The diesel engine in heavy-duty trucks is a complex system with many components working together, and a malfunction in any of these components can impact engine performance and result in increased emissions. Fault detection and diagnosis have therefore become essential in modern vehicles, ensuring optimal performance and compliance with progressively stricter legal requirements. One of the most common faults in a diesel engineis faulty injectors, which can lead to fluctuations in the amount of fuel injected. Detecting these issues is crucial, prompting a growing interest in exploring additional signals beyond the currently used signal to enhance the performance and robustness of diagnosing this fault. In this work, an investigation was conducted to identify signals that correlate with faulty injectors causing over- and underfueling. It was found that the NOx, O2, and exhaust pressure signals are sensitive to this fault and could potentially serve as additional diagnostic signals. With these signals, two different diagnostic methods were evaluated to assess their effectiveness in detecting injector faults. The methods evaluated were data-driven residuals and Random Forest classifier. The data-driven residuals, when combined with the CUSUM algorithm, demonstrated promising results in detecting faulty injectors. The O2 signal proved effective in identifying both fault instances, while NOx and exhaust pressure were more effective at detecting overfueling. The Random Forest classifier also showed good performance in detecting both over- and underfueling. However, it was observed that using a classifier requires more extensive data preprocessing. Two preprocessing methods were employed: integrating previous measurements and calculating statistical measures over a defined time span. Both methods showed promising results, with the latter proving to be the better choice. Additionally, the generalization capabilities of these methods across different operating conditions were evaluated. It was demonstrated thatthe data-driven residuals yielded better results compared to the classifier, which requiredtraining on new cases to perform effectively.