Graduation date: 1996

No description available.

Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (p. 89-97).

Abstract Background: Sustainability practices have become a crucial factor for firms since there are external and internal pressures that expect firms to act environmentally friendly. Especially within organizations that are owned by family, being sustainable enables them to pass their firm in a good condition to the next generation. One way firms can be sustainable is through adopting clean technology strategy as it can provide both environmental and economic benefits to firms. Being sustainable and having the ability to implement clean technology requires a long-term vision or long-term orientation (LTO); a characteristic often associated with family-controlled businesses (FCBs). Purpose: The purpose is to examine the adoption of clean technology within family-controlled firms (FCBs) and non-family-controlled firms (Non-FCBs). The aim is to explore if there are certain characteristics of FCBs that facilitate implementation of clean technologies. Method: This research is based on qualitative research method with an abductive approach and interpretivism philosophy. The primary data is collected through semi-structured interviews with four companies of which three are family-controlled businesses and one is a non-family- controlled business. Conclusion: FCBs are more inclined to invest in clean technologies. The extent to which a company does or does not implement clean technologies depends not only on the institutional values of an organization but also how deeply one or more of the three LTO dimensions are implanted in those values.

The topical application of many substances, including drugs, enzymes, moisturizers and fragrances, contributes largely to the cosmetic and pharmaceutical industries. These components are often volatile in nature and dissipate in a matter of hours. When considering the different types of slow release systems, an overwhelming variety of these systems is available. Each one of the systems is unique in a way, and is designed to perform a particular function, whether it facilitates the controlled release of an active into the body via the skin surface (transdermal delivery) or whether it reduces the rate of loss of an active from the skin surface to the surrounding environment. For the purpose of this study, a previously existing fixative formulation which is believed to reduce the rate of loss of an active component to the environment, through film formation on the skin surface, was investigated. Alternative ingredients or components were incorporated together with the original fixative formulation ingredients into an experimental design which investigates the effect of each group of the components present. 18 formulations with various concentrations of the components within the groups and specified upper and lower limits for each component were formulated. The fixative properties of the formulations were analysed through the incorporation of a fixed amount of a simple fragrance molecule, 4- methoxybenzaldehyde, into each formulation and evaporation studies were conducted in an environmental room at 28±1° C over a period of 5 hours followed by gas chromatography analysis and finally data analyses using statistical methods. The most efficient fixative formulation was established using regression analysis. The fragrance compound in this formulation was found to evaporate at a rate of 0.47 g/L per hour. The least efficient fixative formulation lead to the loss of 0.78 g/L of the fragrance component per hour. From the calculated fragrance concentrations, the rate constant for each individual fixative formulation could be calculated and response surface 8 modelling by backward regression was used in order to determine how each component contributes to the rate of loss of the fragrance compound. Since the sum of the original ingredient and its alternative was constant, each of the original ingredients was coupled directly to its alternative and no conclusion could be made about the contribution of individual components. By increasing the concentration of Hydroxypropylcellulose (HPC) 100K and its alternative HPC 140K, while keeping the effects of the other components constant, a decrease in the rate of fragrance loss was observed. The same conclusion could be made when increasing the concentrations of PEG-12 Dimethicone and its alternative cetyl dimethicone (decreases the evaporation rate). An interaction took place between HPC 100K and PEG-12 dimethicone and their alternatives. The negative effect was, however, not as strong as the combined positive effect on the rate of fragrance loss of the individual components HPC and PEG-12 dimethicone. Evidence suggested that the removal of the components polyvinylpyrrolidone and its alternative, polyurethane-32 (Baycusan® C1003), would improve the effectiveness of the fixative formulation in terms of its slow release properties. A confirmation experiment established that the exclusion of these components from the fixative formulation does improve the “slow release” properties thereof. A larger, more intricate design is required to investigate the effect of each one of the individual components and where the sum of the components (original and its alternative) is not constant.

