Os objetivos do presente estudo foram: 1) mensurar e descrever as medidas de extensão e espessura do véu palatino e da profundidade da nasofaringe em indivíduos com fissura transforame unilateral operada (FTU) que apresentavam disfunção velofaríngea (DVF); 2) calcular e descrever a razão entre a profundidade da nasofaringe e a extensão do véu palatino; 3) comparar as medidas encontradas para os indivíduos deste estudo com as normas descritas por SUBTELNY (1957); 4) comparar as medidas encontradas entre os sexos masculino e feminino; 5) comparar as medidas encontradas para os indivíduos que receberam palatoplastia com procedimento de Furlow (FW) com as medidas daqueles que receberam procedimento de Von Langenbeck (VL); 6) correlacionar as medidas encontradas com as idades dos indivíduos. A casuística foi constituída de 30 indivíduos com FTU e DVF, sendo 15 meninas e 15 meninos, com média de idade de 6 anos e 11 meses. Desses 30, 10 tiveram o palato operado pela técnica de FW e 20 pela de VL, entre as idades de 9 e 18 meses. Para definição da conduta para correção da DVF, todos os indivíduos foram submetidos ao exame de videofluoroscopia. Uma imagem em tomada lateral do MVF em repouso fisiológico foi selecionada e editada em um DVD para análise e mensuração das estruturas velofaríngeas de interesse. Três fonoaudiólogas experientes em videofluoroscopia realizaram as mensurações. Os resultados indicaram média de 27,4 mm para as medidas de extensão do véu palatino, de 9,7 mm para as de espessura do véu palatino, de 22,7 mm para as de profundidade da nasofaringe e de 0,86 para a razão entre a profundidade da nasofaringe e a extensão do véu palatino. Comparando os resultados do presente estudo com os de Subtelny (1957) diferença significante foi encontrada para as medidas da espessura do véu palatino, da profundidade da nasofaringe e da razão entre a profundidade da nasofaringe e a extensão do véu palatino. Os resultados também demonstraram diferença significante entre a média das medidas de extensão do véu palatino nos sexos masculino e feminino. Não houve diferença significante entre a média das medidas das estruturas avaliadas para os indivíduos operados pela técnica de FW nem pelos operados pela VL. Não houve correlação significante entre a variável idade e as medidas obtidas. / The objectives of the present study were: 1) to measure and to describe length and thickness of the velum and depth of nasopharynx for individuals with unilateral operated cleft lip and palate (UCLP) with velopharyngeal dysfunction (VPD); 2) to calculate and describe the depth of nasopharynx to velar length ratio (D/L); 3) to compare measures found for the individuals in this study with the norms described by Subtelny (1957) for normal individuals; 4) to compare the measures between males and females; 5) to compare the measures between individuals who received palatoplasty with the Furlow (FW) procedure to those who received the Von Langenbeck (VL) procedure; 6) correlate measures between different ages. The sample included 30 individuals with UCLP and VPD, 15 girls and 15 boys, with mean age of 6y11m. Ten individuals had palatoplasty with FW procedure and 20 with VL, between the ages of 9 and 18 months. For identifying best procedure for correcting VPD all individuals were submitted to videofluoroscopy assessment. A lateral view of the velopharyngeal mechanism during rest was selected and edited into a DVD, for analysis and measurement of the velopharyngeal structures of interest. Three speech-language pathologists experienced in videofluoroscopic assessment obtained all measures studied. The results revealed a mean velar length of 27.4 mm; mean velar thickness of 9.7 mm; mean depth of nasopharynx of 22.7 mm; D/L of 0.86. Comparing these results to Subtelny\'s (1957) a significant difference was found for measures of velar thickness, depth of nasopharynx velar length and D/L. Significant difference was found between males and females only for velar length. No significant differences were found between different techniques for palatoplasty. There was no significant correlation between age and the measurements obtained.

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No description available.

