Abstract The gear-cam intermittent mechanism, mainly made up by cam, the sun gear, planet gear and planetary shelf , it has been used in automatically high speed die cutting and creasing machine. The main function of die cutting and creasing machine is cutting and creasing the cardboard, and through compounding the cam motion curves, it will can control the intermittent motion of a gear-cam intermittent mechanism and improve its dynamic characteristic. The effects of gear cam profile and driving speed on the dynamic responses of a box folding and die cutting machine are studied in this work. The input driving motor¡Bgear¡Bgear-cam and output chain mechanics are included in the dynamic system. The equation of motion of the whole system in derived by employing Lagrange¡¦s equation the 4th order Runge-Kutta method is used to simulation the fine domain response of the nonlinear equation of motion. The effect of cam profile, and driving speed on the system dynamic response have been simulated and analysed in the work.