The work is focused on combined transport in the Czech Republic and abroad. The theoretical part contains basic information about combined transport, as well as the combined transport in the CR, the most important terminals and information on individual subjects in combined transport. The work discusses the different development of combined transport both at home and in Germany. The next section discussed the problem of international combined transport and of course the positive aspects of its use. Conclusion of the theoretical part contains trend of combined transport and impact of the financial crisis. The practical part contains model calculation of the return on investment to swap bodies and demonstate the benefits of investment.

A LDE é uma nanoemulsão rica em colesterol com composição semelhante às lipoproteínas naturais. Devido a sua capacidade de ligação aos receptores da lipoproteína de baixa densidade (LDL) cuja expressão é aumentada em células neoplásicas, a LDE pode ser usada como veículo de agentes quimioterápicos concentrando os mesmos no tecido tumoral. A base racional da quimioterapia combinada é utilizar medicamentos que atuem em diferentes partes dos processos metabólicos da célula, aumentando dessa forma a probabilidade de destruição de uma maior quantidade de células tumorais. O principal fator limitante do uso combinado dos quimioterápicos paclitaxel e etoposídeo é o efeito mielossupressor. O direcionamento específico do fármaco às células tumorais promovido pela LDE, tornaria possível a terapia antitumoral combinada LDE-oleato de paclitaxel e LDEoleato de etoposídeo, sem produzir os efeitos colaterais observados com o uso combinado das formulações comerciais. O presente estudo tinha como objetivo avaliar os efeitos da terapia antitumoral combinada LDE-oleato de paclitaxel e LDEoleato de etoposídeo em comparação com a terapia dos respectivos fármacos isoladamente, bem como com a terapia combinada do paclitaxel e etoposídeo comerciais. A atividade antitumoral foi determinada em camundongos portadores de melanoma após a administração de intraperitoneal de LDE-oleato de paclitaxel 15 mg/kg e LDE-oleato de etoposídeo 10 mg/kg. Nos grupos dos fármacos comerciais injetou-se paclitaxel 3,75 mg/kg e etoposídeo 2,5 mg/Kg, ou paclitaxel 7,5 mg/Kg e etoposídeo 5 mg/kg. Os fármacos foram administrados em dois esquemas terapêuticos: 11º, 13º, 15º; e 11°, 14°, 19° dias após a inoculação do tumor. Todos os grupos apresentaram aumento na taxa de sobrevida em comparação ao grupo controle. Por outro lado, nos grupos LDE-fármacos foi observada uma redução dos efeitos de mielossupressão, visto que as doses administradas nestes grupos foram 2 e 4 vezes maiores do que nos demais. Os tratamentos do melanoma nos dois protocolos terapêuticos mostraram-se eficazes na redução da massa tumoral, sendo seu efeito inibitório acima de 90% nos grupos LDE-fármacos e na combinação dos quimioterápicos comerciais de maior dose. O número de metástases foi menor nos grupos de combinação LDE-Fármacos. Os resultados mostraram que a terapia antitumoral combinada LDE-oleato de paclitaxel e LDE-oleato de etoposídeo foi mais eficaz que as terapias isoladas destes fármacos e que a terapia combinada com o paclitaxel e etoposídeo comerciais. / LDE is a cholesterol-rich emulsion with similar composition to the natural lipoproteins. Due to its ability of binding to the Low Density Lipoprotein (LDL) receptors and concentrate in neoplastic cells which present overexpression of these receptors, LDE may be used as vehicle to target antineoplastic drugs against cancer cells. Combined chemotherapy is a therapeutic strategy against cancer that usually uses drugs that act in different parts of cells metabolism, increasing the chances of destruction of the cancer cells. In addition, adverse effects can be reduced when combining agents with different toxicities at lower doses than the usual in single therapy. The major limiting factor in combining the chemotherapeutic agents paclitaxel and etoposide is their side effects such as leukopenia, thrombocytopenia and anemia. The ability of LDE to carry the drug into the cell may bring a strong possibility of combining LDE- paclitaxel oleate and LDE-etoposide oleate without producing the toxic effects observed in the combined use of the commercial formulations of these drugs. The current study was designed to evaluate the effects of combined antitumoral therapy of LDE- paclitaxel oleate and LDE-etoposide oleate in comparison to the combination of commercial paclitaxel and etoposide formulations and to the single therapy with the same LDEagents. Antitumoral activity was determined in melanoma-bearing mice after injection of LDE-paclitaxel oleate 15 mg/kg and LDE-etoposide oleate 10 mg/kg, or commercial paclitaxel 3.75 mg/kg and etoposide 2.5 mg/kg, or commercial paclitaxel 7,5 mg/kg and etoposide 5 mg/kg. Drugs were administered in two protocols: 11º, 13º, 15º; and 11°, 14°, 19° days after tumor implantation. All groups had an increase in the survival rate in comparison to the control group, however LDE combination groups showed reduction in the bone marrow toxicity, since the doses used were 2 and 4 fold greater that in the commercial drugs groups. The tumor growth inhibition rate was greater in both LDE-drugs combination groups and in the higher dosage of paclitaxel and etoposide combination (over 90% in comparisson to the control). There were also great reduction of metastatic nodes in LDE-drugs combination groups in comparison to the commercial drugs combination groups. Our results showed that the antitumor combined therapy of LDE-paclitaxel oleate and LDE-etoposide oleate was more effective than the therapies with LDE-paclitaxel oleate and LDE-etoposide oleate alone, and the combined therapy of commercial paclitaxel and etoposide formulations.

