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Lab-on-a-Chip systems and the associated micro-fabrication technologies have been around for almost three decades. However, the rapidly shifting technological landscape and the multidisciplinary nature of the engineering know-how have made it extremely difficult for a majority of these technologies to materialize to find applications and find commercial products. In order to address this gap, researchers worldwide have attempted to implement design automation paradigms typically used for VLSI engineering and apply them to these Lab-on-a-Chip. However, almost all of these efforts have been disconnected, resulting in a delayed/stalled application of algorithmic advances on real-world device design. FluigiCAD will allow the rapid application and integration of innovative ideas into a single cohesive workflow. / 2024-06-13T00:00:00Z

This thesis addresses the design of multiple description lattice vector quantizer (MDLVQ) with a general number L of descriptions, L >= 3. In the previous work on MDLVQ with L>= 3, once the central and side lattice codebooks are fixed, the decoding quality is determined for all numbers k of received descriptions. Therefore, it is not possible to achieve tradeoffs between the quality of reconstruction for different values of k, 1<= k <= L-1. In order to overcome the above drawback, we propose two flexible MDLVQ schemes for L >= 3. Our first design employs a different reconstruction method than in prior work and a heuristic index assignment algorithm, which uses L-2 parameters to control the distortions for 2 <= k <= L-1. Experimental results for the cases L=3 and L=4 show that significant tradeoffs are achieved by controlling the parameters mentioned above. Our second design is based on a structured index assignment. We start with the case L=3 and then generalize the index assignment to any L >= 3. The structured index assignment is able to control the tradeoff by adjusting the sizes of some L-1 subsets of side lattice points. Another important contribution of the thesis is the derivation of analytical expressions of the distortions for the structured index assignment, under the high resolution assumption. These expressions show that a wide range of distortion values can be achieved. / Thesis / Master of Applied Science (MASc)

<p> Architecture Description Languages were developed to support the abstract level of software structuring that is the subject matter of software architecture. CommUnity is an ADL built on co-ordination principles and a categorical framework to support the composition of specifications of components to form the system's specification. However, an important problem of CommUnity is the lack of support for specifying the system's architectural changes in both the set of components and the connections between them.</p> <p> This thesis presents DynaComm, an extension of CommUnity to support hierarchical design and dynamic reconfiguration of component based systems. Several new language constructs are introduced into DynaComm: subsystems are coarse grained components which are considered as the basic unit for the construction of systems, connectors encapsulate a component interaction pattern that can organize the possibly complicated interactions between the components of a subsystem. We also propose the idea of interface manager to solve the problem of incorrectly synchronized actions in CommUnity, and the concept of population manager to manage the live instances of components in a subsystem, through which we can model potentially complicated dynamic reconfigurations in a system.</p> <p> To use the semantics of CommUnity in defining the semantics of DynaComm, a "normalization" technique is introduced to transform the parameterized (indexed) actions into "normal" actions of CommUnity and reduce the specification of connectors and subsystems to flat CommUnity designs, so that we can derive the system's semantics in a certain state.</p> <p> Two illustrative examples, fault-tolerant dynamic client-server and vending machine systems, are also given to show the usage of DynaComm in modeling complicated and dynamic systems.</p> / Thesis / Master of Science (MSc)

