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The Global ETD Search service is a free service for researchers
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Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 7 of 7 (0.082 seconds)Spelling suggestions: "subject:"densecore vesicles"" "subject:"densemble vesicles""
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Roles of Sec5 in the Regulation of Dense-Core Vesicle Secretion in PC12 CellsJiang, Tiandan T. J. 03 January 2011 (has links)
The exocyst is thought to tether secretory vesicles to specific sites on the plasma membrane. As a member of the exocyst, Sec5 is implicated in cell survival and membrane growth in Drosophila. Little is known of the exocyst function in mammals, with previous work suggesting involvement of exocyst in GTP-dependent exocytosis. Using RNA interference, we stably down-regulated Sec5 in PC12 cells. We found that these knockdown cells exhibit decreased GTP- and Ca2+-dependent exocytosis of dense-core vesicles (DCVs), and contain less proportion of docked vesicles. Expression of Sec6/8 is also slightly reduced in Sec5 knockdown cells. Our results suggest that Sec5 is involved in both GTP- and Ca2+-dependent exocytosis, possibly through the regulation of DCV docking. We also established doxycycline-inducible knockdown system for Sec5 in PC12 cells which may be more appropriate to study development-related proteins. Efforts were also made to re-introduce Sec5 into the Sec5 knockdown cells for rescue purposes.
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| 2 |
Roles of Sec5 in the Regulation of Dense-Core Vesicle Secretion in PC12 CellsJiang, Tiandan T. J. 03 January 2011 (has links)
The exocyst is thought to tether secretory vesicles to specific sites on the plasma membrane. As a member of the exocyst, Sec5 is implicated in cell survival and membrane growth in Drosophila. Little is known of the exocyst function in mammals, with previous work suggesting involvement of exocyst in GTP-dependent exocytosis. Using RNA interference, we stably down-regulated Sec5 in PC12 cells. We found that these knockdown cells exhibit decreased GTP- and Ca2+-dependent exocytosis of dense-core vesicles (DCVs), and contain less proportion of docked vesicles. Expression of Sec6/8 is also slightly reduced in Sec5 knockdown cells. Our results suggest that Sec5 is involved in both GTP- and Ca2+-dependent exocytosis, possibly through the regulation of DCV docking. We also established doxycycline-inducible knockdown system for Sec5 in PC12 cells which may be more appropriate to study development-related proteins. Efforts were also made to re-introduce Sec5 into the Sec5 knockdown cells for rescue purposes.
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Phosphorylation of Synaptotagmin 4 captures transiting dense core vesicles at active synapsesBharat, Vinita 26 April 2016 (has links)
No description available.
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Large Dense Core Vesicle Exocytosis in Mouse Chromaffin Cells is Regulated by Munc13s and Baiap3 / Munc13 Proteine und Baiap3 als Regulatoren der Exozytose von Large-Dense-Core-Vesikeln in Chromaffinzellen der MausShin, Yong 27 October 2008 (has links)
No description available.
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Souffle/Spastizin regulates secretory granule maturation by sorting lysosomal cargo from immature secretory granule during zebrafish oogenesisPalsamy, Kanagaraj 18 November 2014 (has links)
No description available.
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The role of UNC-108/RAB-2 in neuronal dense core vesicle maturation in C. elegans / Die Rolle von UNC-108/RAB-2 in der neuronalen Dense-Core-Vesikelreifung in C. elegansSumakovic, Marija 02 October 2009 (has links)
No description available.
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Dense-core vesicle maturation at the Golgi-endosomal interface in Caenorhabditis elegans / Reifung vonHannemann, Mandy 17 April 2012 (has links)
No description available.
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