Bakgrund Under de senare åren har ett flertal länder drabbats av bolagsskandaler som bidragit till en snabb utveckling inom corporate governance. För att förhindra liknande skandaler har mer eller mindre frivilliga regler för bolagsstyrning införts, så kallade koder. Bolagsskandaler har även inträffat i Sverige och 1 juli år 2005 infördes svensk kod för bolagsstyrning. Koden skall bidra till förbättrad styrning av bolag, stärka konkurrenskraften och främja förtroendet på kapitalmarknaden. Syfte Uppsatsens syfte är att beskriva och analysera om roll- och ansvarsfördelningen har förändrats mellan bolagsorganen efter införandet av svensk kod för bolagsstyrning. Genomförande Denna studie bygger på kvalitativ metod och tio intervjuer har genomförts. Intervjuer har skett med representanter från ägare, styrelse, bolagsledning, revisor samt respondenter med god kunskap inom bolagsstyrning. Resultat Studien visar att svensk kod för bolagsstyrning inte har haft någon större effekt på roll- och ansvarsfördelningen. Detta beror dels på att ABL redan har en tydlig fördelning mellan bolagsorganen och att behovet av en roll- och ansvarsförändring inte är lika stort i Sverige som i andra länder. Koden har dock stärkt ägarnas inflytande i bolag och ökat fokus på styrelsen. / Background During last years numerous countries have been hit by corporate scandals which have contributed to a rapid development within corporate governance. To prevent similar scandals, more or less volontary rules for corporate governance have been introduced, so called codes. Corporate scandals have also occurred in Sweden and July 1st 2005 a Swedish code for corporate governance was introduced. The code shall contribute to an improved control of corporations, strengthen competitiveness and promote trust in the capital market. Purpose This papers purpose is to describe and analyse if the role- and responsibility distribution have changed between corporate bodies after the introduction of a Swedish code for corporate governance. Implementation This study is based on qualitative method and ten interviews have been conducted. Interviews have taken place with representatives from owners, board of directors, corporate management, accountants and respondents with good knowledge within corporate governance. Result The study shows that Swedish code for corporate governance have not had any greater affect on the role- and responsibility distribution. Part of this is because ABL already has a clear distribution between the corporate bodies and the need for a role- and responsibility change is not as necessary as in other countries. However, the code have strengthened the owners influence in corporations and increased the focus on the board of directors.