Background: In the face of overwhelming need and increasingly scarce resources, the humanitarian charge of “saving lives and alleviating suffering” is often reduced to simply saving lives. In 2014, World Health Assembly Resolution 67.19 called for the strengthening of palliative care as a key component of comprehensive care. However, even when palliative care is the only available option (ie. 2014-2015 Ebola Crisis), there is little evidence showing it is available in the field. More research is needed to understand this dissonance between policy and practice, and to ensure that humanitarians are providing ethical and contextually appropriate care. Methodology: Twelve individual, in-depth, semi-structured interviews were conducted in English and French with humanitarian healthcare policy makers from North America, Europe, and the Middle East, average 10+ years of experience representing various international organizations. Interviews were transcribed and coded using NVivo11 and an interpretive description framework. Findings: Participant comments suggested the existence of an institutionalized rescue culture, characterized by the fear of failure, equating of death with failure of the humanitarian healthcare professional, and a resultant systemic devaluation of palliative- type care in disaster contexts. The indoctrination of this culture may begin as early as medical school, and manifests clearly in the lack of consistent nomenclature and awareness of palliative care, treatment of palliative-triaged individuals, and resources allocated to palliative care in humanitarian contexts. Palliative care provision is a moral obligation as a final bastion of the human right to dignity and to health. Discussion & Conclusion: In order for palliative care to be integrated into the humanitarian mandate, a significant cultural shift must first take place. The findings of this thesis and the larger Humanitarian Health Ethics study will provide key guidance for the adoption and adaptation of policies that help humanitarians maintain the dignity of individuals in their most vulnerable moments. / Thesis / Master of Science (MSc)

<p> This thesis studies the multiple description vector quantization with lattice codebooks (MDLVQ).</p> <p> The design of index assignment is crucial to the performance of MDLVQ. However, to our best knowledge, none of previous index assignment algorithms for MDLVQ is optimal. In this thesis, we propose a simple linear-time index assignment algorithm for MDLVQ with any K ≥ 2 balanced descriptions. We prove, under the assumption of high resolution, that the algorithm is optimal for K = 2. The optimality holds for many commonly used good lattices of any dimensions, over the entire range of achievable central distortions given the side entropy rate. The optimality is in terms of minimizing the expected distortion given the side description loss rate and given the side entropy rate. We conjecture it to be optimal for K > 2 in general.</p> <p> We also made progress in the analysis of MDLVQ performance. The first exact closed form expression of the expected distortion was derived for K = 2. For K > 2, we improved the current asymptotic expression of the expected distortion.</p> / Thesis / Master of Applied Science (MASc)

This thesis studies multicasting high bandwidth media traffic in wireless mesh networks (WMNs). Traditional multicast methods use a single multicast tree to reach all destinations, and adapt the multicast rate to the destination with the worst path quality. This approach does not fully utilize the network resources nor distinguish the quality of service (QoS) requirements of different users. It also penalizes the users having better path quality and requiring higher QoS. In multi-hop transmissions, the end-to-end transmission rate is limited by the link with the worst transmission conditions. This makes it difficult to multicast high-bandwidth media traffic with good quality. Using multiple description coding (MDC), the source traffic can be split into multiple sub-streams, referred to as descriptions, each of which requires a much lower bandwidth and can be transmitted along separate paths. In this thesis, we study routing and QoS provisioning jointly for multicasting multiple description (MD) encoded media traffic in WMNs. Routing for the multiple descriptions is jointly studied, while considering the channel quality of different links in the network and QoS at individual destinations. The work in this thesis is divided into two parts. The first part (Chapters 3 and 4) considers balanced descriptions, each of which contributes equally to the quality of the recovered media at a destination, and we study the problem of power efficient multicasting for the MD-encoded media traffic in WMNs. In Chapter 3, single-hop transmissions are considered. That is, the access points (APs) that store the source traffic communicate with the destination nodes directly. We study two problems jointly, description assignments and power allocations. The former is to assign a description for each AP to transmit, and the latter is to allocate the transmission power for the APs. Different power efficiency objectives are considered, subject to satisfying the QoS requirements of the destination nodes. For each objective, an optimization problem is formulated and heuristic solutions are proposed. Chapter 4 extends the work to multi-hop transmissions, where relay stations (RSs) are available to forward the traffic from the APs to the destinations. We consider two different routing structures based on whether an RS is allowed to forward more than one description. The objective is to minimize the total transmission power of the APs and the RSs in the network, subject to the QoS requirements of the destinations. An optimum problem is formulated and then translated to an integer and linear programming problem, and a centralized scheme with much lower complexity is proposed. Following that, a distributed scheme, referred to as minimum weight k-path scheme, is proposed, which builds one multicast tree for each description. By permitting only neighboring nodes to exchange related information, the scheme allows each node to find its best parent node based on the additional transmission power needed to establish the link. The second part (Chapter 5) of the thesis considers unbalanced descriptions. Routing for the multiple descriptions is jointly considered with application layer performance, so that the maximum distortion of recovered media at the destinations is minimized. An optimization problem is first formulated, and a centralized scheme with lower complexity is proposed. The centralized scheme first finds a set of candidate paths for each destination based on a predefined set of criteria, then it iteratively expands the multicast trees by only merging the paths that minimize the maximum distortion for all destinations. A distributed scheme is also proposed by modifying the minimum weight k-path scheme. In the modified scheme, each RS makes a local decision to join different multicast trees based on the expected distortion among its connected downstream nodes. The proposed multicasting schemes require much lower implementation complexity, compared to the optimum solutions. The centralized scheme is more suitable for small size networks, and achieves close-to-optimum performance for a wide range of parameter settings. The distributed scheme only requires neighboring nodes to exchange information, and can be implemented to networks with a relatively large number of APs, RSs, and destination nodes. / Thesis / Doctor of Philosophy (PhD)

