Submitted by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-08-22T19:40:10Z No. of bitstreams: 2 Tese - Péricles Silva de Oliveira.pdf: 1875380 bytes, checksum: 014ba89b7fe1929a1461c9d8d3959416 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-08-22T19:40:26Z (GMT) No. of bitstreams: 2 Tese - Péricles Silva de Oliveira.pdf: 1875380 bytes, checksum: 014ba89b7fe1929a1461c9d8d3959416 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-08-22T19:40:44Z (GMT) No. of bitstreams: 2 Tese - Péricles Silva de Oliveira.pdf: 1875380 bytes, checksum: 014ba89b7fe1929a1461c9d8d3959416 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-08-22T19:40:44Z (GMT). No. of bitstreams: 2 Tese - Péricles Silva de Oliveira.pdf: 1875380 bytes, checksum: 014ba89b7fe1929a1461c9d8d3959416 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-04-28 / Several systems proposed for processing keyword queries over relational databases rely on the generation and evaluation of Candidate Networks (CNs), i.e., networks of joined database relations that, when processed as SQL queries, provide a relevant answer to the input keyword query. Although the evaluation of CNs has been extensively addressed in the literature, problems related to efficiently generating meaningful CNs have received much less attention. To generate useful CNs is necessary to automatically locating, given a handful of keywords, relations in the database that may contain relevant pieces of information, and determining suitable ways of joining these relations to satisfy the implicit information need expressed by a user when formulating her query. In this thesis, we present two main contributions related to the processing of Candidate Networks. As our first contribution, we present a novel approach for generating CNs, in which possible matchings of the query in database are efficiently enumerated at first. These query matches are then used to guide the CN generation process, avoiding the exhaustive search procedure used by current state-of-art approaches. We show that our approach allows the generation of a compact set of CNs that leads to superior quality answers, and that demands less resources in terms of processing time and memory. As our second contribution, we initially argue that the number of possible Candidate Networks that can be generated by any algorithm is usually very high, but that, in fact, only very few of them produce answers relevant to the user and are indeed worth processing. Thus, there is no point in wasting resources processing useless CNs. Then, based on such an argument, we present an algorithm for ranking CNs, based on their probability of producing relevant answers to the user. This relevance is estimated based on the current state of the underlying database using a probabilistic Bayesian model we have developed. By doing so we are able do discard a large number of CNs, ultimately leading to better results in terms of quality and performance. Our claims and proposals are supported by a comprehensive set of experiments we carried out using several query sets and datasets used in previous related work and whose results we report and analyse here. / Sem resumo.

In normal cranial suture development, the cranial sutures close at predetermined periods of development to allow the brain the capability to grow in a malleable environment. However, in craniosynostosis, cranial sutures prematurely fuse before birth which can lead to a wide range of developmental issues and complications. Craniosynostosis can be categorized as nonsyndromic which involves the sole fusion of one or more of the cranial sutures, or syndromic in which cranial sutures fuse as well as other abnormalities associated with a genetic disorder. Past research has identified three candidate genes that could be possible disease causing mutations in nonsyndromic sagittal craniosynostosis. The mutations were found were in ITGAV, SLC30A9, and BAMBI. Using zebrafish as a model organism, we assessed the phenotypic effects of mutating itgav, slc30a9, and bambia associated with craniosynostosis. Phenotypic analysis of heterozygous itgav mutants showed when itgav is mutated there is increased bone formation and abnormal suture development. Due to the phenotype seen in zebrafish, it is proposed when mutated, ITGAV can help produce craniosynostosis.

The aim of the thesis is based on the comparison and evaluation of the selection process and recruitment in three selected companies find the optimum process. The paper compares these HR processes with IT developer JetBrains s.r.o., a pharmaceutical company Shire Czech s.r.o. and company providing services in the field of facility management. The thesis is divided into four chapters. The first chapter is devoted to basic theoretical knowledge concerning the chosen topic. In the second chapter describes the process of recruitment and selection of employees in individual companies. The third chapter contains a comparison of selected companies, their processes and are given recommendations for individual companies, which will help improve these processes. The fourth chapter is devoted to a number of possibilities to improve individual aforementioned processes to be more efficient and lead to optimal process of recruitment and selection of employees.

This diploma thesis is concerned with definition of the term recruitment agency and with the description of its activities and services, which are offered to its clients and candidates. First chapter of this thesis depicts conditions of origin of recruitment agencies in Czech Republic and their functioning. There is a close analysis of job market, job applicants and clients of recruitment agencies. The second chapter is the core of this thesis. It contains description of cooperation between specific recruitment agency and its client and candidate. The work of the consultant in this recruitment agency is a central theme of this chapter. Final chapter sums up benefits and risks for all concerned parties, namely client - recruitment agency - candidate.