The United Kingdom Combined Code is today the most fundamental corporate governance code applicable in United Kingdom. The nation of United Kingdom encourages governance practices by implementing the Directive 2006/46/EC on a voluntary basis before being mandatory. While corporate governance is applicable to many corporations, pension providers may be seen as one of the ideal market sector for governing, since they act as institutional investors representing a major shareholder group. Institutional investors may even improve corporate governance practices as they represent a major part of public sector capital. Owning large amount of shares, their function is to supervise in the firms’ corporate governance activities in order to monitor the transparency and disclosure procedures. To be able to monitor other companies' activities, pension providers must set up an example for enforcing corporate governance practices themselves and follow them respectively.   This descriptive case study observes the corporate governance structures represented in annual reports of five large chosen pension providers during the years 2007 to 2009 capturing the financial crisis occurring in 2008, in United Kingdom. The purpose of the study is to examine if strong corporate governance is incorporated in the following pension providers, Aberdeen Asset Management plc, Aviva plc, Prudential plc, Royal London Mutual Insurance Society Limited and Standard Life plc. The focus is on board composition and established committees. The scope of this study answers the following research question: How do the five pension providers, Aberdeen, Prudential, Royal London, Standard Life and Aviva, comply with or explain deviations found in their respectively annual reports from 2007-2009 in accordance with the Combined Code 2008 and the Annotated Combined Code 2005?   Fundamental for pension providers is to work on a long-term basis with value creation as goal. Still the core focus of corporate governance remains, to create a system offering protection for all stakeholders. As the result shows, all of the five chosen corporations strongly implement national corporate governance practices throughout 2007-2009 on both board composition and established committees. Still, they suffered short-term negative fluctuations from the United Kingdom financial crises in 2008, but recovered shortly afterwards. Even though these fluctuations occurred, all of the corporations have long-term value as one of their main objectives. The long-term value can partly be sustained by strong corporate governance practices as it a main objective in corporate governance.

<p>Bakgrund</p><p>Under de senare åren har ett flertal länder drabbats av bolagsskandaler som bidragit till en snabb utveckling inom corporate governance. För att förhindra liknande skandaler har mer eller mindre frivilliga regler för bolagsstyrning införts, så kallade koder. Bolagsskandaler har även inträffat i Sverige och 1 juli år 2005 infördes svensk kod för bolagsstyrning. Koden skall bidra till förbättrad styrning av bolag, stärka konkurrenskraften och främja förtroendet på kapitalmarknaden.</p><p>Syfte</p><p>Uppsatsens syfte är att beskriva och analysera om roll- och ansvarsfördelningen har förändrats mellan bolagsorganen efter införandet av svensk kod för bolagsstyrning.</p><p>Genomförande</p><p>Denna studie bygger på kvalitativ metod och tio intervjuer har genomförts. Intervjuer har skett med representanter från ägare, styrelse, bolagsledning, revisor samt respondenter med god kunskap inom bolagsstyrning.</p><p>Resultat</p><p>Studien visar att svensk kod för bolagsstyrning inte har haft någon större effekt på roll- och ansvarsfördelningen. Detta beror dels på att ABL redan har en tydlig fördelning mellan bolagsorganen och att behovet av en roll- och ansvarsförändring inte är lika stort i Sverige som i andra länder. Koden har dock stärkt ägarnas inflytande i bolag och ökat fokus på styrelsen.</p> / <p>Background</p><p>During last years numerous countries have been hit by corporate scandals which have contributed to a rapid development within corporate governance. To prevent similar scandals, more or less volontary rules for corporate governance have been introduced, so called codes. Corporate scandals have also occurred in Sweden and July 1st 2005 a Swedish code for corporate governance was introduced. The code shall contribute to an improved control of corporations, strengthen competitiveness and promote trust in the capital market.</p><p>Purpose</p><p>This papers purpose is to describe and analyse if the role- and responsibility distribution have changed between corporate bodies after the introduction of a Swedish code for corporate governance.</p><p>Implementation</p><p>This study is based on qualitative method and ten interviews have been conducted. Interviews have taken place with representatives from owners, board of directors, corporate management, accountants and respondents with good knowledge within corporate governance.</p><p>Result</p><p>The study shows that Swedish code for corporate governance have not had any greater affect on the role- and responsibility distribution. Part of this is because ABL already has a clear distribution between the corporate bodies and the need for a role- and responsibility change is not as necessary as in other countries. However, the code have strengthened the owners influence in corporations and increased the focus on the board of directors.</p>