The morphology of the craniofacial complex is prone to alterations resulting from a wide range of external factors. In the first part of the presented thesis, we analysed the influence of slow long- term changes of the environment and population genome by comparing historical (11-12th century AD) and contemporary skulls using cephalometric X-ray images. The second part focuses on the effects of orthodontic treatment on bone thickness in relevant areas, with the analysis being based on Cone Beam computed tomography. A comparison of the palatal angle of 115 historical and 75 contemporary skulls revealed a statistically significant decrease of this parameter. The follow-up of 58 patients utilizing three- dimensional diagnostic imaging measurements before and after treatment revealed a statistically significant decrease in vestibular bone thickness, without changes of total alveolar width. Our analysis revealed a substantial bone response to respective forces, with relevant clinical implications - respecting the anatomical limits of the range of motion is essential to achieve therapeutic success and to avoid alveolar defects. Keywords: 3D imaging, CBCT, cephalometry, orthodontics, dentistry

No description available.

Indiana University-Purdue University Indianapolis (IUPUI) / Tooth mass discrepancies have been studied extensively in Caucasian populations, but little has been done to compare differences between Caucasian and African-American populations. The objective of this study was to determine whether the incidence of tooth mass discrepancies between the maxillary and mandibular arches was greater in African-American populations than Caucasian populations. Pretreatment plaster orthodontic models of 100 African-American and 100 Caucasian patients from the Indiana University Orthodontic Clinic and from one private practitioner were measured with a Mitutoyo Digimatic® caliper accurate to 0.01 mm. Mesiodistal widths of all teeth from first molar to first molar were measured with the mesio-buccal and disto-buccal contact areas normally being the widest area. The investigator was blinded to the gender and ethnicity of the subject by assigning each model a random number which was matched to the patient profile only following statistical analysis. Anterior ratios and total (posterior+ anterior) ratios were calculated according to the methods described by Bolton and were compared to the Bolton means and standard deviations. Incidence of tooth mass discrepancy was also investigated according to gender and dental malocclusion classification of the individuals. Tooth mass discrepancies present a hurdle to the clinician in achieving an ideal occlusion. Reports of the incidence of significant discrepancies in defined populations alerts the practitioner to problems in finishing their patients' occlusions. Results of the study show nearly double the incidence of overall Bolton tooth mass discrepancy in the African-American sample than in the Caucasian. The overall tooth mass discrepancy was more severe in the African-American sample, while anterior tooth mass discrepancies were nearly identical in both populations.

Introduction: The purpose of this study was to subclassify the types of facial asymmetries present in a pre-surgical dentofacial deformity patient population to determine the prevalence of each subcategory. Associations between the craniofacial characteristics of each asymmetry and pre-surgical Jaw Pain and Function Questionnaire (JPFQ) scores, diagnosis of temporomandibular disorders (TMD), and posterior facial asymmetry (PFA) as determined by nasal septum deviation were analyzed. In addition, the data will aid in the development of a phenomics database to allow for subsequent genotyping and gene expression evaluation from patient saliva and masseter muscle samples that were obtained at the time of corrective orthognathic surgery. Methods: Pre-surgical posterio-anterior (PA) cephalograms, submentovertex (SMV) and panoramic (PAN) radiographs from 92 pre-surgical dentofacial deformity patients at the Department of Oral and Maxillofacial Surgery, University of Lille, France were collected to evaluate facial asymmetry. PAs were traced and analyzed according to the Grummons Simplified Frontal analysis and Ramal Height analysis (Dolphin Imaging). SMVs were analyzed