An association between compatible but ABO non-identical red blood cell (RBC) transfusions and increased in-hospital mortality was identified in an observational study. A review of the literature was performed to explore plausible biological mechanisms and inflammation was chosen. This thesis describes a body of work that was performed to develop a PICOT research question and design a pilot feasibility randomized crossover trial in patients with myelodysplastic syndrome (MDS) to determine whether there is evidence of an inflammatory response resulting from transfusion of ABO non-identical RBCs compared with the transfusion of ABO identical RBCs. The work undertaken as part of this thesis included: identifying a theoretical framework to guide the selection of outcome measures that would detect inflammation; identifying an appropriate and feasible population to study; designing the feasibility pilot study to answer the research question that was developed; and a discussion of ethical issues that were considered as the design of the pilot study was developed. The work that was done to develop the elements of PICOT resulted in the following research question: Is it feasible to perform a randomized crossover trial in chronically transfused blood group A patients with myelodysplastic syndrome (MDS), that looks for laboratory evidence of inflammation (in vitro biomarkers measured at baseline and pre-specified times between 1 and 96 hours post transfusion), following the transfusion of group O RBCs (ABO non-identical) compared to transfusion of group A (ABO identical) RBCs? / Thesis / Master of Science (MSc)

The purpose of this thesis is to detail my first professional costume design job after my unofficial graduation in May 2008. This thesis will serve primarily as a design thesis, and will concentrate the majority of its efforts in the presentation of a final, original costume design for a realized production of Sweeney Todd: The Demon Barber of Fleet Street as produced by Duke University. During the course of this presentation, I will seek to detail my own design process and the inspiration and research I used to achieve my goal. I will also discuss the execution of the design, problems that arose within, and my interactions with the shop, staff, and other members of the production team before summarizing my experience and discussing what I learned from the project, and what I took away from it personally.

Abstract: This project explores the ritual of leisure, social interaction, and reflection in a democratic* space. Water is the universal experience. The program for this site examines the ritual of bathing and the role of intimacy within a public domain. *democratic: absence of hereditary or arbitrary class distinctions or privileges

The first part of this masters thesis deals with research of modulat type hydraulics power units from other significant world producers. Design part of thesis contains complete design of three product ranges of hydraulics power units. It also includes simulation by FEM method. Last part descibe safety of machine and brief economic evaluation of product.

Humans were made to move. Many hours in front of a screen leads to stiff bodies and a diminished bodily awareness. The aim of this project was to explore how technology can serve to increase our body awareness and adapt to our physical conditions in everyday life with focus on office spaces. The study is explorative with a user-centered approach and a focus on embodied prototyping, where the user is a subject of design. Data was collected with recordings, interviews, and workshops. Reflexion-on-action, prototyping and iterations lead to the final outcome. The final concept is a wearable that encourage people to move and stretch out more often and spontaneously throughout the day. It does so by vibration patterns along your spine and shoulders. The idea of this concepts is to make people move often and regularly during the day; to react spontaneously to a reminder from the body, mediated by the vibrations. The system is thought to be self-awarding; if it feels good to stretch out, to extend the arms, to move – then you will want to do it again.