Occurrent State'. I propose that we can provide a successful and substantive account of diachronic unity only if we commit to thinking of a subject's phenomenal states as Occurrent States.

This thesis seeks to apply some concepts and theories from predominantly post 1960 research in organisational behaviour to the study of the Arts Council as reflected through its policies, in the belief that few, if any, real attempts have thus far been made by academics to relate some of the profound difficulties of the public administration of the art to this branch of the sciences. The project is based on an examination of the assumption with which the Arts Council historically has justified both its general operations and its particular decisions. A close examination is made of past and recent statements of policy (I am assuming that administrators often make policy and advise in the making of policy and am treating decision making and policy making as synonymous for purposes of this thesis), the main aim being to identify the various ideological and structural determinants which bear upon decision making processes necessary for a subsequent evaluation of the various representative systems. These determinants vary from political pressures to aesthetic preconceptions, and overt to covert hierarchical power structures within the framework. Specific areas of concern have revolved around the problems of co-ordination, accountability and control of public subsidy to the arts and in particular, what model or models of organisational structure and decision-making processes might successfully reconcile traditional cultural criteria and alternative contemporary conceptions of artistic and cultural development and worth, including all current non-art criticism. In particular, the research has focused on what might be termed the Arts Council's 'secondary accountabilities-' (the word 'accountability' is usually only used when explaining its formal relationships with Government), in respect to artistic standards, artists and members of the general public. This is accountability imposed from 'below" the quango, a relatively undeveloped concept which this thesis examines in much greater detail. My points are illustrated by an examination of the policies of the arts agencies in Great Britain, New Zealand, Australia, America and Canada. Further comparisons are made between the Arts Council of Great Britain and Sports Council of this country in view of the proposals in New Zealand and Australia for a more integrated policy framework based on concepts of recreation and leisure which could result in a new Department of Recreation, Arts and Sport whose primary function would be to develop a national recreation policy to allow for coordinated development of all aspects of recreation, arts and sport. The examination is made largely from the point of view of organisation theory. For while I believe the cultural debate outlined in chapter one represents the crucial question for arts councils to resolve, organisation theory fortuitously illustrates these larger issues and also suggests some means of resolving the conflict between public accountability and responsibility to the development of the arts.

I defend the correspondence theory of truth, according to which a statement’s truth consists in a relation of correspondence with extralinguistic fact. There are well-known objections to this view, which I consider and rebut, and also important rival accounts, principal among which are so-called deflationist theories and epistemic theories. Epistemic theories relate the concept of truth to our state of knowledge, but fail, I argue, to respect the crucial distinction between a criterion of truth and the meaning of truth: the view that one cannot do semantics, or metaphysics, without addressing epistemic issues is rejected by this work. Against epistemic theories, I illustrate how truth is independent of epistemic considerations. Deflationism is the more popular of the rival accounts and has gained considerable momentum over the past two decades. It is therefore dealt with in greater detail by this work. Deflationist theories exploit the paradigmatic ‘“Snow is white” is true iff snow is white’ biconditional to argue for an insubstantialist account, according to which truth is conservative with respect to non-semantical facts. On this view, truth’s raison d’être is merely to perform the useful expressive function of generalising over possibly infinite sets of assertions. Against deflationist theories, I claim that the work done by Jeffrey Ketland and Stewart Shapiro conclusively demonstrates how truth is informationally additive over non-semantic facts, while deflationism itself is also an excessively impoverishing theory, inadequate to the tasks it purports to accomplish. This work also defends the thesis that Alfred Tarski’s well-known theory of truth is an authentic correspondence theory. To say this is to say that the clauses of a Tarskian truth-definition can be interpreted in terms of a relation of correspondence that holds between true sentences and the states of affairs they describe. I provide a precise account of what the correspondence in question consists in, claiming that true sentences are homomorphic images of facts, i.e. a true sentence represents, in a form-preserving manner, the truth-making facts in it. This gives precise expression to Wittgenstein’s thesis that true sentences picture the world.