by the refined clinical system of the Ritucci and Burstone analysis proposed by Arnold et al along with original angular measurements for maxillary, mandibular, and nasal septum deviations (ImageJ). PFA was determined by a nasal septum deviation greater than 15 degrees. Lastly, PANs were evaluated visually for condylar pathologies. A comprehensive diagnostic decision tree for facial asymmetry was formulated based upon the current literature for normal variation of landmarks and the study design. Patient diagnosis via the decision tree was compared to visual examination of the appropriate x-rays to verify accuracy. Using this decision tree, patients were classified into subtypes and prevalence of each was calculated to form a phenomics database for future research on genotyping and gene expression. Associations between the subclassifications, mean pre-surgical JPFQ scores, temporomandibular joint (TMJ) clinical examination results (TMD+ or TMD-), and the diagnosis of posterior facial asymmetry (PFA+ or PFA-) were completed. Results: Sixty-two patients were able to fulfill all radiographic requirements to arrive at a diagnosis. Eighteen patients demonstrated facial asymmetry that fell within normal biological variation while the other 44 were diagnosed as having a form of facial asymmetry – Cranial Base Asymmetry: 11 female, 6 male; Non-Condylar Mandibular Asymmetry: 5 female, 3 male; Hemimandibular Elongation: 2 female, 3 male; Maxillary Asymmetry: 3 female, 1 male; Idiopathic Condylar Resorption: 3 female, 1 male; Atypical Asymmetry: 3 female, 1 male; Hemimandibular Hyperplasia: 1 female, 0 male; and Maxillary Base & Mandibular Body Asymmetry: 0 female, 1 male. JPFQ scores for symmetric patients ((x ) ̅= 5.33) and asymmetric patients (x ̅= 4.57) were non-significant overall, however, differences between gender were noted (female symmetric (x ) ̅= 6.13, male symmetric (x ) ̅= 1.33, female asymmetric (x ) ̅= 5.36, male asymmetric (x ) ̅= 3.19). TMD was diagnosed by pre-surgical TMJ examinations and MRIs. Four symmetric patients (3 female, 1 male) were positively diagnosed with TMD while 14 asymmetric patients (11 female, 1 male) also were diagnosed. PFA was diagnosed when nasal septum deviation was greater than 15 degrees – 25⁰ to ≤35⁰: 9 patients; >35⁰ to ≤45⁰: 3 patients; >45⁰: 1 patient. Twenty patients with a positive PFA were asymmetric while the other 8 symmetric. Twenty-one patients with PFA were female while the other 7 were male. Conclusion: A comprehensive diagnostic decision tree for facial asymmetry classification was formulated and validated. With it, it was found that: Females have increased JPFQ scores and clinical diagnosis of TMD versus males. Asymmetric females have decreased JPFQ scores, but increased prevalence of TMD. Presence of PFA does not appear to be a strong influence on development of facial asymmetry but is significantly linked to the presence of TMD. PFA is present in nearly half of all dentofacial deformity subjects. Mandibular asymmetry is most commonly associated with increased JPFQ scores and presence of TMD. However, Hemimandibular Hyperplasia, a particular and less common form of mandibular asymmetry, never associated with TMD. One form of mandibular and mid-facial asymmetry, Atypical Asymmetry, had a relatively high prevalence of TMD. Future directions for this research include continuation of genotypic description of IGF1 and Nodal biologic pathways to determine how gene expression levels in masseter muscle and patient genotypes differ in the eight subclassifications of craniofacial asymmetry compared to the symmetric population. / Oral Biology

O objetivo deste estudo foi comparar os efeitos do tratamento da má oclusão de Classe II por meio do Aparelho de Protração Mandibular (APM) e do aparelho Jasper Jumper, associados ao aparelho ortodôntico fixo. Para tanto, utilizou-se uma amostra de 71 indivíduos, divididos em três grupos: Grupo 1, constituído de 24 pacientes com idade inicial média de 12,36 anos, tratados com o Aparelho de Protração Mandibular (APM) por um período médio de 2,74 anos; Grupo 2, contendo 25 pacientes com idade média inicial de 12,72 anos, tratados com o Jasper Jumper por um período médio de 2,15 anos; e Grupo Controle, composto por 22 indivíduos com idade inicial média de 12,67 anos, não submetidos