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Magister Public Health - MPH / Background: Childhood obesity is on the rise in South Africa (SA) and child-directed marketing (CDM) is one of the contributing factors to children’s unhealthy food choices and consumption. This study assessed CDM on pre-packaged breakfast cereals available in South African supermarkets and describe the nutrient composition of these pre-packaged products. Methods: A descriptive observational study of CDM on pre-packaged breakfast cereals was undertaken with quantitative analysis of the nutrient composition of these products. Secondary data from the “Researching obesogenic food environments in South Africa and Ghana” study in 2019 was examined. An independently reviewed codebook of definitions of CDM was developed and breakfast cereals were assessed to identify CDM. The CDM questionnaire was developed in REDCap, an online research database and data captured therein. Statistical Package for Social Sciences (SPSS) was used for cross tabulations and one-way ANOVAs. All analysis with p value < 0.05 was taken as significant.

“Anaphora” is a label used for a referential expression that connects one entity (e.g. a pronoun) to another previously established entity (e.g. a proper name). The previously established entity is called an antecedent. The use of anaphora will, in this study, be referred to as referential behaviour. The study was based around audio and video recordings of free play between a Swedish parent and his/her child. 10 parents and their children were recorded. The referential behaviour of the parents was analysed. The sessions took place when the children were 3, 6, 9 and 12 months old. Recent studies indicate that speech directed at children during a child's first six months contains a larger amount of pronouns than the speech directed at children between 6 and 12 months of age. The purpose of the study was to examine if the decline of pronouns was visible in Swedish child- directed speech, and to see how different types of anaphora appeared in the same speech. Correlations between the visible changes of different types of referential expressions were also examined. A drop in the use of anaphoric pronoun with an explicit antecedent was found for the last two ages, which confirmed the study’s hypothesis. The results were also compared to each child’s vocabulary development.

We investigate power graphs of quasigroups. The power graph of a quasigroup takes the elements of the quasigroup as its vertices, and there is an edge from one element to a second distinct element when the second is a left power of the first. We first compute the power graphs of small quasigroups (up to four elements). Next we describe quasigroups whose power graphs are directed paths, directed cycles, in-stars, out-stars, and empty. We do so by specifying partial Cayley tables, which cannot always be completed in small examples. We then consider sinks in the power graph of a quasigroup, as subquasigroups give rise to sinks. We show that certain structures cannot occur as sinks in the power graph of a quasigroup. More generally, we show that certain highly connected substructures must have edges leading out of the substructure. We briefly comment on power graphs of Bol loops.

The objective of this correlation study was to describe the association between the self-directed learning readiness (SDLR) and academic achievement among community college students enrolled in student success courses. Data were collected from a convenience sample of 35 community college students enrolled in student success seminar courses in central New Jersey. Total scores obtained from the administration of the Self-Directed Learning Readiness Scale (SDLRS) were used to measure participants’ degree of SDLR. Participants’ GPA and final student success course grade was used as metrics of academic achievement. Additional analyses were conducted to determine if participants’ age and gender changed the association between SDLRS score and academic achievement. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2020. / FAU Electronic Theses and Dissertations Collection

Technology is changing the face of both the sales and service domains. Honebein and Cammarano (2006) note that properly implemented self-service technologies serve dual purposes of decreasing firm overhead costs, while simultaneously engaging the customer in a way encourages the co-create of value for both parties. To get these benefits stakeholders must be willing to adopt and use the technologies that are available. Traditionally, this has lead to the research question "How do firms do this?" However, according to a recent article by Woodall, Colby and Parasuraman (2007), consumers are now demanding more technology-based options and becoming more technologically savvy. This changes the research focus to answering the question "How can firms be seen as able to deliver technology-based options effectively, efficiently and securely to meet the demands of this new "e-service" model?" The purpose of this dissertation is to examine the role of stakeholder perceptions of firm attitudes toward technology in answering this question. Perceived corporate affinity for technology (Fleming and Artis forthcoming) is a measure stakeholder perception of a firm's general positive affect toward technology, and was developed and validated in sales and services contexts using samples of both employees and customers. The studies of this dissertation test potential antecedents, consequence and boundary conditions of stakeholder perceptions of corporate affinity for technology in three key groups, namely managers, employees and customers. To accomplish this purpose, the following research questions, one for each key group of stakeholders, were proposed for this study: 1) Do manager perceptions of corporate affinity for technology influence employee perceptions of corporate affinity for technology?; 2) Do employee perceptions of corporate affinity for technology influence employee learning behavior?; 3) Do customer perceptions of corporate affinity for technology influence how they perceive the quality of the service delivery and their rating of other key customer service outcomes? Separate conceptual models were developed and tested to answer these questions.