Background & Purpose: Sustaining an acquired brain injury (ABI) can often lead to admission to an inpatient rehabilitation program. The purpose of inpatient rehabilitation is to provide individualized, patient-centered therapy in order to facilitate community re-integration. Considering the patient perspective is beneficial for informing patient-centered care because clinicians and program administrators may develop greater awareness and understanding of patient needs and preferences. There is a lack of qualitative research investigating patient experiences and perspectives of ABI inpatient rehabilitation, and the majority of existing research was conducted in non-Canadian contexts. The present study was thus designed to describe and interpret patient experiences of an ABI inpatient rehabilitation program in urban Ontario. The purpose was to contribute to a patient lens that inpatient rehabilitation staff could consider in their work. Methods: An interpretive description approach was adopted for this qualitative study. Twelve participants were purposively sampled from a regional ABI rehabilitation program. They completed semi-structured interviews about their experiences. Interviews were transcribed, coded, and analyzed to identify major themes. Results: Three major themes were identified from the analysis and arranged around three time points. At the time point prior to admission to inpatient rehabilitation, the theme was “Life Rerouted,” where participants described their lives being diverted from what was “normal” after sustaining an ABI. Inpatient rehabilitation was seen as a way to return to their pre-injury life. The second theme described experiences within inpatient rehabilitation and was entitled, “Autonomy within Rehab.” Under this theme, participants emphasized the importance of personal autonomy over their choices and abilities while in rehabilitation, with three related sub-themes: interactions with clinicians, perceptions of institutional policy, and the involvement of family members. Under a minor theme, not directly related to aspects of autonomy, entitled “social comparisons,” participants also made comparisons of their recovery progress to other patients. The third and final theme reflected participants experiences just after discharge and was entitled, “Life (and Recovery) Go On.” Under this theme, participants described an ongoing recovery process leading to sentiments of both frustration and hope for the future. Discussion: An overarching key message was developed from these themes: “re-establishing personal identity is important to the recovery process.” Two theories (biographical disruption and relational autonomy) are used to interpret this message and describe the strategies and perspectives adopted by patients during inpatient rehabilitation as they attempted to cope with the psychosocial impacts of ABI on their lives. Conclusions: The findings of this study provide knowledge and a theoretical lens in which program staff can view and understand patients’ experiences, needs and preferences. These findings may enhance patient-centered care within the context of ABI inpatient rehabilitation. / Thesis / Master of Science (MSc)

