The purpose of this dissertation is to utilize an intersectional approach to determine what external factors (social, political, and economic) contribute to the health challenges of black heterosexual women and black queer women in the American South. The dissertation made a comparison between black heterosexual women and black queer women to explore whether their health challenges result from their social, political, and economic experiences. The research further examined how the daily experiences of these black women impact their health. This dissertation found that the daily lives of black heterosexual and black queer women associated with their social, economic, and political experiences create vulnerability in the health challenges of these populations. The dissertation also found that black queer women appear to become a sub-population whose health is poorer than their black heterosexual female counterparts because they suffer additional challenges, in the form of isolation and stigmatization, resulting from their sexual orientation in the American South.