Thesis (M.Phil.) - University of Queensland, 2005. / Includes bibliography.

Thesis (PH. D.) - University of Michigan, 1943. / Reprinted from the Journal of immunology, vol. 47, no. 5, November, 1943. References: p. 423-424.

Class of 2014 Abstract / Specific Aims: Tetanus, diphtheria, and pertussis are diseases, which are preventable through proper vaccination. In spite of the availability these vaccines, however, there has recently been a surge in the number of pertussis cases in the United States. The objective of this study is to determine provider adherence to tetanus, diphtheria and pertussis guidelines set forth by the Advisory Committee on Immunization Practices in a primary care setting before and after a clinical pharmacist intervention. Methods: A retrospective cohort of chart reviews was conducted between January 1 – September 30, 2013 to determine immunization adherence to tetanus, diphteria, and pertussis vaccination guidelines. A clinical pharmacist then preformed a series of cross-sectional chart reviews as an intervention. Following the intervention, a retrospective chart review was conducted to evaluate if Tdap vaccination rates improved between March 17-23, 2014. Main Results: Overall immunization rates greatly improved following the intervention (p<0.0001; x2=44.988). For non-pregnant adults between the ages of 19-64 the vaccination rate improved from 26% to 61.1% (p<0.0001; x2=47.07). A statistically significant improvement was not seen in the groups with patients 65 or older or pregnant women (p>0.05). Tdap vaccination status was appropriately evaluated and vaccinations given by primary doctors improved from 17.7% to 61.2% and those prescribed by nurse practitioners improved from 22.4% to 56.3%. Conclusion: Intervention by a Clinical Pharmacist helped improve overall provider adherence to the tetanus, diphteria, and pertussis vaccination guidelines.

Thesis (Ph. D.)--Florida State University, 2005. / Advisor: Dr. Timothy M. Logan, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Sept. 14, 2005). Document formatted into pages; contains xix, 166 pages. Includes bibliographical references.

No description available.

Wermland was affected by the Spanish flu like the Swedish national average, about a half percentage of Wermlands population would lose their lives to the flu during the autumn 1918. The flu has for many fallen into oblivion. This oblivion is so wide spread that it´s possible to talk about a "collective forgetfulness". The society have selected to remember 1918 for "when the guns went quiet on the western front" and not for the millions who died from the treacherous Spanish flu. The world had already suffered enough from the four years of war that had been fought, thus the victims of the flu would be honored but would soon fade in to oblivion.   When you investigate deeper you get the picture that the national average don´t do Wermland and its cities or rural areas any justice when a large variations seems to occur within regional areas. One of Sweden's hardest effected cities was Kristinehamn and some miles north of this city you could find Kroppa rural county. This small county focused on iron works has two small central communities. Both of them had iron/tube mill owned by the same company, Storfors Bruk AB. During the autumn of 1918, Kroppa came in firsthand experience the Spanish flu and it´s expansion, which will get considerable effects how people in these areas could live their lives. As this wouldn´t be enough a diphtheria epidemic would also cause havoc and despair in Kroppa at the same time as the flu. The diphtheria will harvest new victims from a group that during the flu had been relative safe, the children. Even that Kroppa rural county experience a difficult period there behavior will prevent that fear are spread to the public.

Thesis (M.Sc. (Public Health))--Mahidol University, 1982.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Carta al editor. / Revisión por pares

A eficácia da associação quádrupla (DPT + BCG) foi estudada através da proteção e comparação da soro conversão das vacinas, usando como adjuvante o hidróxido de alumínio e ou BCG. A potência da vacina pertussis foi avaliada pelo teste de proteção em camundongos e o BCG pelo teste de consumo de oxigênio e de vitalidade, sendo considerada satisfatória. Sendo os toxóides diftérico e tetânico considerados proteínas inertes e estáveis, suas potências não foram determinadas depois de associadas. Os níveis de anticorpos foram determinados para difteria e tétano pela reação imunoenzimática, para vacina pertussis pela reação de imunofluorescência e para o BCG pela conversão tuberculínica. Os níveis de conversão foram satisfatórios, revelando ser possível a associação sem prejuízo para nenhum dos antígenos. A associação DPT + BCG não causou reação local ou geral significante, possibilitando uma simplificação operacional. / The efficacy of the quadruple association (DPT + BCG) was studied though protection and comparison ot the conversion serum in vaccines using aluminium hydroxide or BCG as adjuvant. Both the protection power of the Pertussis vaccine evaluated by the protection test in mice and BCG by the oxygen uptake and counts of viable particles were considered satisfactory. Being difteria and tetanus toxoids considered inert and stable proteins, their protection wasn\'t determined after their combination. The antibody levels produced by the antigens were determined by the enzyme-linked immunosorbent assay to the difteria and tetanus toxoids, by the fluorescent antibody technique to the Pertussis vaccine and by the tuberculin conversion to the BCG. The conversion levels were satisfatory and there was no damage in their association. There was no meaningful local or general reaction in this association making an operational simplification possible.

As we learn more about immune cell subpopulations, we find an increasingly complex system of cells with diverse functions. L2pB1 cells are a PD-L2 positive B1a B lymphocyte subpopulation that has unusual properties and characteristics that are not fully understood by many. By creating and implementing a transgenic mouse model that allows for targeted depletion of this specific group of cells, we can further elucidate their physiological functions and roles in both healthy and diseased states. Here we demonstrate the depletion of L2pB1 cells utilizing a transgenic mouse model expressing Diphtheria Toxin Receptors on their surface. After a course of 4 injections of 25ng of Diphtheria Toxin per gram bodyweight, we observed a successful depletion of L2pB1 cell population. Further studies are underway investigating the effects of a high fat diet on these L2pB1 depleted mice. / 2017-04-01T00:00:00Z