Studies of cerebellum-like circuits in fish have demonstrated that synaptic plasticity shapes the motor corollary discharge responses of granule cells into highly-specific predictions of self- generated sensory input. However, the functional significance of such predictions, known as negative images, has not been directly tested. Here we provide evidence for improvements in neural coding and behavioral detection of prey-like stimuli due to negative images. In addition, we find that manipulating synaptic plasticity leads to specific changes in circuit output that disrupt neural coding and detection of prey-like stimuli. These results link synaptic plasticity, neural coding, and behavior and also provide a circuit-level account of how combining external sensory input with internally-generated predictions enhances sensory processing. In addition, the mammalian dorsal cochlear nucleus (DCN) integrates auditory nerve input with a diverse array of sensory and motor signals processed within circuity similar to the cerebellum. Yet how the DCN contributes to early auditory processing has been a longstanding puzzle. Using electrophysiological recordings in mice during licking behavior we show that DCN neurons are largely unaffected by self-generated sounds while remaining sensitive to external acoustic stimuli. Recordings in deafened mice, together with neural activity manipulations, indicate that self-generated sounds are cancelled by non-auditory signals conveyed by mossy fibers. In addition, DCN neurons exhibit gradual reductions in their responses to acoustic stimuli that are temporally correlated with licking. Together, these findings suggest that DCN may act as an adaptive filter for cancelling self-generated sounds. Adaptive filtering has been established previously for cerebellum-like sensory structures in fish suggesting a conserved function for such structures across vertebrates.

The study of cerebellum-like circuits allows many points of entry. These circuits are often involved in very specific systems not found in all animals (for example electrolocation in weakly electric fish) and thus can be studied with a neuroethological approach in mind. There are many cerebellum-like circuits found across the animal kingdom, and so studies of these systems allow us to make interesting comparative observations. Cerebellum-like circuits are involved in computations that touch many domains of theoretical interest - the formation of internal predictions, adaptive filtering, cancellation of self-generated sensory inputs. This latter is linked both conceptually and historically to philosophical questions about the nature of perception and the distinction between the self and the outside world. The computation thought to be performed in cerebellum-like structures is further related, especially through studies of the cerebellum, to theories of motor control and cognition. The cerebellum itself is known to be involved in much more than motor learning, its traditionally assumed function, with particularly interesting links to schizophrenia and to autism. The particular advantage of studying cerbellum-like structures is that they sit at such a rich confluence of interests while being involved in well-defined computations and being accessible at the synaptic, cellular, and circuit levels. In this thesis we present work on two cerebellum-like structures: the electrosensory lobe (ELL) of mormyrid fish and the dorsal cochlear nucleus (DCN) of mice. Recent work in ELL has shown that a temporal basis of granule cells allows the formation of predictions of the sensory consequences of a simple motor act - the electric organ discharge (EOD). Here we demonstrate that such predictions generalize between electric organ discharge rates - an ability crucial to the ethological relevance of such predictions. We develop a model of how such generalization is made possible at the circuit level. In a second section we show that the DCN is able to adaptively cancel self-generated sounds. In the conclusion we discuss some differences between DCN and ELL and suggest future studies of both structures motivated by a reading of different aspects of the machine learning literature.

In this study, five deaf individuals with cochlear implants were presented with noise that was manipulated systematically, to test the hypothesis that deaf persons using cochlear prostheses will demonstrate intensity regulation of their vocal output that is more appropriate when their implants are turned on than when turned off. The intensity of their vocal output was measured to determine if they demonstrated a Lombard response, that is, a systematic increase in vocal intensity with increasing intensity of background noise. Results from the study were mixed. With implants on, three subjects made systematic increases in vocal intensity with increasing background noise, while two subjects did not make such increases. In addition, the relation between intensity of vocal output and background noise was closer to the normal function for the three subjects who demonstrated a Lombard response. The "normal function" was defined by measuring the vocal intensity responses of five normal hearing control subjects who performed the same tasks as the experimental subjects.

Children with cochlear implants (CIs) typically have smaller lexicons in relation to their same-age hearing peers. There is also evidence that children with CIs show slower rates of vocabulary growth compared to hearing children. To understand why children with CIs have smaller vocabularies, we proposed to investigate their word learning process and determine how it compares to children with normal hearing. The present study explores multiple aspects of word learning - acquisition, extension, and retention - to better inform us about the real-world process of lexical acquisition in children with CIs. We evaluated 24 children with cochlear implants, 24 children with normal hearing matched by chronological age, and 23 children with normal hearing who were matched by vocabulary size. Participants were trained and tested on a word learning task that incorporated fast mapping, word extension, and word retention over two days. We also administered a battery of tests that included measures of receptive vocabulary and speech perception skills to determine which variables might be significant predictors of fast mapping and word retention. Children with CIs performed more poorly on word learning measures compared to their age-mates, but similarly to their vocabulary-mates. These findings indicate that children with CIs experience a reduced ability to initially form word-referent pairs, as well as extend and retain these pairs over time, in relation to their same-age hearing peers. Additionally, hearing age-mates and vocabulary-mates showed enhancement in their production of novel words over time, while the CI group maintained performance. Thus, children with CIs may not take the same route in learning new words as typically-developing children. These results could help explain, in part, why this population consistently demonstrates slower rates of vocabulary learning over time. Furthermore, we expected that speech perception and vocabulary size would relate to variations in fast mapping, as well as word retention. Neither of these variables proved to be significant predictors of fast mapping, but they were highly significant for word retention. Based on these findings, we may conclude that the factors that account for acquiring that first link between a word and its referent are not the same as those that are important for storing in a word in long-term memory.

Zugl.: Heidelberg, Pädag. Hochsch., Diss., 2005

Thesis (doctoral)--Medizinische Hochschule, 2001.

Zugl.: München, Univ., Diss., 2009

Thesis (Ph. D.)(Electronic Eng.)--University of Pretoria, 2004. / Includes bibliographical references.

The aim of this research is to improve the understanding of the impact on the cochlear dynamics corresponding to surgical tools, processes and hearing implants such that these can be designed more appropriately in the future. The results suggest that enhanced performance of implants can be achieved by optimisation of the location with respect to the cochlea and have shown that robotic surgical tools used to enable precise, simplified processes can reduce harm and offer other benefits. With an ageing population, and where exposure to noise on daily basis is increased rather than industrial settings, at least two factors of age and noise, will contribute to a greater incidence of hearing loss in the population in the future. In the research a mathematical model of the passive cochlea was produced to increase understanding of the sensitivity and behaviour of the fluid, structure and pressure transients within the cochlea. The investigation has been complemented by an innovative experimental technique developed to evaluate the dynamics in the cochlear fluids while maintaining the integrity of the cochlear structure. This technique builds on the success of the state-of-the-art surgical robotic micro-drill. The micro-drill enables removal of bone tissue to prepare a consistent aperture onto the endosteal membrane within the cochlea. This is known as preparing a ‘Third window’. In this technique the motion of the exposed endosteal membrane is treated as the diaphragm element of a pressure transducer and is measured using a Micro- Scanning Laser Vibrometer operating through a microscope. There are two principal outcomes of the research: First, the approach has enabled disturbances in the cochlea to be contrasted for different surgical techniques, which it is expected to allude preferential methods in future surgery in otology. In particular it was shown that when using the robotic micro-drill to create a cochleostomy that the disturbance amplitude reduces to 1% of that experienced when using conventional drilling. Secondly, an empirically derived frequency map of the cochlea has been produced to understand how the location of implants affects maximum power transmission over the required frequency band. This has also shown the feasibility of exciting the cochlea at a third window in order to amplify cochlear response.

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