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Surrogate markers of atherosclerosis and cardiovascular disease劉巨基, Lau, Kui-kai, Gary. January 2008 (has links)
published_or_final_version / Medicine / Master / Master of Research in Medicine
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Effects of dietary soy isoflavones for cardiovascular disease (Review)毛皚炘, Mo, Yee-yan. January 2009 (has links)
published_or_final_version / Community Medicine / Master / Master of Public Health
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Life course determinants of cognitive function and cardiovascularriskHeys, Michelle. January 2010 (has links)
published_or_final_version / Public Health / Master / Doctor of Medicine
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Flow cytometric analysis of intra-platelet VASP for evaluation of clopidogrel resistance in ischemic heart disease patients undergoingpercutaneous coronary interventionLam, Lap-fung., 林立峰. January 2012 (has links)
Ischemic heart disease (IHD) is the most common cause of death around the world. The underlying cause of IHD is myocardial ischemia as a result of progressive narrowing of coronary arteries due to atherosclerosis with potential thrombotic complications mediated by platelets. In addition to the role in hemostasis, platelets are increasingly recognized as an important mediator in this atherothrombotic disease. Basic management of IHD lies on medical therapy and coronary revascularization procedures. Percutaneous coronary intervention (PCI) is a commonly used revascularization procedure in the treatment of IHD especially for relief and reduction of symptoms. On the other hand, antiplatelet therapy is often administrated to patients undergoing PCI in an attempt to prevent major adverse cardiac events (MACE) following the procedures. However not all patients respond to the same degree of the antiplatelet therapy and some still develop MACE or stent thrombosis in the presence of the treatment with antiplatelet drugs.
Recently a flow cytometric-based assay has been developed to monitor the effect of the antiplatelet drug, particularly the P2Y12 receptor antagonist, in patients treated with this kind of drug. This assay measures the activity of platelets as platelet reactivity index (PRI) based on the phosphorylation state of an intracellular platelet protein called vasodilator stimulated phosphoprotein (VASP). The measured value of PRI is inversely related to the response of patient to the antiplatelet drug.
In this study, the response of patients to the P2Y12 receptor antagonist Clopidogrel was investigated following PCI. The PRI of patients was found to be significantly lower than normal subjects without taking this drug, indicating the therapeutic effect of this drug on the patients. However nearly one-third of patients (17 out of 59) studied were found to be non-responsive to clopidogrel treatment based on a cut-off established in this study for classifying patients into responders or non-responders. Furthermore, significant difference between the two types of stents used in PCI procedure, namely bare metal stent (BMS) and drug eluting stent (DES), was observed in the study. Patients receiving DES had nearly three times higher percentage of being non-responsive to clopidogrel than the BMS counterpart (45% vs. 16%, p<0.028). This study provides evidence that DES may be implicated in the non-responsiveness or drug resistance of clopidogrel in patient undergoing PCI. / published_or_final_version / Pathology / Master / Master of Medical Sciences
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Innovative cuboid method to attenuate noises from site-measured heart sound signalsZeng, Ke Han January 2015 (has links)
University of Macau / Faculty of Science and Technology / Department of Electrical and Computer Engineering
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Packaging multiple interventions in a wellness clinic to promote cardiovascular wellness in Soshanguve.Li, Yuqiu January 2012 (has links)
D. Tech. Nursing / Cardiovascular disease is the most common and yet one of the most preventable causes of death in the world. Risk factors for cardiovascular disease are numerous and well known. These risk factors are amongst others, hypertension, diabetes, physical inactivity, obesity, smoking and behaviour patterns. The intention of the study was to use the concept of a wellness clinic to promote cardiovascular wellness in the community. Packaging multiple interventions in a single visit would enable the research team to identify risk factors and educate the person regarding their own risk factors. The objectives of the study were to determine the prevalence of risk factors for cardiovascular disease in Soshanguve, determine personnel time and direct cost for promoting cardiovascular wellness taking into consideration screening, diagnostic testing and teaching including time, travel and personnel; and develop the optimal package of cardiovascular wellness interventions as determined by a binary Integer Programming model that maximizes cardiovascular wellness subject to constrains of shortage of funds and human resources in a resource poor setting.
