Orientadores: Francisco Humberto Nociti Junior, Daiane Cristina Peruzzo / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-21T19:09:34Z (GMT). No. of bitstreams: 1 Meulman_TatianaLeiteBortolaci_D.pdf: 1764919 bytes, checksum: afb2f8556158918830ad6c82d7e864d8 (MD5) Previous issue date: 2012 / Resumo: O objetivo do presente estudo foi avaliar a resposta do paciente fumante com doença periodontal inflamatória crônica (DPIC) aos desafios bacterianos do biofilme dental e às diferentes modalidades de tratamento periodontal. Foram avaliados o perfil microbiológico dos fumantes comparado com os não-fumantes e a resposta aos tratamentos de raspagem e alisamento radicular (RAR), terapia gold standard, e debridamento periodontal (DBR) que envolve o tratamento da DPIC em sessão única ...Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital / Abstract: The aim of these studies was to evaluate the responses of smokers with chronic inflammatory periodontitis (CIP) to the challenges of dental biofilme and differents modalities of periodontal therapy, including scaling and root planning (SRP), gold standard therapy, and one session periodontal debridement (DB). ...Note: The complete abstract is available with the full electronic document / Doutorado / Periodontia / Doutora em Clínica Odontológica

Purpose: The aim of the study was to evaluate the outcomes of corneal manual epithelial debridement (MED) for the treatment of painful bullous keratopathy (BK). Methods: In a prospective interventional case series, 15 eyes of 15 consecutive patients presenting with painful BK of varying aetiology underwent MED. Patients were followed up at 10 days, 1 month, 2 months, 3 months and 6 months post procedure. Outcome parameters evaluated include numeric rating pain score (NRS), visual acuity (VA), corneal transparency and size of corneal bullae. Results: The mean NRS was significantly decreased from its baseline value of 7.2 +- 1.7 at all follow-up visits (p < 0.02). Mean VA and corneal transparency remained stable for the duration of the study. In most patients the average size of corneal bullae was initially reduced, but returned to baseline by the end of the study. Conclusion: MED reduces mean pain scores and temporarily reduces the size of corneal bullae in BK. MED may be considered as a simple, low cost alternative for reducing pain in patients awaiting corneal transplant. Further studies are required to evaluate MED for the treatment of BK and compare outcomes against other palliative treatment options.

No / Lower limb ulcers (LLU) are a common manifestation of long-standing vascular disease and may be exacerbated by trauma or dependency. Ulcers can be grouped according to the underlying aetiology with approximately 76% due to venous disease, 22% due to arterial and 5% occurring as a complication of diabetes. In up to 20% of patients there is some crossover where a mixed picture is present. / BioMonde

Submitted by NAIRA MARIA REBELATTO BECHARA ANDERE null (nairaandere@hotmail.com) on 2016-01-25T17:55:36Z No. of bitstreams: 1 DISSERTAÇÃO VERSÃO BIBLIOTECA 2.pdf: 565381 bytes, checksum: 5dd2c824058fd7cf7771ace43cb0c34a (MD5) / Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2016-01-27T12:03:13Z (GMT) No. of bitstreams: 1 andere_nmrb_me_prud_par.pdf: 311280 bytes, checksum: 666ddf37e738a3ca488e4b697c9c212f (MD5) / Made available in DSpace on 2016-01-27T12:03:13Z (GMT). No. of bitstreams: 1 andere_nmrb_me_prud_par.pdf: 311280 bytes, checksum: 666ddf37e738a3ca488e4b697c9c212f (MD5) Previous issue date: 2016-01-07 / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / O presente estudo clínico controlado randomizado teve como objetivo avaliar a resposta clínica periodontal e os possíveis efeitos adversos da utilização da claritromicina (CLM) associada à terapia mecânica periodontal no tratamento de pacientes com periodontite agressiva generalizada. Para tal, foram selecionados 40 pacientes apresentando periodontite agressiva generalizada que foram distribuídos aleatoriamente, dentro de dois grupos: grupo claritromicina com 20 indivíduos que receberam RAR associado à claritromicina (500 mg – 12/12 horas) durante 3 dias; grupo placebo com 20 indivíduos que receberam RAR associado ao placebo. Foram avaliados profundidade de sondagem (PS), ganho de nível de inserção clínica (NIC) e sangramento à sondagem no baseline, 3 e 6 meses após o procedimento. Quanto aos resultados, ambos os tratamentos obtiveram melhorias clínicas em relação ao baseline, com diferença estatisticamente significativa apenas para redução em PS à favor do grupo claritromicina. Concluímos que o uso da claritromicina associado à terapia mecânia mostra-se superior à terapia padrão ouro para o tratamento de periodontite agressiva generalizada. / The present randomized, clinical trial aimed to assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. To this, 40 patients were select and randomly assigned into two groups: Group clatithromycin with 20 subjects received SRP associated with clarithromycin (500 mg – 12/12 hours) for 3 days; group placebo with 20 subjects received SRP associated with placebo. Probing depth (PD), gain in clinical attachment level (CAL) and bleeding probing were evaluated at baseline, 3 and 6 months post- operatively. As results, both treatments had clinical benefits better than baseline, just differing statistically to PD reduction for the clarithromycin group. It may be concluded that the use of clarithromycin associated with mechanical treatment is better than the gold standard for the treatment of generalized aggressive periodontitis.

