Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder with onset at preschool age Approximately 5-10% of school-aged children worldwide have ADHD. Psychostimulants are the most common treatments for ADHD, although the precise etiology and pathological mechanisms underlying ADHD are poorly understood. Animal models could help to elucidate and further the understanding of this disorder. Among the major rodent models of ADHD of the genetic and neurotoxin-exposed animal models, the spontaneously hypertensive rats (SHR) are more extensively studied. Nevertheless, the mechanism of ADHD is complex and the evidence of SHR model for ADHD has been conflicting. Objective. In this work, we combined behavioral, neurochemical, neuroimaging, pharmacological and molecular studies to examine SHR as an animal model of ADHD. At the same time, the results of our studies could help us to explore the potential mechanism of ADHD. Material and methods. We compared the locomotor activity, attention, inhibition, learning and memory of juvenile male SHR with those of age- and gender-matched genetic control Wistar-Kyoto rats (WKY) by using the open field test, Morris water maze and prepulse inhibition test. We employed magnetic resonance imaging (MRI) to measure potential morphological differences between different brain areas of SHR and WKY, and the functional MRI (fMRI) for functional differences in these brain areas. We also measured dopamine concentration and dopamine related genes expression in the different dopamine pathways by using enzyme-linked immunosorbent assay (ELISA) to measure the dopamine concentration and by using real time PCR to assay genes expression. We examined SHR responses to D-amphetamine (D-AMP), which is psychostimulant. These included locomotor activity and inhibition ability during D-AMP treatment, expression of dopamine related genes after D-AMP treatment measured by real time PCR and c-fos protein after repeated treatment of D-AMP by the Western Blotting. Results . Hyperactivity, impulsivity and attention deficit were observed in SHR. Decreased brain volume in caudate-putamen and vermis cerebelli in SHR were demarcated using MRI. Functional MRI (fMRI) and altered c-fos expression indicated plasticity changes of the prefrontal cortex (PFC) in SHR. Dopamine content was found to decrease in mesocortical and mesolimbic dopamine pathways, but increased in the striatum. Dopamine D4 receptors gene and protein expression were decreased in the PFC in SHR. We also found that the expression of the synaptosomal-associated protein 25 (SNAP-25) gene was initially lower in the PFC but higher in the striatum in SHR. However, this disparity of SNAP-25 in the PFC vanished after repeated treatment of D-AMP between SHR and WKY. Conclusions. In the present study, we demonstrated that SHR could be established as an ADHD model by completing complex assessments of face validity, construct validity and prediction validity. We suggested that the "synaptogenesis hypotheses" might contribute to the abnormal release of dopamine and dysfunction of PFC and the striatum in SEER. In conclusion, our results have provided further new information relevant to the understanding of ADHD in human via the analysis of the SHR model. / Li, Qi. / Adviser: David Yen. / Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 1375. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2007. / Includes bibliographical references (leaves 108-125). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese. / School code: 1307.

There has been an increase of attention placed on the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), within South Africa. This has led to a number of controversies surrounding the legitimacy of ADHD diagnoses. And how effective the systems of categorising and diagnosing disorders are in aiding a number of practitioners in formulating a disorder. There is a substantial agreement within the literature that the understanding of ADHD is limited, the focus is mainly on the symptoms of disorders. This study explores the perceptions practitioners in the field, in identifying the effectiveness of the Diagnostic and Statistical Manual for Mental disorders (DSM) is for diagnosing ADHD. It became evident throughout this study that there is no consensus around the efficacy of the DSM. Furthermore, ADHD is not completely understood and therefore creates serious implications for the treatment and diagnosis of the disorder.

The theme of the master thesis is the intervention approaches used to support pupils with a specific behavioral disorder. The main aim of the thesis is to map the content of the consultancy services in Zlin Region, which are provided to pupils with specific behavioral disorders in schools and school counseling facilities, specifically pedagogical-psychological counselling centres. The thesis is divided into theoretical and practical parts. Basic concepts will be defined in the first chapter. The following chapter presents classification and differentiation of specific behavioral disorder from a medical point of view, risk factors of development of specific behavioral disorder, major and associated shows of specific behavioral disorder and its consequences. The third chapter deals with interventions and treatment options for specific behavioral disorders including prevention. Foreign approaches to pupils with a specific behavioral disorder are also outlined in this chapter. The researching part contains a chapter devoted to the methodology of research. There are included research objectives, research issues, data collection methods and the definition of a research sample. The following chapter already provides data analysis and interpretation. The chapter concludes by answering research questions....