a qualquer tipo de tratamento ortodôntico e com má oclusão de Classe II, observados por um período médio de 2,12 anos. Foram avaliadas as telerradiografias em norma lateral ao início e ao final do tratamento ortodôntico de cada um dos indivíduos dos três grupos estudados. As variáveis cefalométricas dentoesqueléticas iniciais, finais e as alterações com o tratamento foram comparadas entre os grupos por meio da Análise de Variância e teste de Tukey. O grupo Jasper Jumper apresentou uma maior restrição do crescimento e do deslocamento anterior da maxila e uma maior retrusão maxilar e o grupo APM mostrou um aumento significantemente maior do comprimento efetivo da mandíbula. Ambos os grupos experimentais demonstraram uma melhora significante da relação maxilomandibular e uma diminuição significante da convexidade facial em relação ao grupo controle. Houve um aumento da altura facial posterior no grupo APM com relação ao controle. Os incisivos superiores mostraram maior retrusão e inclinação para palatino no grupo APM, com diferenças significantes em relação aos grupos Jasper Jumper e controle. Com relação aos incisivos inferiores, o grupo APM apresentou maior inclinação para vestibular e o grupo Jasper Jumper apresentou maior protrusão desses incisivos, com diferenças significantes em relação ao grupo controle. Os grupos APM e Jasper Jumper apresentaram uma extrusão dos molares inferiores, uma diminuição dos trespasses vertical e horizontal com o tratamento em relação ao controle, e o grupo APM apresentou diminuição significante do trespasse horizontal também em relação ao grupo Jasper Jumper. / The objective of this study was to compare the effects of the treatment of Class II malocclusion with the Mandibular Protraction Appliance (MPA) and the Jasper Jumper, associated with fixed orthodontic appliances. The sample used comprised 71 subjects, divided into three groups: Group 1, with 24 patients at a mean initial age of 12.36 years, treated with the Mandibular Protraction Appliance (MPA) for a mean period of 2.74 years; Group 2, with 25 patients at a mean initial age of 12.72 years, treated with the Jasper Jumper for a mean period of 2.15 years; and Control Group, including 22 subjects at a mean initial age of 12.67 years, who were not submitted to any type of orthodontic treatment and presenting Class II malocclusion, observed by a mean period of 2.12 years. It was evaluated the lateral cephalograms before and after orthodontic treatment of each subject from the three groups evaluated. Initial and final dentoskeletal cephalometric variables and changes with treatment were compared among the groups by ANOVA and Tukey test. The Jasper Jumper group presented a greater restriction of growth and anterior displacement of the maxilla and a greater maxillary retrusion and the MPA group showed a significantly greater increase of mandibular effective length. Both experimental groups showed a significant improve of maxillomandibular relationship and a significant reduction of the facial convexity in relation to control group. There was increase of posterior facial height in MPA group related to control. Maxillary incisors presented greater retrusion and palatal inclination in MPA group, with significant differences with Jasper Jumper and control groups. Regarding mandibular incisors, the MPA groups presented greater buccal inclination and Jasper Jumper group showed greater protrusion of these incisors, with significant differences to control group. MPA and Jasper Jumper groups presented an extrusion of mandibular molars, a decrease in overbite and overjet related to control, and MPA group presented decrease of overjet also in relation to the Jasper Jumper group.