No description available.

No / The resurgence of larval biotherapy as a debridement tool in wound management has been accompanied by several clinical reports highlighting concomitant tissue regeneration. Studies employing in vitro cell motility assays have found that purified excretory/secretory (ES) products from Greenbottle larvae (blowfly, Lucilia sericata) are motogenic for human dermal fibroblasts when used as a supplement in culture media. The objective of the present study was to determine whether ES delivered using a prototype hydrogel wound dressing induced similar motogenic effects on fibroblastic (3T3) and epithelial cells (HaCaTs) comprising a scratched-monolayer wound model. Quantitative analysis by MTT assay failed to detect significant mitogenic effects of ES on either cell type. Quantitative image analysis revealed that ES exposure markedly accelerated wound closure through a motogenic effect on both fibroblasts and keratinocytes. Quantitative histochemical analysis detected significantly higher phosphotyrosine (pTyr) expression in ES-exposed cell cultures than in controls; moreover immunocytochemistry revealed conspicuously raised levels of pTyr expression in cells located at the wound margin. By attenuation with a panel of enzyme inhibitors these effects were attributed to the protease components of ES. The present results suggest that controlled delivery of ES as a follow-up to maggot debridement therapy may be an effective therapeutic option for stimulation of tissue regeneration in wound management.

Indiana University School of Dentistry located on the campus of Indiana University-Purdue University Indianapolis (IUPUI) / This in-vitro, prospective, randomized study microscopically compared the debridement efficacy of negative pressure irrigation with the EndoVac (Discus Dental, Culver City, CA) versus the Canal CleanMax (Maximum Dental, Inc., Secaucus, NJ). Sixty extracted human canines were instrumented using a combination of hand-instrumentation with Lexicon K-type files and rotary instrumentation with ProTaper files. All canals were irrigated with 6.0-percent sodium hypochlorite and 17- percent ethylenediaminetetraacetic acid (EDTA). However, the irrigation/aspiration techniques differed among three groups of 20 randomly selected teeth. Group one (control) was irrigated with only a 12-ml Monoject syringe via 30-gauge side-vented, closed-end needle. Group two was irrigated with the EndoVac system. Group three was irrigated similar to group one, but with the adjunct of the Canal CleanMax system. All teeth were sectioned longitudinally, and the more intact sections were divided into coronal, middle, and apical thirds. Each portion of the canal was photographed with a scanning electron microscope (SEM). The photographs were scored by two independent examiners according to relative amount of debris and/or smear layer present, as well as relative number of patent dentinal tubules. These scores were statistically analyzed using a Krustal-Wallis test and Wilcoxon Rank Sum tests to determine differences between groups. The coronal aspect of root canal walls irrigated with the EndoVac system exhibited significantly less debris and/or smear layer present when compared to the coronal aspect of root canals irrigated with only a standard 12-ml Monoject syringe equipped with 30-gauge ProRinse side-vented, closed-end needle (control). There were no other significant differences in scores between any groups at any location. For all locations combined, the EndoVac system produced significantly cleaner root canal walls as compared to the control. No significant differences were seen between the Canal CleanMax and Control or Canal CleanMax and EndoVac. This study suggested negative pressure irrigation delivery with the EndoVac system during and after hand-rotary instrumentation is more effective in removal of debris and smear layer from the coronal third and combined thirds of root canal walls compared to irrigation with a standard 12-ml Monoject syringe equipped with 30-gauge ProRinse side-vented, closed-end needle.