Os sistemas combinados anaeróbio/aeróbio, para tratamento de água residuária, têm sido considerados alternativas viáveis do ponto de vista técnico-econômico em relação aos sistemas tradicionais. Este trabalho consiste no desenvolvimento de nova configuração para um sistema, com dois reatores operados seqüencialmente, composto por Reator Misto Radial de Leito Fixo para tratamento e nitrificação de esgoto sanitário e Reator Anóxico Horizontal de Leito Fixo para desnitrificação da água residuária. O RMRLF mostrou ser uma configuração promissora, promoveu a remoção de matéria orgânica, favoreceu a transferência de oxigênio dissolvido devido à distribuição das espumas em seções circuncêntricas, obteve boa nitrificação e possibilitou a desnitrificação simultânea com a nitrificação. O RAHLFa obteve baixa eficiência no processo de desnitrificação. O bom desempenho do sistema é decorrente, principalmente, da operação do RMRLF e apresentou eficiências de 88%, 86% e 95% na remoção de matéria orgânica em termos de demanda química de oxigênio, retenção de sólidos suspensos voláteis e nitrificação, respectivamente. O efluente final do sistema atingiu valores de demanda química de oxigênio, sólidos suspensos voláteis, nitrito e nitrato de 41 mg.l-1, 8 mg.l-1, 0,3 mg.l-1 e 16,7 mg.l-1, respectivamente. No efluente final não foi detectada a presença de nitrogênio amoniacal. / The combined, anaerobic/aerobic systems for wastewater treatment, are considered as possible alternatives from the technical-economical perspective, in relation to the traditional systems. The data obtained on the development and operation of a new system configuration of two reactor sequentially operated, composed of a Radial Flow Anaerobic/Aerobic Immobilized Biomass reactor (RFAAIB) for domestic sewage treatment and a Horizontal-flow Anoxic Immobilized Biomass (HAIBa) for wastewater denitrification are presented. The RFAAIB reactor was found to be a very promising configuration for promoting the organic matter removal, due to its round shape distribution of the foam matrix it favored the dissolved oxygen transfer, obtaining good nitrification and making possible to achieve simultaneous nitrification and denitrification. The HAIBa reactor obtained low efficiency in the denitrification process. The good system performance is mainly due to the RFAAIB reactor it achieved efficiency of 88%, 86% and 95% in the biochemical oxygen demand reduction process, volatile suspended solids retention and nitrification, respectively. The system final effluent achieved chemical oxygen demand, volatile suspended solids, nitrite and nitrate values of 41 mg.l-1, 8 mg.l-1, 0,3 mg.l-1 and 16,7 mg.l-1, respectively. In the final effluent no ammonium nitrogen was detected.

