This dissertation reports the preparation of several types of anthraquinones structurally related to adriamycin. It describes the synthesis of two types of 2-aminoquinizarin compounds. It also presents two new syntheses of a heterocyclic tetracyclic ring system, similar to the aglicone ring system of adriamycin. A series of 2-aminoquinizarins was prepared by adding several primary amines to quinizarin. Quinizarin was shown to be essentially inert toward secondary amines. Several secondary amine adducts with quinizarin have been prepared, however, by treating the bis-boroacetate ester of quinizarin with the amines. Both types of 2-aminoquinizarin compounds exhibit outstanding potential for possessing antineoplastic activity, and several have been submitted to the National Cancer Institute for testing in their screening program for antineoplastic agents.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第22155号 / 工博第4659号 / 新制||工||1727(附属図書館) / 京都大学大学院工学研究科高分子化学専攻 / (主査)教授 田中 一生, 教授 秋吉 一成, 教授 古賀 毅 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第22891号 / 工博第4788号 / 新制||工||1749(附属図書館) / 京都大学大学院工学研究科高分子化学専攻 / (主査)教授 田中 一生, 教授 秋吉 一成, 教授 古賀 毅 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

Colorectal cancer is the third most common cancer and the fourth most common cause of cancer-related death in the world. The global burden of colorectal cancer is also expected to increase by 60%, to over 2.2 million new cases and 1.1 million annual deaths, by the year 2030. Jackfruit is known for its packed nutrition including many antioxidants: vitamin C, carotenoids and flavanones. It has also been used in traditional medicine due to its potential protection against many chronic diseases. However, there is limited research studying the potential effect of jackfruit on colorectal cancer. Here, we used a well-established AOM/DSS mice model to investigate the impact of jackfruit-derived extracts on colitis-associated colorectal cancer. After 6-week treatment with diet containing 480 ppm jackfruit-derived extracts, the mice showed significantly alleviated colon tumorigenesis with a 46% decrease in tumor numbers of each mouse compared to vehicle group (2.1 ± 0.31 for 480 ppm jackfruit-derived fraction group vs 3.9 ± 0.67 for vehicle group, P < 0.05). The expression of the pro-inflammatory cytokines (Il-6 and Inf- γ) and pro-tumorigenic genes (Axin2, Vegf, Myc and Pcna) was also decreased in the group consuming 480 ppm jackfruit-derived extracts compared to the vehicle group. Together the results suggest that the consumption of jackfruit-derived extracts could protect against colitis-associated colorectal carcinogenesis in mice.

The probability distribution of a random variable created by summing a random number of the independent and identically distributed random variables is called a compound probability distribution. In this work is described a compound distribution as well as a calculation of its characteristics. Especially, the thesis is focused on studying a special case of compound distribution where each addend has the log-normal distribution and their number has the negative binomial distribution. Here are also described some approaches to estimate the parameters of LN and NB distribution. Further, the impact of these estimates on the final compound distribution is analyzed.

Purpose of this diploma thesis is a design of a compound tool for manufacturing the form shim. The form shim is made by shearing and bending technology from steel sheet 11 343.1. Thickness is 2 mm. On the basis of a literary study and design calculations was designed the compound tool, which will manufacture this component by 4 actions on the automated line containing rewinder, feeding levelling machine and eccentric press with designed compound tool. Economic calculations show that the designed manufacturing is profitable.

Project have for purpose propose acceptable technology for manufacturing corner fitting by compound tool. Corner fitting is made from steel sheet 11 321.1 thickness 1,5 mm in production set 600 000 pieces in a year. Was select variant with manufacturing compound tool, which make to part on four steps on automatized manufacturing line. This line includes press about power press 1000 kN, feeding and levelling serving and containing rewinder. In economic results are calculated costs production of a piece, final costs and break-even point which is coming after production 216 049 pieces.

This Diploma Thesis deals with the research and advancements in the field of sulphate binders, especially the anhydrite binder. The theoretical part of the thesis is dedicated to the fundamentals of sulphate binders and anhydrite binders. Its second part also introduces standard requirements for screed coatings together with technological methods of their application. Practical part of the thesis looks at the research and production of anhydrite binder with special emphasis on self-levelling compounds. Various types of plasticizers were used in these compounds and their effectiveness and final product quality are compared.

This master’s thesis conducted within the master's degree focuses on the design of production for component, which is a wall-mount the TV. The blank is sheet steel DC03 and the annual production is 300,000 pieces. After exploring possible options of manufacturing was chosen compound tool. In the theoretical part were explored technology used cutting and bending. Further, the manufacturing process and tool design were made. The suitability of the solution was verified by economic evaluation.

The thesis concerns the layout of manufacture technology of the bracket for TV wall mount. Based on a trade-off study of several technologies, a solution using a compound tool was selected as the most appropriate for given application. Non-alloy quality steel 11 321.1 was selected as a material for the bracket, with a synthetic paint applied as a surface finish. Analysis of manufacturing parameters was conducted, based on which the two-stroke crank press LKDR 200 was selected. Capability of that machine is sufficient in terms of press force and working space. Forming tools are made of high alloy tool steel 19 436.4, heat treated by quenching and annealing. An evaluation of economic aspects is included in the thesis.