A periodontite é causada por bactérias patogênicas, podendo ser tratada com sucesso por meio de procedimentos que incluem instruções de higiene oral, eliminação de fatores retentivos de biofilme, raspagem e alisamento radicular (RAR), combinados ou não com cirurgias periodontais. A literatura tem relatado que os pacientes fumantes apresentam uma resposta inferior ao tratamento periodontal convencional, cirúrgico ou não, quando comparados aos pacientes não-fumantes. Assim, justifica-se a avaliação de terapias complementares aos procedimentos convencionais de raspagem e alisamento radicular (RAR) nesses pacientes. Estudos in vitro e in vivo têm demonstrado o potencial da terapia fotodinâmica antimicrobiana (TFDa) contra as bactérias periodontopatogênicas. Desta forma, o presente estudo visou analisar a ação complementar da TFDa à RAR em pacientes fumantes portadores de periodontite crônica. Foram selecionados 20 pacientes fumantes com periodontite crônica, apresentando um par de dentes contralaterais com sangramento à sondagem e profundidade de sondagem maior ou igual a 5 mm. Cada par de dentes foi aleatoriamente dividido em grupo controle (GC), no qual foi realizada a RAR e em grupo teste (GT), no qual além da RAR foi realizada a TFDa, em aplicação única. Parâmetros clínicos de índice de placa (IP), sangramento à sondagem (SS), profundidade de sondagem (PS), nível clínico de inserção relativo (NCI), recessão gengival (RG) foram registrados no exame inicial, 4 e 12 semanas após o tratamento periodontal. Além disso, no exame inicial e 1, 4 e 12 semanas após o tratamento periodontal foram coletadas amostras de biofilme subgengival para a identificação e quantificação das espécies bacterianas através da técnica de Checkerboard DNA-DNA Hybridization e também de fluido crevicular gengival (FCG) para a quantificação da Interleucina-1 beta (IL-1&beta;) e Metaloproteinase 8 (MMP-8) por meio do teste ELISA. Houve uma redução estatisticamente significante na PS (GT: 1,81±0,52 mm / GC: 1,58±1,28 mm; p<0,001) e um ganho estatisticamente significante no NCI (GT: 1,60±0,92 mm/GC: 1,41±1,58 mm; p<0,001) para ambos os grupos. Diferenças estatisticamente significantes não foram observadas nas comparações entre os grupos. A concentração de IL-1&beta; no FCG foi maior no GC no exame realizado 1 semana após o tratamento periodontal (GT: 24,65±18,85 pg/&mu;L / GC-34,07±24,81 pg/&mu;L; p=0,048) e a concentração de MMP-8 foi maior também no GC 12 semanas após o tratamento periodontal (GT: 303,31±331,62 pg/&mu;L / CG: 534,23±647,37 pg/&mu;L; p=0,024). Não houve diferenças estatisticamente significantes na análise intragrupos. As 40 espécies bacterianas avaliadas foram detectadas em diferentes níveis no exame inicial, sem diferenças estatisticamente significantes entre os grupos. Após o tratamento periodontal, o nível de algumas bactérias diminuiu enquanto outras espécies apresentaram um aumento. Apesar dessa variação, a análise estatística não foi capaz de identificar diferenças estatisticamente significantes nas comparações intra e intergrupos. Assim, este estudo não foi capaz de demonstrar que o efeito adjunto da TFDa (em aplicação única) associada à RAR melhora os parâmetros clínicos em pacientes fumantes. Contudo, a TFDa foi capaz de reduzir significativamente a concentração de IL-1&beta; (no exame de uma semana) e MMP-8 (no exame de 12 semanas), sugerindo uma possível vantagem na cicatrização periodontal. Isso não foi confirmado, no entanto, pela analise microbiológica, que mostrou que nenhum dos tratamentos reduziu significamente os níveis bacterianos. / Periodontitis is caused by pathogenic bacteria and it can be successfully treated by procedures that include oral hygiene instructions, elimination of plaque retentive factors and scaling and root planing (SRP) alone or in combination with periodontal surgery. The literature has reported that smokers present a poorer response to conventional periodontal treatment when compared with nonsmoking patients. Thus, it is appropriate to evaluate adjunctive therapies to conventional treatment of scaling and root planing (SRP) in these patients. In vitro and in vivo studies have demonstrated the potential of antimicrobial photodynamic therapy (aPDT) against periodontopathic