Proefschrift Universiteit van Amsterdam. / Auteursnaam op omslag: Stephan ten Hagen. Met lit. opg. - Met samenvatting in het Nederlands.

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Thesis (PhD (Biochemistry))--University of Stellenbosch, 2011. / ENGLISH ABSTRACT: Metabolic Control Analysis (MCA) provides a powerful quantitative framework for understanding and explaining the control and regulation within a cellular system. MCA allows the global control of a steady-state system to be quantified in terms of control coeficients, which we can express in terms of the local properties referred to as elasticity coeficients. MCA relates elasticities to control coeficients through a matrix inversion, thus allowing scientists to predict and quantify how the kinetics of the individual enzymes affect the systemic behaviour of cellular systems. Traditionally we solved this problem numerically, while we used algebraic and symbolic control analysis techniques less frequently. By using symbolic algebraic computation we present a general implementation of the symbolic matrix inversion of MCA, known as SymCA, which requires only the description of any allosteric modifier interactions and the stoichiometry of a cellular system. The algebraic expressions generated allow an in-depth analysis of the distribution of the control within a system and also of the parameters which exhibit the greatest effect on this control distribution. This also applies when the exact values for the elasticities or control coeficients are unknown. We have demonstrated that by quantifying the control patterns, referred to as `routes of regulation', inherent in all control coeficient expressions, we can gain insight into how perturbations are propagated through a cellular system and which regulatory pathways are favoured under changing conditions. / AFRIKAANSE OPSOMMING: Metaboliese Kontrole-Analise (MKA) bied 'n kragtige kwantitatiewe raamwerk om die beheer en regulering binne sellulere sisteme te verstaan en te verduidelik. 'n Sleutelaspek van MKA is dat die globale beheer van 'n sisteem met 'n bestendige toestand gekwantifiseer kan word in terme van kontrole-koefisente en dat hierdie koefisente uitgedruk kan word in terme van die sisteem se lokale eienskappe, genaamd elastisiteitskoefisente. Deur van matriksinversie gebruik te maak kan MKA die verband tussen elastisiteitskoefisente en kontrole-koefisente aflei wat mens in staat stel om te sien hoe die kinetika van die individuele ensiemreaksies die sisteemgedrag op sellulere vlak beinvloed. Die probleem word tradisioneel hoofsaaklik op numeriese wyse bereken terwyl die gebruik van algebraiese en simboliese kontrole-analise minder gereeld gebruik word. In hierdie proefskrif verskaf ons, deur van simboliese algebraiese metodes gebruik te maak, 'n generiese implementasie van die simboliese matriksinversie van MKA, genaamd SymCA, wat slegs 'n beskrywing van 'n sellulere sisteem se allosetriese interaksies en die stoichiometrie benodig. Die algebraiese uitdrukkings sodanig gegenereer stel mens in staat om 'n in-diepte analise te doen om vas te stel waar die beheer binne 'n sisteem le, asook watter parameters die grootste effek op die kontrole-verspreiding het. Dit geld selfs in die geval waar die presiese waardes van die elastisiteitskoefisente of kontrole-koefisente onbekend is. Hierdie proefskrif demonstreer hoe die kwantifisering van kontrole-patrone, ook gesien as 'roetes van regulering', wat inherent is aan kontrole-koefisent vergelykings, mens in staat stel om te sien hoe perturbasies in 'n sellulere sisteem voortplant en watter regulatoriese paaie bevoordeel word onder veranderde kondisies.

Thesis (M.S. in Management)--Naval Postgraduate School, June 2009. / Thesis Advisor(s): Eberling, Glenn. Second Reader: McCaffery, Jerry L. "June 1990." Description based on title screen as viewed on 19 October 2009. DTIC Identifier(s): management, internal control system, audits, command evaluation program, economy and efficiency reviews, theses, comptrollers, accounting. Author(s) subject terms: Internal control; internal control system; audits; reviews; command evaluation program, economy & efficiency reviews; inspection and investigative agencies. Includes bibliographical references (p. 85-87). Also available online.

Thesis (M.S. in Information Technology Management)--Naval Postgraduate School, June 2008. Thesis (M.S. in Systems Technology (Command, Control, and Communications (C3)))--Naval Postgraduate School, June 2008. / Thesis Advisor(s): MacKinnon, Douglas. "June 2008." Description based on title screen as viewed on August 25, 2008. M.S. in Information Technology Management awarded to Joseph J. Sundland, June 2008. M.S. in Systems Technology (Command, Control, and Communications (C3)) awarded to Christopher J. Carroll, June 2008. Includes bibliographical references (p. 93-96). Also available in print.

