Background: Approximately 1000 children with a congenital heart disease are born in Sweden each year. Congenital heart diseases include malformations of the heart which comprise various anatomical differences. Progresses in diagnostics and treatment of the cardiac diseases have contributed to the survival of these young adults which makes a new and growing group of patients. Aim: The aim of this study was to describe young adults' between the ages of 13-40 experiences of living with congenital heart disease. Method: A literature study based on qualitative studies from Cinahl and PubMed was performed. Ten articles were analyzed by content analysis. Results: The results of the study present two main categories "accept one's heart disease" and "challenge to accept one's heart disease" with a total of ten subcategories. Conclusion: Individuals with congenital heart disease may experience their situation in various ways and they may or may not have accepted their congenital heart disease. Some individuals feel that the disease contributes to personal strength, while others are living with a constant presence of anxiety over the fact that life can change for the worse at any time.

This dissertation should supplement the knowledge of the genetic coronary heart disease (CHD) architecture by analysing known common variation as well as finding novel associated loci and genes. Genotype and allele frequencies, also haplotype blocks were determined in the Lithuanian population according to the list of 60 SNPs associated with CHD. The number of risk alleles per person was determined. The intrapopulation comparison of allele frequencies and haplotype blocks was performed. Allele frequencies were compared with different populations of European ancestry. The association analyses for new loci and candidate gene identification were performed. It was revealed that the common and unique genetic disease architecture variants for different populations exist. Regarding the genetic structure and diversity of the risk SNPs of CHD, Lithuanian population as compared with the European populations falls into the Northern-Southern gradient showing that the Lithuanian gene pool could have experienced the geographical climate and ecological influence during the evolution process. Considering the risk allele number per person of the investigated SNPs, the majority of Lithuanian population individuals have a relatively average risk of developing CHD. Association analyses showed eight new loci associated with CHD, four of which were confirmed and ITPR2 and FBXL17 were found to be the putative candidate genes that could participate in the pathogenesis of CHD and atherosclerosis. / Siekiant papildyti žinias apie genetinę koronarinės širdies ligos (KŠL) architektūrą, užsibrėžta atlikti žinomų genetinių sričių siejamų su KŠL analizę ir naujų genetinių sričių siejamų su šia liga paiešką Lietuvos populiacijoje. Pagal atrinktas žinomas 60 genetinių sričių, siejamų su rizika susirgti KŠL, tiriamiems asmenims nustatyti genotipų ir alelių dažniai, sukonstruoti haplotipų blokai, atliktas vidupopuliacinis alelių dažnių ir haplotipų blokų palyginimas, tarppopuliacinis alelių dažnių palyginimas, nustatytas rizikos alelių tenkančių asmeniui pasiskirstymas populiacijoje. Nustatyta, kad skirtingoms populiacijoms yra būdingi tiek bendri, tiek ir unikalūs genetinės architektūros vienetai, o bendros Lietuvos lietuvių populiacijos genetinę struktūrą ir įvairovę pagal tirtus žymenis galima orientuoti gradientiškai Europos Šiaurės-Pietų kryptimi, tai aiškinant geografinių platumų lemiama klimato ir ekologijos įtaka genofondui evoliucijos eigoje. Pagal tirtų rizikos alelių skaičių tenkantį asmeniui, daugiausia asmenų tirtoje Lietuvos lietuvių populiacijoje turi vidutinę riziką susirgti KŠL. Genetinės asociacijos analize nustatytos aštuonios potencialios naujos kandidatinės su KŠL asocijuotos genetinės sritys, iš jų patvirtintos – keturios, o ITPR2 ir FBXL17 genai yra galimi genai kandidatai dalyvaujantys KŠL ir aterosklerozės patogenezėje.