bacteria. Thus, this study aimed to analyze the adjunctive action of aPDT to SRP in smokers with chronic periodontitis. We selected 20 smokers with chronic periodontitis, presenting a pair of contralateral teeth with bleeding on probing and probing depth greater than or equal to 5 mm. Each pair of teeth was randomly alocated on control group (CG), in which SRP was performed, and on test group (TG), in which PDT was performed in addition to SRP. Clinical parameters of plaque index (PI), bleeding on probing (BOP), probing depth (PD), relative clinical attachment level (CAL), gingival recession (GR) were recorded at the baseline and 4 and 12 weeks after periodontal treatment. Moreover, at baseline and 1, 4 and 12 weeks after periodontal treatment, subgingival plaque samples were collected for identification and quantification of periodontopathic bacteria using Checkerboard DNA-DNA hybridization technique, as well as gingival crevicular fluid (GCF) samples for quantification of Interleukin-1 beta (IL-1&beta;) and metalloproteinase 8 (MMP-8) using ELISA. There was a statistically significant reduction in PD (GT-1.81 ± 0.52 mm / GC-1.58 ± 1.28 mm, p <0.001) and a statistically significant gain in CAL (GT-1.60 ± 0, 92 mm / GC-1.41 ± 1.58 mm, p <0.001) for both groups. Statistically significant differences were not observed in comparisons between groups. The concentration of IL-1&beta; in GCF was higher in GC in the examinations performed 1 week after periodontal treatment (GT-24, 65 ± 18.85 pg / &mu;L / GC-34, 07 ± 24.81 pg / &mu;L, p = 0.048) and MMP-8 was also higher in GC 12 weeks after periodontal treatment (GT-303, 31 ± 331.62 pg / &mu;L / CG-534, 23 ± 647.37 pg / &mu;L, p = 0.024). There was no statistically significant differences in the intra-groups analyses. The 40 bacterial species tested were detected at different levels at baseline, with no statistically significant differences between groups. After periodontal treatment, the level of some bacterial species had decreased while others presented an increasing. Despite this variation, statistical analysis was not able to identify statistically significant differences in comparisons within and between groups. Thus, the present study failed to demonstrate that the adjunctive effect of a single episode of aPDT to SRP improves clinical parameters in smokers. However, it resulted in a significantly suppression of IL-1&beta; and of MMP-8, suggesting an advantage on periodontal healing. This has not been confirmed, on the other hand, by the microbiological analysis, which showed that none of the treatments was able to significantly reduce the bacteria levels

A periodontite é causada por bactérias patogênicas, podendo ser tratada com sucesso por meio de procedimentos que incluem instruções de higiene oral, eliminação de fatores retentivos de biofilme, raspagem e alisamento radicular (RAR), combinados ou não com cirurgias periodontais. A literatura tem relatado que os pacientes fumantes apresentam uma resposta inferior ao tratamento periodontal convencional, cirúrgico ou não, quando comparados aos pacientes não-fumantes. Assim, justifica-se a avaliação de terapias complementares aos procedimentos convencionais de raspagem e alisamento radicular (RAR) nesses pacientes. Estudos in vitro e in vivo têm demonstrado o potencial da terapia fotodinâmica antimicrobiana (TFDa) contra as bactérias periodontopatogênicas. Desta forma, o presente estudo visou analisar a ação complementar da TFDa à RAR em pacientes fumantes portadores de periodontite crônica. Foram selecionados 20 pacientes fumantes com periodontite crônica, apresentando um par de dentes contralaterais com sangramento à sondagem e profundidade de sondagem maior ou igual a 5 mm. Cada par de dentes foi aleatoriamente dividido em grupo controle (GC), no qual foi realizada a RAR e em grupo teste (GT), no qual além da RAR foi realizada a TFDa, em aplicação única. Parâmetros clínicos de índice de placa (IP), sangramento à sondagem (SS), profundidade de sondagem (PS), nível clínico de inserção relativo (NCI), recessão gengival (RG) foram registrados no exame inicial, 4 e 12 semanas após o tratamento periodontal. Além disso, no exame inicial e 1, 4 e 12 semanas após o tratamento periodontal foram coletadas