Contemporary political liberalism defends the view that any legitimate law ought to be justified to those reasonable citizens subject to it. A standard way in which to accomplish this task is to construct a set of public reasons, comprised of constitutional essentials and public democratic values, which are then used to justify all political mandates. The dissertation begins with a criticism of this process of justification for outcomes of legitimate procedures of public decision-making. It argues that given how reasons contribute to judgment formation, it is highly optimistic to assume that reasonable consent on procedures of collective decision-making correspond to the justifiability of procedural outcomes. Instead, I argue for an ideal of legitimate decision-making which enables each citizen to assume a threshold level of personal responsibility for all political decisions made by the political collective. Integrating responsibility into a theory of liberal legitimacy requires a reformulation of the rules of public justification. I argue that citizens concerned with making responsible political decisions must be allowed to justify their political positions through both reasonable judgments as well as sympathetic judgments such as compassion for those who live with disability and mercy towards the criminally motivated. The notion of sympathy, as formulated by David Hume and expanded by Adam Smith, provides an account of how individuals’ ethical evaluations are affected by their ability to be in fellow-feeling with other people. A substantial portion of my doctoral thesis considers the situations in which a private judgment couched in sympathetic terms can meet political liberalism’s demands of publicity and reciprocity.

This PhD thesis focuses on the philosophical foundations of Neuroeconomics, an innovative research program which combines findings and modelling tools from economics, psychology and neuroscience to account for human choice behaviour. The proponents of Neuroeconomics often manifest the ambition to foster radical modifications in the accounts of choice behaviour developed by its parent disciplines. This enquiry provides a philosophically informed appraisal of the potential for success and the relevance of neuroeconomic research for economics. My central claim is that neuroeconomists can help other economists to build more predictive and explanatory models, yet are unlikely to foster revolutionary modifications in the economic theory of choice. The contents are organized as follows. In chapters 1-2, I present neuroeconomists’ investigative tools, distinguish the most influential approaches to neuroeconomic research and reconstruct the case in favour of a neural enrichment of economic theory. In chapters 3-7, I combine insights from neuro-psychology, economic methodology and philosophy of science to develop a systematic critique of Neuroeconomics. In particular, I articulate four lines of argument to demonstrate that economists are provisionally justified in retaining a methodologically distinctive approach to the modelling of decision making. My first argument points to several evidential and epistemological concerns which complicate the interpretation of neural data and cast doubt on the inferences neuroeconomists often make in their studies. My second argument aims to show that the trade-offs between the modelling desiderata that neuroeconomists and other economists respectively value severely constrain the incorporation of neural insights into economic models. My third argument questions neuroeconomists’ attempts to develop a unified theory of choice behaviour by identifying some central issues on which they hold contrasting positions. My fourth argument differentiates various senses of the term ‘revolution’ and illustrates that neuroeconomists are unlikely to provide revolutionary contributions to economic theory in any of these senses.

The aim of this study is to illuminate in a novel and original manner the political and ethical character of Nietzche's project of revaluation and to demonstrate its continued import and significance for thinking on culture and society today. In order to achieve this, I have placed Nietzsche's work in relation to the fiction, poetry, and prose of D.H. Lawrence, who, it is argued, provides the most imaginative and vital development of the above. In turn, Lawrence's thinking is exposed to more recent theoretical developments, thereby giving a good indication of the wider philosophical and political traditions within which the Nietzschean narrative of revaluation is produced, circulated, and maintained - and those against which it moves. It is argued that this narrative, although now widely studied and debated, remains an illicit and marginalized form of philosophical discourse; one that is often derided and condemned by those whose own narratives form the dominant and legitimized language games within modern liberal society. Nietzsche's philosophy thus provides a vital counter-discourse which allows things to be said and voices to be heard that few other forms of philosophical discourse dare to allow. It is crucial, therefore, that such a text be explored, developed, and enabled to perform a role in as wide a social arena as possible. In attempting to do this over the course of the five chapters that make up the work, several of the major themes and concerns of Nietzschean and post-Nietzschean philosophy, such as power and the reconfiguration of the subject, are examined at length and the thesis provides an exciting contribution both to Nietzsche studies and to the critical work on Lawrence, demonstrating the validity of Foucault's contention that the relation between philosophy, literature, and politics is permanent and fundamental. It is concluded that Nietzsche's and Lawrence's political thinking is of most interest and use to us today when it becomes molecularized and minoritarianized; a politics of desire that frees itself from molar ambition and ascetic militancy, and, perhaps, opens the way not to fascism as is often feared, but, on the contrary, to a radically new notion of democracy: the democracy of touch.