Siekiant papildyti žinias apie genetinę koronarinės širdies ligos (KŠL) architektūrą, užsibrėžta atlikti žinomų genetinių sričių siejamų su KŠL analizę ir naujų genetinių sričių siejamų su šia liga paiešką Lietuvos populiacijoje. Pagal atrinktas žinomas 60 genetinių sričių, siejamų su rizika susirgti KŠL, tiriamiems asmenims nustatyti genotipų ir alelių dažniai, sukonstruoti haplotipų blokai, atliktas vidupopuliacinis alelių dažnių ir haplotipų blokų palyginimas, tarppopuliacinis alelių dažnių palyginimas, nustatytas rizikos alelių tenkančių asmeniui pasiskirstymas populiacijoje. Nustatyta, kad skirtingoms populiacijoms yra būdingi tiek bendri, tiek ir unikalūs genetinės architektūros vienetai, o bendros Lietuvos lietuvių populiacijos genetinę struktūrą ir įvairovę pagal tirtus žymenis galima orientuoti gradientiškai Europos Šiaurės-Pietų kryptimi, tai aiškinant geografinių platumų lemiama klimato ir ekologijos įtaka genofondui evoliucijos eigoje. Pagal tirtų rizikos alelių skaičių tenkantį asmeniui, daugiausia asmenų tirtoje Lietuvos lietuvių populiacijoje turi vidutinę riziką susirgti KŠL. Genetinės asociacijos analize nustatytos aštuonios potencialios naujos kandidatinės su KŠL asocijuotos genetinės sritys, iš jų patvirtintos – keturios, o ITPR2 ir FBXL17 genai yra galimi genai kandidatai dalyvaujantys KŠL ir aterosklerozės patogenezėje. / This dissertation should supplement the knowledge of the genetic coronary heart disease (CHD) architecture by analysing known common variation as well as finding novel associated loci and genes. Genotype and allele frequencies, also haplotype blocks were determined in the Lithuanian population according to the list of 60 SNPs associated with CHD. The number of risk alleles per person was determined. The intrapopulation comparison of allele frequencies and haplotype blocks was performed. Allele frequencies were compared with different populations of European ancestry. The association analyses for new loci and candidate gene identification were performed. It was revealed that the common and unique genetic disease architecture variants for different populations exist. Regarding the genetic structure and diversity of the risk SNPs of CHD, Lithuanian population as compared with the European populations falls into the Northern-Southern gradient showing that the Lithuanian gene pool could have experienced the geographical climate and ecological influence during the evolution process. Considering the risk allele number per person of the investigated SNPs, the majority of Lithuanian population individuals have a relatively average risk of developing CHD. Association analyses showed eight new loci associated with CHD, four of which were confirmed and ITPR2 and FBXL17 were found to be the putative candidate genes that could participate in the pathogenesis of CHD and atherosclerosis.

No description available.

No description available.

Magister Chirurgiae Dentium - MChD (Oral Medicine and Periodontics) / The aim of this study was to assess whether a mouthwash containing carbohydrate derived fulvic acid, is effective in reducing the salivary microbial count pre-operatively. Endeavours have been made to reduce the risk of infection, bacteraemia and cross-contamination during dental procedures by the application of topical antimicrobial agents. To date chlorhexidine is the most widely evaluated and efficacious agent against oral biofilms but there have been reports of adverse effects ranging from contact dermatitis to severe anaphylactic shock. A new mouth rinse containing carbohydrate derived fulvic acid are reported to have broad spectrum antimicrobial activity against specific oral microbes and Candida albicans with no side effects.