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Hair trace metal levels and cardiovascular disease mortality rates in GeorgiaMohr, William Charles 08 1900 (has links)
No description available.
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Wild Blueberry Consumption and Risks for Cardiovascular DiseaseBarker, Ann Elizabeth January 2006 (has links) (PDF)
No description available.
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Cardiovascular disease : knowledge, motivation and risk factors in adultsReid, Diane S. 01 January 1998 (has links)
No description available.
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Longitudinal analysis of genetic risk factors for cardiovascular disease: the birth to twenty plus cohortMunthali, Richard Junganiko January 2017 (has links)
A thesis
submitted to the School of Molecular and Cell Biology, Faculty of Science, University
of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree
of
Doctor of Philosophy
June 2017
Johannesburg, South Africa / Non-communicable diseases (NCDs) pose an increasing burden on public health and economic
growth worldwide. The highest increase in prevalence and death rates of NCDs has been seen in low
and middle-income countries (LMICs). World Health Organization (WHO) estimates that by 2030,
NCDs will account for five times as many deaths as communicable diseases in LMICs and that there
will be more than 2.16 billion overweight and 1.12 billion obese individuals in the world. It is also
estimated that by 2020 NCDs will contribute 80 percent of the global burden of disease and the
largest increase in NCD deaths will occur in Africa. Recent reports indicate that six of the ten leading
natural causes of death in South Africa are NCDs.
There are few studies that have used longitudinal data to understand the effects of life-course
childhood adiposity on future health risks and the early life factors responsible for variations in lifecourse
childhood obesity. However, it is not known whether there is a genetic basis for the variability
in BMI developmental patterns over time. Lack of comprehensive longitudinal and genetic
association data for obesity have made it difficult to do such studies in an African setting. It is still not
clear whether the same genetic variants associated with obesity in Europeans and other populations
are also associated with these traits in African populations. Understanding the genetic contribution to
obesity in the black South African population may help to come up with effective interventions to
deal with this emerging epidemic in Africa.
The aim of this thesis was to better understand the contribution of genetics and explain the
longitudinal genetic basis of childhood and adolescence obesity in black South African children. To
deal with this, I firstly studied identification of distinct trajectories of BMI and then relate the
established BMI trajectories to the future health risks of elevated blood pressure. Secondly, I explored
the early life factors behind BMI trajectory membership, this would help to identify factors that may
accelerate an individual’s progression from a normal BMI trajectory pattern membership to the one
characterized with elevated BMI. Then lastly, I looked at the additive genetic effect for BMI and
determine whether genetic risk of obesity in early adulthood was mediated by early life rapid growth.
Results showed variation in BMI developmental patterns between boys and girls; three and four
distinct sex-specific BMI trajectories were identified in boys and girls respectively. Children
belonging to early onset overweight or obese BMI trajectories, characterized by elevated BMI, had an
increased risk of elevated blood pressure in late adolescence, compared to their peers in the normal
trajectories.
Rapid conditional relative weight gain in early life was associated with increased risk of belonging to
a BMI trajectory characterized by consistent elevated BMI over time. Individuals in overweight or
obese trajectories had a higher chance of being overweight or obese in early adulthood.
I found that a genetic risk score, based on known adult BMI Caucasian risk variants, showed
significant longitudinal effects of genetic loci with BMI in childhood and adolescent and significant
age-GRS interactions were observed. A higher genetic risk score predicted membership of early onset
obese or overweight BMI trajectories. The genetic risk of obesity at 18 years of age was mediated by
pre-adolescence and adolescence rapid weight gain.
The results from this thesis emphasize the importance of studying individual’s BMI developmental
patterns when studying development and progression of obesity. These findings also show that the
information obtained from GWAS done in other populations can be equally relevant to African
populations and this could be used in early identification of individuals at increased risk of obesity
and other NCDs risk factors. Combing genetic risk score, BMI trajectories membership and weight
status can be used to help improve the screening process of individuals to be targeted in coming up
with targeted educational and behavior intervention programmes for obesity. These programmes
should target individuals at risk at early stage in order to reduce the adverse health risk outcomes later
in life. / MT 2017
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