The primary objective of this research was to quantify the improvement in service life of a flexible pavement constructed using full-depth reclamation (FDR) in conjunction with cement stabilization when specified reductions in the spatial variability of specific construction-related parameters are achieved. This study analyzed pavement data obtained through field and laboratory testing of a reconstruction project in northern Utah. Data analyses included multivariate regression, Monte Carlo simulation, and mechanistic-empirical analyses of a model pavement structure. The results of the research show a steadily increasing trend in 28-day unconfined compressive strength of the cement-treated base (CTB) layer with increasing reductions in variability for cement content, moisture content, and reclaimed asphalt pavement (RAP) content across each of five different reliability levels. The most significant increases in CTB strength occurred with reductions in the standard deviations of moisture content and RAP content. Decreasing the variability of cement content did not provide significant additional strength to the CTB layer. Therefore, when involved on FDR projects, members of the pavement industry should focus energy on reducing the variability of both moisture content and RAP content, which both significantly impact pavement life, to achieve high-quality, long-lasting pavements.