Les études de pharmacoépidémiologie consistent à étudier l’effet de médicaments en vie réelle, et sont menées de plus en plus souvent sur bases de données médico-administratives. Ce sont principalement des études observationnelles, et sont donc soumises à des biais liés à des facteurs de confusion. Ces facteurs ne sont pas toujours recueillis dans les bases de données médico-administratives qui sont implémentées à d’autres fins que la recherche. Des plans expérimentaux self-controlled designs (où le patient est son propre témoin, et dont les principaux sont le case-crossover et le self-controlled case-series) permettent d’étudier l’effet transitoire d'expositions brèves sur des évènements à début brutal. Ils sont soumis à certaines conditions d’application. Ils ont la particularité de réaliser des comparaisons sur différentes périodes plutôt que sur différents groupes de patients, permettant ainsi de prendre en compte des facteurs de confusion, y compris non mesurés, et qui ne varient pas entre les périodes observées. Ces méthodes ont montré leur utilité pour pallier l’absence de randomisation, et leur utilisation est recommandée quand leurs conditions d’application sont remplies. Nous avons étudié la fréquence d’utilisation des self-controlled designs en pharmacoépidémiologie sur bases de données, les opportunités manquées d’utilisation et leur usage approprié au regard de leurs conditions d’application, ainsi que la qualité de l’information rapportée dans les articles. Nous avons montré que leur utilisation est rare, que 15% des articles correspondent à des situations d’opportunité où ces méthodes auraient pu être implémentées, que 34% des case-crossover et 13% des self-controlled case-series étaient appliqué de façon inapproprié, et que pour 16% des articles la méthode aurait pu être adaptée pour être valide. Un usage plus approprié permettrait de contribuer à l’investigation en pharmacoépidémiologie tout en bénéficiant des avantages de ces méthodes en particulier sur bases de données de santé. / Pharmacoepidemiology consists in the study of efficacy or safety of drugs in real life, with the use more and more frequently of medico-administrative databases. Study designs are generally observational, thus they are prone to confounding bias. Confounders are not systematically collected in databases, which are implemented for other purposes than research. Self-controlled designs (mainly represented by case-crossover and self-controlled case-series, and in which the patient acts as his own control), have been developed for the study of intermittent exposure with short-term effect on abrupt onset event. They require that validity assumptions being fulfilled. They consist in the comparison over different periods, rather than different groups of patients, thus allowing for confounding factors, also if not measured, which are invariant over observed periods. Such designs have been proved useful in observational studies in the absence of randomization, and their implementation is recommended in case of validity assumptions are fulfilled. We studied their frequency of use in pharmacoepidemiology in healthcare databases, missed opportunities for use, inappropriate use with respect to validity assumptions, as well as quality of reporting. We showed that self-controlled designs are rarely used, that opportunity for use was founds in 15% of articles where such methods could have been implemented, that 34% of case-crossover and 13% of self-controlled case series were inappropriately used, and that the method could have been adapted to be valid in 16% of articles. A more appropriate use of self-controlled designs could contribute to improve investigation in pharmacoepidemiology, while beneficiating from their advantages, especially in healthcare databases.