Though patient participation is recognized as an important element of rehabilitation, few studies have used a qualitative lens to specifically examine factors influencing patient-participation in stroke rehabilitation. Thus, the purpose of this work was to explore factors perceived by service users to influence their participation in hospital-based stroke rehabilitation activities and to use this information to generate knowledge relevant for the clinical context of stroke rehabilitation. The following research gaps provided rationale for this work: 1) no published studies from the patients’ perspective on influencers of participating in hospital-based stroke rehabilitation programs, and 2) limited studies about influences on participation in hospital-based stroke rehabilitation. The first manuscript (chapter two) was designed to specifically address these gaps while the second manuscript (chapter three) was developed to highlight important findings surrounding rehabilitation intensity from chapter two. This thesis has discussed a number of patient-perceived barriers and facilitators to participating in stroke rehabilitation, which the final chapter conceptualizes into a framework of personalized rehabilitation representing a patient-centred approach to providing rehabilitation that encourages patient participation. Together, this thesis contributes knowledge about: 1) patient perspectives on factors affecting participation in stroke rehabilitation, 2) promoting patient participation, 3) shortcomings in closing the evidence-to-practice gap with respect to therapy intensity during inpatient stroke rehabilitation, and 4) insights into an exploratory framework of personalized rehabilitation developed from service users’ perspectives of stroke rehabilitation. In addition, this work emphasizes a call to action for the delivery of user-centered stroke care, specifically in regard to rehabilitation intensity during inpatient stroke rehabilitation. The implications of this work are directed at stroke rehabilitation providers as well as policy makers and stroke health system planners in order to develop appropriate and effective services and strategies for optimal recovery and successful implementation of best practice recommendations. / Thesis / Master of Science (MSc) / Rehabilitation is a crucial part of recovery after stroke and patient participation is recognized as an important element of rehabilitation. A less explored perspective is patients’ experiences participating in stroke rehabilitation and barriers/facilitators to participation. This study interviewed individuals who participated in stroke rehabilitation to ask about factors influencing their participation. Eleven individuals were interviewed, and four key themes were identified as barriers and/or facilitators to patient-participation in stroke rehabilitation: 1) environmental factors, 2) components of therapy, 3) physical and emotional well-being, and 4) personal motivators. A sub-theme, amount of therapy, was explored further and this work draws attention to the rehabilitation intensity evidence-to-practice gap apparent as a prevalent issue in Canada and elsewhere. This exploration of patients’ experiences and factors perceived as influencing participation can help to shape the development of strategies to facilitate participation in rehabilitation and improve implementation of existing recommendations to maximize recovery after stroke.

<p>Two important deficiencies have been identified for the integration of CAD and automated process planning. These deficiencies stem from the lack of a uniform representation scheme of pans and products, and an effective communication for CAD and process planning. This thesis presents a new approach and original knowledge regarding the integration and individual aspects of feature-based design, cellular manufacturing planning, inspection planning and assembly sequence planning.</p> <p>A high-level new language called Feature-based Design Description Language (FDDL) has been proposed and designed with a feature representation scheme. Its syntax, semantics and vocabulary have been defined with consideration given to the user, the engineering terminology, and the computer implementation. The FDDL system consists of a number of lexical analyzers, a parser and three code generators. Once the products or parts modeled by the FDDL, or by a feature-based modeler, are processed using the FDDL system, inputs are created for manufacturing tasks planning systems.</p> <p>A feature-based modeling and manufacturing tasks planning system has been designed and implemented, and consists of a prototype of a feature-based modeler, the FDDL system, a feature-based cellular manufacturing planning system, a feature-based automated inspection task planner, and a prototype assembly sequence planner. The prototype feature-based modeler is used to model components using features. All expert tolerancing consultant module has been included in the modeler to assist the user. Cellular manufacturing planning deals with group formation and parts assignment to cells. A clustering-based optimization approach has been proposed and implemented for the formation of machine cells and part families. A feature-based assignment system has been developed to integrate the feature-based design and the formed cells. Automata and pattern recognition techniques, in combination with manufacturing knowledge, are used in the system. The feature-based inspection planner has been developed to integrate the feature-based design and a Coordinate Measuring Machine (CMM). Original inspection strategies and knowledge have been developed for CMM, based on the analysis of CMM characteristics, tolerancing theories, features representation, part structure and geometry. A knowledge-based approach has been presented to integrate CAD with the assembly sequence planning. A prototype of such an assembly sequence planner has been developed for generating the assembly sequence for products from the design directly.</p> / Doctor of Philosophy (PhD)