O objetivo deste estudo prospectivo foi avaliar as alterações dentoesqueléticas e tegumentares de jovens com má oclusão de Classe II tratados com distalizador First Class em dois tipos diferentes de ancoragem. Foram selecionados 30 pacientes e divididos, aleatoriamente, em dois grupos de 15: G1 (5 masculino e 10 feminino) que recebeu o distalizador com ancoragem convencional no botão de Nance e G2 (10 masculino e 5 feminino) que recebeu o distalizador com ancoragem esquelética apoiado em 2 mini-implantes no palato, com médias de 13,00 e 13,28 anos de idade, respectivamente. As telerradiografias foram obtidas antes e após a distalização dos molares para a realização das análises cefalométricas. A análise estatística foi realizada pelo teste t dependente com a finalidade de verificar as alterações ocorridas dentro de um mesmo grupo e pelo teste t independente para verificar as diferenças entre os grupos. Foi calculado também o erro sistemático e casual. O tempo médio de tratamento foi de 4,51 e 6,28 meses para G1 e G2, respectivamente. Ambos os grupos apresentaram alterações dentárias significantes com distalização (G1=2,39 mm; G2=2,21 mm), angulação distal (G1=10,51º; G2=4,49º) e intrusão (G1=0,53 mm; G2=0,10 mm) dos primeiros molares superiores, sendo apenas sem significância a intrusão em G2. A perda de ancoragem foi semelhante entre os dois grupos, com significante mesialização (G1=2,78 mm; G2=3,11 mm) e angulação mesial (G1=4,95°; G2=4,69°) dos segundos pré-molares, protrusão (G1=1 ,55 mm; G2=1,94 mm) e vestibularização (G1=5,78°; G2=3,13°) significantes dos incisivos superiores e um aumento significante no trespasse horizontal (G1=1,07 mm; G2=0,81 mm). A mecânica de distalização não interferiu nos componentes esqueléticos e tegumentares dos pacientes. Em ambos os grupos, o distalizador First Class promoveu correção da relação molar, porém apresentou efeitos de perda de ancoragem verificada nos pré-molares e incisivos superiores mesmo quando associada à mini-implantes. Não houve diferença significante entre os grupos quanto às alterações dentárias lineares, porém as angulares foram significantemente menores no grupo com ancoragem esquelética. / The aim of this prospective study was to evaluate the dental, skeletal and soft tissue changes in youngsters with Class II malocclusion treated with First Class distalizer in two different types of anchorage. Thirty patients were included and divided, randomly, in two groups of 15. G1 (5 boys and 10 girls) that received distalizers with conventional anchorage (Nance button) and G2 (10 boys and 5 girls) that received distalizers with skeletal anchorage supported in two palatal mini-implants, average age of 13.00 and 13.28 years old, respectively. Lateral cephalometric radiographs were taken before and after molar distalization in order to the cephalometric analysis. Statistical analysis was performed by dependent t test to verify the changes occurred in the same group and by independent t test to verify the difference between the groups. The systematic and casual errors were calculated as well. The mean treatment period was 4.51 and 6.28 months for G1 and G2, respectively. Both groups showed significant dental changes with distalization (G1=2.39 mm; G2=2.21 mm), distal tipping (G1=10.51º; G2=4.49º) and intrusion (G1=0.53 mm; G2=0.10 mm) of maxillary first molars, just intrusion in G2 was not significant. Anchorage loss showed similar in both groups with significant mesialization (G1=2.78 mm; G2=3.11 mm) and mesial tipping (G1=4.95°; G2=4.69°) of maxillary second premolars, significant protrusion (G1=1.55 mm; G2=1.94 mm) and proclination (G1=5.78°; G2=3.13°) of maxillary incisors and significant increase in overjet (G1=1.07 mm; G2=0.81 mm). Distalization mechanic did not interfere in skeletal and soft tissue measurements of patients. In both groups, the First Class distalizer corrected the molar relationship, however it showed anchorage loss effects in maxillary premolars and incisors even when associated to mini-implants. There was no significant difference between the groups on dental linear changes, however the dental angular changes were significantly lower in skeletal anchorage group.

O objetivo deste estudo foi avaliar as alterações dentoesqueléticas, tegumentares e transversais do arco superior de jovens com má oclusão de Classe II predominantemente dentária, tratados com o distalizador First Class em ancoragem convencional e esquelética. A amostra foi composta por 30 pacientes divididos em três grupos com 10 pacientes cada, nomeados G1 (ancoragem convencional), G2 (ancoragem esquelética) e G3 (modificado com ancoragem squelética). As telerradiografias laterais, para todos os grupos, e os modelos de documentação, para G2 e G3, foram obtidos antes e após a distalização dos molares sendo posteriormente digitalizados para a realização da análise cefalométrica e de modelos digitais. Os dados foram analisados por meio