Five models for designing work teams from the Work Group Design Measure (Campion & Medsker, 1992b) and the models7 relationships to effectiveness criteria were compared using 30 self-directed work teams (SDWTs) in a manufacturing/production setting of a large defense contractor. The models which are from social psychology, socio-technical systems theory, industrial engineering, and organizational psychology include Job Design, Composition, Context/Resources, Potency/Interdependence, and Process. The study also examined distinguishing demographics, team characteristics, and interpersonal processes within the teams that differentiate higher performing teams and/or teams with higher job satisfaction. Effectiveness criteria were performance and job satisfaction. Among the findings, four of the five team design models (i.e., excluding the Composition Model), and the team-oriented interpersonal group processes correlated with performance and SDWT member job satisfaction.

Montelukast (ML) is primarily an antagonist of type 1 cysteinyl leukotriene receptors (CysLT1R), an activity which underpins its therapeutic efficacy in bronchial asthma. However, ML has also been reported to be useful in the treatment of acute and chronic inflammatory disorders of both infective and non-infective origin in which CysLTs are unlikely to be the predominant mediators of harmful inflammatory responses. These include conditions such as chronic obstructive pulmonary disease and cystic fibrosis in which the neutrophil is believed to be the primary offender, suggesting that ML may possess neutrophil-targeted, CysLT1R-independent mechanisms of anti-inflammatory activity. Accordingly, the laboratory research presented in this thesis was designed with the primary objectives of characterizing possible CysLT1R-dependent and – independent neutrophil-targeted anti-inflammatory activities of ML in vitro, and consisted of 3 phases. These were investigation of: i) the effects of the CysLTs, LTC4 and LTD4 (in the absence and presence of ML) on mobilization of intracellular Ca2+ stores, generation of reactive oxygen species (ROS) and release of primary and secondary granule proteinases; ii) the effects of ML on a series of pro-inflammatory activities of neutrophils following activation of the cells with the chemoattractants FMLP and platelet-activating factor (PAF); and iii) the interactive, anti-inflammatory effects on neutrophils of ML in combination with the long-acting beta-2 agonist, formoterol. In addition to the aforementioned activities, measurement of the production and expression of CR3, as well as generation of inositol triphosphate (IP3), cyclic AMP, and activities of the enzymes cAMP- and cGMP-phosphodiesterases (PDEs) in isolated neutrophil cytosol and membrane fractions, were also included. The following assays were used: i) chemiluminescence procedures for the detection of ROS; ii) a colourimetric procedure for the detection of elastase; iii) ELISA procedures for the detection of the matrix metalloproteinases (MMPs) 8- and -9, LTB4, and cyclic AMP; iv) fura-2-based spectrofluorimetry and a radiometric procedure for monitoring cytosolic Ca2+ fluxes; v) flow cytometry for CR3; and vi) radioassays for IP3 and activity of cAMP- and cGMP-PDEs. Exposure of neutrophils to LTD4, but not LTC4, activated a very modest and transient increase in cytosolic Ca2+, but failed to initiate the generation of ROS or release of elastase or MMP-8. However, brief pre-treatment with either LTC4 or LTD4 sensitized the cells for increased production of ROS and release of granule proteinases following activation with FMLP, which was partially attenuated by inclusion of ML. In the second part of the study, pre-treatment of neutrophils with ML, at therapeutically relevant concentrations, resulted in dose-related inhibition of the FMLP- or PAF-activated generation of ROS and LTB4, as well as the release of elastase, with the former being unaffected by an inhibitor of 5-lipoxygenase (MK886), compatible with a CysLT1R-independent mechanism of anti-inflammatory activity. From a mechanistic perspective, these interactions of ML with neutrophils were associated with accelerated clearance of Ca2+ from the cytosol of the cells which could not be attributed to inhibition of production of IP3, but was, however, associated with increased levels of cAMP, apparently as a consequence of non- specific inhibition of cyclic nucleotide phosphodiesterases. In the third part of the study, combining ML with formoterol caused (in most cases) additive inhibitory effects on the generation of ROS and LTB4, release of granule proteinases, as well as expression of CR3, which again were associated with elevations in cAMP and interference with Ca2+ mobilization. In conclusion, ML appears to attenuate neutrophil activation by CysLT1R-dependent and –independent mechanisms. In the case of the former by interfering with the modest sensitizing (priming) interactions of LTC4 and LTD4 with neutrophils, and in the latter by inhibition of PDEs, leading a to sustained elevation in cAMP, resulting in rapid clearance of Ca2+ from the cytosol and decreased uptake of the cation from the extracellular milieu. / Thesis (PhD)--University of Pretoria, 2011. / Immunology / Unrestricted