Thesis (M.S. in Systems Technology) Naval Postgraduate School, June 1997. / Thesis advisors, Donald v.Z. Wadsworth, John H. Gibson. Includes bibliographical references (p. 89-90). Also available online.

Abstract. The environment around open source version control software is very opinionated and therefore it is hard to find unbiased comparison between different open source version control software. This Bachelor’s thesis provides background and covers the basics of version control systems. Thesis also categorizes and differentiates the main types of version control systems, by investigating the way they handle repositories and by categorizing them to centralized and distributed. Finally, this thesis provides the unbiased technical comparison of the selected open source version control software and a way to map a suitable one for a software project. Comparison of technical details is collected into tables for easy interpretation and the main differentiators are explained more carefully. Mapping is achieved by pairing the major characteristics of different software projects with the technical features of version control systems and then with version control software that best supports these specific features. Pairing of the software project and the version control software is further refined with technical details that are not covered by the needs of major characteristics of the software project. Selection of the open source version control software is restricted to the four most popular ones.Avoimen lähdekoodin versionhallintaohjelmistot. Tiivistelmä. Avoimen lähdekoodin versionhallintaohjelmistoista on vaikea löytää puolueetonta vertailua, koska mielipiteet niiden ympärillä ovat hyvin polarisoituneita. Tämä kandidaatintyö tarjoaa taustatietoa ja käy läpi versionhallintajärjestelmien perusteet. Lisäksi tutkielma luokittelee ja erottaa versionhallintajärjestelmien päätyypit tarkastelemalla järjestelmien tapaa käyttää versionhallinnan varastoa ja kategorisoimalla järjestelmät sen mukaan keskitettyihin ja hajautettuihin. Tämä kandidaatintyö esittää myös puolueettoman teknisen vertailun yleisimmistä avoimen lähdekoodin versionhallintaohjelmistoista ja tavan kartoittaa ohjelmistoprojektiin sopiva versionhallintaohjelmisto. Tekninen vertailu on koottu taulukoiksi tulkinnan helpottamiseksi. Lisäksi pääeroavaisuudet on käyty läpi tarkemmin. Sopivan versionhallintaohjelmiston kartoittaminen ohjelmistoprojektiin on toteutettu yhdistämällä ohjelmistoprojektien tunnusomaiset piirteet versionhallintajärjestelmien ominaisuuksiin ja tämän jälkeen valitsemalla versionhallintaohjelmisto, joka toteuttaa kyseiset ominaisuudet. Tämän lisäksi versionhallintaohjelmiston valintaa tarkennetaan ottamalla huomioon ne tekniset eroavaisuudet, jotka eivät tule esiin tarkasteltaessa ohjelmistoprojektin tunnusomaisia piirteitä. Avoimen lähdekoodin versionhallintaohjelmistoista mukaan on valittu vain neljä käytetyintä.

Versionsverwaltungssysteme (VCS) ermöglichen es Entwicklern, Änderungen an Softwareartifakten zu verwalten. VCS werden mit Hilfe einer Vielzahl verschiedener Werkzeuge bedient, wie z.,B. graphische Front-ends oder Kommandozeilenwerkzeuge. Es ist wünschenswert mit einzelnen solcher Werkzeuge unterschiedliche VCS bedienen zu können. Bislang hat sich jedoch keine Abstraktion für Versionsverwaltungssysteme durchgesetzt, mit deren Hilfe solche Werkzeuge erstellt werden können. Stattdessen implementieren Werkzeuge zur Interaktion mit mehreren VCS ad-hoc Lösungen. Diese Masterarbeit stellt Pur vor, eine Abstraktion über Versionsverwaltungskonzepte. Mit Hilfe von Pur können Anwendungsprogramme entwickelt werden, die mit mehreren Versionsverwaltungssystemen interagieren können. Im Rahmen dieser Arbeit wird eine Implementierung dieser Abstraktion bereitgestellt und mit Hilfe eines Anwendungsprogramms validiert. / Version Control Systems (VCS) allow developers to manage changes to software artifacts. Developers interact with VCSs through a variety of client programs, such as graphical front-ends or command line tools. It is desirable to use the same version control client program against different VCSs. Unfortunately, no established abstraction over VCS concepts exists. Instead, VCS client programs implement ad-hoc solutions to support interaction with multiple VCSs. This thesis presents Pur, an abstraction over version control concepts that allows building rich client programs that can interact with multiple VCSs. We provide an implementation of this abstraction and validate it by implementing a client application.

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