This thesis concerns the role of nutrients in cognitive and behaviour problems associated with child attention deficit hyperactivity disorder (ADHD). Study 1 investigated relationships between Conners' ADHD Index ratings, fatty acid deficiency symptoms (FADS), and cognitive performance in a normal population of children. Studies 2 and 3 comprised a 30 week intervention trial investigating effects of n-3 PUFA supplementation on ADHD symptoms in 7-12 year old children with high ADHD scores.

Thesis (MSc. (Human Physiology, Faculty of Health Sciences))--University of Pretoria, 2008. / Summary in English. Includes bibliographical references.

Thesis (M.A.)--James Madison University, 2009. / Includes bibliographical references.

Project (B.S.)--James Madison University, 2009. / Includes bibliographical references.

The purpose of this study was to gain insight into whether inattentive, hyperactive/ impulsive, and depressive symptoms differ among young adolescents with negative, accurate, or positive self-perceptions of their academic and social competence. Current literature suggests that elementary-age children with ADHD display overly positive self-perceptions, often referred to as the positive illusory bias (PIB; Owens, Goldfine, Evangelista, Hoza, & Kaiser, 2007). Self-reports of academic and social self-concept were compared to teacher ratings and test scores for 164 middle school students in an effort to determine if the PIB was present within this sample. Inattentive and hyperactive/impulsive symptoms were found to be significantly higher among the positive self-perception group in the academic domain with teacher ratings as the indicator of competence, while depressive symptoms were found to be significantly higher among the negative self-perception group. In the social domain, only inattentive symptoms were shown to be significantly higher in the positive self-perception group compared to the negative and accurate groups. Interestingly, there were no significant differences between groups with achievement test scores as the indicator of academic competence. These findings provide information about the PIB in young adolescents, an understudied group. Implications related to research and practice are also presented.

The purpose of this study was to investigate perceptions of academic and social competence among adolescents with a continuum of inattentive and hyperactive/impulsive symptoms. Past literature suggests that children with Attention-Deficit/Hyperactivity Disorder (ADHD) display self-perceptions that are overly positive compared to external indicators of competence, a phenomenon that is referred to as the positive illusory bias (PIB; Owens, Goldfine, Evangelista, Hoza, & Kaiser, 2007). The PIB is well supported among children with ADHD, and recent research suggests that the PIB persists into adolescence. To date, research on the PIB has relied on difference scores (i.e., an indicator of competence is subtracted from student self-ratings); however, difference scores suffer from numerous methodological limitations (Edwards, 2002). The current study investigated the relationship between self and teacher ratings of academic and social competence and inattentive, hyperactive/impulsive, and overall ADHD symptoms among a diverse sample of 395 students and their teachers. Polynomial regression and response surface methods were used to account for self and teacher ratings separately and decrease reliance on differences scores. These methods have been recommended to answer complex questions related to agreement and disagreement between ratings. The results of this study suggest that some adolescents with ADHD symptoms demonstrate the PIB, while others perceive their impairments and rate themselves as having low competence aligned with teacher ratings. Accurate ratings of low competence were more common within the academic domain than the social domain for students with overall ADHD symptoms as well as specific inattentive and hyperactive/impulsive symptoms. Results within the social domain indicate that all ADHD symptoms increased more sharply as the discrepancy between self and teacher ratings increased. Student overestimation of competence in both the academic and social domains was shown to be more predictive of high inattentive symptoms compared to hyperactive/impulsive symptoms. These findings suggest this new analysis approach allowed for a more nuanced understanding of the complex relationship between student and teacher competence ratings and ADHD symptoms. Gaining a better understanding of the PIB through this improved methodology has the potential to influence assessment and intervention practices among school psychologists, and to contribute to future research in this area. This study contributes to the literature by being the first to (1) examine the PIB in relation to a range of general and specific ADHD symptoms, (2) use polynomial regression/response surface methods to address limitations of difference scores, and (3) explore the PIB among a school-based sample of adolescents.

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