Introduction and Background: Measles, mumps and rubella (MMR) are infectious diseases, primarily of childhood, which cause significant mortality and morbidity globally. These infections are, however, vaccine preventable and there is potential for them to be eradicated worldwide through the strategic use of organised population immunisation programmes. Following the introduction of the MMR vaccination in the UK in 1988, uptake was initially good and a high level of population vaccination coverage was achieved. This was sustained until 1998 when a study by Dr Wakefield and colleagues was published in the Lancet suggesting the theoretical possibility of an association between MMR and Autism/bowel disease. Intense media coverage followed, uptake of MMR vaccine fell to less than 80% in Somerset, and community outbreaks of measles, which had almost been eliminated in the UK, began to reappear. The Wakefield study was subsequently discredited and was eventually retracted by the Lancet in 2010. In August 2008 the Chief Medical Officer announced a national MMR catch-up campaign, targeting all children between the age of 13 months and 18 years who had either not been vaccinated against measles, mumps and rubella, or had only partial immunisation. These children were invited again for vaccination and the campaign was completed in January 2009. This study was undertaken to explore, in depth, the quantitative data available in respect of the uptake of MMR at the time of the 2009 campaign, and also to provide new qualitative data in relation to the attitudes, beliefs and experience of MMR and immunisation services of parents who continued to decline MMR for their children after the 2009 campaign, in order to identify factors which affected parental decision-making, add to the wider knowledge base, and to use this knowledge to improve the future development of immunisation services in Somerset. Methods: The overall objective of the study was to investigate a number of social, demographic and geographic characteristics of parents and children associated with MMR uptake, to compare these characteristics within and between defined sub-sets of the Somerset population, and to explore the basis on which parents in Somerset make decisions in relation to MMR immunisation. The study design adopted was a ‘mixed methods’ approach comprising of a cross-sectional design with three sequential phases - an exploration of baseline epidemiological data; a survey conducted with parents of children who remained unimmunised after 2009; and finally, semi-structured interviews with a sub-set of these parents. Results: The key findings from the study are: Parents who decline MMR for their children are not a homogenous group, but consist of a number of sub-groups each of which have different motives, decision pathways and predicted outcomes in relation to potential to change their mind and accept MMR There are differences in geographic distribution between the two age groups investigated Whilst the ‘Wakefield’ study did, and still does have, an impact, it is not the only or most important factor in their continuing decision-making. There is evidence that health professionals have a key role in addressing parental concerns in respect of immunisation. GP practice was the most significant factor associated with uptake in the Phase 1 study, and this was further confirmed in interviews with parents. Parents make decisions through engagement, through communicating and relating to others and this offers a potential mechanism for health professionals to influence decisions through open engagement with parents. Discussion and Conclusions: Three parent sub-groups were identified (Single Vaccines; Medical Comorbidities and Natural Health). These sub-groups were further investigated and factors associated with the decision-making pathways of each group were identified. This resulted in the development of the ‘MMR Parent Engagement Framework’ as a tool for use by professionals in planning their interactions with parents to improve and encourage more open dialogue in order to positively influence parental decision-making in relation to accepting MMR or other vaccinations. From a commissioning perspective, embedding frameworks such as this in service specifications offers a more cost-effective approach to improving immunisation uptake than funding large, poorly targeted catch-up campaigns. It is therefore recommended that further research is undertaken to provide evidence of the effectiveness of the approach in practice, and to inform future commissioning decisions. Additional recommendations to improve the effectiveness and delivery of immunisation services are also made in respect of GP Practice specific factors, independent schools, ethnic minority communities, vaccine overload, media, and data validation. The study has already directly influenced changes in current practice at both a local and a national level.

The goal of this thesis is to give an overview of road-rail combined transport in Czech republic and in Europe. On the example of combined transport operator Bohemiakombi s.r.o. will be described how do such operators work and which obstacles they face under Czech and European conditions.

This master’s thesis deals with the design of a heat recovery steam generator. The introductory part of the thesis is dedicated to waste heat boilers, their division and their utilization in combined cycles gas turbine. In the following chapter, an analysis of the existing combined heat and power plant operation is performed. In the next part of the thesis, the conceptual layout of the new source is designed. Subsequently, the thermal calculation of the boiler is carried out as well as the design of individual heat exchanging surfaces. The sixth chapter deals with the strength calculation of the boiler and the outer piping, chambers and drum are designed here. At the end of the thesis there are described off-design states of the new combined cycle gas turbine.

Aus der Einleitung: "Durch die Verwendung von Kraft-Wärme-Kopplung (KWK) kann sowohl die erzeugte elektrische als auch die anfallende thermische Energie genutzt und somit der Nutzungsgrad der eingesetzten Primärenergie deutlich gesteigert werden. Dieses Konzept wird sowohl in Blockheizkraftwerken (BHKW) wie auch in Range Extendern (RE) verwendet (Ferrari et al. 2012). Die bisher geringe Reichweite von Elektrofahrzeugen wird durch die zusätzlich vom RE bereitgestellte elektrische Energie erweitert. ..."