Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 146-151).

Thesis (M.S.)--University of Missouri-Columbia, 2008. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 14, 2009) Includes bibliographical references.

Thesis (Ph.D.)--University of Central Florida, 2009. / Adviser: James J. Hickman. Includes bibliographical references (p. 151-163).

No description available.

Defective alkanethiol monolayers were studied as a model system to understand the stress changes observed in microcantilever-based DNA hybridization experiments. An exponential relationship between defect density and surface stress was found by performing simultaneous electrochemical/stress-sensing experiments. Microcantilevers with a range of defective alkylthiol self assembled monolayers were prepared and stress change/electrochemical data were collected in perchlorate, chloride, and bromide-containing electrolytes. Defects were probed using a ferrocene-thiol labeling technique which provides quantitative measurement of defect area. Using defects and solutions containing charge transferring adsorbates is suggested as a method for enhancing the surface stress signals in cantilever sensor systems. The best response from this study was obtained in bromide, as its exponential function had the sharpest increase with defect density.

Thesis (Ph.D.)--University of Missouri-Columbia, 2006. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on May 1, 2009) Vita. Includes bibliographical references.

No description available.

Thesis (Ph. D.)--Auburn University, 2009. / Abstract. Vita. Includes bibliographical references (p. 168-174).

No description available.

Orientadores: Roberto Ricardo Panepucci, Roberto José María Covolan / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Física Gleb Wataghin / Made available in DSpace on 2018-08-30T01:13:32Z (GMT). No. of bitstreams: 1 BenavidesGuevara_JesusArbey_M.pdf: 3401823 bytes, checksum: 461e1559d0928ed82b7c63870d75a3e5 (MD5) Previous issue date: 2015 / Resumo: O desenvolvimento de novas tecnologias aplicadas à pesquisa da atividade elétrica do cérebro é um dos tópicos de vanguarda na atualidade em neurociências. Nas últimas décadas, dispositivos denominados sondas neurais têm sido desenvolvidos, baseados nas técnicas atuais de produção e fabricação de biomedical (ou biological) microelectromechanical systems (Bio-MEMS). Estes dispositivos permitem registrar ou estimular eletricamente diferentes regiões do cérebro in vivo, ou conjuntos de células de cultura, in vitro. A consolidação desta nova tecnologia fornece uma ferramenta de alta precisão para pesquisa em neurociência, além de permitir seu uso clínico em condições patológicas tais como lesão medular, acidente vascular cerebral e distúrbios neurológicos, entre outras. O desenvolvimento de sondas neurais tem-se dado através de estudos que exploram diferentes possibilidades de desenho, fabricação e utilização de novos materiais, orientado pelas possíveis vantagens biológicas, de custo e de fabricação que possam ter. De particular interesse nesta área, é o entendimento dos mecanismos subjacentes ao comportamento eletroquímico durante estimulação e registro de atividade neuronal por microeletrodos do dispositivo, assim como a investigação de materiais que forneçam uma alta densidade de carga durante este processo. Neste projeto, foram fabricadas e caracterizadas sondas neurais baseadas no polímero SU-8, tanto quanto se saiba, as primeiras desenvolvidas no Brasil. Apresenta-se as metodologias empregadas nos processos de fabricação, em que foram testados diferentes protótipos de sondas e sondas funcionais com diferentes geometrias. Metais como Ti/Au, Ti, Cr/Au e TiN foram depositados por meio de sputtering e eletrodeposição. As propriedades eletroquímicas destes materiais condutores foram determinadas por técnicas de voltametria cíclica e espectroscopia de impedância eletroquímica. As sondas de Ti/Au foram as que apresentaram os melhores resultados em nossa pesquisa, tendo em vista a metodologia de fabricação utilizada, que manteve a integridade física dos microeletrodos e do dispositivo em geral, não obstante certas inomogeneidades apresentadas em diferentes etapas da fabricação, que ainda demandam um maior entendimento. Em conclusão, as sondas funcionais de Ti/Au produzidas e caracterizadas neste trabalho se apresentam como um dispositivo potencialmente adequado para registro da atividade neural em modelos animais / Abstract: The development of new technologies applied to the research of the cerebral electrical activity is one of the leading topics in neuroscience today. In recent decades, the so-called neural probe devices have been developed, based on current production and manufacturing techniques of biomedical (or biological) microelectromechanical systems (BioMEMS). These devices allow one to record or electrically stimulate different brain regions in vivo, or systems of cultured cells in vitro. The consolidation of this new technology provides a highly accurate tool for research in neuroscience, and allows their clinical use in pathological conditions such as spinal cord injury, stroke and neurological disorders, among others. The development of neural probes have been given through studies exploring different possibilities of design, manufacture and use of new materials, guided by the possible advantages they might have in terms of biology, manufacturing process and costs. Of particular interest in this area is the understanding of the mechanisms underlying the electrochemical behavior during stimulation and recording of neuronal activity by the microelectrodes of the device, as well as the research of materials providing a high density of charge during this process. In this project, were manufactured and characterized neural probes based on SU-8 polymer, to our knowledge the first developed in Brazil. The methods used in the manufacturing processes are presented for the various tested prototypes of probes and functional probes with different geometries. Metals such as Ti/Au, Ti, Cr/Au and TiN were deposited by sputtering and electrodeposition. The electrochemical properties of these conducting materials were determined by cyclic voltammetry and electrochemical impedance spectroscopy. Probes of Ti/Au showed the best results in our research, taking into consideration the manufacturing methodology, which kept the physical integrity of microelectrodes and the device in general, despite certain inhomogeneities presented in different stages of the manufacturing process, which still demand a greater understanding. In conclusion, the functional Ti/Au probes produced and characterized in this work have shown to be a potentially suitable device for recording neural activity in animal models / Mestrado / Física / Mestre em Física / 2012/151275-2 / CNPQ