In this diploma thesis I describe the instruments of recruiting and selection of the candidates which include the classic format of the curriculum vitae and also social networks like LinkedIn and Facebook The thesis is divided into theoretical part, which is based on books and other online sources, where you can find the definitions of personnel work and management, but also the definition of a worker his working performance and his motivation. The important part explains different ways of recruiting the candidates and the description of instruments which are used, especially the CV and social networks. Analytical part is based on the questionnaire research about the structure and content of the CV according to the point of view of the recruiters. The second part is based in the interviews with recruiters about the usage of the social networks. In the conclusion, there is a summary of the results from the analytical part.

The relationship of attitude measurement with the political campaign process provides the problem area that this study considers. The purpose of this political communication study is to explore in detail and describe various "attitude" profiles of voters and resulting candidate "images" of the 1972 presidential election. These "attitudes" and "images" are determined through the use of three primary research instruments: the semantic differential scale, the Method of Ordered Alternatives, and the political philosophy continuum. In addition to these, a record of actual voting behavior serves as validating support of the measured attitudes. This study deals with "attitudes" toward and candidate "images" of George McGovern, R. Sargent Shriver, Richard M. Nixon, and Spiro T. Agnew, the Democratic and Republican candidates for President and Vice-President in 1972. This descriptive investigation unfolds into three major problem areas: 1. to report and describe "panoramic images" of Nixon,. McGovern, Agnew, and Shriver, as measured by the semantic differential scale. 2. to give an account of voter preferred positions A through I as measured by the Method of Ordered Alternatives in connection with "attitude" as measured by the evaluative factor of the semantic differential scale, and subsequently aligned with actual voting behavior. 3. to determine the relationship between voters' own political philosophies and their perceived political philosophies of the four candidates as measured by the political philosophy continuum. The remainder of this chapter overviews the historical mileau of the 1972 presidential campaign, explains the research design and procedures, and offers an organizational preview of the remaining five chapters.

The goal of this study is to propose a concept of Assessment Centre as an effective recruitment tool for a personal banker in the financial institution. The theoretical part describes general process of a recruitment and a Assessment Centre method. The effectivity of this method is compared with other recruitment methods. It also depicts the objectives of the method and mentions utilized methods. Attention is paid to particular AC stages, from finding out demands and requirements of the Assessment Centre up to evaluation of the data, which had been obtained during AC. The aim of the practical part is to bring a concept of AC for a recruitment of a personal banker in particular financial institution and to assess whether the AC method is suitable for recruitment in that case, together with economic evaluation in comparison with classic recruitment method.

