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The aim of the thesis was to describe and compare relations arising from carriage of persons or articles, namely liability of contracting parties according to individual contractual types. Another goal was to compare individual principles of liability. Kinds of liability of the contracting parties ensuring carriage services by the contract type are as follows: (1) carrier - carriage of the person (a) timeliness of carriage, (b) damage to health, (c) damage to baggage carried with the passenger, (d) damage to the article which the passenger had with him during carriage (e) damage to baggage carried separately from the passenger; (2) carrier - carriage of goods a) loss of consignment, b) destruction of consignment, c) damage to consignment, d) depreciation of consignment, e) exceeding delivery time; (3) operator; (a) incapacity of the means of transport; (b) damage caused by operation of the means of transport; (4) lessor - incapacity of the means of transport; (5) storage provider - storage and custody of articles; (6) freight forwarder - provision of carriage; (7) mandatory - informing the mandator about true fulfillment of his order. Reasons to be relieved of liability apply to all contracting parties providing carriage services. Reasons to be relieved of liability may be unprivileged (common...

MS, Pharmaceutical Affairs, Faculty of Health Sciences, University of the Witwatersrand / PEO (Polyethylene Oxide) is one of the most important biodegradable polymers used in pharmaceutical formulations, mainly because of its non-toxicity, high water-solubility and swellability, insensitivity to the pH of the biological medium and flexibility during dosage form production (Kim, 1995; Picker-Freyer, 2006; Kiss et al., 2008). The lack of studies attempting to achieve controlled drug delivery of hydrophilic drugs has provided us with motivation to use a drug of this nature but we have combined it with a PEO-electrolyte combination in order to control drug delivery. This study was aimed at modifying the physicochemical and physicomechanical properties of PEO in order to influence the hydrodynamic diffusion of its three-dimensional network. Hence, through such alteration, it was envisaged that if drug is loaded into its PEO matrix, its solubility and dissolution can be regulated in order to achieve zero-order influx of dissolution medium. The interaction between PEO and electrolytes may allow for precipitation of ions on the polymer backbone. This would lead to the attraction of water molecules to the ions. As a result, this would cause dehydration of the polymer matrix, hence minimising its mobility and relaxation. In this study, 36 PEO-electrolyte combinations were prepared by combining a high molecular weight PEO with different statistically planned combinations of electrolytes. The 36 formulations were microscopically analyzed and subjected to textural analysis. The salted-out PEO-electrolyte combinations were then further selected and analyzed. Assessment of the molecular structural transition and thermal compatibility analysis indicated minimal interaction between the electrolytes and PEO indicating that the polymer-electrolyte combination was stable enough to be employed as a medium for controlled drug release. The polymer-electrolyte combination was combined with a model drug, diphenhydramine HCl to form a tablet matrix and then subjected to dissolution. In vitro drug release varied depending on the different electrolytes and their combinations. The type of polymer, molecular weight of the polymer, concentration of the polymer, different electrolyte combinations and solubility of the drug played a significant role in controlling drug release. After optimization of the fracture force, resilience and work performed values, results have established that equal concentrations of Na2CO3 and K2HPO4 are desirable for achieving controlled release of drug from the salted-out PEO combination in a zero-order manner. Furthermore, Na2CO3 and K2HPO4 had a significant influence on controlling the release of drug from the salted-out PEO combination due to crosslinking between PEO and the electrolytes ultimately leading to zero-order release kinetics. The salting-out of PEO notably modified the physicochemical and micromechanical properties of basic PEO, which demonstrably enhanced the ability of the sample to achieve controlled drug release. The formulation strategy employed in this study where in our sample drug, diphenhydramine HCl was combined with a PEO-electrolyte combination has shown promising results in regulating drug release.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24495号 / 医博第4937号 / 新制||医||1063(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 杉田 昌彦, 教授 鈴木 実 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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Page 139 not included in the thesis. / <p> The problem of coherent carrier recovery and the effects of phase error on the performance of an offset quadrature-phase-shift-keying (QPSK) duobinary system have been investigated in the thesis. The system of interest is similar to RD -3 digital system that is being developed and installed as an efficient high data-rate digital radio communication system by Bell Northern Research Laboratory (BNR). </p> <p> Four carrier regeneration loop structures are investigated and analysed in the thesis. These are: (i) estimate-aided suppressed carrier loop (ii) decision-directed feedback loop (iii) shifted decision-directed feedback loop (iv) half-shifted decision-directed feedback loop All of these loop structures employ the technique of data-aided carrier synchronization. The estimate-aided loop structure exhibits steadystate behavior similar to that of a conventional Costas loop. The remaining three loop structures differ from the estimate-aided loop in the sense that they require decisions to make on the noisy received signal. These are then fedback to the carrier recovery circuit in such a way as to create a spectral line at carrier frequency. The loop behavior in the presence of additive noise has been investigated in some detail. For each loop, analytical expressions for the phase detector characteristic (S-curve) and the steady-state phase error probability density function (pdf) are derived, and provide a means of comparing the performance of the different recovery schemes.</p> / Thesis / Master of Engineering (MEngr)

Väderstad Ab is a family business established in the 1960: s that manufactures farm equipmentsuch as harrows, cultivators and seeders. This master thesis is done on the disc cultivator Carrier300. Depending on the configuration, Carrier 300-400 can be mounted or trailed, the trailed versioncan be fitted with a CrossBoard. This allows the trailed version to better cultivate the soil. Thetask was to design a product that allow the usage of CrossBoard and CrossCutter Knife on themounted version. The product had to fit in well with the original machine, be able to retro fit andhave a weight below 150 kg. The project was performed using the product development methodby Ulrich &amp; Eppinger. This method aims to divide the work in phases that ends with a gate atthe end. At the gate the project is evaluated and it´s determined if the work should continue tothe next phase. After it was decided what concept to go forward with, a FEM model was set up inCreo Simulate to calculate the stresses in the part. From the result of this model the design wasthan improved in several steps.The result of the project resulted in a welded product of plates and pipes that enable retro fitof CrossCutter knife and CrossBoard on a mounted Carrier 300-400. The product was than testedunder different driving conditions in both field and on road. As future work it could be investigatedif this concept can be implemented on other mounted machines such as Carrier X.

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Aircraft Carriers are naval vessels that allow for landing and take-off of military aircraft. Typically, Aircraft Carriers are active for 50 to 60 years then need to be retired or decommissioned. The ship is either torn apart for resources, sunk to the bottom of the ocean to serve as an artificial reef, or tied up to a dock indefinitely to serve as a sterile museum. The purpose of this research is to explore a fourth option that allows the public to appreciate the steel beasts in a manner that is respective and full of awe. / Master of Architecture