published_or_final_version / Paediatrics and Adolescent Medicine / Doctoral / Doctor of Philosophy

Hepatitis B virus covalently closed circular DNA (HBV cccDNA) forms a mini-chromosome structure inside infected hepatocyte nuclei and plays an important role in chronic hepatitis B infection. Methylation of cccDNA-bound histone and the associations of heterochromatin HP1 complex related proteins with cccDNA were investigated in this thesis using transient transfection study system and chromatin immunoprecipitation assay. Di- and tri-methylation of histone H3 lysine 4 residue (H3K4), which plays an activating role in eukaryotic transcription, were found to associate with cccDNA in a way in parallel to the level of HBV replication in our system. On the other hand, tri-methylation of H3K9, which plays an inhibitory role in eukaryotic transcription, was found to associate with cccDNA during decline of HBV replication. During the decline of HBV replication, cccDNA was associated with histone methyltransferases SUV39H1 and SUV420H1 and histone demethylase PLU1. The dynamic of the association of heterochromatin protein 1 (HP1) to cccDNA was similar to that of SUV39H1. The association of cccDNA with five HP1 complex-related proteins (three DNA methyltransferases Dnmt3a, Dnmt3b and Dnmt1 and two methylated DNA binding proteins MBD1 and MeCP2) was studied, and their associations could be roughly divided into two stages. From 72 hours to 96 hours post-transfection, there was an increased association of cccDNA with Dnmt3a, Dnmt3b and MBD1, which was in parallel to the increased association of HP1 and SUV39H1with -cccDNA. From 96 hours to 120 hours after transfection, an increased association of Dnmt1 and MeCP2 with cccDNA was detected, which was correlated to that of SUV420H1. At the time when HBV replication was declining at 120 hours post-transfection, a highest association of SUV39H1, SUV420H1, HP1 and all 5 HP1 complex-related proteins with cccDNA was found. In conclusion, methylation of cccDNA-bound histone was associated with HBV replication. Activating H3K4 methylation was found to correlate with increase in HBV replication, while inhibitory H3K9 methylation correlated with decrease in HBV replication. The association of HP1 was in parallel to that of SUV39H1, indicating that HP1-SUV39H1 complex might be involved, and thereby recruiting other proteins for transcription suppression. Recruitment of DNA methyltransferases and methylated DNA binding proteins to cccDNA provided further evidence that methylation of cccDNA plays a role in transcription suppression. This study identified the associations of methylated histone and other related proteins with cccDNA and their correlations with viral replication. These results enhance our knowledge in HBV replication cycles and transcription regulation. It may show a novel area in development of antiviral drugs such as histone methyltransferase modulators. / published_or_final_version / Medicine / Master / Master of Philosophy