amostras de biofilme subgengival para a identificação e quantificação das espécies bacterianas através da técnica de Checkerboard DNA-DNA Hybridization e também de fluido crevicular gengival (FCG) para a quantificação da Interleucina-1 beta (IL-1&beta;) e Metaloproteinase 8 (MMP-8) por meio do teste ELISA. Houve uma redução estatisticamente significante na PS (GT: 1,81±0,52 mm / GC: 1,58±1,28 mm; p<0,001) e um ganho estatisticamente significante no NCI (GT: 1,60±0,92 mm/GC: 1,41±1,58 mm; p<0,001) para ambos os grupos. Diferenças estatisticamente significantes não foram observadas nas comparações entre os grupos. A concentração de IL-1&beta; no FCG foi maior no GC no exame realizado 1 semana após o tratamento periodontal (GT: 24,65±18,85 pg/&mu;L / GC-34,07±24,81 pg/&mu;L; p=0,048) e a concentração de MMP-8 foi maior também no GC 12 semanas após o tratamento periodontal (GT: 303,31±331,62 pg/&mu;L / CG: 534,23±647,37 pg/&mu;L; p=0,024). Não houve diferenças estatisticamente significantes na análise intragrupos. As 40 espécies bacterianas avaliadas foram detectadas em diferentes níveis no exame inicial, sem diferenças estatisticamente significantes entre os grupos. Após o tratamento periodontal, o nível de algumas bactérias diminuiu enquanto outras espécies apresentaram um aumento. Apesar dessa variação, a análise estatística não foi capaz de identificar diferenças estatisticamente significantes nas comparações intra e intergrupos. Assim, este estudo não foi capaz de demonstrar que o efeito adjunto da TFDa (em aplicação única) associada à RAR melhora os parâmetros clínicos em pacientes fumantes. Contudo, a TFDa foi capaz de reduzir significativamente a concentração de IL-1&beta; (no exame de uma semana) e MMP-8 (no exame de 12 semanas), sugerindo uma possível vantagem na cicatrização periodontal. Isso não foi confirmado, no entanto, pela analise microbiológica, que mostrou que nenhum dos tratamentos reduziu significamente os níveis bacterianos. / Periodontitis is caused by pathogenic bacteria and it can be successfully treated by procedures that include oral hygiene instructions, elimination of plaque retentive factors and scaling and root planing (SRP) alone or in combination with periodontal surgery. The literature has reported that smokers present a poorer response to conventional periodontal treatment when compared with nonsmoking patients. Thus, it is appropriate to evaluate adjunctive therapies to conventional treatment of scaling and root planing (SRP) in these patients. In vitro and in vivo studies have demonstrated the potential of antimicrobial photodynamic therapy (aPDT) against periodontopathic bacteria. Thus, this study aimed to analyze the adjunctive action of aPDT to SRP in smokers with chronic periodontitis. We selected 20 smokers with chronic periodontitis, presenting a pair of contralateral teeth with bleeding on probing and probing depth greater than or equal to 5 mm. Each pair of teeth was randomly alocated on control group (CG), in which SRP was performed, and on test group (TG), in which PDT was performed in addition to SRP. Clinical parameters of plaque index (PI), bleeding on probing (BOP), probing depth (PD), relative clinical attachment level (CAL), gingival recession (GR) were recorded at the baseline and 4 and 12 weeks after periodontal treatment. Moreover, at baseline and 1, 4 and 12 weeks after periodontal treatment, subgingival plaque samples were collected for identification and quantification of periodontopathic bacteria using Checkerboard DNA-DNA hybridization technique, as well as gingival crevicular fluid (GCF) samples for quantification of Interleukin-1 beta (IL-1&beta;) and metalloproteinase 8 (MMP-8) using ELISA. There was a statistically significant reduction in PD (GT-1.81 ± 0.52 mm / GC-1.58 ± 1.28 mm, p <0.001) and a statistically significant gain in CAL (GT-1.60 ± 0, 92 mm / GC-1.41 ± 1.58 mm, p <0.001) for both groups. Statistically significant differences were not observed in comparisons between groups. The concentration of IL-1&beta; in GCF was higher in GC in the examinations performed 1 week after periodontal treatment (GT-24, 65 ± 18.85 pg / &mu;L / GC-34, 07 ± 24.81 pg / &mu;L, p = 0.048) and MMP-8 was also higher in GC 12 weeks after periodontal