Global ETD Search

111	The Toll-Like Receptor 9 Ligand, CpG Oligodeoxynucleotide, Attenuates Cardiac Dysfunction in Polymicrobial Sepsis, Involving Activation of Both Phosphoinositide 3 Kinase/AKT and Extracellular-Signal-Related Kinase Signaling Gao, Ming, Ha, Tuanzhu, Zhang, Xia, Wang, Xiaohui, Liu, Li, Kalbfleisch, John, Singh, Krishna, Williams, David, Li, Chuanfu 01 May 2013 (has links) Background. Toll-like receptors (TLRs) play a role in the pathophysiology of sepsis and multiple organ failure. This study examined the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis-induced cardiac dysfunction.Methods. Male C57BL/6 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to cecal ligation and puncture (CLP)-induced sepsis. Mice that underwent sham surgery served as sham controls. Cardiac function was examined by echocardiography before and 6 hours after CLP.Results. Cardiac function was significantly decreased 6 hours after CLP. CpG-ODN prevented CLP-induced cardiac dysfunction, as evidenced by maintenance of the ejection fraction and fractional shortening. Control-ODN or iCpG-ODN did not alter CLP-induced cardiac dysfunction. CpG-ODN significantly attenuated CLP-induced myocardial apoptosis and increased myocardial Akt and extracellular-signal-related kinase (ERK) phosphorylation levels following CLP. In vitro experiments demonstrated that CpG-ODN promotes an association between TLR9 and Ras, resulting in Akt and ERK phosphorylation. Inhibition of phosphoinositide 3-kinase (PI3K) by Ly294002 or inhibition of ERK by U0126 in vivo abolished CpG-ODN attenuation of CLP-induced cardiac dysfunction.Conclusions. CpG-ODN prevents CLP-induced cardiac dysfunction, in part through activation of PI3K/Akt and ERK signaling. Modulation of TLR9 could be an effective approach for treatment of cardiovascular dysfunction in patients with sepsis or septic shock. cardiac function CpG-ODN ERK PI3K/Akt signaling sepsis TLR9 Biomedical Sciences Surgery
112	Development of Immunostimulatory Motif-containing DNA-based Delivery System for Drugs and Antigens / 免疫刺激性モチーフを含むDNAを基盤とする薬物および抗原デリバリーシステムの開発に関する研究 Mizuno(Ishii), Yumiko 23 March 2016 (has links) 1. Author can archive pre and post-print after embargo period of 12 months. 2. Author cannnot archive publisher's version/PDF. 3. Author must link to publisher version with DOI. / 京都大学 / 0048 / 新制・課程博士 / 博士(薬科学) / 甲第19667号 / 薬科博第55号 / 新制\|\|薬科\|\|6(附属図書館) / 32703 / 京都大学大学院薬学研究科薬科学専攻 / (主査)教授髙倉喜信, 教授橋田充, 教授佐治英郎 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DFAM CpGモチーフ免疫活性化ドラッグデリバリーシステムコントロールドリリースプラスミドDNA DNAハイドロゲル 499.3
113	Forensic age prediction by use of methylation-sensitive high resolution melting / メチル化感受性高精度融解分析を用いた法医学的年齢推定 Hamano, Yuya 26 March 2018 (has links) 京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13162号 / 論医博第2149号 / 新制\|\|医\|\|1029(附属図書館) / (主査)教授武田俊一, 教授松田文彦, 教授清水章 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM age prediction DNA methylation high resolution melting CpG site forensic science 490
114	Effects of Paternal Obesity on the Metabolic Profile of Offspring: Alterations in Gastrocnemius Muscle GLUT4 Trafficking and Mesenteric Adipose Tissue Transcriptome Liu, Xinhao 01 October 2018 (has links) No description available. Biomedical Research Paternal obesity gastrocnemius Insulin resistance GLUT4 adipose tissue RNA sequencing pyrosequencing CpG methylation
115	Genome-wide studies of DNA and RNA with modifications through high-throughput sequencing analysis Moreland, Blythe S. January 2018 (has links) No description available. Physics Biophysics High-throughput sequencing Methyl-CpG binding domain proteins DNA methylation Thg1 Thg1-like proteins
116	Nano-sized Polymeric Particles for Safe Delivery of Vaccine Adjuvants to Combat Fungal Pathogens Reid, Sandy M. January 2018 (has links) No description available. Biomedical Engineering Biomedical Research Nanoscience Polymers PLGA nanoparticles Cryptococcus neoformans CpG ODN
117	Design and Analysis of Neuromechanical Models of the Rat Hindlimb with Two-layer CPGs Deng, Kaiyu 26 May 2023 (has links) No description available. Biomechanics Neurosciences Engineering rat hindlimb neuromechanical model synthetic nervous system simulation two-layer CPG perturbation analysis
118	Adjuvant Guided T cell Responses Tigno-Aranjuez, Justine Daphne Tiglao 07 October 2009 (has links) No description available. Immunology T cell adjuvant CFA CpG IL-17 Th1 Th2 Th17 EAE
119	Characterization of Genomic MidRange Inhomogeneity Bechtel, Jason M. 02 September 2008 (has links) No description available. Bioinformatics Biostatistics Genetics inhomogeneity cluster CpG island genomic MRI RNA secondary structures mid-range
120	Neurologically Based Control for Quadruped Walking Hunt, Alexander Jacob 27 January 2016 (has links) No description available. Robotics Robots Neurosciences Mechanical Engineering Robotics Computational Neuroscience McKibben Rat Dog Control Festo CPG Afferent Feedback

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