dos testes t pareado, para verificar as alterações produzidas em um mesmo grupo nos tempos inicial e pós distalização, e ANOVA seguido do Teste de Tukey para verificar as diferenças entre os grupos, para dados com distribuição não normal foram utilizados os testes de Wilcoxon e Kruskal-Wallis. O tempo médio de tratamento foi de 4,62 meses para o G1; 5,41 meses para o G2 e 3,91 meses para o G3, não havendo diferença entre eles. A análise dos primeiros molares demonstrou que todos os grupos presentaram alterações dentárias significantes na angulação (G1= -8,42o; G2= -5,98o; G3= - 6,12o), apenas os grupos G1 e G3 (G1= -1,63 mm; G2= -1,31 mm; G3= - 1,91 mm) apresentaram alterações significantes na distalização e não foram detectadas alterações verticais (G1= -1,63 mm; G2= -1,31 mm; G3= -1,91 mm). A perda de ancoragem anterior foi significantemente menor para os valores angulares no G3 demonstrando uma suave vestibularização dos incisivos centrais (G1= 4,76o; G2= 4,49o; G3= 0,64o) e menor angulação mesial dos segundos pré-molares (G1= 6,69o; G2= 10,29o; G3= 3,55o), não havendo diferenças entre os grupos para os componentes lineares horizontais (G1= 1,77 mm; G2= 1,72 mm; G3= 1,05 mm) e verticais (G1= -0,17 mm; G2= -0,02 mm; G3= 0,31mm) dos incisivos e lineares horizontais (G1= 2,88 mm; G2= 3,19 mm; G3= 2,43 mm) e verticais (G1= 0,37 mm; G2= 0,63 mm; G3= 0,95 mm) dos segundos pré-molares. A distalização promoveu ainda um aumento mais acentuado da AFAI para o G3 (G1= 0,49 mm; G2= 1,20 mm; G3= 1,71 mm) e uma menor alteração do ANL também para o G3 (G1= -4,71o; G2= -2,82º; G3= 0,42o). A análise dos modelos digitais demonstrou diferença significante apenas para a distância entre segundos pré-molares (G2= -2,14 mm; G3= -1,10 mm). Todos os aparelhos estudados são eficazes para realizar a correção da relação molar promovendo uma perda de ancoragem anterior, sendo este efeito indesejado menor para o distalizador First Class modificado associado à ancoragem esquelética. / The aim of this study was to evaluate the dentoskeletal, soft tissue and maxillary transverse dimensions changes in youngsters with dental Class II malocclusion treated with First Class distalizer in skeletal and conventional anchorage. Thirty patients were included and divided in three groups of 10 patients each, named G1 (conventional anchorage), G2 (skeletal anchorage) and G3 (modified First Class with skeletal anchorage). Lateral radiographs, for all groups, and dental casts, for G2 and G3, were obtained before and after molar distalization and subsequently scanned to perform cephalometric and digital models analysis. Data were analyzed using paired t tests to verify the same group changes at initial and after distalization time, and ANOVA followed by Tukey test to detect differences between groups, for data with non-normal distribution were used Wilcoxon and Kruskal-Wallis tests. No difference was found in treatment time (G1= 4.62 months, G2= 5.41 months, G3= 3.91 months). First molars analysis showed that all groups had significant dental angulation changes (G1= -8.42o, G2= -5.98o, G3= -6.12°), G1 an d G3 showed significant distalization changes (G1= -1.63 mm, G2= -1.31 mm; G3= - 1.91 mm) and no vertical changes were detected (G1= -1.63 mm, G2= -1.31 mm, G3= -1.91 mm). Anchorage loss was significantly smaller to the G3 angular measurements, demonstrating a little incisors vestibularization (G1= 4.76o, G2= 4.49o, G3= 0.64o) and little second premolars mesial angulation (G1= 6.69o, G2= 10.29o, G3= 3.55o), with no horizontal linear changes (G1= 1.77 mm, G2= 1.72 mm, G3= 1.05 mm) and no vertical linear differences between groups (G1= -0.17 mm , G2= -0.02 mm, G3= 0.31 mm) of incisors and horizontal linear (G1= 2.88 mm, G2= 3.19 mm, G3= 2,43 mm) and vertical (G1= 0.37 mm, G2= 0.63 mm, G3= 0.95 mm) of the second premolars. Distalization increased the LAFH to G3 (G1= 0.49 mm, G2= 1.20 mm, G3= 1.71 mm) and also promoted changes in G3 NLA (G1= -4.71o, G2= -2.82o, G3= 0.42°). Digital models analysis showed a significant difference only for the second premolars transverse dimension (G2 = -2.14 mm; G3= -1.10 mm). All devices studied were effective to perform the molar relationship correction, resulting an anchorage loss, this unwanted effect was lesser with modified First Class distalizer with skeletal anchorage.