treatment (GT-303, 31 ± 331.62 pg / &mu;L / CG-534, 23 ± 647.37 pg / &mu;L, p = 0.024). There was no statistically significant differences in the intra-groups analyses. The 40 bacterial species tested were detected at different levels at baseline, with no statistically significant differences between groups. After periodontal treatment, the level of some bacterial species had decreased while others presented an increasing. Despite this variation, statistical analysis was not able to identify statistically significant differences in comparisons within and between groups. Thus, the present study failed to demonstrate that the adjunctive effect of a single episode of aPDT to SRP improves clinical parameters in smokers. However, it resulted in a significantly suppression of IL-1&beta; and of MMP-8, suggesting an advantage on periodontal healing. This has not been confirmed, on the other hand, by the microbiological analysis, which showed that none of the treatments was able to significantly reduce the bacteria levels

Orientador: Leticia Helena Theodoro / Coorientador Valdir Gouveia Garcia / Banca: Sandra Helena Penha de Oliveira / Banca: Rossana Abud Cabrera Rosa / Resumo: Introdução: A presença de bolsas residuais representa um fator de risco preditor de progressão da doença periodontal. A presença de Diabetes Mellitus (DM) aumenta a prevalência de periodontite e influencia negativamente na capacidade de reparo tecidual. O objetivo do estudo foi avaliar a eficácia clínica da terapia fotodinâmica antimicrobiana (aPDT) com curcumina e LED, como terapia coadjuvante à raspagem e alisamento radicular (RAR), no tratamento de bolsas residuais de pacientes com DM tipo 2. Métodos: Para este estudo clínico controlado randomizado de boca dividida, vinte e cinco pacientes foram selecionados. Em cada paciente, todas as bolsas residuais com profundidade de sondagem (PS) ≥5 mm e sangramento à sondagem (SS), por quadrante, foram aleatoriamente alocados para receber: 1) RAR (grupo RAR); 2) RAR e irrigação com solução de curcumina (grupo CUR); 3) RAR e irradiação com LED (grupo LED); 4) RAR e terapia fotodinâmica antimicrobiana (grupo aPDT). Para a aPDT, utilizou-se solução de curcumina (100 mg/L) seguida de irradiação com LED (InGaN, 465 - 485 nm, 100 mW/cm², 60 segundos). Os parâmetros clínicos de PS, recessão gengival (RG), nível de inserção clínica (NIC), SS e índice de placa visível (IP) foram avaliados no início (baseline), 3 e 6 meses após os tratamentos. Resultados: Na comparação intergrupo, não houve diferença estatisticamente significante nos valores médios dos parâmetros clínicos avaliados (PS, RG, NIC, SS e IP) no início do estudo (baseline), aos 3 ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Residual pockets represent a risk factor for periodontal disease progression, which is exacerbated by Diabetes Mellitus (DM) by increasing the prevalence of periodontal disease and negatively influencing healing capacity. The present study aimed to evaluate the clinical efficacy of antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an adjunctive therapy to scaling and root planing (SRP), in the treatment of residual pockets in patients with type 2 DM. Methods: A randomized and controlled split-mouth clinical trial was conducted with twenty-five patients. In each patient, all residual pockets with probing depth (PD) ≥5 mm and bleeding on probing (BOP), per quadrant, were randomly allocated to receive: 1) SRP (SRP group); 2) SRP and irrigation with curcumin solution (CUR group); 3) SRP and LED irradiation (LED group); 4) SRP and aPDT (aPDT group). The aPDT was performed with curcumin solution (100 mg/L) followed by LED irradiation (InGaN, 465 - 485 nm, 100 mW/cm², 60 seconds). Clinical parameters of PD, gingival recession (GR), clinical attachment level (CAL), BOP and visible plaque index (PI) were evaluated at baseline, 3 and 6 months post-therapies. Results: In an intergroup comparison, the mean values for PD, GR, CAL, BOP and PI were not different at baseline, 3 and 6 months (p > 0.05). Similarly, the mean difference in the reduction of PD and CAL gain between baseline and 3 or 6 months were not statistically different (p > 0.05). The intragrou... (Complete abstract click electronic access below) / Mestre