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Die Ursachen für genetisch bedingte neurologische Entwicklungsstörungen sind sehr vielfältig. Aufgrund der heterogenen und unspezifischen klinischen Präsentation ist eine eindeutige Diagnosestellung durch eine rein klinische Beschreibung selten möglich. Eine frühzeitige und effiziente Diagnosestellung erspart den Betroffenen und auch dem Gesundheitssystem unnötige Untersuchungen und Krankenhausaufenthalte und verbessert die prognostischen und therapeutischen Möglichkeiten. Mit Hilfe der massiven Parallelsequenzierung, der Next-Generation-Sequencing Technologie, sind in den letzten Jahren bereits über tausend krankheitsassoziierte Gene für NDD identifiziert worden. Weltweit werden mittels der Sequenzierung und Auswertung von tausenden Exomen betroffener Menschen große Studien zur Identifizierung neuer valider Kandidatengene durchgeführt. Die Zahl valider Kandidatengene bleibt, im Vergleich zum Aufwand, jedoch hinter den Erwartungen zurück. Am Institut für Humangenetik Leipzig wird daher von jedem Fall einer neurologischen Entwicklungsstörung, soweit Material und Einwilligung der Betroffenen vorhanden sind, ein Trio-Exom sequenziert. Das bedeutet, dass die Exome der Eltern oder der Geschwister mit dem Exom des betroffenen Menschen verglichen werden. Somit ist es möglich, Varianten in bereits bekannten krankheitsassoziierten Genen zu finden und folgend eine genetische Diagnose zu stellen. Wenn in dieser Routinediagnostik keine Diagnosestellung möglich war, analysierte ich die Trio-Exome erneut auf Forschungsbasis, um mögliche, bisher noch nicht bekannte neue Kandidatengene zu finden, welche die Erkrankungen der Betroffenen erklären können. Um die Masse an Kandidatengenvarianten einzugrenzen, eine Vergleichbarkeit von verschiedenen Kandidatengenvarianten zu schaffen und die wissenschaftlichen Ressourcen bestmöglich zu nutzen, entwickelte ich einen Kandidatengenscore zur Priorisierung jeder einzelnen Variante. Dieser Score besteht aus 4 Übergruppen zusammengesetzt aus 12 verschiedenen Parametern, welche die Eigenschaften des konkreten Vererbungsmodus, des einzelnen Gens, der spezifischen Variante und Aspekte der Literaturrecherche widerspiegeln. Aus der untersuchten Kohorte von 198 Betroffenen mit neurologischen Entwicklungsstörungen konnten 63 Fälle in der Routinediagnostik mit einer klaren genetischen Diagnose geklärt und in den restlichen ungeklärten Fällen insgesamt 158 Kandidatengenvarianten identifiziert werden. Allein aus den Top 15% (21 Kandidatengene) der gescorten Kandidatengene, wurden bisher bereits 10 Gene als krankheitsverursachend durch Publikationen validiert. Diese Gene sind TANC2, GLS, ACTL6B, GRIN3B, CUX1, UNC13A, GRIA4, MAPK8IP3, CACNB4 und WDFY3. An den Publikationen von TANC2 und WDFY3 arbeitete ich im Zuge meiner Doktorarbeit aktiv als Co-Autor mit. Als Erstautor und als Grundlage dieser publikationsbasierten Dissertation konnte ich ein neues rezessiv-vererbtes Krankheitsbild ausgelöst durch Varianten im GLS-Gen beschreiben: Im Rahmen der wissenschaftlichen Auswertung der Trio-Exome und während der Entwicklung des Kandidatengenscores fielen zwei Fälle mit gleichem Kandidatengen und ähnlicher klinischer Symptomatik auf. Zwei nicht verwandte Kinder von gesunden Eltern besaßen rezessive Varianten im GLS-Gen, welches das Enzym Glutaminase kodiert. Beide Betroffenen verstarben innerhalb des ersten Lebensmonats an einer sich rasch entwickelnden epileptischen Enzephalopathie. Des Weiteren wurden in beiden Fällen verstorbene Geschwisterkinder beschrieben, welche an vergleichbaren Symptomen kurz nach der Geburt verstarben. Da das Enzym Glutaminase ein wichtiger Bestandteil der Glutamin/Glutamat-Homöostase ist und Glutamat einen wichtigen Neurotransmitter des Menschen darstellt, lag die Vermutung nahe, dass eine Störung des Glutamat-Stoffwechsels zu neurologischen Entwicklungsstörungen führen kann. In Zusammenarbeit mit der niederländischen Arbeitsgruppe um Prof. van Hasselt konnten erhöhte Glutaminkonzentrationen in den Trockenblutkarten des Neugeborenenscreenings der beiden verstorbenen Geschwister einer Familie nachgewiesen werden. Ebenfalls war es möglich, die von jeweils einem Elternteil vererbten compound heterozygoten Varianten in beiden Erbanlagen der verstorbenen Geschwister nachzuweisen und das gemeinsame Auftreten beider Varianten im genetischen Code der gesunden Geschwister auszuschließen. Somit konnte durch die Entwicklung des Kandidatengenscores mit Priorisierung der verschiedenen Kandidatengene und Fokussierung auf die vielversprechendsten Gene mit folgender intensiver wissenschaftlicher Evaluation ein neues autosomal rezessives Krankheitsbild beschrieben werden, welches aufgrund von Varianten im GLS-Gen zu einer neonatalen, tödlich verlaufenden Enzephalopathie führt. Mit Hilfe des Kandidatengenscores ist es gelungen, sich auf die überzeugendsten neuen Kandidatengene zu fokussieren, neue wissenschaftliche Kooperationen zu knüpfen und hierdurch die Liste an validen krankheitsassoziierten Genen, wie zum Beispiel des GLS-Gens, zu erweitern. Der Kandidatengenscore wird weiterhin am Institut für Humangenetik Leipzig erfolgreich eingesetzt.

Research has shown a relationship between having a strict father upbringing, defined by rules reinforcement and self-discipline beliefs, and the presence of high levels of social dominance orientation (SDO) and right-wing authoritarianism (RWA). The relationship between these variables and issue choice has been established, but no study has explored the connection between parental upbringing and moral foundations. Furthermore, the connection to political candidate choice has not been shown. This study investigated the relationship between people's parental upbringing beliefs, their adult morality, and their rating of ideal presidential candidate characteristics. Based on the moral foundation theory, a mixed methods study was conducted to examine the relationship among upbringing, moral foundations, RWA, SDO, socioeconomic status (SES), and candidate selection by surveying 221 adult participants recruited online and in the community. Linear regression analysis was conducted to examine how levels of SDO, RWA, and the strict father variables predict the 5 five moral foundations. Qualitative analysis, through the use of open-ended questions, explored presidential candidate choice by rating people's preference of the 5 moral foundations, the strict father nurturing parent worldviews, SDO, RWA, and subjective SES, as expressed in their ideal president. Results indicated that upbringing is related to RWA for conservatives and inversely related to SDO for liberals. Also, participants exhibited a rules reinforcement versus self-discipline left-right political dichotomy. Participants favored a tough-minded president on foreign affairs. This study's results will enable voters to understand how their political attitudes may be formed and how they could be scrutinized and manipulated by those with an interest in doing so.