The conceptual relation theory postulates that English noun-noun compound words (e.g., snowman) have an underlying predicate structure that is not present in the surface form, but is recovered during compound processing (e.g., man made of snow). The relational nature of constituent binding in compound words marks them as a linguistic construction that is distinct from both the simplex words (monomorphemic) and other complex words (derived and inflected words) previously examined in the context of verbal working memory. In short-term memory research, a growing body of evidence suggests that semantic properties of words influence verbal recall; however, such effects have not been examined in the context of compound conceptual relations. The present study investigated the possible effects of compound conceptual relations in verbal working memory via an immediate serial recall task. The task was designed to examine whether sharing of an individual relation leads to facilitative or inhibitory effects for compounds associated with that relation and, more generally, whether this semantic property of compound words contributes to their recollection from short-term memory. Evidence from the serial recall experiment suggested an effect of compound relation priming in working memory. Relational similarity between recall list items appeared to inhibit recall performance. The thesis discusses how this may be the result of increased competition between compound constituents as a result of heightened constituent-level activation during word recall. This effect was not observed in relations that appeared to be overly general, suggesting that the effect is only present when compound words are matched according to salient, sufficiently specified relations. / Thesis / Master of Science (MSc)

Flooding is of particular concern in low-lying coastal zones that are prone to impacts from multiple flooding drivers, such as coastal (storm surge and waves), fluvial (excessive river discharge), and pluvial (excessive surface runoff). Failure to account for dependence (and its changes over time) between flood drivers, when dependence exists between them, may lead to underestimation of flood risk and under-design of flood defense measures. Characterizing the dependence between compound flooding drivers in space and across seasons (tropical and extra-tropical), and how this dependence changed over time is essential in this context. In this dissertation, compound flooding potential from all relevant flooding drivers is assessed at 35 locations along the contiguous United States (CONUS) coastline. Different dependence measures are derived and analyzed using observations and state-of-the-art re-analysis data sets. In addition, temporal changes in the extremal dependence are assessed, using a sliding time window approach and possible associations with large-scale climate indices are explored. The effects of changes in dependence and marginal distributions over time between coastal and fluvial flooding drivers are investigated in more detail for a selected case study location. To overcome the computational expense of numerical modeling for flood mapping of large sets of events, a framework is introduced based on hybrid statistical modeling and one-dimensional hydraulic modeling combined with a flood inundation tool capable of propagating spatially variable along-river water surface elevations inland. The framework to delineate the flood transition zone is implemented for the Potomac River and different flood scenarios are analyzed to assess how different combinations of coastal water levels and river discharge modulate the flood hazard (specifically flood depth and extent). Overall, the findings provide new insights into characterizing compound flooding potential, its changes in space and time and how incorporating flood driver dependencies affects flood hazard.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第25132号 / 理博第5039号 / 新制||理||1718(附属図書館) / 京都大学大学院理学研究科化学専攻 / (主査)教授 依光 英樹, 教授 畠山 琢次, 教授 松永 茂樹 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM

This thesis investigates the changes in whether compound nouns were closed (written as one word), open (written as separate words) or hyphenated in Early New High German between 1550 and 1710. Due to the fact that there were no orthographic norms in the German of this time, graphematic phenomena in this period of the German language are very fruitful to examine. The study is based on a corpus of 249 sermons in 90 different postils. Since this thesis aims to show a diachronic development, the corpus texts originate from six time windows centred around the years 1550, 1570, 1600, 1620, 1660 and 1710. The results of the study show a general development from 1550, when around 80% of the occurrences of compound nouns were written as one word, to 1620, when this way of writing dominated almost entirely. In the texts from the last two time windows, the hyphenation spreads, and by 1710, nearly two thirds of the instances of compound nouns were written with a hyphen. The present study also shows that the geographical origin of a text is of lesser importance for the writing of compound nouns as one word, separate words or with a hyphen. However, the distinction between genuine compound nouns (a compound noun with the modifier in an unmarked case) and artificial ones (a compound noun with the modifier in an oblique case) seems to be of greater relevance. The artificial compound nouns are closed to a lesser extent in the period between 1550 and 1620 and hyphenated to a higher extent from 1660 onwards than the genuine compound nouns. In a second part of the study, the compound nouns of the different time windows are examined from a lexical point of view, showing that many compound noun lexemes were almost consistently written in the same way (either as one word, as separate words, or with a hyphen) in all occurrences within each time window.