Background/Aim: Hepatitis C virus infection is a known risk factor of impaired glucose metabolism and diabetes mellitus. Whether hepatitis B virus (HBV) infection is also associated with impaired glucose tolerance remains uncertain. The aim of the study was to conduct a systematic review on the association between HBV infection and impaired glucose metabolism Methods: Studies reporting the association between HBV infection and markers of impaired glucose metabolism were identified through keyword search in PubMed and Google Scholar. 10 studies (out of 320) were included in this systematic review. Results were included. Majority (n=7) of the included studies were conducted among the Asian populations. Of the 10 included studies, eight studies reported a significant association between HBV infection and impaired glucose metabolism, proxied by impaired glucose tolerance, impaired fasting glucose, diabetes mellitus, insulin resistance, and metabolic syndromes. The remaining two studies using diabetes mellitus and insulin resistance as outcome measures did not find a positive association with HBV infection. Conclusions: The association between HBV and impaired glucose metabolism is suggestive from the evidence compiled from included articles. However, whether the development of glucose intolerance or diabetes mellitus is linked to an infectious cause of HBV is still inconclusive. Further studies that could improve on the current understanding of the associations between HBV infection and impaired glucose metabolism are necessary. / published_or_final_version / Public Health / Master / Master of Public Health

Introduction: China has about 120 million hepatitis B virus (HBV) carriers and a 7.2% hepatitis B surface antigen (HBsAg) prevalence in 2006.This creates a huge disease burden and also leads to significant economic losses. Since 2002, a free universal infant hepatitis B vaccination programme has provideda 3-dose primary vaccination for all infants. Although some economic evaluations of this programme have been conducted, a comprehensive cost-effectiveness analysis (CEA) to estimate long-term benefit using mathematical modeling would aid understanding of population strategies for hepatitis B control in large populations. Moreover, the most common mode of infection is perinataltransmission at birth. However the more effective immunization programme involving screening women during pregnancy for HBV-carrier status and providing passive-active vaccination for newborns has not been implemented in China. Aims: To identify the most cost-effective universal infant hepatitis B vaccination strategy for China. Method: A hospital-based survey was conducted during 2010-2011 in a general hospital in Shenzhen, China, in order to obtain costing data to estimate the economic burden of chronic hepatitis B patients. Annual direct and indirect costs from this study were used as cost parameters in the CEA models. Mathematical models were developed to simulate perinatal transmission, vaccination programmes and disease progression using Markov modeling and decision trees. Quality-adjusted life year (QALYs) as well as health and monetary outcomes were also assessed. Univariate sensitivity analysis and probabilistic sensitivity analysis using Monte Carlo simulation were performed to test parameter uncertainty. Two programmes of screening of pregnant women for both HBsAg and/or HBeAg and the infant passive-active vaccination were compared with the current vaccine-only programme in one CEA, while the other CEA estimated the effect of the current infant programme compared with no vaccination. Findings: The estimated total economic burden including annual direct and indirect cost among hepatitis B patients of RMB 43104.5 (US$6340.8). The economic burdens of associated disease states of hepatitis B infection were highest for hepatocellular carcinoma (HCC) (RMB 77297.1), decompensated cirrhosis (RMB 50725.7), chronic active hepatitis B (CAH) (RMB 37449.5) and finally compensated cirrhosis (RMB 37276.9). The average total economic burden per hepatitis B patient amounted to 46% of Shenzhen GDP per capitain 2010, and 5.4% of the city’s annual per capita income. The current vaccine-only infant vaccination programme was justified by costsavings, from both a societal and health care payer’s perspective, reducing new HBV infections by about 76%. This has produced a gain of 743,000 life-years and 620,000 QALYs given current numbers and savings of US$2~3billion saved over the lifetime of a national cohortof 10,000,000 newborns. A universal control programme involving the screening of pregnant women for HBsAg and passive-active vaccination, would reduce new infections by 13%, saving 436,000 life years and gaining 121,000 QALYs for a saving of about US$546 million compared with current vaccine-only programme. Implications: The universal infant hepatitis B vaccination programme is currently a cost-effective strategy for hepatitis B control in China.A beneficial amendment to the current strategy wouldinclude screening of all pregnant women for HBsAg and vaccinating newborns in a passive-active way. / published_or_final_version / Public Health / Doctoral / Doctor of Philosophy