Diss. (sammanfattning) Stockholm : Univ., 2001. / Härtill 5 uppsatser.

This study tested the hypotheses that 1) 28h head-down bed-rest (HDBR) would result in significant hypovolemia and cardiovascular deconditioning, and that 2) NASA’s fluid loading protocol (ingestion of 15 ml/kg water with a 1g NaCl for every 125ml of water consumed) would restore normovolemia and prevent cardiovascular deconditioning resulting from 28h HDBR. Nine healthy men were tested in 5 testing scenarios, with a progressive lower body negative pressure (LBNP) protocol performed before and after each scenario to measure the subjects’ cardiovascular responses to orthostasis. Subjects were tested in two 28h HDBR conditions, without fluid loading (NFL) and with fluid loading (FL), as well as in three 4-hour control conditions to isolate the effects of circadian rhythm, HDBR, and fluid loading. After 28h NFL HDBR, plasma volume was reduced by 8%. There were no symptoms of syncope during orthostatic testing following 28h NFL HDBR, however cardiovascular deconditioning was apparent as there were significant increases in heart rate, reductions in central venous pressure, and reductions in portal vein diameter during LBNP testing. There were no changes in stroke volume, cardiac output, systemic vasoconstriction, cardiac measures, and arterial and cardiopulmonary baroreflex responses, and no evidence of splanchnic or venous pooling. This study also found that NASA’s fluid loading protocol was ineffective at restoring normovolemia after 28h HDBR, as there were no differences in plasma volume between 28h FL HDBR post and 28h NFL HDBR post tests (p=0.22). Cardiovascular deconditioning was not prevented by fluid loading as the heart rate response remained elevated and central venous pressure remained reduced after 28h FL HDBR. In addition, four of the nine subjects experienced nausea during administration of the fluid loading protocol prescription and two subjects vomited, further evidence that NASA’s fluid loading protocol is not effective at preventing orthostatic hypotension. Investigation of control models verified that deconditioning was the result of HDBR. It was also concluded that circadian rhythm did not affect the measured cardiovascular responses and the fluid loading protocol was ineffective at increasing blood volume in the absence of HDBR.

This study tested the hypotheses that 1) 28h head-down bed-rest (HDBR) would result in significant hypovolemia and cardiovascular deconditioning, and that 2) NASA’s fluid loading protocol (ingestion of 15 ml/kg water with a 1g NaCl for every 125ml of water consumed) would restore normovolemia and prevent cardiovascular deconditioning resulting from 28h HDBR. Nine healthy men were tested in 5 testing scenarios, with a progressive lower body negative pressure (LBNP) protocol performed before and after each scenario to measure the subjects’ cardiovascular responses to orthostasis. Subjects were tested in two 28h HDBR conditions, without fluid loading (NFL) and with fluid loading (FL), as well as in three 4-hour control conditions to isolate the effects of circadian rhythm, HDBR, and fluid loading. After 28h NFL HDBR, plasma volume was reduced by 8%. There were no symptoms of syncope during orthostatic testing following 28h NFL HDBR, however cardiovascular deconditioning was apparent as there were significant increases in heart rate, reductions in central venous pressure, and reductions in portal vein diameter during LBNP testing. There were no changes in stroke volume, cardiac output, systemic vasoconstriction, cardiac measures, and arterial and cardiopulmonary baroreflex responses, and no evidence of splanchnic or venous pooling. This study also found that NASA’s fluid loading protocol was ineffective at restoring normovolemia after 28h HDBR, as there were no differences in plasma volume between 28h FL HDBR post and 28h NFL HDBR post tests (p=0.22). Cardiovascular deconditioning was not prevented by fluid loading as the heart rate response remained elevated and central venous pressure remained reduced after 28h FL HDBR. In addition, four of the nine subjects experienced nausea during administration of the fluid loading protocol prescription and two subjects vomited, further evidence that NASA’s fluid loading protocol is not effective at preventing orthostatic hypotension. Investigation of control models verified that deconditioning was the result of HDBR. It was also concluded that circadian rhythm did not affect the measured cardiovascular responses and the fluid loading protocol was ineffective at increasing blood volume in the absence of HDBR.

Thesis (Ph. D.)--New York University, School of Education. / Also on microfilm. eContent provider-neutral record in process. Description based on print version record.

Thesis (Ph. D.)--New York University, School of Education. / Also on microfilm. eContent provider-neutral record in process. Description based on print version record.

Thesis (M.S.)--University of Wisconsin--Madison, 1990. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 86-93).

Thesis (M.S.)--Boston University

Thesis (M.S.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / 2031-01-01

Antepartum bed rest is a prescribed therapy for women with high risk pregnancies to reduce the occurrence of preterm labor, preeclampsia, risks associated with incompetent cervix and other complications. Activity restriction, or bed rest, in high risk pregnancies is based on assumptions that it is both effective for preventing adverse pregnancy outcomes and it is safe; however, the efficacy of prescribed antepartum bed rest has been questioned. The purpose of this thesis is to provide a comprehensive review of research findings about the efficacy of antepartum bed rest and the potential side effects that may result. For this literature review an interdisciplinary review of research was performed using Cumulative Index of Nursing and Allied Health, PubMed, and PsychINFO. Current literature shows that activity restriction during pregnancy can have negative effects on the mother including increased levels of anxiety and depression, muscle atrophy, increased risk of thromboembolic events, cardiovascular side effects, and an increase in postpartum recovery time. Considering these common themes, nursing interventions to reduce the instance of these events were studied including music therapy, support groups, family involvement, and fall prevention.

Thesis (M.S.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / 2031-01-01