This item was digitized as part of the Million Books Project led by Carnegie Mellon University and supported by grants from the National Science Foundation (NSF). Cornell University coordinated the participation of land-grant and agricultural libraries in providing historical agricultural information for the digitization project; the University of Arizona Libraries, the College of Agriculture and Life Sciences, and the Office of Arid Lands Studies collaborated in the selection and provision of material for the digitization project.

This item was digitized as part of the Million Books Project led by Carnegie Mellon University and supported by grants from the National Science Foundation (NSF). Cornell University coordinated the participation of land-grant and agricultural libraries in providing historical agricultural information for the digitization project; the University of Arizona Libraries, the College of Agriculture and Life Sciences, and the Office of Arid Lands Studies collaborated in the selection and provision of material for the digitization project.

Thesis (MSc (Biochemistry))--University of Stellenbosch, 2010. / ENGLISH ABSTRACT: Crosstalk exists between the stress- and immune-system and this crosstalk has pharmacological importance in the use of glucocorticoids (GCs) as anti-inflammatory drugs for diseases such as asthma and arthritis. The focus of studies on this crosstalk has mainly been on the effects of GCs on immune function. The effect of the immune system on GC action, especially in the periphery, is not as well studied. The liver plays an important role in inflammation and stress in producing the acute phase proteins (APPs) required for the resolution of inflammation as well as in producing systemic glucose, through gluconeogenesis, required to fuel the stress responses. Understanding effects of stress and inflammation and their interplay in the liver is thus not only useful to expand our understanding of these systems but could also have clinical applications in understanding the side-effects associated with pharmacological use of GCs. CpdA has been identified as a selective glucocorticoid receptor (GR) modulator (SEGRM) in that it is able to repress genes but is not capable of activating genes via the GR. This attribute suggests that CpdA has the potential to be developed as an anti-inflammatory drug that displays fewer side effects. The current study investigated and compared effects of dexamethasone, a potent GR agonist, and CpdA, in the presence and absence of interleukin 6 (IL6), on the glucocorticoid receptor, three metabolic enzyme genes, involved in gluconeogenesis, and three APP genes. The metabolic enzyme genes investigated were tyrosine amintotransferase (TAT), phosphoenolpyruvate carboxykinase (PEPCK), and gamma glutmayltransferase (GGT), while the APP genes were serum amyloid A (SAA), Creactive protein (CRP), and corticosteroid-binding globulin (CBG). The study investigated effects at the protein level, using Western blotting and ELISA assays, the protein activity level, using enzyme activity assays and whole cell binding, and at the mRNA level, using quantitive polymerase chain reactions (qPCR), in a mouse hepatoma cell line (BWTG3). The study showed that dexamethasone (Dex) and IL6 generally have divergent effects on the GR and metabolic enzymes Crosstalk exists between the stress- and immune-system and this crosstalk has pharmacological importance in the use of glucocorticoids (GCs) as anti-inflammatory drugs for diseases such as asthma and arthritis. The focus of studies on this crosstalk has mainly been on the effects of GCs on immune function. The effect of the immune system on GC action, especially in the periphery, is not as well studied. The liver plays an important role in inflammation and stress in producing the acute phase proteins (APPs) required for the resolution of inflammation as well as in producing systemic glucose, through gluconeogenesis, required to fuel the stress responses. Understanding effects of stress and inflammation and their interplay in the liver is thus not only useful to expand our understanding of these systems but could also have clinical applications in understanding the side-effects associated with pharmacological use of GCs. CpdA has been identified as a selective glucocorticoid receptor (GR) modulator (SEGRM) in that it is able to repress genes but is not capable of activating genes via the GR. This