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Finding a visually pleasing layout from a set of vertices and edges is the goal of automatic graph drawing. A requirement that has been barely explored however, is that users would like to specify portions of their layouts that are not altered by such algorithms. For example the user may have put a lot of manual effort into fixing a portion of a large layout and, while they would like an automatic layout applied to most of the layout, they do not want their work undone on the portion they manually fixed earlier. CluStic, the system developed and evaluated in this thesis, provides this capability. CluStic maintain the internal structure of a cluster by giving it priority over other elements in the graph. After high priority element has been positioned, non-priority vertices may be placed at the most appropriate remaining positions. Furthermore CluStic produces layouts which also maintain common aesthetic criteria: edge crossing minimization, layout height and edge straightening. Our method in this thesis is to first conduct an initial exploration study where we cross compare four industrial tools: Cytogate, GraphDraw, Diagram.Net and GraphNet. A set of layouts are generated with these tools and the user is timed on a task to identify the longest path. Through this exploration study we develop out intuition and determined that Cytogate is the best performing tool for longest path identification. Given this experience we fully develop CluStic and conduct our main study where we cross compare it with Cytogate and a baseline Breadth-first Search algorithm. Results show that CluStic produces drawings of good quality, Clustic achieves a visualization efficiency score of 1,4 which is an increase compared to the BFS layout (-3,8). CluStic is outperformed by Cytogate which achieves a visualization efficiency score of 1,9 and therefore produces less visually pleasing drawings. However Clustic, unlike Cytogate can preserve initial static structures, thus when a graph contains elements in which their position cannot be altered CluStic is a better choice. / Målet med automatiserad grafritning är att utifrån en uppsättning noder och kanter hitta en layout som är visuellt tillfredställande. Ett delområde som inte utforskats nog är möjligheten till att låsa vissa komponenter i grafen som sedan inte får alterneras av grafritningsalgoritmen. En användare som exempel, strukturerar vissa delar av grafen manuellt och applicerar sedan automatisk layout av resterande element utan att förstöra den struktur som manuellt skapats. CluStic, grafritningsverktyget som skapats och utvärderats i denna masters uppsats fyller denna funktion. CluStic bevarar den interna strukturen för ett kluster genom att tilldela en högre prioritet för noder i klustret med avseende på övriga element i grafen. Efter att högprioritets element placerats tilldelas resterande element sina bäst tillgängliga positioner. Utöver detta så uppfyller CluStic några av de vanligaste estetiska mål inom grafritning: minimera antalet kantkorsningar, minimera höjden, och räta ut kanter. Metoden som används i denna master uppsatts var att först gör en inledande studie där vi undersöker fyra populära grafritnings verktyg: Cytogate, GraphDraw, Diagram.Net och GraphNet. En uppsättning grafer genereras av dessa verktyg och vi mäter hur lång tid det tar för en användare att hitta den längsta vägen i grafen. Genom denna studie konstaterar vi att Cytogate presenterade grafer med best kvalitet. Från kunskap samlad i den inledande studien utvecklar vi CluStic och utför uppsatsens huvud studie där vi jämför CluStic med avseende på Cytogate och en bas layout Breddenförst algoritm. CluStic uppnår ett visualiserings effektivitetsvärde på 1,4 vilket är en ökning jämtemot Bredden-först algoritmen (-3,8). CluStic levererar inte layouter som är mer visuellt tillfredställande än de som skapats av Cytogate som får ett visualiserings effektivitetsvärde på 1,9. CluStic tillskillnad från Cytogate bevarar den internt fixa strukturen mellan element med hög prioritet vilket gör CluStic till det bättre verktyget för grafer med statiska element.