Made available in DSpace on 2014-12-17T14:13:26Z (GMT). No. of bitstreams: 1 EduardoJGS.pdf: 119973 bytes, checksum: dbdb322fee12ba3edd9d72e5446d9c91 (MD5) Previous issue date: 2009-09-23 / The science of Dentistry wishes obtains the ideal solution for the dental plaque chemical control. This research evaluated antimicrobial action capacity in calcium hydroxide and tergentol various solutions starting for the CHD 20, a root canals irrigating solution with a reason of 80% calcium hydroxide saturated solution and 20% tergentol detergent with the aim of evaluate this drug mouth rinse indication with prevention or combat objective for dental caries and periodontal diseases. Antibiogram disks and biofilm tests were accomplished for the microorganisms: Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus and Lactobacillus casei. Different reasons of detergent for the calcium hydroxide saturated solution, tergentol and distillated water solution, 0,12% clorhexydine digluconate solution was positive control and distillated water was negative control. The results showed better performance of clorhexydine in relation to calcium hydroxide directing to not accept this (CHD20) as mouth rinse solution / Na busca pela ci?ncia odontol?gica de se chegar ao composto que possa ser considerado o agente ideal para o controle qu?mico do biofilme dental foi idealizado este estudo. Avaliou-se a capacidade antimicrobiana in vitro de diferentes solu??es a base de hidr?xido de c?lcio e tergentol partindo em princ?pio do HCT 20, solu??o irrigadora dos canais radiculares composta por 80% da solu??o saturada de hidr?xido de c?lcio (?gua de cal) e 20% do detergente tergentol buscando verificar sua poss?vel indica??o como solu??o para bochechos, visando preven??o ou combate a doen?as como c?rie dent?ria e doen?a periodontal. No laborat?rio de microbiologia do Departamento de Odontologia da UFRN, foram realizados testes em discos de antibiograma para os microrganismos: Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Bem como em bact?rias formadoras de biofilme para os mesmos, ? exce??o do L. casei. Estipulou-se diferentes concentra??es de tergentol para a ?gua de cal, al?m do tergentol em ?gua destilada, usou-se digluconato de clorexidina a 0,12% como controle positivo e ?gua destilada como controle negativo. Os resultados mostraram desempenho inferior das solu??es a base de Ca(OH)2 em rela??o ? clorexidina frente a estes microrganismos e ? metodologia empregada, direcionando pois, para a n?o indica??o do uso do HCT 20 como colut?rio bucal

As the leading cause of death in the United States, coronary heart disease (CHD) is a growing public health problem, despite the fact that many risk factors for the disease are preventable, especially if addressed early in life. The purpose of the current study was to examine the effects of loss-framed versus gain-framed versus information-only health messages on both intention to attend and actual attendance at an appointment to get screened for CHD risk factors (i.e., hypertension, diabetes, and dyslipidemia). It was hypothesized that a population of young adults would be more likely to view screening for CHD risk factors as a low-risk, health-affirming behavior as opposed to a risky, illness-detecting behavior and would thus be more strongly influenced by gain-framed messages than loss-framed messages. Additional goals included the exploration of the extensively researched individual health beliefs of perceived threat (as defined by the health belief model) and health locus of control as they relate to message frames. One hundred forty-three undergraduate students were randomly assigned to either the loss-framed, gain-framed, or information-only control conditions. Framing manipulation checks revealed that participants failed to discern differences in the tone and emphasis of the experimental pamphlets. As a result, no tests of framing effects could be conducted. Sixteen (11.2%) of the 143 participants who participated in Part 1 of the experiment participated in Part 2 (i.e., attended a risk factor screening appointment). Multiple regression analysis revealed risk index, age, and powerful others health locus of control as significant predictors of screening intention. Gender was the only demographic or health related variable that was significantly related to screening outcome, such that women were more likely to get screened than men. Limitations and recommendations are discussed.

Having a heart healthy lifestyle at a younger age is beneficial in reducing the risk of coronary heart disease (CHD) in adulthood and various health education programs for CHD prevention exist to persuade young adults to adopt a heart healthy lifestyle. Little is known, however, about the influence of watching live open heart surgery on young adults' adoption of a heart healthy lifestyle. To address that gap in knowledge, this study was conducted at a health facility in Virginia where students came to observe live open heart surgery. The purpose of the study was to understand whether watching live open heart surgery can influence young adults' attitudes and behaviors towards adopting a heart healthy lifestyle. The theory of health belief model and the theory of reasoned action were used in guiding this research. A quantitative design involving observation and administration of surveys was used. A survey with questions about participants' lifestyle practices was administered prior to observation of open heart surgery and 3 or more months afterwards. A total number of 179 young adults at baseline were considered eligible for the study. Ages of the research participants were between 18 and 35 years old. The t test and ANOVA results showed no significant differences between baseline and follow up data with regards to changes in behaviors of young adult students towards adopting a heart healthy lifestyle. The study concluded that observing live heart surgery did not significantly change behaviors of the students in adopting a heart healthy lifestyle. In order to achieve the desired changes in attitudes and behavior of students, looking into other evidence based options and pursuing those that can influence and motivate young adult students to adopt a heart healthy lifestyle can be a positive social change.

No description available.