Electrically controllable propellants (ECPs) provide a new method to increase the control and functionality of rocket motors in particular solid rockets. Traditional solid rockets do not have the capability to modify the burning rate on demand during operation, which greatly limits operational capabilities. The research outlined in this dissertation explores the fundamentals in the creation of ECPs to enable increased control in the burning rate of solid rockets. The research is organized into four studies which step through the fundamentals of ECPs, starting with a focus on the solid oxidizers, then moving into the creation of electrically controllable gel propellants (ECGPs). Next, electrically controllable solid propellants (ECSPs) were explored under atmospheric conditions, and then finally under elevated pressures. The first study explores the ability to electrically control the decomposition characteristics of various solid oxidizers. Typical composite solid propellants are composed of solid fuels and oxidizers and isolating the oxidizer in this study enables the ability to characterize critical components of ECSPs individually. This study discovered that certain solid oxidizers respond differently to applied voltages, but generally the decomposition rate of the solid oxidizers is greatly increased when voltage is applied using metal electrodes. The melt layer formed in the decomposition of the solid oxidizers was observed to be critical in the ability to manipulate the decomposition rate of the oxidizers. The second study built upon the knowledge that the melt layer was critical in the functionality of ECPs and explored the utilization of ECGPs which combined a viscous liquid polymer fuel in which solid oxidizers were dissolved. The ECGPs used in this study readily decomposed and ignited when a voltage potential was applied. The composition of the ECGPs along with the magnitude of the voltage being applied greatly impacted the ignition delay and overall burning characteristics of the propellants. This study illustrated the potential to create ECPs that enable increased control over the burning characteristics compared to conventional propellants. The third study utilized a solid polymer binder along with the solid oxidizers to create ECSPs that would readily decompose and ignite when a voltage potential was applied. Compositional changes in the propellant along with the magnitude of the applied voltage potential were observed to impact the regression rate of the ECSPs utilized in this study. The electrochemical decomposition characteristics of the ECSPs were explored to better characterize the contribution of the electrochemical reactions and how they differ from the more conventional thermochemical decomposition. The fourth and final study builds upon the prior ECSP study, but now experiments utilize compositions with electrically conductive additives to increase the responsiveness of the ECSPs to the applied voltage. This enabled the creation of ECSPs which ignite much more readily and with a higher degree of consistency. Experiments were also conducted at elevated pressures to analyze the combined impact that voltage and pressure play on the regression rate of the ECSPs. / Doctor of Philosophy / Solid rockets have many applications in both the civilian and defense industries due to their relatively low costs and long-term storage capabilities. However, traditional solid rockets have a limited degree of control as a result of the fuel and oxidizer being combined in the propellant and the combustion of the propellant being self-sustaining. The ability to change the thrust of the solid rocket motor on demand is something not currently possible without greatly increasing the complexity of the rocket motor, and even then the thrust control is limited. The addition of a simple method to vary the thrust of the rocket motor would drastically improve the functional capabilities and safety of the rocket. The method explored in this study to enable the creation of controllable solid rockets is through the use of electrically controllable propellants. These are propellants whose burning characteristics can be modified when subjected to an electric field. The work outlined in this dissertation develops a fundamental understanding of the methods to create electrically controllable solid and gel propellants. The electrically controllable propellants in this study demonstrated the capability to have their burning rate greatly increase or decrease by increasing or decreasing the voltage being applied to them. In addition to changing the burning rate, several compositions developed in this study were able to have their burning extinguished by removing the voltage and reignited by reapplying the voltage. These capabilities and the fundamentals behind their development enable the creation of much more functional rocket motors that overcome the limitations of current systems.

A Voltage Controlled Oscillator (VCO) is used to generate a signal with a frequency that is a function of an input voltage amplitude, and is an integral part of circuits such as phase locked loops, frequency synthesizers, down conversion receivers, and clock generators. A typical design flow for a VCO involves architecture selection based on specification, calculation of circuit parameters, simulation, and iterations of circuit parameters based on the simulation result. In such a design flow, changes in specification or process can lead to significant redesign. This report focuses on a C++ based LC VCO generation software that seeks to automate the design process and that includes calculation of circuit parameters, creation of Spectre netlist, invocation of simulation, automated checking of the result, and a feedback mechanism to modify circuit parameters until the design can converge to the desired specification. Object Oriented Programming principles such as inheritance, polymorphism, encapsulation, class abstraction are exercised to maximize reusability and portability to other projects which may require different foundry device models and supply voltages. / text

The Department of Energy national laboratories, like Los Alamos National Lab or Sandia National Lab, perform work on radioactive and chemically dangerous materials. Gloveboxes are often used to shield workers from these hazards, but they cannot completely eliminate the danger and often create new safety concerns due to reduced operator dexterity and ergonomic posture. When feasible, robots can be employed to remove the human from the radioactive hazard; allowing them to analyze the situation and make decisions remotely. Force sensor data from the manipulator can be used to simplify the control of these remote systems as well as make them more robust. Much research has been done to develop force and torque control algorithms to introduce compliance or detect collisions. Many of these algorithms are very complicated and currently only implemented in research institutions on torque-controlled manipulators. The literature review discusses many such controllers which have been developed and/or demonstrated. This thesis reviews, develops, and demonstrates several beneficial algorithms which can be implemented on commercially-available kinematically-controlled robots using commercially-available sensors with a reasonable investment of time. Force data is used to improve safety and manage contact forces while kinematically controlling the robot, as well as improve the world model. Safety is improved by detecting anomalous and/or excessive forces during operation. Environmental modeling data is inferred from position and/or force data. A six-axis sensor and joint torque sensors on 2 7DOF manipulators are used to demonstrate the proposed algorithms in two DOE relevant applications: remotely opening an incompletely modeled cabinet door and moving a robot in a confined space. / text

Thesis (M.Sc. (Hons.)) -- University of Western Sydney, 2002. / "A thesis submitted as part of the requirements for the degree of Master of Science (Honours)" Bibliography : leaves 175-181.