attribute suggests that CpdA has the potential to be developed as an anti-inflammatory drug that displays fewer side effects. The current study investigated and compared effects of dexamethasone, a potent GR agonist, and CpdA, in the presence and absence of interleukin 6 (IL6), on the glucocorticoid receptor, three metabolic enzyme genes, involved in gluconeogenesis, and three APP genes. The metabolic enzyme genes investigated were tyrosine amintotransferase (TAT), phosphoenolpyruvate carboxykinase (PEPCK), and gamma glutmayltransferase (GGT), while the APP genes were serum amyloid A (SAA), Creactive protein (CRP), and corticosteroid-binding globulin (CBG). The study investigated effects at the protein level, using Western blotting and ELISA assays, the protein activity level, using enzyme activity assays and whole cell binding, and at the mRNA level, using quantitive polymerase chain reactions (qPCR), in a mouse hepatoma cell line (BWTG3). The study showed that dexamethasone (Dex) and IL6 generally have divergent effects on the GR and metabolic enzymes / AFRIKAANSE OPSOMMING: Kruiskommunikasie bestaan tussen die stres– en die immuunsisteem en hierdie kruiskommunikasie is van farmakologiese belang vir die gebruik van glukokortikoïede (GKe) as anti-inflammatoriese medikasie vir siektes soos asma en artritis. Tot dusver was die fokus van studies oor hierdie kruiskommunikasie hoofsaaklik op die effek van GKe op immuunfunksie. Die effek van die immuunsisteem op GK werking, veral in die periferie, is nie so goed bestudeer nie. Die lewer speel ʼn belangrike rol in inflammasie en stres deurdat dit die akute fase proteïene (AFPs) produseer wat benodig word vir die resolusie van inflammasie en omdat dit ook sistemiese glukose produseer, d.m.v. glukoneogenese, wat benodig word om die stres reaksie te dryf. ’n Beter insig in die effek van stres en inflammasie sowel as hul interaksie in die lewer is dus handig, nie net om ons begrip van hierdie sisteme te verbeter nie, maar ook omdat dit kliniese toepassing kan hê deurdat dit ons begrip van die newe-effekte wat gepaard gaan met die farmakologiese gebruik van GKe verbeter. Verbinding A (CpdA) is geïdentifiseer as ʼn selektiewe glukokortikoïed reseptor (GR) moderator (SERGM) omdat dit die vermoë het om gene te onderdruk maar nie te aktiveer d.m.v. die GR. Hierdie eienskap dui op die potensiaal van CpdA om ontwikkel te word as ʼn anti-inflammatoriese middel met minder newe-effekte. Die huidige studie het die effekte van dexamethasone, ʼn sterk GR agonis, en CpdA, beide in die teenwoordigheid en afwesigheid van interleukin 6 (IL6), op die GR, drie metaboliese ensiem gene wat betrokke is by glukoneogenese, sowel as drie APP gene, ondersoek en vergelyk. Die metaboliese ensiem gene wat ondersoek is, is tirosien aminotransferase (TAT), fosfoenolpirovaat karboksikinase (PEPCK), en gamma glutamieltransferase (GGT), terwyl die APP gene serum amiloïede A (SAA), C-reaktiewe proteïen (CRP), en kortikosteroïed bindings globien (CBG) was. Die studie het die effekte in ʼn muis hepatoma sellyn (BWTG3) op die proteïen vlak, deur van Western blotting en ELISA essays gebruik te maak, die proteïen aktiwiteits vlak, deur van ensiem aktiwiteits essays en vol-sel binding gebruik te maak, sowel as op die mRNA vlak, deur van kwantitatiewe polimerase ketting reaksie (qPCR) gebruik te maak, ondersoek. Die studie toon dat dexamethasone (Dex) en IL6 in die algemeen divergente effekte het op die GR en metaboliese ensieme deurdat Dex GR af-reguleer en die metaboliese ensieme op-reguleer, terwyl IL6 die GR op-reguleer en die metaboliese ensieme af-reguleer, en dat hulle funksies konvergerend is vir die APPs deurdat beide positiewe APPs opreguleer en negatiewe APPs afreguleer. In teenstelling met Dex het CpdA die GR op-gereguleer en die metaboliese ensieme af-gereguleer terwyl dit, soos Dex, die positiewe APPs op-gereguleer en die negatiewe APPs af-gereguleer het. Ons resultate vir Dex en IL6 word ondersteun deur vorige werk in die literatuur. Ons studie is wel uniek omdat dit die ondersoek van drie metaboliese ensieme kombineer met die ondersoek van drie APPs, sowel as GR vlakke in ʼn enkele sisteem onder dieselfde eksperimentele kondisies. Verder het ons resultate met CpdA verskeie nuwe aspekte, soos die af-regulering van metaboliese gene, opgelewer wat bydra tot die groeiende poel van kennis oor hierdie ongewone GR ligand en die moontlike farmakologiese gebruik daarvan.

published_or_final_version / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

The goal of my doctoral work is to understand how proteins involved in vesicle trafficking contribute to proper animal development. To understand aspects of this process, I studied how two vesicle trafficking proteins, Liquid facets(Lqf)/epsin1 and D-Epsin-Related, affect Drosophila eye development. I determined that Lqf, an endocytosis protein, together with Fat facets (Faf), a deubiquitinating enzyme, regulate the Notch and Delta signaling in the developing Drosophila eye. Notch signaling pathway is used in most developmental processes and is dependent on its ligand Delta. Faf deubiquitinates Lqf in the signaling cells, thereby increasing Lqf protein levels and also levels of Delta endocytosis. This event is necessary for Notch activation in neighboring cells. Lqf probably works in concert with the E3 ubiquitin ligase Neuralized (Neur), which ubiquitinates Delta. These conclusions are consistent with a relatively new model describing an obligate role for endocytosis in the signaling cells to effect activation in neighboring cells. To understand how Lqf functions mechanistically in this process, I performed a structure/function analysis of the Lqf protein. Lqf proteins with strategic deletions of certain functional domains were tested for their ability to function in vivo. The major result of these experiments is that the N-terminal ENTH domain of Lqf and a protein without the ENTH domain each retain significant activity. This suggests that Lqf has two functions: the ENTH domain function and the ENTH-less function. These data are in contrast with the most popular model suggesting that ENTH-less epsins are non-functional proteins. I present possible models for how ENTH-less epsins may retain function. The final part of my thesis focuses on D-Epsin-Related (D-Epsin-R) protein. I showed that D-Epsin-R is a Golgi protein, like its homologs. Surprisingly, D-Epsin-R ENTH domain is not required for function because an ENTH-less D-Epsin-R can substitute for endogenous D-Epsin-R. Also, D-Epsin-R has essential and probably specific developmental roles in the eye as D-Epsin-R mutants exhibit impaired cell growth. This work suggests that epsins are specific components of certain developmental pathways. / text

Internal crossflow is an important element to actual gas turbine blade cooling; however, there are very few studies in open literature that have documented its effects on turbine blade film cooling. Experiments measuring adiabatic effectiveness were conducted to investigate the effects of perpendicular crossflow on a row of 45 degree compound angle, cylindrical film cooling holes. Tests included a standard plenum condition, a baseline crossflow case consisting of a smooth-walled channel, and various crossflow configurations with ribs. The ribs were angled to the direction of prevailing internal crossflow at 45 and 135 degrees and were positioned at different locations. Experiments were conducted at a density ratio of DR=1.5 for a range of blowing ratios including M=0.5, 0.75, 1.0, 1.5, and 2.0. Results showed that internal crossflow can significantly influence adiabatic effectiveness when compared to the standard plenum condition. The implementation of ribs generally decreased the adiabatic effectiveness when compared to the smooth-walled crossflow case. The highest adiabatic effectiveness measurements were recorded for the smooth-walled case in which crossflow was directed against the spanwise hole orientation angle. Tests indicated that the direction of perpendicular crossflow in relation to the hole orientation can significantly influence the adiabatic effectiveness. Among the rib crossflow tests, rib configurations that directed the coolant forward in the direction of the mainstream resulted in higher adiabatic effectiveness measurements. However, no other parameters could consistently be identified correlating to increased film cooling performance. It is likely that a combination of factors are responsible for influencing performance, including internal local pressure caused by the ribs, the internal channel flow field, jet exit velocity profiles, and in-hole vortices. / text